KR900003208A - 인체 γ-인터페론과 그 제조방법 및 용도 - Google Patents

인체 γ-인터페론과 그 제조방법 및 용도 Download PDF

Info

Publication number
KR900003208A
KR900003208A KR1019890010440A KR890010440A KR900003208A KR 900003208 A KR900003208 A KR 900003208A KR 1019890010440 A KR1019890010440 A KR 1019890010440A KR 890010440 A KR890010440 A KR 890010440A KR 900003208 A KR900003208 A KR 900003208A
Authority
KR
South Korea
Prior art keywords
equation
expression
formula
abbreviation
interferon
Prior art date
Application number
KR1019890010440A
Other languages
English (en)
Other versions
KR100190555B1 (ko
Inventor
마사시 구리모도
마사가즈 미쓰하시
Original Assignee
하야시바라 겡
가부시기 가이샤 하야시바라 세이부쓰 가가꾸 겡뀨우죠
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 하야시바라 겡, 가부시기 가이샤 하야시바라 세이부쓰 가가꾸 겡뀨우죠 filed Critical 하야시바라 겡
Publication of KR900003208A publication Critical patent/KR900003208A/ko
Application granted granted Critical
Publication of KR100190555B1 publication Critical patent/KR100190555B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/249—Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/217—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

내용 없음

Description

인체 γ-인터페론과 그 제조방법 및 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 식 I :
    식 II :
    식 Ⅲ :
    식 Ⅳ :
    또는 식 Ⅴ :
    (단, 이것들 식의 중에서 약호표기는 당해분야에서 관용되고 있는 L-아미노산의 약호표기를 나타낸 것이다). 으로 나타내는 폴리페프티드연쇄의 N말단측으로부터 제25번째 및 제97번째에 존재하는 아스파라긴의 한편 또는 양편에,
    식 Ⅵ :
    식 Ⅶ :
    식 Ⅷ :
    식 Ⅸ :
    식 Ⅹ :
    또는 식 XI :
    (단, 이것들 식중의 NeuAc,GlcNAc,Gal,Man 및 Fac는, 각기 N-아세틸노이라민산, N-아세틸-D-글루코사민, D-갈락토오스, D-만토오스 및 L-푸코오스를 나타낸 것이다) 으로 나타내는 당연쇄를 결합하고 있는 인체 γ-인터페론.
  2. 인체로 연유하는 세포에 유도체를 접촉시켜,
    식 I :
    식 II :
    식 Ⅲ :
    식 Ⅳ :
    또는 식 V :
    (단, 이것들 식중의 약호표기는, 당해분야에서 관용되고 있는 L-아미노산의 약호표기를 나타낸 것이다.) 으로 나타내는 폴리페프티드연쇄의 N말단측으로부터 제25번째 및 제97번째에 존재하는 아스파라긴의 한편 또는 양편에,
    식 Ⅵ :
    식 Ⅶ :
    식 Ⅷ :
    식 Ⅸ :
    식 Ⅹ :
    또는 식 XI :
    (단, 이것들 식중의 NeuAc, GlcNAc,Gal,Man 및 Fuc는, 각기, N-아세틸노이라민산, N-아세틸-D-글루코사민, D-갈락토오스, D-만노오스 및 L-푸코오스를 나타낸 것이다)으로 나타내는 당연쇄를 결합하고 있는 인체γ-인터페론을 신생시켜, 이것을 채취하는 것을 특징으로 하는 인체γ-인터페론의 제조방법.
  3. 식 I :
    식 II :
    식 III :
    식 Ⅳ :
    또는 식 V :
    (단, 이것들 식중의 약호표기는 당해분야에서 관용되고 있는 L-아미노산의 약호표기를 나타낸 것이다.) 으로 나타내는 폴리페프티드연쇄의 N말단측으로부터 제25번째 및 제97번째에 존재하는 아스파라긴의 한편 또는 양편에,
    식 Ⅵ :
    식 Ⅶ :
    식 Ⅷ :
    식 IX :
    식 X :
    또는 식 XI :
    (단, 이것들 식중에서 NeuAc,GlcNAc,Gal,Man 및 Fac는, 각기, N-아세틸뉴라민산, N-아세틸-D-글루코사민, D-갈락토오스, D-만노오스 및 L-푸코오스를 뜻한다) 으로 나타내는 당연쇄(carbohydratechain)를 결합하고 있는 인체γ-인터페론을 유효성분으로 하여 함유시킨 것을 특징으로 하는 인터페론 감수성질환의 치료제 또는 예방제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890010440A 1988-07-23 1989-07-24 인체 γ-인터페론의 그 제조 방법 및 용도 KR100190555B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP63-184069 1988-07-23
JP63184069A JP2969461B2 (ja) 1988-07-23 1988-07-23 ヒトγ−インターフェロンとその製造方法並びに用途

Publications (2)

Publication Number Publication Date
KR900003208A true KR900003208A (ko) 1990-03-26
KR100190555B1 KR100190555B1 (ko) 1999-06-01

Family

ID=16146838

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890010440A KR100190555B1 (ko) 1988-07-23 1989-07-24 인체 γ-인터페론의 그 제조 방법 및 용도

Country Status (8)

Country Link
EP (1) EP0353910B1 (ko)
JP (1) JP2969461B2 (ko)
KR (1) KR100190555B1 (ko)
AT (1) ATE128188T1 (ko)
AU (1) AU618382B2 (ko)
CA (1) CA1340704C (ko)
DE (1) DE68924316T2 (ko)
ES (1) ES2096559T3 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05247078A (ja) * 1992-03-03 1993-09-24 Japan Tobacco Inc 糖化合物、シアル酸含有糖鎖類生合成阻害剤、その製造方法、並びに新規な中間体
EP0721780A3 (en) * 1994-12-16 1997-12-17 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Agent for promoting platelet and/or leukocyte production
US6509313B1 (en) 1996-02-28 2003-01-21 Cornell Research Foundation, Inc. Stimulation of immune response with low doses of cytokines
AU2019313339A1 (en) * 2018-07-30 2021-03-11 The Board Of Trustees Of The Leland Stanford Junior University Interferon-gamma biased agonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU184972B (en) * 1981-12-01 1984-11-28 Egyt Gyogyszervegyeszeti Gyar Process for preparing human gamma interferone
EP0107498B1 (en) * 1982-10-25 1990-05-16 Genentech, Inc. Synergistic human interferon activity
ZA844070B (en) * 1983-06-01 1984-12-24 Genentech Inc Gamma interferon-lymphotoxin synergism
DE3536939A1 (de) * 1985-10-17 1987-04-23 Hoechst Ag Biologisch aktive derivate des human-(gamma)-interferons, ihre herstellung und arzneimittel, die solche derivate enthalten
JP2632849B2 (ja) * 1986-07-25 1997-07-23 株式会社 林原生物化学研究所 γ―インターフェロンの製造方法
CA1340698C (en) * 1986-07-25 1999-08-10 Kabushiki Kaisha Hayashibara Seibutsu Kaguku Kenkyujo Preparation and uses of interferon-gamma
GB8619725D0 (en) * 1986-08-13 1986-09-24 Hoffmann La Roche Homogenous interferon fragments

Also Published As

Publication number Publication date
KR100190555B1 (ko) 1999-06-01
AU618382B2 (en) 1991-12-19
ES2096559T3 (es) 1997-03-16
CA1340704C (en) 1999-08-10
ATE128188T1 (de) 1995-10-15
DE68924316T2 (de) 1996-04-04
AU3881889A (en) 1990-01-25
DE68924316D1 (de) 1995-10-26
JP2969461B2 (ja) 1999-11-02
EP0353910A2 (en) 1990-02-07
JPH02152998A (ja) 1990-06-12
EP0353910B1 (en) 1995-09-20
EP0353910A3 (en) 1990-06-06

Similar Documents

Publication Publication Date Title
ES2058291T3 (es) Derivados de piperazinilo de las purinas e isosteros de las mismas como agentes hipoglucemicos.
IT1195497B (it) Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
ATE480256T1 (de) Plazentäre alkalische phosphatase zur diabeteskontrolle
DE69127615T2 (de) Transformierte Erythrozyten, Verfahren zu deren Herstellung, und ihre Verwendung in pharmazeutischen Zusammensetzungen
KR960000222A (ko) 구강 건조증 치료제
NL960024I2 (nl) Farmaceutisch preparaat omvattend 3'-deoxythymidine-2'-een (3'-deoxy-2',3'-didehydrothymidine) voor de behandeling van met retrovirus besmette patiënten.
DE3485843T2 (de) Sucralfat-suspension zur verwendung in der behandlung von geschwueren.
FI855014A (fi) Soetningsmedel, dess framstaellning och anvaendning.
ES2033464T3 (es) Composiciones de relleno que contienen psyllium.
JPS56128794A (en) Aldohexose derivatives, their manufacture and medicine containing them
KR900003208A (ko) 인체 γ-인터페론과 그 제조방법 및 용도
BR9610481A (pt) Agonistas adrenérgicos beta seletivos
GB8523338D0 (en) Treatment of obesity
DE3579471D1 (de) Orales dextran enthaltende zusammensetzungen.
DE68900516D1 (de) Therapeutische mittel zur behandlung von magengeschwueren.
FI875729A0 (fi) Cytostatiska platinafoereningar.
EP0207483A3 (en) Benzimidazoles, process for their preparation, medicaments containing them and intermediates
FR2559157B1 (fr) Nouvel hexapeptide, son procede d'obtention et les compositions pharmaceutiques qui le contiennent
EP0324520A3 (en) Alkyl-piperazinyl-5-6-alkylenepyrimidines
KR900007835A (ko) 벤즈옥사진 유도체
BE900063A (fr) Nouveaux derives de l'ethanol, leur preparation et leur utilisation comme fongicides.
KR830006182A (ko) 신규한 옥시아세트산 유도체, 그의 제법 및 그것을 유효성분으로 하는 혈중지질 저하제(血中脂質低下劑)

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E601 Decision to refuse application
J2X1 Appeal (before the patent court)

Free format text: APPEAL AGAINST DECISION TO DECLINE REFUSAL

E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20061108

Year of fee payment: 9

LAPS Lapse due to unpaid annual fee