DE122006000058I2 - 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline - Google Patents

7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline

Info

Publication number
DE122006000058I2
DE122006000058I2 DE200612000058 DE122006000058C DE122006000058I2 DE 122006000058 I2 DE122006000058 I2 DE 122006000058I2 DE 200612000058 DE200612000058 DE 200612000058 DE 122006000058 C DE122006000058 C DE 122006000058C DE 122006000058 I2 DE122006000058 I2 DE 122006000058I2
Authority
DE
Germany
Prior art keywords
substituted
demethyl
tetracyclines
amino
deoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE200612000058
Other languages
German (de)
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Wyeth LLC
Original Assignee
Wyeth Holdings LLC
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25092264&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE122006000058(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Holdings LLC, Wyeth LLC filed Critical Wyeth Holdings LLC
Publication of DE122006000058I2 publication Critical patent/DE122006000058I2/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Moulding By Coating Moulds (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE200612000058 1991-10-04 1992-08-21 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline Active DE122006000058I2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77157691A 1991-10-04 1991-10-04

Publications (1)

Publication Number Publication Date
DE122006000058I2 true DE122006000058I2 (de) 2007-09-13

Family

ID=25092264

Family Applications (4)

Application Number Title Priority Date Filing Date
DE200612000058 Active DE122006000058I2 (de) 1991-10-04 1992-08-21 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline
DE69232302T Expired - Lifetime DE69232302T4 (de) 1991-10-04 1992-08-21 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline
DE1992632302 Pending DE122006000058I1 (de) 1991-10-04 1992-08-21 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline
DE69232302A Expired - Lifetime DE69232302D1 (de) 1991-10-04 1992-08-21 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline

Family Applications After (3)

Application Number Title Priority Date Filing Date
DE69232302T Expired - Lifetime DE69232302T4 (de) 1991-10-04 1992-08-21 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline
DE1992632302 Pending DE122006000058I1 (de) 1991-10-04 1992-08-21 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline
DE69232302A Expired - Lifetime DE69232302D1 (de) 1991-10-04 1992-08-21 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline

Country Status (27)

Country Link
EP (1) EP0536515B1 (cg-RX-API-DMAC7.html)
JP (1) JP3186863B2 (cg-RX-API-DMAC7.html)
KR (1) KR100269072B1 (cg-RX-API-DMAC7.html)
CN (1) CN1048240C (cg-RX-API-DMAC7.html)
AT (1) ATE211128T1 (cg-RX-API-DMAC7.html)
AU (1) AU654049B2 (cg-RX-API-DMAC7.html)
BR (1) BR1100853A (cg-RX-API-DMAC7.html)
CA (1) CA2079692C (cg-RX-API-DMAC7.html)
CL (1) CL2004001623A1 (cg-RX-API-DMAC7.html)
CZ (2) CZ309397A3 (cg-RX-API-DMAC7.html)
DE (4) DE122006000058I2 (cg-RX-API-DMAC7.html)
DK (1) DK0536515T3 (cg-RX-API-DMAC7.html)
ES (1) ES2168254T3 (cg-RX-API-DMAC7.html)
FI (1) FI114911B (cg-RX-API-DMAC7.html)
HU (2) HU219973B (cg-RX-API-DMAC7.html)
IL (3) IL103320A (cg-RX-API-DMAC7.html)
LU (1) LU91279I2 (cg-RX-API-DMAC7.html)
MX (1) MX9205532A (cg-RX-API-DMAC7.html)
NL (1) NL300244I1 (cg-RX-API-DMAC7.html)
NO (3) NO301472B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ244585A (cg-RX-API-DMAC7.html)
PL (4) PL172282B1 (cg-RX-API-DMAC7.html)
PT (1) PT536515E (cg-RX-API-DMAC7.html)
SG (1) SG52361A1 (cg-RX-API-DMAC7.html)
SK (2) SK284826B6 (cg-RX-API-DMAC7.html)
TW (1) TW275616B (cg-RX-API-DMAC7.html)
ZA (1) ZA927607B (cg-RX-API-DMAC7.html)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
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US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
WO1995022529A1 (en) * 1994-02-17 1995-08-24 Pfizer Inc. 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
US8106225B2 (en) 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
CZ301835B6 (cs) 1999-09-14 2010-07-07 Trustees Of Tufts College Zpusob prípravy 7-, 9- nebo 13- substituované tetracyklinové slouceniny, reaktivní tetracyklinový chemický komplex a tetracyklinová sloucenina substituovaná v poloze 7 nebo 9
ATE365710T1 (de) 2000-03-31 2007-07-15 Tufts College 7- und 9-carbamat, harnstoff, thioharnstoff, thiocarbamat und heteroaryl-amino substituierte tetracyclinverbindungen
AU2001259701A1 (en) * 2000-05-15 2001-11-26 Paratek Pharmaceuticals, Inc 7-substituted fused ring tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
CZ2003344A3 (cs) * 2000-07-07 2003-05-14 Trustees Of Tufts College 9-Substituované minocyklinové sloučeniny
AU2002250331A1 (en) 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
WO2002072532A1 (en) 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7, 9-substituted tetracycline compounds
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP1241160A1 (en) 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
EP1399414B1 (en) * 2001-04-24 2010-01-13 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP1408987B1 (en) 2001-07-13 2013-04-10 Paratek Pharmaceuticals, Inc. Tetracycline compounds having target therapeutic activities
WO2003055441A2 (en) 2001-08-02 2003-07-10 Paratek Pharmaceuticals, Inc. Medicaments
EP2311797A1 (en) 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
JP2005526754A (ja) * 2002-03-08 2005-09-08 パラテック ファーマシューティカルズ インコーポレイテッド アミノメチル置換されたテトラサイクリン化合物
WO2005009943A2 (en) 2003-07-09 2005-02-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
UA83266C2 (en) * 2003-12-08 2008-06-25 Уайет Oxazole derivatives of tetracyclines
KR101171408B1 (ko) 2004-05-21 2012-08-08 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 테트라사이클린 및 이의 유사체의 합성
US7534766B2 (en) 2004-11-05 2009-05-19 Wyeth Glucuronide metabolites and epimers thereof of tigecycline
AR057649A1 (es) 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
JP2009507793A (ja) * 2005-08-31 2009-02-26 ワイス グリシルサイクリンの９−アミノカルボニル置換誘導体
WO2007133797A2 (en) 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
RU2483072C2 (ru) 2007-11-29 2013-05-27 Актелион Фармасьютиклз Лтд Производные фосфоновой кислоты и их применение в качестве антагонистов рецептора p2y12
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
ITMI20080807A1 (it) 2008-05-05 2009-11-06 Antibioticos Spa Procedimento per la preparazione di tigeciclina in forma amorfa
TWI585071B (zh) 2008-05-19 2017-06-01 派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
HUE026562T2 (hu) * 2008-08-08 2016-06-28 Tetraphase Pharmaceuticals Inc C7-fluor-helyettesített tetraciklin vegyületek
WO2010126607A2 (en) 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
CN102459153A (zh) 2009-05-08 2012-05-16 四相制药公司 四环素类化合物
EP2470500B1 (en) 2009-08-28 2017-10-04 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
MX347919B (es) 2010-05-12 2017-05-17 Rempex Pharmaceuticals Inc * Composiciones de tetraciclina.
CN103635456B (zh) * 2011-07-26 2016-03-09 山东亨利医药科技有限责任公司 替加环素衍生物
TR201902057T4 (tr) 2012-08-31 2019-03-21 Tetraphase Pharmaceuticals Inc Tetrasiklin bileşikleri.
WO2015071299A2 (en) 2013-11-12 2015-05-21 Galenicum Health S.L. Stable pharmaceutical compositions
MA46567A (fr) 2016-10-19 2019-08-28 Tetraphase Pharmaceuticals Inc Formes cristallines de l'éravacycline

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Publication number Priority date Publication date Assignee Title
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3579579A (en) * 1968-04-18 1971-05-18 American Cyanamid Co Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines

Also Published As

Publication number Publication date
CL2004001623A1 (es) 2005-06-03
NO2006015I2 (no) 2011-03-14
KR930007894A (ko) 1993-05-20
IL119590A0 (en) 1997-02-18
IL119590A (en) 1999-03-12
ATE211128T1 (de) 2002-01-15
PL173311B1 (pl) 1998-02-27
SK298492A3 (en) 1995-03-08
LU91279I2 (fr) 2006-12-11
NO301472B1 (no) 1997-11-03
NL300244I2 (nl) 2007-01-02
ZA927607B (en) 1993-04-13
AU2618392A (en) 1993-04-08
ES2168254T3 (es) 2002-06-16
PL176333B1 (pl) 1999-05-31
NL300244I1 (nl) 2007-01-02
HUT63145A (en) 1993-07-28
SK284826B6 (sk) 2005-12-01
PT536515E (pt) 2002-05-31
HU9203110D0 (en) 1992-12-28
NO2017037I1 (no) 2017-08-01
HU211172A9 (en) 1995-11-28
EP0536515B1 (en) 2001-12-19
CN1048240C (zh) 2000-01-12
CZ284209B6 (cs) 1998-09-16
JPH05255219A (ja) 1993-10-05
KR100269072B1 (ko) 2000-10-16
JP3186863B2 (ja) 2001-07-11
CA2079692C (en) 2004-06-08
SG52361A1 (en) 1998-09-28
DE69232302T2 (de) 2002-08-14
NO2006015I1 (no) 2006-11-27
PL175957B1 (pl) 1999-03-31
PL296143A1 (en) 1993-05-31
DK0536515T3 (da) 2002-04-08
DE69232302T4 (de) 2003-02-13
NO923857L (no) 1993-04-05
IL103320A (en) 1998-12-06
AU654049B2 (en) 1994-10-20
NO2017037I2 (no) 2017-08-01
SK280837B6 (sk) 2000-08-14
SK114999A3 (en) 2000-07-11
MX9205532A (es) 1993-04-01
NO923857D0 (no) 1992-10-02
CZ298492A3 (en) 1993-05-12
HK1011348A1 (en) 1999-07-09
PL172282B1 (pl) 1997-08-29
FI924454L (fi) 1993-04-05
DE122006000058I1 (de) 2007-01-18
CZ284159B6 (cs) 1998-08-12
CA2079692A1 (en) 1993-04-05
IL103320A0 (en) 1993-03-15
BR1100853A (pt) 1999-12-07
CN1072172A (zh) 1993-05-19
NZ244585A (en) 1995-07-26
DE69232302D1 (de) 2002-01-31
FI924454A0 (fi) 1992-10-02
EP0536515A1 (en) 1993-04-14
TW275616B (cg-RX-API-DMAC7.html) 1996-05-11
HU219973B (hu) 2001-10-28
CZ309397A3 (cs) 1998-09-16
FI114911B (fi) 2005-01-31

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