GB9014704D0 - Sustained release formulations of water soluble peptides - Google Patents

Sustained release formulations of water soluble peptides

Info

Publication number
GB9014704D0
GB9014704D0 GB909014704A GB9014704A GB9014704D0 GB 9014704 D0 GB9014704 D0 GB 9014704D0 GB 909014704 A GB909014704 A GB 909014704A GB 9014704 A GB9014704 A GB 9014704A GB 9014704 D0 GB9014704 D0 GB 9014704D0
Authority
GB
United Kingdom
Prior art keywords
water soluble
sustained release
release formulations
soluble peptides
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB909014704A
Other versions
GB2234896B (en
GB2234896A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB9014704D0 publication Critical patent/GB9014704D0/en
Publication of GB2234896A publication Critical patent/GB2234896A/en
Application granted granted Critical
Publication of GB2234896B publication Critical patent/GB2234896B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GB9014704A 1989-07-07 1990-07-03 Processes for the preparation of sustained release formulations of water soluble peptides Expired - Lifetime GB2234896B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37702389A 1989-07-07 1989-07-07
US41134789A 1989-09-22 1989-09-22

Publications (3)

Publication Number Publication Date
GB9014704D0 true GB9014704D0 (en) 1990-08-22
GB2234896A GB2234896A (en) 1991-02-20
GB2234896B GB2234896B (en) 1994-01-19

Family

ID=27007654

Family Applications (2)

Application Number Title Priority Date Filing Date
GB9014704A Expired - Lifetime GB2234896B (en) 1989-07-07 1990-07-03 Processes for the preparation of sustained release formulations of water soluble peptides
GB9306204A Expired - Lifetime GB2265311B (en) 1989-07-07 1993-03-25 Sustained release formulations of water soluble peptides

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB9306204A Expired - Lifetime GB2265311B (en) 1989-07-07 1993-03-25 Sustained release formulations of water soluble peptides

Country Status (27)

Country Link
JP (5) JPH0832624B2 (en)
KR (2) KR100303681B1 (en)
AT (1) AT406225B (en)
AU (2) AU641407B2 (en)
BE (1) BE1004486A3 (en)
CA (1) CA2020477C (en)
CH (1) CH685230A5 (en)
CY (1) CY1965A (en)
DE (2) DE4042752B4 (en)
DK (1) DK175849B1 (en)
FI (3) FI108611B (en)
FR (1) FR2649319A1 (en)
GB (2) GB2234896B (en)
GR (1) GR1001121B (en)
HK (2) HK97695A (en)
HU (2) HU221294B1 (en)
IE (2) IE64411B1 (en)
IL (3) IL131880A (en)
IT (1) IT1241460B (en)
LU (1) LU87764A1 (en)
MY (1) MY106722A (en)
NL (1) NL195027C (en)
NO (2) NO302928B1 (en)
NZ (1) NZ234384A (en)
PT (1) PT94628B (en)
SE (1) SE512992C2 (en)
SG (1) SG26416G (en)

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US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
DE4218510A1 (en) * 1992-06-02 1993-12-09 Pharmatech Gmbh Process for the preparation of biodegradable polyesters
AU4198793A (en) † 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
JP2944419B2 (en) * 1993-05-10 1999-09-06 ノバルティス アクチエンゲゼルシャフト Stability of pharmacologically active ingredients in sustained release compositions
GB9310781D0 (en) * 1993-05-25 1993-07-14 Davis Stanley S Preparation of microparticles
US5603960A (en) * 1993-05-25 1997-02-18 O'hagan; Derek T. Preparation of microparticles and method of immunization
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US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
AU717113B2 (en) 1995-11-09 2000-03-16 Health Protection Agency Microencapsulated DNA for vaccination and gene therapy
DE19545257A1 (en) 1995-11-24 1997-06-19 Schering Ag Process for the production of morphologically uniform microcapsules and microcapsules produced by this process
US5817343A (en) * 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
GB9810236D0 (en) * 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6226656B1 (en) 1998-11-12 2001-05-01 Sourcefinder, Inc. System and method for creating, generating and processing user-defined generic specs
US7107268B1 (en) 1998-11-12 2006-09-12 Printable Technologies, Inc. Centralized system and method for managing enterprise operations
US6204308B1 (en) 1999-03-01 2001-03-20 Novartis Ag Organic compounds
EP1044683A1 (en) * 1999-04-15 2000-10-18 Debio Recherche Pharmaceutique S.A. One-step dispersion method for the microencapsulation of water soluble substances
US6461631B1 (en) * 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
KR100392501B1 (en) * 2000-06-28 2003-07-22 동국제약 주식회사 Preparation Method for Sustained Release Microparticles by Multiple Emulsion Method and Micropartic les Thereof
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
AU2002235253A1 (en) 2000-12-21 2002-07-01 Inhale Therapeutic Systems, Inc. Induced phase transition method for the production of microparticles containing hydrophilic active agents
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
AR044852A1 (en) * 2003-06-24 2005-10-05 Novartis Ag A PHARMACEUTICAL COMPOSITION FOR PARENTERAL ADMINISTRATION THAT INCLUDES A SOMATOSTATINE ANALOG
DK1660039T3 (en) * 2003-07-18 2017-01-16 Oakwood Laboratories L L C PREVENTION OF REDUCTION OF THE POLYMER MOLECULE WEIGHT, THE PREPARATION OF PURPOSES AND GELING IN POLYMER COMPOSITIONS
MY158342A (en) 2003-11-14 2016-09-30 Novartis Ag Pharmaceutical composition
CN1921880A (en) * 2004-02-26 2007-02-28 独立行政法人科学技术振兴机构 Protein drug sustained-release microparticle preparation for injection and process for producing the same
DE102004053373A1 (en) * 2004-11-02 2006-05-04 Justus-Liebig-Universität Giessen Invention relating to nano / meso-fiber anisometric particles in the form of nano / meso-fiber tubes, cables and their curved or branched modifications
KR100741867B1 (en) * 2005-07-05 2007-07-24 전북대학교산학협력단 Preparation method of double-layered sphere using oil-in-water and solvent evaporation
PL1968549T3 (en) * 2005-12-22 2014-10-31 Novartis Ag Sustained release formulation comprising octreotide and two or more polylactide-co-glycolide polymers
KR100816065B1 (en) * 2006-11-27 2008-03-24 동국제약 주식회사 Preparation method of sustained-release microcapsules having good initial burst inhibiting property and the microcapsules thereby
KR101921800B1 (en) 2008-01-30 2018-11-23 노파르티스 아게 Sustained release formulation comprising octreotide and three linear polylactide-co-glycolide polymers
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
CA2813301A1 (en) * 2010-09-30 2012-04-05 Evonik Corporation Method for removing residual organic solvent from microparticles
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Also Published As

Publication number Publication date
GR1001121B (en) 1993-04-28
NO302928B1 (en) 1998-05-11
ATA144090A (en) 1999-08-15
FR2649319B1 (en) 1994-12-09
CA2020477C (en) 2000-11-21
NL9001537A (en) 1991-02-01
AU641407B2 (en) 1993-09-23
GB2265311B (en) 1994-02-09
NO903001D0 (en) 1990-07-05
GB2265311A (en) 1993-09-29
HU903974D0 (en) 1990-11-28
DE4042752B4 (en) 2009-05-07
IE902435A1 (en) 1991-02-13
KR910002430A (en) 1991-02-25
IL131881A (en) 2001-12-23
FI20000059A (en) 2000-01-12
JPH08198771A (en) 1996-08-06
AU2332195A (en) 1995-09-07
DK175849B1 (en) 2005-03-29
JPH0832624B2 (en) 1996-03-29
CA2020477A1 (en) 1991-01-08
HU221294B1 (en) 2002-09-28
AU5874690A (en) 1991-01-10
IL131880A (en) 2001-12-23
CY1965A (en) 1997-07-04
KR100442931B1 (en) 2004-08-02
AT406225B (en) 2000-03-27
KR100303681B1 (en) 2002-05-16
JP2001233897A (en) 2001-08-28
FI108611B (en) 2002-02-28
GB2234896B (en) 1994-01-19
FI109543B (en) 2002-08-30
NO320444B1 (en) 2005-12-05
BE1004486A3 (en) 1992-12-01
MY106722A (en) 1995-07-31
LU87764A1 (en) 1992-03-11
NL195027B (en) 2003-08-01
AU687553B2 (en) 1998-02-26
IL94983A (en) 1999-08-17
IE64216B1 (en) 1995-07-26
HUT54037A (en) 1991-01-28
SE9002364L (en) 1991-01-08
FI20000060A (en) 2000-01-12
SG26416G (en) 1995-09-01
IT9048113A0 (en) 1990-07-05
PT94628A (en) 1991-03-20
JP2931773B2 (en) 1999-08-09
IL94983A0 (en) 1991-06-10
HK97695A (en) 1995-06-23
JPH0368511A (en) 1991-03-25
DK162590A (en) 1991-01-08
DE4021517A1 (en) 1991-01-17
CH685230A5 (en) 1995-05-15
NO983923D0 (en) 1998-08-26
GB9306204D0 (en) 1993-05-19
IT1241460B (en) 1994-01-17
FR2649319A1 (en) 1991-01-11
NL195027C (en) 2003-12-02
PT94628B (en) 1997-06-30
FI903429A0 (en) 1990-07-06
NO983923L (en) 1991-01-08
DE4021517B4 (en) 2009-04-09
DK162590D0 (en) 1990-07-05
JPH07309897A (en) 1995-11-28
IT9048113A1 (en) 1992-01-05
IE64411B1 (en) 1995-08-09
NO903001L (en) 1991-01-08
SE512992C2 (en) 2000-06-12
SE9002364D0 (en) 1990-07-05
HK197496A (en) 1996-11-08
GB2234896A (en) 1991-02-20
NZ234384A (en) 1994-05-26
HU211602A9 (en) 1995-12-28
GR900100513A (en) 1991-12-10
FI109334B (en) 2002-07-15
JPH07285853A (en) 1995-10-31

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