NL195027B - Werkwijze voor het bereiden van microdeeltjes voor langzame afgifte van in water oplosbare peptiden en preparaten daarvan. - Google Patents

Werkwijze voor het bereiden van microdeeltjes voor langzame afgifte van in water oplosbare peptiden en preparaten daarvan.

Info

Publication number
NL195027B
NL195027B NL9001537A NL9001537A NL195027B NL 195027 B NL195027 B NL 195027B NL 9001537 A NL9001537 A NL 9001537A NL 9001537 A NL9001537 A NL 9001537A NL 195027 B NL195027 B NL 195027B
Authority
NL
Netherlands
Prior art keywords
preparations
water
slow release
soluble peptides
preparing microparticles
Prior art date
Application number
NL9001537A
Other languages
English (en)
Other versions
NL9001537A (nl
NL195027C (nl
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NL9001537A publication Critical patent/NL9001537A/nl
Publication of NL195027B publication Critical patent/NL195027B/nl
Priority to NL9900037A priority Critical patent/NL195092C/nl
Priority to NL9900038A priority patent/NL195089C/nl
Priority to NL9900039A priority patent/NL195090C/nl
Application granted granted Critical
Publication of NL195027C publication Critical patent/NL195027C/nl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
NL9001537A 1989-07-07 1990-07-05 Werkwijze voor het bereiden van microdeeltjes voor langzame afgifte van in water oplosbare peptiden en preparaten daarvan. NL195027C (nl)

Priority Applications (3)

Application Number Priority Date Filing Date Title
NL9900037A NL195092C (nl) 1989-07-07 2003-08-19 Preparaten van in water oplosbare peptiden met een langzame afgifte.
NL9900038A NL195089C (nl) 1989-07-07 2003-08-19 Preparaten van in water oplosbare peptiden met een langzame afgifte.
NL9900039A NL195090C (nl) 1989-07-07 2003-08-19 Preparaten van in water oplosbare peptiden met een langzame afgifte.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37702389A 1989-07-07 1989-07-07
US37702389 1989-07-07
US41134789A 1989-09-22 1989-09-22
US41134789 1989-09-22

Publications (3)

Publication Number Publication Date
NL9001537A NL9001537A (nl) 1991-02-01
NL195027B true NL195027B (nl) 2003-08-01
NL195027C NL195027C (nl) 2003-12-02

Family

ID=27007654

Family Applications (1)

Application Number Title Priority Date Filing Date
NL9001537A NL195027C (nl) 1989-07-07 1990-07-05 Werkwijze voor het bereiden van microdeeltjes voor langzame afgifte van in water oplosbare peptiden en preparaten daarvan.

Country Status (27)

Country Link
JP (5) JPH0832624B2 (nl)
KR (2) KR100303681B1 (nl)
AT (1) AT406225B (nl)
AU (2) AU641407B2 (nl)
BE (1) BE1004486A3 (nl)
CA (1) CA2020477C (nl)
CH (1) CH685230A5 (nl)
CY (1) CY1965A (nl)
DE (2) DE4021517B4 (nl)
DK (1) DK175849B1 (nl)
FI (3) FI108611B (nl)
FR (1) FR2649319A1 (nl)
GB (2) GB2234896B (nl)
GR (1) GR1001121B (nl)
HK (2) HK97695A (nl)
HU (2) HU221294B1 (nl)
IE (2) IE64411B1 (nl)
IL (3) IL131881A (nl)
IT (1) IT1241460B (nl)
LU (1) LU87764A1 (nl)
MY (1) MY106722A (nl)
NL (1) NL195027C (nl)
NO (2) NO302928B1 (nl)
NZ (1) NZ234384A (nl)
PT (1) PT94628B (nl)
SE (1) SE512992C2 (nl)
SG (1) SG26416G (nl)

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PE20050285A1 (es) * 2003-06-24 2005-06-09 Novartis Ag Composicion farmaceutica que comprende analogos ciclicos de somatostatina
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MY158342A (en) 2003-11-14 2016-09-30 Novartis Ag Pharmaceutical composition
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DE102004053373A1 (de) * 2004-11-02 2006-05-04 Justus-Liebig-Universität Giessen Erfindung betreffend anisometrische Partikel in Form von Nano-/Meso-Fasern -Röhren, -Kabeln -Bändern und deren gekrümmte oder verzweigte Abwandlungen
KR100741867B1 (ko) * 2005-07-05 2007-07-24 전북대학교산학협력단 수중유적 및 용매 증발법을 이용한 이중층 미립구의제조방법
CA2631811C (en) * 2005-12-22 2017-06-20 Novartis Ag Sustained release formulation comprising octreotide and two or more polylactide-co-glycolide polymers
KR100816065B1 (ko) 2006-11-27 2008-03-24 동국제약 주식회사 초기 방출억제 특성이 우수한 서방출성 마이크로캡슐의제조방법 및 이에 의해 제조되는 마이크로캡슐
EP2247282B1 (en) 2008-01-30 2014-08-20 Novartis AG Sustained release formulation comprising octreotide and three linear polylactide-co-glycolide polymers
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KR102464650B1 (ko) 2016-05-03 2022-11-10 엘에스일렉트릭(주) 배선용 차단기의 한류장치
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Also Published As

Publication number Publication date
GB2234896A (en) 1991-02-20
FI109334B (fi) 2002-07-15
FI20000060A (fi) 2000-01-12
AU687553B2 (en) 1998-02-26
JP2931773B2 (ja) 1999-08-09
CA2020477C (en) 2000-11-21
JPH07285853A (ja) 1995-10-31
NO302928B1 (no) 1998-05-11
GR1001121B (el) 1993-04-28
GB2265311A (en) 1993-09-29
FR2649319B1 (nl) 1994-12-09
AT406225B (de) 2000-03-27
DK162590D0 (da) 1990-07-05
CY1965A (en) 1997-07-04
IT9048113A0 (it) 1990-07-05
FR2649319A1 (fr) 1991-01-11
JPH0832624B2 (ja) 1996-03-29
SG26416G (en) 1995-09-01
HU903974D0 (en) 1990-11-28
DE4021517B4 (de) 2009-04-09
IE64411B1 (en) 1995-08-09
NO903001L (no) 1991-01-08
NL9001537A (nl) 1991-02-01
GB9014704D0 (en) 1990-08-22
CA2020477A1 (en) 1991-01-08
LU87764A1 (fr) 1992-03-11
FI108611B (fi) 2002-02-28
FI20000059A (fi) 2000-01-12
IT1241460B (it) 1994-01-17
KR910002430A (ko) 1991-02-25
NO903001D0 (no) 1990-07-05
GR900100513A (en) 1991-12-10
NO983923D0 (no) 1998-08-26
AU641407B2 (en) 1993-09-23
JPH07309897A (ja) 1995-11-28
IE902435A1 (en) 1991-02-13
GB9306204D0 (en) 1993-05-19
MY106722A (en) 1995-07-31
JP2001233897A (ja) 2001-08-28
NO320444B1 (no) 2005-12-05
KR100442931B1 (ko) 2004-08-02
IL131881A (en) 2001-12-23
IE64216B1 (en) 1995-07-26
HK97695A (en) 1995-06-23
JPH0368511A (ja) 1991-03-25
SE512992C2 (sv) 2000-06-12
PT94628B (pt) 1997-06-30
CH685230A5 (de) 1995-05-15
HK197496A (en) 1996-11-08
DK175849B1 (da) 2005-03-29
AU5874690A (en) 1991-01-10
AU2332195A (en) 1995-09-07
HUT54037A (en) 1991-01-28
GB2234896B (en) 1994-01-19
SE9002364L (sv) 1991-01-08
NL195027C (nl) 2003-12-02
JPH08198771A (ja) 1996-08-06
IL94983A0 (en) 1991-06-10
SE9002364D0 (sv) 1990-07-05
DE4021517A1 (de) 1991-01-17
GB2265311B (en) 1994-02-09
IL94983A (en) 1999-08-17
PT94628A (pt) 1991-03-20
IL131880A (en) 2001-12-23
IT9048113A1 (it) 1992-01-05
ATA144090A (de) 1999-08-15
FI903429A0 (fi) 1990-07-06
DE4042752B4 (de) 2009-05-07
KR100303681B1 (ko) 2002-05-16
HU221294B1 (en) 2002-09-28
NZ234384A (en) 1994-05-26
DK162590A (da) 1991-01-08
HU211602A9 (en) 1995-12-28
BE1004486A3 (fr) 1992-12-01
FI109543B (fi) 2002-08-30
NO983923L (no) 1991-01-08

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