ATE480256T1 - Plazentäre alkalische phosphatase zur diabeteskontrolle - Google Patents

Plazentäre alkalische phosphatase zur diabeteskontrolle

Info

Publication number
ATE480256T1
ATE480256T1 AT03796758T AT03796758T ATE480256T1 AT E480256 T1 ATE480256 T1 AT E480256T1 AT 03796758 T AT03796758 T AT 03796758T AT 03796758 T AT03796758 T AT 03796758T AT E480256 T1 ATE480256 T1 AT E480256T1
Authority
AT
Austria
Prior art keywords
alkaline phosphatase
treatment regimens
human
methods
diabetes
Prior art date
Application number
AT03796758T
Other languages
English (en)
Inventor
Zoltan Kiss
Original Assignee
Zoltan Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoltan Lab filed Critical Zoltan Lab
Priority claimed from PCT/US2003/038838 external-priority patent/WO2004054609A1/en
Application granted granted Critical
Publication of ATE480256T1 publication Critical patent/ATE480256T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03001—Alkaline phosphatase (3.1.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT03796758T 2002-12-12 2003-12-05 Plazentäre alkalische phosphatase zur diabeteskontrolle ATE480256T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/317,916 US7048914B2 (en) 2002-12-12 2002-12-12 Placental alkaline phosphatase to control diabetes
US10/441,992 US7014852B2 (en) 2002-12-12 2003-05-20 Alkaline phosphatase to induce weight loss or to reduce weight gain
PCT/US2003/038838 WO2004054609A1 (en) 2002-12-12 2003-12-05 Placental alkaline phosphatase to control diabetes

Publications (1)

Publication Number Publication Date
ATE480256T1 true ATE480256T1 (de) 2010-09-15

Family

ID=32506246

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03796758T ATE480256T1 (de) 2002-12-12 2003-12-05 Plazentäre alkalische phosphatase zur diabeteskontrolle

Country Status (6)

Country Link
US (4) US7048914B2 (de)
EP (1) EP1733734B1 (de)
AT (1) ATE480256T1 (de)
DE (1) DE60334147D1 (de)
DK (1) DK1572230T3 (de)
ES (1) ES2354976T3 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004054609A1 (en) * 2002-12-12 2004-07-01 Zoltan Laboratories Placental alkaline phosphatase to control diabetes
US7048914B2 (en) * 2002-12-12 2006-05-23 Zoltan Laboratories Placental alkaline phosphatase to control diabetes
WO2005055956A2 (en) * 2003-12-09 2005-06-23 Essential Skincare, Llc Method for improving insulin sensitivity by administering an inhibitor of antitrypsin
ES2624905T3 (es) 2004-02-04 2017-07-18 Am-Pharma B.V. Uso de fosfatasa alcalina para la desintoxicación de LPS
US20110142817A1 (en) * 2004-02-04 2011-06-16 Pharmaaware Sepsis B.V. Means and method for treating and/or preventing necrotizing enterocolitis
WO2005117937A2 (en) * 2004-05-27 2005-12-15 Essential Skincare Llc Alpha-1- acid glycoprotein for the treatment of diabetes
WO2007075199A1 (en) * 2005-12-28 2007-07-05 Zoltan Laboratories Llc Use of alkaline phosphatase to maintain healthy tissue mass in mammals
WO2007081654A2 (en) * 2005-12-28 2007-07-19 Zoltan Laboratories Llc Compositions and methods to enhance viability and function of islet cells
WO2007076505A2 (en) * 2005-12-28 2007-07-05 Essential Skincare, Llc Transferrin and transferrin-based compositions for diabetes treatment
EP1952823A1 (de) * 2007-01-30 2008-08-06 AM-Pharma B.V. Verwendung von alkalischer Phosphatase bei der Behandlung eingeschränkter Nierenfunktion
US20090317372A1 (en) * 2008-06-20 2009-12-24 Zoltan Kiss Small molecules for the reduction of high blood glucose level
JP2010031006A (ja) * 2008-07-17 2010-02-12 Novartis Ag 有機化合物の使用
US20100215635A1 (en) * 2009-02-23 2010-08-26 Zoltan Kiss Small molecules to induce weight loss or to reduce weight gain
US20130251701A1 (en) * 2010-10-22 2013-09-26 Zoltan Kiss Consulting Alkaline phosphatase to correct insulin resistance, hyperinsulinemia, and dyslipidemia
US8679480B2 (en) * 2011-06-20 2014-03-25 Wisconsin Alumni Research Foundation Method to inhibit neuropathic pain by intrathecal injection of protein phosphatases
US9926544B2 (en) 2014-01-24 2018-03-27 Am-Pharma B.V. Chimeric alkaline phosphatase-like proteins
ES2688066T3 (es) 2014-01-24 2018-10-30 Am-Pharma B.V. Procesamiento para recuperación y purificación de una fosfatasa alcalina
CA2978604A1 (en) 2015-03-06 2016-09-15 Synthetic Biologics, Inc. Safe and effective beta-lactamase dosing for microbiome protection
WO2018175413A1 (en) 2017-03-21 2018-09-27 Synthetic Biologics, Inc. Alkaline phosphatase formulations
US11338020B2 (en) 2018-01-09 2022-05-24 Synthetic Biologics, Inc. Alkaline phosphatase agents for treatment of neurodevelopmental disorders
US11654184B2 (en) 2018-03-20 2023-05-23 Theriva Biologics, Inc. Alkaline phosphatase agents for treatment of radiation disorders
EP3768302A4 (de) 2018-03-20 2021-12-15 Synthetic Biologics, Inc. Intestinale alkalische phosphataseformulierungen
WO2022150034A1 (en) * 2021-01-06 2022-07-14 Zoltan Laboratories, Llc Placental alkaline phosphatase for starting early treatment of cancer patients exhibiting no detectable loss of body and muscle weight as yet to prevent or reduce the loss of muscle proteins
WO2022177547A1 (en) * 2021-02-16 2022-08-25 Zoltan Laboratories, Llc Placental alkaline phosphatase for reducing the loss of red blood cells, white blood cells, and platelets in chemotherapy treated cancer patients

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4030995A (en) 1976-07-13 1977-06-21 Sigma Chemical Company Alkaline phosphatase isoenzyme determination
GB1594389A (en) 1977-06-03 1981-07-30 Max Planck Gesellschaft Dressing material for wounds
IT1108964B (it) 1978-01-20 1985-12-16 Sclavo Inst Sieroterapeut Composizione adatta all'analisi della fosfatasi alcalina e metodo utilizzante la stessa
US4265233A (en) 1978-04-12 1981-05-05 Unitika Ltd. Material for wound healing
DE3007226A1 (de) 1980-02-27 1981-09-10 Erich 2400 Lübeck Hofacker Arzneikapsel
SU1138410A1 (ru) 1982-09-10 1985-02-07 Астраханский государственный медицинский институт им.А.В.Луначарского Способ выделени термостабильной плацентарной щелочной фосфатазы
US4818540A (en) 1985-02-25 1989-04-04 Rutgers, The State University Of New Jersey Transdermal fertility control system and process
JPS61277626A (ja) 1985-05-31 1986-12-08 Sugiura Shinyaku Kaihatsu Kenkyusho:Kk ス−パ−オキシドジスムタ−ゼを高濃度に含有する胎盤エキスおよびその製法
DE3836971C1 (de) 1988-10-31 1990-05-17 Weck, Wolfgang, Dr.Med., 6990 Bad Mergentheim, De
SU1814764A3 (ru) 1990-04-20 1995-03-20 Тихоокеанский институт биоорганической химии Дальневосточного отделения АН СССР Способ получения средства для лечения гнойно-некротических ран
AU1462392A (en) 1991-02-22 1992-09-15 Amgen, Inc. Use of gm-csf and g-csf to promote accelerated wound healing
JPH08501203A (ja) 1992-06-03 1996-02-13 ケイス・ウエスタン・リザーブ・ユニバーシティー 生理活性物質を連続的に適用するための包帯
WO1995005455A1 (en) * 1993-08-13 1995-02-23 Rijksuniversiteit Te Groningen Pharmaceutical composition comprising phosphatase or a derivative thereof
US5707624A (en) 1994-06-03 1998-01-13 The Regents Of The University Of Michigan Treatment of Kaposi's sarcoma by inhibition of scatter factor
US5932779A (en) 1996-06-10 1999-08-03 Millennium Pharmaceuticals, Inc. Screening methods for compounds useful in the regulation of body weight
US6005000A (en) 1996-08-22 1999-12-21 Oxis International, Inc. 5,5-Disubstituted-3, 4-dihydroxy-2(5H)-furanones and methods of use therefor
US6414036B1 (en) 1999-09-01 2002-07-02 Van Beek Global/Ninkov Llc Composition for treatment of infections of humans and animals
US6627425B1 (en) 2000-06-02 2003-09-30 Millennium Pharmaceuticals, Inc. Human glucose-6-phosphatase molecules and uses thereof
US7011965B2 (en) 2001-03-09 2006-03-14 Regents Of The University Of Minnesota Compositions and methods for stimulating wound healing and fibroblast proliferation
US7048914B2 (en) 2002-12-12 2006-05-23 Zoltan Laboratories Placental alkaline phosphatase to control diabetes
WO2004054609A1 (en) 2002-12-12 2004-07-01 Zoltan Laboratories Placental alkaline phosphatase to control diabetes
US7374754B2 (en) 2003-09-02 2008-05-20 Essential Skincare, Llc Use of placental alkaline phosphatase to promote skin cell proliferation
WO2007075199A1 (en) 2005-12-28 2007-07-05 Zoltan Laboratories Llc Use of alkaline phosphatase to maintain healthy tissue mass in mammals

Also Published As

Publication number Publication date
US20110123513A1 (en) 2011-05-26
US20040115185A1 (en) 2004-06-17
DK1572230T3 (da) 2011-01-03
US20090130080A1 (en) 2009-05-21
US7858085B2 (en) 2010-12-28
EP1733734B1 (de) 2020-01-22
US7048914B2 (en) 2006-05-23
EP1733734A2 (de) 2006-12-20
ES2354976T3 (es) 2011-03-21
US8603464B2 (en) 2013-12-10
DE60334147D1 (de) 2010-10-21
US20040120940A1 (en) 2004-06-24
EP1733734A3 (de) 2011-09-28
US7014852B2 (en) 2006-03-21

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