DE3051175C2 - - Google Patents

Info

Publication number
DE3051175C2
DE3051175C2 DE3051175A DE3051175A DE3051175C2 DE 3051175 C2 DE3051175 C2 DE 3051175C2 DE 3051175 A DE3051175 A DE 3051175A DE 3051175 A DE3051175 A DE 3051175A DE 3051175 C2 DE3051175 C2 DE 3051175C2
Authority
DE
Germany
Prior art keywords
monacolin
colony
days
culture medium
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3051175A
Other languages
German (de)
English (en)
Inventor
Akira Tokio/Tokyo Jp Endo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of DE3051175C2 publication Critical patent/DE3051175C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE3051175A 1979-02-20 1980-02-20 Expired DE3051175C2 (US06312121-20011106-C00051.png)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54017856A JPS5925599B2 (ja) 1979-02-20 1979-02-20 新生理活性物質モナコリンｋおよびその製造法

Publications (1)

Publication Number Publication Date
DE3051175C2 true DE3051175C2 (US06312121-20011106-C00051.png) 1989-12-21

Family

ID=11955290

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3051175A Expired DE3051175C2 (US06312121-20011106-C00051.png) 1979-02-20 1980-02-20
DE3006216A Expired DE3006216C2 (de) 1979-02-20 1980-02-20 Monacolin K, Verfahren zu dessen Herstellung und diese Verbindung enthaltende Arzneimittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE3006216A Expired DE3006216C2 (de) 1979-02-20 1980-02-20 Monacolin K, Verfahren zu dessen Herstellung und diese Verbindung enthaltende Arzneimittel

Country Status (27)

Country Link
JP (1) JPS5925599B2 (US06312121-20011106-C00051.png)
KR (1) KR830002801B1 (US06312121-20011106-C00051.png)
AT (1) AT373915B (US06312121-20011106-C00051.png)
AU (1) AU532626B2 (US06312121-20011106-C00051.png)
BE (1) BE881825A (US06312121-20011106-C00051.png)
CA (1) CA1129794A (US06312121-20011106-C00051.png)
CH (1) CH645890A5 (US06312121-20011106-C00051.png)
DD (1) DD154494A5 (US06312121-20011106-C00051.png)
DE (2) DE3051175C2 (US06312121-20011106-C00051.png)
DK (2) DK149095C (US06312121-20011106-C00051.png)
ES (1) ES488796A0 (US06312121-20011106-C00051.png)
FI (1) FI66427C (US06312121-20011106-C00051.png)
FR (1) FR2449685B1 (US06312121-20011106-C00051.png)
GB (1) GB2046737B (US06312121-20011106-C00051.png)
HU (1) HU182069B (US06312121-20011106-C00051.png)
IE (1) IE49743B1 (US06312121-20011106-C00051.png)
IT (1) IT1175260B (US06312121-20011106-C00051.png)
MX (1) MX6314E (US06312121-20011106-C00051.png)
NL (1) NL191540C (US06312121-20011106-C00051.png)
NO (1) NO153974C (US06312121-20011106-C00051.png)
NZ (1) NZ192919A (US06312121-20011106-C00051.png)
PH (1) PH15145A (US06312121-20011106-C00051.png)
PL (1) PL124304B1 (US06312121-20011106-C00051.png)
SE (1) SE453301B (US06312121-20011106-C00051.png)
SG (1) SG6784G (US06312121-20011106-C00051.png)
SU (2) SU1158048A3 (US06312121-20011106-C00051.png)
ZA (1) ZA80962B (US06312121-20011106-C00051.png)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7238348B2 (en) 1996-09-30 2007-07-03 Beijing Peking University Wbl Corporation Ltd. Method of treatment of osteoporosis with compositions of red rice fermentation products
WO2010069593A1 (en) 2008-12-19 2010-06-24 Krka, D. D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
JPS5621594A (en) * 1979-07-27 1981-02-28 Sankyo Co Ltd Mb-530b carboxylic acid metal salt and its preparation
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
JPH0692381B2 (ja) * 1980-03-31 1994-11-16 三共株式会社 Ｍｂ−５３０ａ誘導体
JPS56142236A (en) 1980-04-08 1981-11-06 Sankyo Co Ltd Ml-236a and mb-530a derivative
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
JPS5835144A (ja) * 1981-08-27 1983-03-01 Sankyo Co Ltd Ｍｂ−５３０ｂ誘導体およびその製造法
US4782084A (en) * 1987-06-29 1988-11-01 Merck & Co., Inc. HMG-COA reductase inhibitors
US4997848A (en) * 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
CA2062023A1 (en) * 1992-02-10 1993-08-11 Jagroop S. Dahiya Novel fungal strains and use thereof in antibiotic production
WO1993017991A1 (en) * 1992-03-04 1993-09-16 Fujisawa Pharmaceutical Co., Ltd. TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS
NZ247617A (en) 1992-05-15 1995-07-26 Sankyo Co Octahydronaphthalene oxime derivatives and pharmaceutical compositions
US6812007B1 (en) * 1992-11-04 2004-11-02 Keri Vilmos Process for the isolation and purification of mevinolin
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5409820A (en) * 1993-08-06 1995-04-25 Apotex, Inc. Process for the production of lovastatin using Coniothyrium fuckelii
US6046022A (en) 1996-09-30 2000-04-04 Peking University Methods and compositions employing red rice fermentation products
AU753564B2 (en) 1998-03-20 2002-10-24 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid
WO2001062949A1 (en) 2000-02-24 2001-08-30 Biogal Gyogyszergyar Rt Method of purifying a fermentation broth
TR200403001T3 (tr) 2000-03-03 2005-02-21 Plus Chemical, S.A. Lovastatin ve simvastatinin, azaltılmış dimerik katışkı seviyelerine sahip olacak şekilde arıtılması için bir işlem
KR20010095780A (ko) * 2000-04-12 2001-11-07 나가오카 마사시 배아 홍국
IN192861B (US06312121-20011106-C00051.png) 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
WO2002063976A1 (en) 2001-02-09 2002-08-22 Unilever N.V. Food product comprising soy protein and statins
KR100379075B1 (en) 2002-03-07 2003-04-08 Jinis Biopharmaceuticals Co Method for producing low cholesterol animal food product and food product therefrom
KR20020093147A (ko) * 2002-05-30 2002-12-13 지니스생명공학 주식회사 성인병 예방 및 치료 보조제
KR100710500B1 (ko) 2005-05-18 2007-04-24 고려대학교 산학협력단 홍국균을 이용한 모나콜린 ｋ 생산방법
RO128803A0 (ro) 2012-10-12 2013-09-30 Ion Gigel Fulga Compoziţie pentru tratamentul sau prevenirea dislipidemiilor
CN110331151A (zh) * 2019-04-11 2019-10-15 北京工商大学 紫色红曲菌mokH基因过表达菌株的构建方法
CN111297938A (zh) * 2020-03-11 2020-06-19 北京康立生医药技术开发有限公司 一种辅助降血脂组合物中洛伐他汀的检测方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1453425A (en) * 1974-06-07 1976-10-20 Sankyo Co 2-oxo-tetrahydropyran derivatives and fermentative process for producing the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
AU535944B2 (en) * 1979-06-15 1984-04-12 Merck & Co., Inc. Hypocholestermic fermentation products from aspergillus

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1453425A (en) * 1974-06-07 1976-10-20 Sankyo Co 2-oxo-tetrahydropyran derivatives and fermentative process for producing the same

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7238348B2 (en) 1996-09-30 2007-07-03 Beijing Peking University Wbl Corporation Ltd. Method of treatment of osteoporosis with compositions of red rice fermentation products
WO2010069593A1 (en) 2008-12-19 2010-06-24 Krka, D. D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates

Also Published As

Publication number Publication date
FI66427B (fi) 1984-06-29
CA1129794A (en) 1982-08-17
DK149095C (da) 1986-06-16
AT373915B (de) 1984-03-12
GB2046737A (en) 1980-11-19
ZA80962B (en) 1981-03-25
IE800321L (en) 1980-08-20
NO153974C (no) 1986-06-25
AU5567380A (en) 1980-08-28
DK149095B (da) 1986-01-20
DE3006216A1 (de) 1980-09-04
IT1175260B (it) 1987-07-01
AU532626B2 (en) 1983-10-06
DK73080A (da) 1980-08-21
HU182069B (en) 1983-12-28
NL8001041A (nl) 1980-08-22
FR2449685B1 (fr) 1985-06-28
MX6314E (es) 1985-04-01
IT8067262A0 (it) 1980-02-20
NZ192919A (en) 1984-07-06
CH645890A5 (de) 1984-10-31
SG6784G (en) 1985-02-08
GB2046737B (en) 1983-01-12
JPS5925599B2 (ja) 1984-06-19
KR830002801B1 (ko) 1983-12-16
BE881825A (fr) 1980-08-20
SU1158048A3 (ru) 1985-05-23
IE49743B1 (en) 1985-12-11
PL222120A1 (US06312121-20011106-C00051.png) 1980-10-20
NO153974B (no) 1986-03-17
FI66427C (fi) 1984-10-10
NL191540B (nl) 1995-05-01
NL191540C (nl) 1995-09-04
KR830002030A (ko) 1983-05-21
ES8103171A1 (es) 1981-02-16
NO800451L (no) 1980-08-21
JPS55111790A (en) 1980-08-28
PL124304B1 (en) 1983-01-31
PH15145A (en) 1982-08-24
SE8001339L (sv) 1980-08-21
SE453301B (sv) 1988-01-25
SU969702A1 (ru) 1982-10-30
ES488796A0 (es) 1981-02-16
DD154494A5 (de) 1982-03-24
DE3006216C2 (de) 1985-10-31
FR2449685A1 (fr) 1980-09-19
DK21889D0 (da) 1989-01-18
DK21889A (da) 1989-01-18
ATA92980A (de) 1983-07-15
FI800506A (fi) 1980-08-21

Similar Documents

Publication Publication Date Title
DE3051175C2 (US06312121-20011106-C00051.png)
DE69422526T2 (de) Polyzyklische antiparasitäre derivate, verfahren und stamm zu ihrer herstellung und ihrer verwendung
DE3006215C2 (US06312121-20011106-C00051.png)
DE2509820A1 (de) Aculeacin-antibiotika
DE68910213T2 (de) Antibiotikum R106.
DE68928606T2 (de) Antiparasitäre Makrolid-Antibiotika
DE3028284A1 (de) Monacolin k-derivate, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel
DD153834A5 (de) Verfahren zur herstellung eines neuen faktors von antibiotikum a-30912
DE2715255B2 (de) Anthracyclinglykoside MA 144-M1 und MA 144-M2 und deren Salze, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
DE69526452T2 (de) Indolditerpen alkaloide
DE3243924C2 (US06312121-20011106-C00051.png)
DE2921148A1 (de) Neue metaboliten, ihre herstellung und verwendung
DE3247175A1 (de) Dihydro- und tetrahydromonacolin l, ihre metallsalze und alkylester sowie verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE69218067T2 (de) Verfahren zur Herstellung von 3-deacylierten Derivaten eines 16-gliedrigen Macrolid-Antibiotikums, hierfür verwendeter Mikroorganismus, sowie neues Macrolid-Antibiotikum
DE2839668A1 (de) Als antibiotika wirksame saframycine a, b, c, d und e und verfahren zu ihrer herstellung
DE69718141T2 (de) Fungizid
DE2316429A1 (de) Verfahren zur herstellung eines neuen metaboliten
DE3889213T2 (de) Antibiotika NK 86-0279, deren Verfahren zur Herstellung und deren Benutzung.
DE3881566T2 (de) Antitumor-derivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
DE1617346A1 (de) 3'-Chlor-5,2'-dihydroxy-3,7,8-trimethoxy-flavon und Verfahren zu seiner Herstellung auf biologischem Wege
DE69002337T2 (de) Antibiotikum NK130119, Verfahren zu dessen Herstellung und Verwendung.
DE2510868C3 (de) Nanaomycin A und Verfahren zur Herstellung der Antibiorica Nanaomycin A und Nanaomycin B
DE3312502A1 (de) Physiologisch aktive substanzen ss 12538, ihre herstellung und neuer mikroorganismus zu ihrer herstellung
AT361619B (de) Verfahren zur herstellung von neuen antibiotika
DE1039198B (de) Verfahren zur Herstellung und Gewinnung von Antibiotika

Legal Events

Date Code Title Description
Q369 Divided out of:

Ref document number: 3006216

Country of ref document: DE

8110 Request for examination paragraph 44
8125 Change of the main classification

Ipc: C07D309/30

AC Divided out of

Ref country code: DE

Ref document number: 3006216

Format of ref document f/p: P

D2 Grant after examination
8364 No opposition during term of opposition
V448 Application of spc

Free format text: PRODUCT NAME: LOVASTATIN; REGISTRATION NO/DATE: 15971.00.00, 15971.01.00, 15971.02.00, 15974.00.00,15974.01.00, 15974.02.00; 19890223

Spc suppl protection certif: 193 75 044

Filing date: 19930618

V457 Spc granted

Free format text: PRODUCT NAME: LOVASTATIN; REGISTRATION NO/DATE: 15971.00.00, 15971.01.00, 15971.02.00, 15974.00.00,15974.01.00, 15974.02.00; 19890223

Spc suppl protection certif: 193 75 044

Filing date: 19930618

V464 Spc expired

Free format text: PRODUCT NAME: LOVASTATIN; REGISTRATION NO/DATE: 15971.00.00, 15971.01.00, 15971.02.00, 15974.00.00,15974.01.00, 15974.02.00; 19890223

Spc suppl protection certif: 193 75 044

Filing date: 19930618