IT1243987B - Procedimento per la preparazione di epossi-eparidi prodotti ottenuti ecomposizioni farmaceutiche che li contengono - Google Patents

Procedimento per la preparazione di epossi-eparidi prodotti ottenuti ecomposizioni farmaceutiche che li contengono

Info

Publication number
IT1243987B
IT1243987B IT02190990A IT2190990A IT1243987B IT 1243987 B IT1243987 B IT 1243987B IT 02190990 A IT02190990 A IT 02190990A IT 2190990 A IT2190990 A IT 2190990A IT 1243987 B IT1243987 B IT 1243987B
Authority
IT
Italy
Prior art keywords
epoxy
preparation
heparid
ecompositions
procedure
Prior art date
Application number
IT02190990A
Other languages
English (en)
Other versions
IT9021909A0 (it
IT9021909A1 (it
Inventor
Ambrosi Luigi De
Original Assignee
Derivati Organici Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Derivati Organici Lab filed Critical Derivati Organici Lab
Priority to IT02190990A priority Critical patent/IT1243987B/it
Publication of IT9021909A0 publication Critical patent/IT9021909A0/it
Priority to EP91118366A priority patent/EP0483733B1/en
Priority to AT91118366T priority patent/ATE141929T1/de
Priority to CA002054347A priority patent/CA2054347A1/en
Priority to DE69121666T priority patent/DE69121666D1/de
Priority to JP3308254A priority patent/JPH04288301A/ja
Publication of IT9021909A1 publication Critical patent/IT9021909A1/it
Priority to US08/146,805 priority patent/US5403827A/en
Application granted granted Critical
Publication of IT1243987B publication Critical patent/IT1243987B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Epoxy Compounds (AREA)
IT02190990A 1990-10-29 1990-10-29 Procedimento per la preparazione di epossi-eparidi prodotti ottenuti ecomposizioni farmaceutiche che li contengono IT1243987B (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT02190990A IT1243987B (it) 1990-10-29 1990-10-29 Procedimento per la preparazione di epossi-eparidi prodotti ottenuti ecomposizioni farmaceutiche che li contengono
EP91118366A EP0483733B1 (en) 1990-10-29 1991-10-28 Process for preparing epoxy-heparides, the products obtained and pharmaceutical compositions containing them
AT91118366T ATE141929T1 (de) 1990-10-29 1991-10-28 Verfahren zur herstellung von epoxy-hepariden; die so hergestellten produkte und diese enthaltende pharmazeutische zusammensetzungen
CA002054347A CA2054347A1 (en) 1990-10-29 1991-10-28 Process for preparing epoxy-heparides, the products obtained and pharmaceutical compositions containing them
DE69121666T DE69121666D1 (de) 1990-10-29 1991-10-28 Verfahren zur Herstellung von Epoxy-Hepariden; die so hergestellten Produkte und diese enthaltende pharmazeutische Zusammensetzungen
JP3308254A JPH04288301A (ja) 1990-10-29 1991-10-29 エポキシヘパリドの製法、その生成物及びそれらを含む医薬組成物
US08/146,805 US5403827A (en) 1990-10-29 1993-11-02 Process for preparing epoxy-heparides, the products obtained and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02190990A IT1243987B (it) 1990-10-29 1990-10-29 Procedimento per la preparazione di epossi-eparidi prodotti ottenuti ecomposizioni farmaceutiche che li contengono

Publications (3)

Publication Number Publication Date
IT9021909A0 IT9021909A0 (it) 1990-10-29
IT9021909A1 IT9021909A1 (it) 1992-04-29
IT1243987B true IT1243987B (it) 1994-06-28

Family

ID=11188614

Family Applications (1)

Application Number Title Priority Date Filing Date
IT02190990A IT1243987B (it) 1990-10-29 1990-10-29 Procedimento per la preparazione di epossi-eparidi prodotti ottenuti ecomposizioni farmaceutiche che li contengono

Country Status (7)

Country Link
US (1) US5403827A (it)
EP (1) EP0483733B1 (it)
JP (1) JPH04288301A (it)
AT (1) ATE141929T1 (it)
CA (1) CA2054347A1 (it)
DE (1) DE69121666D1 (it)
IT (1) IT1243987B (it)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5296471A (en) * 1992-12-22 1994-03-22 Glycomed Incorporated Method for controlling o-desulfation of heparin and compositions produced thereby
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
US20020040008A1 (en) * 1995-01-24 2002-04-04 Wagner Denisa D. Method for treating and preventing atherosclerosis
US5891196A (en) * 1997-04-16 1999-04-06 Baxter International Inc. Method for actively binding heparin to crosslinked biological tissues
RU2129001C1 (ru) * 1998-06-03 1999-04-20 Всероссийский научно-исследовательский институт мясной промышленности Средство для лечения атеросклероза "алиприл"
JP4828795B2 (ja) 2002-03-11 2011-11-30 モメンタ ファーマシューティカルズ インコーポレイテッド 硫酸化多糖類の分析
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
US8569262B2 (en) * 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
EP2205642B1 (en) * 2007-11-02 2016-01-27 Momenta Pharmaceuticals, Inc. Non-anticoagulant polysaccharide compositions
US8592393B2 (en) * 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US8435795B2 (en) * 2010-01-19 2013-05-07 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
BR112012026542A2 (pt) 2010-04-16 2016-07-12 Momenta Pharmaceuticals Inc abordagem seletiva de tecido
WO2011159770A2 (en) 2010-06-17 2011-12-22 Momenta Pharmaceuticals, Inc. Methods and compositions for modulating hair growth
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
WO2014193818A1 (en) 2013-05-28 2014-12-04 Momenta Pharmaceuticals, Inc. Pharmaceutical compositions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3179566A (en) * 1963-05-16 1965-04-20 Canada Packers Ltd Purification of heparin
FR2538404B1 (it) * 1982-12-28 1985-08-23 Anic Spa
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
DE3422518A1 (de) * 1984-06-16 1985-12-19 B. Braun Melsungen Ag, 3508 Melsungen Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen
IT1214609B (it) * 1985-05-17 1990-01-18 Opocrin Spa Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono.
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US4981955A (en) * 1988-06-28 1991-01-01 Lopez Lorenzo L Depolymerization method of heparin

Also Published As

Publication number Publication date
US5403827A (en) 1995-04-04
EP0483733B1 (en) 1996-08-28
IT9021909A0 (it) 1990-10-29
CA2054347A1 (en) 1992-04-30
IT9021909A1 (it) 1992-04-29
EP0483733A1 (en) 1992-05-06
ATE141929T1 (de) 1996-09-15
DE69121666D1 (de) 1996-10-02
JPH04288301A (ja) 1992-10-13

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19961015