DE1038528T1 - Pentosan polysulfate enthaltendes Medikament und Implantat zur Behandlung der Fibrose - Google Patents

Pentosan polysulfate enthaltendes Medikament und Implantat zur Behandlung der Fibrose

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Publication number
DE1038528T1
DE1038528T1 DE1038528T DE00201293T DE1038528T1 DE 1038528 T1 DE1038528 T1 DE 1038528T1 DE 1038528 T DE1038528 T DE 1038528T DE 00201293 T DE00201293 T DE 00201293T DE 1038528 T1 DE1038528 T1 DE 1038528T1
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Prior art keywords
implant
composition
fibrosis
pentosan polysulfate
surgery
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Pending
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DE1038528T
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DE20001293U1 (de
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Robert C.A. Frederickson
Adrian Harel
Dikla Roufa
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Gliatech Inc
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Gliatech Inc
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Publication of DE1038528T1 publication Critical patent/DE1038528T1/de
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/734—Alginic acid
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    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/738—Cross-linked polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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    • A61L27/28—Materials for coating prostheses
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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Claims (28)

00201293.8 y/ 3534 Patentansprüche
1. Verwendung einer Zusammensetzung, die eine solche Menge an Pentosanpolysulfat aufweist, die im Hinblick auf eine Inhibierung einer Fibröse wirksam ist, bei der Herstellung eines Medikaments zur Inhibierung der Fibröse einer Läsion bei einem Säugetier.
2. Verwendung nach Anspruch 1, bei der die Läsion eine chirurgische Läsion ist.
3. Verwendung nach Anspruch 1, bei der die Läsion das Ergebnis einer traumatischen Verletzung ist.
4. Verwendung nach den Ansprüchen 1 bis 3, bei der das Säugetier menschlich ist.
5. Verwendung nach Anspruch 2, bei der die chirurgische Läsion Folge einer Laminektomie, Diskektomie, Eileiteroperation oder einer Operation zur Behandlung einer Kiefergelenks-Dysfunktion, einer Bauchoperation, einer Gelenksoperation, einer Sehnenoperation, einer Operation zur Entfernung von Beckenseitenwand-Verwachsungen, einer Bauchraumoperation, einer Thoraxoperation, einer Gefäßoperation, einer Herzoperation, einer Herz-Bypass-Operation, einer Herzklappenersatz-Operation oder einer Operation am offenen Herzen ist.
6. Verwendung nach Anspruch 5 zur Inhibierung einer Fibröse bei einer Person im Anschluß an eine Laminektomie oder Diskektomie.
7. Verwendung nach irgendeinem der Ansprüche 1 bis 6, bei der die Zusammensetzung außerdem ein pharmazeutisch annehmbares chirurgisches Implantat umfaßt.
2" DE/EP 1 03 8 52ÖT1
8. Verwendung nach irgendeinem der Ansprüche 1 bis 7, bei der die Zusammensetzung umfaßt:
(a) eine zur Inhibierung einer Fibröse wirksame Menge an Pentosanpolysulfat; und
(b) eine Menge eines Adhäsionsproteins, das zur Verankerung des Pentosanpolysulfats an Ort und Stelle wirksam ist.
9. Verwendung nach Anspruch 8, bei der das Pentosanpolysulf at kovalent an das Adhäsionsprotein gebunden ist.
10. Verwendung nach Anspruch 8 oder 9, bei der das Adhäsionprotein aus der Gruppe ausgewählt ist, die besteht aus Fibrin, dem polyphenolischen Muscheladhäsionsprotein, dem polyphenolischen Entenmuscheladhäsionsprotein, dem polyphenolischen Austernmuscheladhäsionsprotein, einem chemisch polymerisierten Peptid eines Adhäsionsproteins und einem rekombinant hergestellten analogen Adhäsionsprotein.
11. Verfahren zur Herstellung eines chirurgischen Implantats zur Inhibierung einer Fibröse am Einsatzort des Implantats, das das Aufbringen einer zur Inhibierung der Fibröse wirksamen Menge an Pentosanpolysulfat auf das chirurgische Implantat umfaßt, wobei das genannte chirurgische Implantat ausgewählt ist aus der Gruppe, die aus einem Nephrostomiekatheter, einem peritonealen Drainrohr, einem künstlichen Hüftgelenk, einer künstlichen Herzklappe, einer Reparaturprothese für periphere Nerven und anderen Prothesen besteht.
12. Verfahren nach Anspruch 11, bei dem das chirurgische Implantat für Menschen geeignet ist.
13. Verfahren nach irgendeinem der Ansprüche 11 bis 12, bei dem das zur Inhibierung einer Fibröse wirksame Pentosanpolysulf at kovalent mit dem Implantat assoziiert ist.
14. Verfahren nach irgendeinem der Ansprüche 11 bis 12, bei dem das zur Inhibierung einer Fibröse wirksame Pentosanpolysulf at nicht-kovalent mit dem Implantat assoziiert ist.
15. Zusammensetzung, die eine zur Inhibierung einer Fibröse wirksame Menge an Pentosanpolysulfat und ein pharmazeutisch annehmbares Polymerimplantat umfaßt.
16. Zusammensetzung nach Anspruch 15, bei der das Polymer Dextran ist.
17. Zusammensetzung nach Anspruch 15, bei der das Polymer denaturiertes Kollagen ist.
18. Zusammensetzung nach Anspruch 17, bei der das denaturierte Kollagen pulverförmig ist.
19. Zusammensetzung nach Anspruch 17 oder 18, bei der das denaturierte Kollagen wenigstens 5 %, vorzugsweise 10 % der Zusammensetzung ausmacht.
20. Verbessertes Implantat, das nach dem Verfahren nach irgendeinem der Ansprüche 11 bis 14 erhältlich ist, bei dem die Beschichtung eine Zusammensetzung umfaßt, die aufweist
(a) eine zur Inhibierung einer Fibröse wirksame Menge an Pentosanpolysulfat; und
(b) eine zur Verankerung des Pentosanpolysulfats an Ort und Stelle wirksame Menge eines Adhäsionsproteins.
21. Verbessertes Implantat nach Anspruch 20, bei dem das Pentosanpolysulfat kovalent an das Adhäsionsprotein gebunden ist.
22. Verbessertes Implantat nach Anspruch 20 oder 21, bei dem das zur Inhibierung einer Fibröse wirksame Pentosanpolysulf at kovalent mit dem Implantat assoziiert ist.
DE"/EP 1 038528T1
23. Verbessertes Implantat nach Anspruch 20 oder 21, bei dem das zu Inhibierung einer Fibröse wirksame Pentosanpolysulfat nicht-kovalent mit in dem Implantat assoziiert ist.
24. Verbessertes Implantat nach irgendeinem der Ansprüche 20 bis 23, bei dem das Implantat polymer ist und aus der Gruppe ausgewählt ist, die aus einem Nephrostomiekatheter, einem peritonealen Drainrohr, einem künstlichen Hüftgelenk, einer künstlichen Herzklappe, einer Reparaturprothese für periphere Nerven und anderen Prothesen besteht.
25. Zusammensetzung mit einer zur Inhibierung einer Fibröse wirksamen Menge an Pentosanpolysulfat und einem denaturiertem Kollagengel.
26. Zusammensetzung nach Anspruch 25, bei der das denaturierte Kollagen pulverförmig ist.
27. Zusammensetzung nach Anspruch 25, bei der das denaturierte Kollagen wenigstens 5 %, vorzugsweise 10 % der Zusammensetzung ausmacht.
28. Zusammensetzung, die eine zur Inhibierung einer Fibröse wirksame Menge an Pentosanpolysulfat und ein pharmazeutisch annehmbares chirurgisches Implantat umfaßt, wobei das chirurgische Implantat aus der Gruppe ausgewählt ist, die besteht aus einem Nephrostomiekatheter, einem peritonealen Drainrohr, einem künstlichen Hüftgelenk, einer künstlichen Herzklappe, einer Reparaturprothese für periphere Nerven und anderen Prothesen.
DE1038528T 1991-05-31 1992-05-29 Pentosan polysulfate enthaltendes Medikament und Implantat zur Behandlung der Fibrose Pending DE1038528T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/708,660 US5605938A (en) 1991-05-31 1991-05-31 Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate

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DE1038528T1 true DE1038528T1 (de) 2001-09-20

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DE69231574T Expired - Lifetime DE69231574T2 (de) 1991-05-31 1992-05-29 Verfahren und zusammensetzungen beruhend auf der hemmung von zellinvasion und fibrose durch dextran sulfat
DE69233753T Expired - Fee Related DE69233753D1 (de) 1991-05-31 1992-05-29 Alginat-enthaltendes Medikament und Implantat zur Behandlung der Fibrose
DE1027893T Pending DE1027893T1 (de) 1991-05-31 1992-05-29 Alginat-enthaltendes Medikament und Implantat zur Behandlung der Fibrose
DE1038528T Pending DE1038528T1 (de) 1991-05-31 1992-05-29 Pentosan polysulfate enthaltendes Medikament und Implantat zur Behandlung der Fibrose
DE69233527T Expired - Lifetime DE69233527D1 (de) 1991-05-31 1992-05-29 Pentosan polysulfate enthaltendes Medikament und Implantat zur Behandlung der Fibrose

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DE69233753T Expired - Fee Related DE69233753D1 (de) 1991-05-31 1992-05-29 Alginat-enthaltendes Medikament und Implantat zur Behandlung der Fibrose
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JP2002154972A (ja) 2002-05-28
ATE297212T1 (de) 2005-06-15
US20030069205A1 (en) 2003-04-10
EP1038528A1 (de) 2000-09-27
US6756362B2 (en) 2004-06-29
US6020326A (en) 2000-02-01
DE69233527D1 (de) 2005-07-14
DK0586535T3 (da) 2001-03-05
HUT66427A (en) 1994-11-28
JP3923290B2 (ja) 2007-05-30
WO1992021354A1 (en) 1992-12-10
ES2156840T1 (es) 2001-08-01
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US6083930A (en) 2000-07-04
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US6127348A (en) 2000-10-03
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EP0586535B1 (de) 2000-11-22
JP3379757B2 (ja) 2003-02-24
GR3034760T3 (en) 2001-02-28
DE69231574T2 (de) 2001-05-31
AU671256B2 (en) 1996-08-22
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CZ259493A3 (en) 1994-11-16
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US5605938A (en) 1997-02-25
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BG98333A (en) 1994-12-02
US6417173B1 (en) 2002-07-09
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NO934319D0 (no) 1993-11-29
FI935345A0 (fi) 1993-11-30
ATE197673T1 (de) 2000-12-15
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BR9206077A (pt) 1994-11-15

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