IT1208509B - Processo per la produzione di eparan solfato e dermatan solfato naturali sostanzialmente puri eloro impiego farmaceutico. - Google Patents

Processo per la produzione di eparan solfato e dermatan solfato naturali sostanzialmente puri eloro impiego farmaceutico.

Info

Publication number
IT1208509B
IT1208509B IT8519885A IT1988585A IT1208509B IT 1208509 B IT1208509 B IT 1208509B IT 8519885 A IT8519885 A IT 8519885A IT 1988585 A IT1988585 A IT 1988585A IT 1208509 B IT1208509 B IT 1208509B
Authority
IT
Italy
Prior art keywords
sulphate
dermatan
eparan
production
pharmaceutical use
Prior art date
Application number
IT8519885A
Other languages
English (en)
Other versions
IT8519885A0 (it
Inventor
Piergiuseppe Pagella
Rinaldo Del Bono
Gianni Ferrari
Luigi De Ambrosi
Original Assignee
Mediolanum Farmaceutici Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediolanum Farmaceutici Srl filed Critical Mediolanum Farmaceutici Srl
Publication of IT8519885A0 publication Critical patent/IT8519885A0/it
Priority to IT8519885A priority Critical patent/IT1208509B/it
Priority to DE86102963T priority patent/DE3689493T2/de
Priority to EP86102963A priority patent/EP0199033B1/en
Priority to AT86102963T priority patent/ATE99702T1/de
Priority to US06/838,133 priority patent/US4783447A/en
Priority to NZ215435A priority patent/NZ215435A/xx
Priority to FI861020A priority patent/FI82700C/fi
Priority to PH33516A priority patent/PH22370A/en
Priority to NO860940A priority patent/NO166187C/no
Priority to GR860677A priority patent/GR860677B/el
Priority to ES552898A priority patent/ES8705894A1/es
Priority to IN184/CAL/86A priority patent/IN163616B/en
Priority to DK113886A priority patent/DK113886A/da
Priority to ZA861855A priority patent/ZA861855B/xx
Priority to CA000503943A priority patent/CA1286286C/en
Priority to PT82198A priority patent/PT82198B/pt
Priority to KR1019860001805A priority patent/KR910006809B1/ko
Priority to JP61053838A priority patent/JPS61218601A/ja
Priority to AU54727/86A priority patent/AU582221B2/en
Priority to YU37586A priority patent/YU46303B/sh
Priority to PH35381A priority patent/PH25136A/en
Application granted granted Critical
Publication of IT1208509B publication Critical patent/IT1208509B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0066—Isolation or extraction of proteoglycans from organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
IT8519885A 1985-03-13 1985-03-13 Processo per la produzione di eparan solfato e dermatan solfato naturali sostanzialmente puri eloro impiego farmaceutico. IT1208509B (it)

Priority Applications (21)

Application Number Priority Date Filing Date Title
IT8519885A IT1208509B (it) 1985-03-13 1985-03-13 Processo per la produzione di eparan solfato e dermatan solfato naturali sostanzialmente puri eloro impiego farmaceutico.
DE86102963T DE3689493T2 (de) 1985-03-13 1986-03-06 Verfahren zur Herstellung von reinem natürlichen Heparansulfat und Dermatansulfat und ihre pharmazeutische Verwendung.
EP86102963A EP0199033B1 (en) 1985-03-13 1986-03-06 Process for producing natural heparan sulphate and dermatan sulphate in substantially pure form, and their pharmaceutical use
AT86102963T ATE99702T1 (de) 1985-03-13 1986-03-06 Verfahren zur herstellung von reinem natuerlichen heparansulfat und dermatansulfat und ihre pharmazeutische verwendung.
US06/838,133 US4783447A (en) 1985-03-13 1986-03-10 Process for producing natural heparan sulphate and dermatan sulphate in substantially pure form, and their pharmaceutical use
NZ215435A NZ215435A (en) 1985-03-13 1986-03-11 Preparation of heparan sulphate and dermatan sulphate
ES552898A ES8705894A1 (es) 1985-03-13 1986-03-12 Procedimiento para producir heparan sulfato natural y dermatan sulfato en forma sustancialmente pura
PH33516A PH22370A (en) 1985-03-13 1986-03-12 Process for producing natural heparan sulphate and dermatan sulphate in substantially pure form
NO860940A NO166187C (no) 1985-03-13 1986-03-12 Fremgangsmaate for fremstilling av naturlig heparansulfat og dermatansulfat i hovedsakelig ren form.
GR860677A GR860677B (en) 1985-03-13 1986-03-12 Process for producing natural heparan sulphate and dermatan sulphate in substantially pure form and their pharmaceutical use
FI861020A FI82700C (fi) 1985-03-13 1986-03-12 Foerfarande foer framstaellning av naturligt heparansulfat och dermatansulfat i vaesentligen ren form.
IN184/CAL/86A IN163616B (it) 1985-03-13 1986-03-12
DK113886A DK113886A (da) 1985-03-13 1986-03-12 Fremgangsmaade til fremstilling af heparansulfat og dermatansulfat ogfarmaceutisk anvendelse af disse stoffer
ZA861855A ZA861855B (en) 1985-03-13 1986-03-12 Process for producing natural heparan sulphate and dermatan sulphate in substantially pure form,and their pharmaceutical use
CA000503943A CA1286286C (en) 1985-03-13 1986-03-12 Process for producing natural heparan sulphate and dermatan sulphate in substantially pure form, and their pharmaceutical use
PT82198A PT82198B (pt) 1985-03-13 1986-03-13 Processo de producao de sulfato de heparano e sulfato de dermatano, naturais, em forma substancialmente pura e de composicoes farmaceuticas que os contem
KR1019860001805A KR910006809B1 (ko) 1985-03-13 1986-03-13 천연 헤파란 설페이트 및 더머탄 설페이트의 제조방법
JP61053838A JPS61218601A (ja) 1985-03-13 1986-03-13 実質上、純粋な形状の、天然のヘパラン硫酸およびデルマタン硫酸の製造法およびそれらの医薬的使用
AU54727/86A AU582221B2 (en) 1985-03-13 1986-03-13 Process for producing natural heparan sulphate in substantially pure form,and their pharmaceutical use
YU37586A YU46303B (sh) 1985-03-13 1986-03-13 Postupak za proizvodnju prirodnog heparan-sulfata i dermatan-sulfata u suštinski čistom obliku
PH35381A PH25136A (en) 1985-03-13 1987-06-10 Natural heparan sulphate and dermatan sulphate in substantially pure form and method of use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8519885A IT1208509B (it) 1985-03-13 1985-03-13 Processo per la produzione di eparan solfato e dermatan solfato naturali sostanzialmente puri eloro impiego farmaceutico.

Publications (2)

Publication Number Publication Date
IT8519885A0 IT8519885A0 (it) 1985-03-13
IT1208509B true IT1208509B (it) 1989-07-10

Family

ID=11162062

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8519885A IT1208509B (it) 1985-03-13 1985-03-13 Processo per la produzione di eparan solfato e dermatan solfato naturali sostanzialmente puri eloro impiego farmaceutico.

Country Status (20)

Country Link
US (1) US4783447A (it)
EP (1) EP0199033B1 (it)
JP (1) JPS61218601A (it)
KR (1) KR910006809B1 (it)
AT (1) ATE99702T1 (it)
AU (1) AU582221B2 (it)
CA (1) CA1286286C (it)
DE (1) DE3689493T2 (it)
DK (1) DK113886A (it)
ES (1) ES8705894A1 (it)
FI (1) FI82700C (it)
GR (1) GR860677B (it)
IN (1) IN163616B (it)
IT (1) IT1208509B (it)
NO (1) NO166187C (it)
NZ (1) NZ215435A (it)
PH (2) PH22370A (it)
PT (1) PT82198B (it)
YU (1) YU46303B (it)
ZA (1) ZA861855B (it)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1189085B (it) * 1986-03-25 1988-01-28 Mediolanum Farmaceutici Srl Processo per la preparazione di dermatan solfato ad alta purezza e composizioni farmaceutiche che lo contengono
US5707604A (en) * 1986-11-18 1998-01-13 Access Pharmaceuticals, Inc. Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles
DE3639561A1 (de) * 1986-11-20 1988-06-01 Baumann Hanno Verfahren zur herstellung von nicht-thrombogenen substraten
IT1232939B (it) * 1987-11-06 1992-03-10 Opocrin Spa Eparan solfato caratterizzato da elevata attivita' antitrombotica, elevata biodisponibilita', assenza di attivita' anticoagulante; suo processo di estrazione da organi e da tessuti e relative composizioni farmaceutiche
AU630359B2 (en) * 1988-06-03 1992-10-29 Italfarmaco S.P.A. Glycosaminoglycan salts, processes for the preparation thereof and pharmaceutical compositions containing them
IE64121B1 (en) * 1989-10-04 1995-07-12 Akzo Nv Sulphated glycosaminoglycuronan with antithrombotic activity
AU6872691A (en) * 1989-10-27 1991-05-31 Case Western Reserve University Inhibition of cell growth by keratan sulfate, chondroitin sulfate, dermatan sulfate and other glycans
IT1240615B (it) * 1990-04-03 1993-12-17 Mediolanum Farmaceutici Spa Impiego del dermatan solfato nella prevenzione e terapia dell'invecchiamento cerebrale e degli stati di deficit funzionale del sistema nervoso centrale
WO1991015217A1 (en) * 1990-04-06 1991-10-17 Washington University Anticoagulant oligosaccharides
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
US5705178A (en) * 1991-05-31 1998-01-06 Gliatech, Inc. Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
FR2691066B1 (fr) * 1992-05-15 1995-06-09 Sanofi Elf Utilisation de glycosaminoglycanes exogenes, de leurs analogues ainsi que de leurs fragments, fractions et derives, pour la preparation de medicaments destines au traitement de thrombopenies.
IT1256236B (it) * 1992-12-23 1995-11-29 Mediolanum Farmaceutici Srl Oligosaccaridi aventi attivita' biologica e procedimento per la loro preparazione di glicosaminoglicani
CA2150552C (en) * 1993-09-30 1999-12-21 Akikazu Takada Antithrombotic
US6106866A (en) * 1995-07-31 2000-08-22 Access Pharmaceuticals, Inc. In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites
IT1296581B1 (it) * 1997-11-28 1999-07-14 Istituto Scient Di Chimica E B Materiali polimerici non trombogenici e ad esaltata compatibilita' con fluidi e tessuti organici
BR0012202A (pt) * 1999-06-30 2002-04-02 Hamilton Civic Hospitals Res Composições de heparina de peso molecular médio (mmwh), método de tratamento de uma condição trombótica, método de prevenção da formação de um trombo, método de inibição da formação de trombos, composição farmacêutica, método de tratamento de trombose venosa profunda, método de prevenção de embolia pulmonar, método de preparação e usos de uma composição de mmwh
KR20030069990A (ko) * 2000-09-08 2003-08-27 해밀톤 시빅 호스피탈즈 리서치 디벨로프먼트 인코포레이티드 항혈전 조성물
CN107098989A (zh) * 2017-04-27 2017-08-29 甘肃省金羚集团药业有限公司 一种肝素钠的制备方法
CN114478832B (zh) * 2022-02-14 2023-03-03 河北常山生化药业股份有限公司 从肝素钠副产物中提纯四种多糖类产品的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3179566A (en) * 1963-05-16 1965-04-20 Canada Packers Ltd Purification of heparin
JPS5318520B2 (it) * 1972-07-05 1978-06-15
AR207237A1 (es) * 1974-02-25 1976-09-22 Thomas A Procedimiento para obtener extractos biologicos estables liofilizados solubles constituidos por complejos proteicos termorresistentes
US4243582A (en) * 1979-04-26 1981-01-06 Monsanto Company Novel glycoproteins from bovine cartilage
JPS58171403A (ja) * 1982-04-01 1983-10-08 Eisai Co Ltd ヘパラン硫酸の精製法
IT1189298B (it) * 1982-06-18 1988-02-04 Manetti & Roberts Italo Brit Procedimento per produrre i glicosa minoglicani dermatansolfato ed eparan-solfato sostanzialmente puri e loro impiego farmaceutico
FR2555993B1 (fr) * 1983-12-06 1986-11-07 Anic Spa Chitosanes 6-sulfates et procede pour leur preparation
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
IT1163772B (it) * 1983-07-13 1987-04-08 Baldacci Lab Spa Oligosaccaridi eterogenei complessabili ed alfa-idosani ad attivita' terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche

Also Published As

Publication number Publication date
DE3689493T2 (de) 1994-04-28
IN163616B (it) 1988-10-15
ATE99702T1 (de) 1994-01-15
DK113886D0 (da) 1986-03-12
DE3689493D1 (de) 1994-02-17
CA1286286C (en) 1991-07-16
KR860007278A (ko) 1986-10-10
IT8519885A0 (it) 1985-03-13
ZA861855B (en) 1986-10-29
PH25136A (en) 1991-02-19
KR910006809B1 (ko) 1991-09-02
AU5472786A (en) 1986-09-18
EP0199033A3 (en) 1988-03-30
AU582221B2 (en) 1989-03-16
EP0199033A2 (en) 1986-10-29
FI82700C (fi) 1991-04-10
YU46303B (sh) 1993-05-28
JPS61218601A (ja) 1986-09-29
ES8705894A1 (es) 1987-05-16
US4783447A (en) 1988-11-08
DK113886A (da) 1986-09-14
PH22370A (en) 1988-08-12
EP0199033B1 (en) 1994-01-05
FI82700B (fi) 1990-12-31
NO166187C (no) 1991-06-12
GR860677B (en) 1986-07-14
YU37586A (en) 1988-04-30
FI861020A (fi) 1986-09-14
PT82198B (pt) 1988-02-17
PT82198A (en) 1986-04-01
JPH0238601B2 (it) 1990-08-31
NO166187B (no) 1991-03-04
FI861020A0 (fi) 1986-03-12
NZ215435A (en) 1989-01-06
NO860940L (no) 1986-09-15
ES552898A0 (es) 1987-05-16

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19940330