IT1195497B - Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina - Google Patents

Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina

Info

Publication number
IT1195497B
IT1195497B IT40021/83A IT4002183A IT1195497B IT 1195497 B IT1195497 B IT 1195497B IT 40021/83 A IT40021/83 A IT 40021/83A IT 4002183 A IT4002183 A IT 4002183A IT 1195497 B IT1195497 B IT 1195497B
Authority
IT
Italy
Prior art keywords
heparin
preparation
procedure
pharmacological properties
chemical degradation
Prior art date
Application number
IT40021/83A
Other languages
English (en)
Other versions
IT8340021A0 (it
IT8340021A1 (it
Inventor
Pietro Bianchini
Original Assignee
Opocrin Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Opocrin Spa filed Critical Opocrin Spa
Publication of IT8340021A0 publication Critical patent/IT8340021A0/it
Priority to IT40021/83A priority Critical patent/IT1195497B/it
Priority to EP84101701A priority patent/EP0121067B1/en
Priority to AT84101701T priority patent/ATE26843T1/de
Priority to DE198484101701T priority patent/DE121067T1/de
Priority to DE8484101701T priority patent/DE3463386D1/de
Priority to US06/582,933 priority patent/US4629699A/en
Priority to AU25093/84A priority patent/AU549885B2/en
Priority to ZA841520A priority patent/ZA841520B/xx
Priority to CA000448827A priority patent/CA1212942A/en
Priority to JP59044787A priority patent/JPS59187002A/ja
Publication of IT8340021A1 publication Critical patent/IT8340021A1/it
Priority to US06/921,332 priority patent/US4791195A/en
Priority to US07/247,154 priority patent/US4933326A/en
Application granted granted Critical
Publication of IT1195497B publication Critical patent/IT1195497B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
IT40021/83A 1983-03-08 1983-03-08 Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina IT1195497B (it)

Priority Applications (12)

Application Number Priority Date Filing Date Title
IT40021/83A IT1195497B (it) 1983-03-08 1983-03-08 Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
EP84101701A EP0121067B1 (en) 1983-03-08 1984-02-18 Process for the preparation of oligosaccharide fractions having pharmacological properties by chemical degradation of heparin
AT84101701T ATE26843T1 (de) 1983-03-08 1984-02-18 Verfahren zur herstellung von oligosaccharidfraktionen mit pharmakologischen eigenschaften durch chemische degradierung von heparin.
DE198484101701T DE121067T1 (de) 1983-03-08 1984-02-18 Verfahren zur herstellung von oligosaccharidfraktionen mit pharmakologischen eigenschaften durch chemische degradierung von heparin.
DE8484101701T DE3463386D1 (en) 1983-03-08 1984-02-18 Process for the preparation of oligosaccharide fractions having pharmacological properties by chemical degradation of heparin
US06/582,933 US4629699A (en) 1983-03-08 1984-02-23 Process for the preparation of oligosaccharide fractions by degradation of heparin
AU25093/84A AU549885B2 (en) 1983-03-08 1984-02-27 Heparin degradation via ascorbic acid, cupric acetate and hydrogen peroxide
ZA841520A ZA841520B (en) 1983-03-08 1984-02-29 Process for the preparation of oligosaccharide fractions having pharmacological properties by chemical degradation of heparin
CA000448827A CA1212942A (en) 1983-03-08 1984-03-05 Process for the preparation of oligosaccharide fractions having pharmaceutical properties by chemical degradation of heparin
JP59044787A JPS59187002A (ja) 1983-03-08 1984-03-07 薬理活性を有するオリゴ糖分画およびその製造法
US06/921,332 US4791195A (en) 1983-03-08 1986-10-21 Novel oligosaccharides having pharmacological properties by depolymerization of heparin
US07/247,154 US4933326A (en) 1983-03-08 1988-09-21 Oligosaccharides obtained by heparin depolymerization having antiatherosclerotic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT40021/83A IT1195497B (it) 1983-03-08 1983-03-08 Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina

Publications (3)

Publication Number Publication Date
IT8340021A0 IT8340021A0 (it) 1983-03-08
IT8340021A1 IT8340021A1 (it) 1984-09-08
IT1195497B true IT1195497B (it) 1988-10-19

Family

ID=11246670

Family Applications (1)

Application Number Title Priority Date Filing Date
IT40021/83A IT1195497B (it) 1983-03-08 1983-03-08 Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina

Country Status (9)

Country Link
US (3) US4629699A (it)
EP (1) EP0121067B1 (it)
JP (1) JPS59187002A (it)
AT (1) ATE26843T1 (it)
AU (1) AU549885B2 (it)
CA (1) CA1212942A (it)
DE (2) DE3463386D1 (it)
IT (1) IT1195497B (it)
ZA (1) ZA841520B (it)

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IT1208509B (it) * 1985-03-13 1989-07-10 Mediolanum Farmaceutici Srl Processo per la produzione di eparan solfato e dermatan solfato naturali sostanzialmente puri eloro impiego farmaceutico.
IT1214609B (it) * 1985-05-17 1990-01-18 Opocrin Spa Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono.
IT1213384B (it) * 1986-11-24 1989-12-20 Lab Derivati Organici Mediolan Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare.
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
EP0337327A1 (en) * 1988-04-09 1989-10-18 Bioiberica, S.A. Process for the preparation of new oligosaccharide fractions by controlled chemical depolimerization of heparin
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5519010A (en) * 1989-02-06 1996-05-21 Taiho Pharmaceutical Co., Ltd. Sulfated polysaccharide, pharmaceutically acceptable salt thereof, process for preparing same and medicament containing same as effective component
AU7742591A (en) * 1990-04-06 1991-10-30 Washington University Anticoagulant oligosaccharides
IT1243987B (it) * 1990-10-29 1994-06-28 Derivati Organici Lab Procedimento per la preparazione di epossi-eparidi prodotti ottenuti ecomposizioni farmaceutiche che li contengono
US5280016A (en) * 1991-03-29 1994-01-18 Glycomed Incorporated Non-anticoagulant heparin derivatives
GB9206291D0 (en) * 1992-03-23 1992-05-06 Cancer Res Campaign Tech Oligosaccharides having growth factor binding affinity
US5861382A (en) * 1992-05-01 1999-01-19 Yeda Research And Development Co. Ltd. Methods for regulation of active TNF-α
WO1994011006A1 (en) * 1992-11-10 1994-05-26 Yeda Research And Development Co. Ltd. Compositions for the regulation of cytokine activity
US6750207B1 (en) 1992-05-01 2004-06-15 Yeda Research And Development Co. Ltd. Compositions for the regulation of cytokine activity
IT1264709B1 (it) * 1993-07-12 1996-10-04 Italfarmaco Spa Derivati eparinici ad attivita' antimetastatica
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5980865A (en) 1995-08-18 1999-11-09 Baker Norton Pharmaceuticals, Inc. Method for treating late phase allergic reactions and inflammatory diseases
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
WO1998023279A1 (en) * 1996-11-27 1998-06-04 Rhone-Poulenc Rorer Pharmaceuticals Inc. PHARMACEUTICAL COMPOSITION COMPRISING A COMPOUND HAVING ANTI-Xa ACTIVITY AND A PLATELET AGGREGATION ANTAGONIST COMPOUND
EP0986581A1 (en) * 1997-06-06 2000-03-22 Hamilton Civic Hospitals Research Development, Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors
AUPO888497A0 (en) 1997-09-01 1997-09-25 Australian National University, The Use of sulfated oligosaccharides as inhibitors of cardiovascular disease
US5965714A (en) * 1997-10-02 1999-10-12 Connaught Laboratories, Inc. Method for the covalent attachment of polysaccharides to protein molecules
AUPO976897A0 (en) * 1997-10-14 1997-11-06 Australian National University, The Use of sulfated oligosaccharides in lowering blood triglyceride levels
US6235725B1 (en) 1998-10-30 2001-05-22 Baker Norton Pharmaceuticals, Inc. Methods and compositions for the prevention of tolerance to medications
CA2377734A1 (en) * 1999-06-30 2001-01-11 Hamilton Civic Hospitals Research Development, Inc. Heparin compositions that inhibit clot associated coagulation factors
JP4585072B2 (ja) * 2000-02-29 2010-11-24 扶桑薬品工業株式会社 ヘパリン解重合法、解重合ヘパリン、その誘導体および医薬組成物
HUP0300939A2 (hu) * 2000-09-08 2003-09-29 Hamilton Civic Hospitals Research Development, Inc. Antitrombotikus készítmények
US7285536B2 (en) * 2001-12-05 2007-10-23 Yeda Research And Development Co., Ltd. Anti-cancer therapeutic compounds
EP2402753A1 (en) 2002-03-11 2012-01-04 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
WO2005018564A2 (en) * 2003-08-22 2005-03-03 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a low-molecular-weight heparin for the treatment of central nervous system damage
EP1582531A1 (en) * 2004-03-24 2005-10-05 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
ITMI20042068A1 (it) * 2004-10-29 2005-01-29 Opocrin Spa Nuovo uso di eparine a bassissimo peso molecolare
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
US8592393B2 (en) 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
WO2009059284A2 (en) 2007-11-02 2009-05-07 Momenta Pharmaceuticals, Inc. Non-anticoagulant polysaccharide compositions
US8569262B2 (en) 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US20100048488A1 (en) * 2008-08-01 2010-02-25 Syntonix Pharmaceuticals, Inc. Immunomodulatory peptides
US8186278B2 (en) * 2008-08-04 2012-05-29 Industrial Design Fabrication & Installation, Inc. Gear switch for a conveyor assembly
US8435795B2 (en) 2010-01-19 2013-05-07 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
JP5982361B2 (ja) 2010-04-16 2016-08-31 モメンタ ファーマシューティカルズ インコーポレイテッド 組織標的化方法
JP5905455B2 (ja) 2010-06-17 2016-04-20 モメンタ ファーマシューティカルズ インコーポレイテッド 発毛を促進する方法および組成物
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
EP3003324A4 (en) 2013-05-28 2017-01-25 Momenta Pharmaceuticals, Inc. Pharmaceutical compositions
CN106947004A (zh) * 2017-03-02 2017-07-14 浙江大学 一种低分子量肝素的制备方法
CN107090052A (zh) * 2017-05-16 2017-08-25 浙江大学 一种低分子量果胶的制备方法
KR20200020804A (ko) * 2017-06-20 2020-02-26 더 리전트 오브 더 유니버시티 오브 캘리포니아 생체활성 올리고당 제조
WO2021007429A1 (en) 2019-07-09 2021-01-14 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides
EP4182452A1 (en) 2020-07-14 2023-05-24 Optimvia, LLC Methods for synthesizing non-anticoagulant heparan sulfate

Family Cites Families (8)

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IT1083903B (it) * 1977-08-09 1985-05-25 Lobo Srl Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche
US4500519A (en) * 1978-11-06 1985-02-19 Choay S.A. Mucopolysaccharides having biological properties, preparation and method of use
FR2440376A1 (fr) * 1978-11-06 1980-05-30 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
US4281108A (en) * 1980-01-28 1981-07-28 Hepar Industries, Inc. Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained
JPS56120704A (en) * 1980-01-28 1981-09-22 Hepar Ind Inc Method of obtaining low molecular weight heparin having heightened pharmacologic property* product manufactured thereby and its use
US4351938A (en) * 1980-05-19 1982-09-28 Riker Laboratories, Inc. Anticoagulant substance

Also Published As

Publication number Publication date
DE3463386D1 (en) 1987-06-04
JPS59187002A (ja) 1984-10-24
AU2509384A (en) 1984-09-13
ZA841520B (en) 1984-10-31
DE121067T1 (de) 1985-01-17
AU549885B2 (en) 1986-02-20
US4791195A (en) 1988-12-13
JPS6344765B2 (it) 1988-09-06
US4933326A (en) 1990-06-12
US4629699A (en) 1986-12-16
IT8340021A0 (it) 1983-03-08
CA1212942A (en) 1986-10-21
ATE26843T1 (de) 1987-05-15
EP0121067A1 (en) 1984-10-10
EP0121067B1 (en) 1987-04-29
IT8340021A1 (it) 1984-09-08

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