IT1264709B1 - Derivati eparinici ad attivita' antimetastatica - Google Patents

Derivati eparinici ad attivita' antimetastatica

Info

Publication number
IT1264709B1
IT1264709B1 IT93MI001518A ITMI931518A IT1264709B1 IT 1264709 B1 IT1264709 B1 IT 1264709B1 IT 93MI001518 A IT93MI001518 A IT 93MI001518A IT MI931518 A ITMI931518 A IT MI931518A IT 1264709 B1 IT1264709 B1 IT 1264709B1
Authority
IT
Italy
Prior art keywords
activity
metastastic
derivatives
heparinic
heparinic derivatives
Prior art date
Application number
IT93MI001518A
Other languages
English (en)
Inventor
Patrizia Caretto
Teresa Sciumbata
Flavio Leoni
Gianni Gromo
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Publication of ITMI931518A0 publication Critical patent/ITMI931518A0/it
Priority to IT93MI001518A priority Critical patent/IT1264709B1/it
Priority to US08/591,575 priority patent/US5763421A/en
Priority to CA002167059A priority patent/CA2167059A1/en
Priority to ES94922246T priority patent/ES2128573T3/es
Priority to JP7504319A priority patent/JPH08512353A/ja
Priority to PCT/EP1994/002133 priority patent/WO1995002613A2/en
Priority to AU73451/94A priority patent/AU7345194A/en
Priority to DK94922246T priority patent/DK0708785T3/da
Priority to EP94922246A priority patent/EP0708785B1/en
Priority to DE69417035T priority patent/DE69417035T2/de
Priority to AT94922246T priority patent/ATE177433T1/de
Priority to ZA945005A priority patent/ZA945005B/xx
Priority to IL11028794A priority patent/IL110287A0/xx
Publication of ITMI931518A1 publication Critical patent/ITMI931518A1/it
Priority to FI960130A priority patent/FI960130A/fi
Application granted granted Critical
Publication of IT1264709B1 publication Critical patent/IT1264709B1/it
Priority to US09/050,996 priority patent/US6130210A/en
Priority to GR990400950T priority patent/GR3029861T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Abstract

Derivati e/o frammenti e frazioni eparinici mostrano un'attività inibitoria della proliferazione metastatica.
IT93MI001518A 1993-07-12 1993-07-12 Derivati eparinici ad attivita' antimetastatica IT1264709B1 (it)

Priority Applications (16)

Application Number Priority Date Filing Date Title
IT93MI001518A IT1264709B1 (it) 1993-07-12 1993-07-12 Derivati eparinici ad attivita' antimetastatica
EP94922246A EP0708785B1 (en) 1993-07-12 1994-06-30 Heparin derivatives having antimetastatic activity
AT94922246T ATE177433T1 (de) 1993-07-12 1994-06-30 Heparinderivate mit antimetastatischer wirkung
ES94922246T ES2128573T3 (es) 1993-07-12 1994-06-30 Derivados de heparina con actividad antimetastatica.
JP7504319A JPH08512353A (ja) 1993-07-12 1994-06-30 抗転移活性を有するヘパリン誘導体
PCT/EP1994/002133 WO1995002613A2 (en) 1993-07-12 1994-06-30 Heparin derivatives having antimetastatic activity
AU73451/94A AU7345194A (en) 1993-07-12 1994-06-30 Heparin derivatives having antimetastatic activity
DK94922246T DK0708785T3 (da) 1993-07-12 1994-06-30 Heparin-derivater med antimetastatisk aktivitet
US08/591,575 US5763421A (en) 1993-07-12 1994-06-30 Heparin derivatives having antimetastatic activity
DE69417035T DE69417035T2 (de) 1993-07-12 1994-06-30 Heparinderivate mit antimetastatischer wirkung
CA002167059A CA2167059A1 (en) 1993-07-12 1994-06-30 Heparin derivatives having antimetastatic activity
ZA945005A ZA945005B (en) 1993-07-12 1994-07-11 Heparin derivatives having antimetastatic activity
IL11028794A IL110287A0 (en) 1993-07-12 1994-07-11 Heparin derivatives having antimetastatic activity
FI960130A FI960130A (fi) 1993-07-12 1996-01-11 Hepariinijohdannaiset, joilla on etäpesäkkeitä vastustava vaikutus
US09/050,996 US6130210A (en) 1993-07-12 1998-03-31 Heparin derivatives having antimetastatic activity
GR990400950T GR3029861T3 (en) 1993-07-12 1999-04-05 Heparin derivatives having antimetastatic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93MI001518A IT1264709B1 (it) 1993-07-12 1993-07-12 Derivati eparinici ad attivita' antimetastatica

Publications (3)

Publication Number Publication Date
ITMI931518A0 ITMI931518A0 (it) 1993-07-12
ITMI931518A1 ITMI931518A1 (it) 1995-01-12
IT1264709B1 true IT1264709B1 (it) 1996-10-04

Family

ID=11366579

Family Applications (1)

Application Number Title Priority Date Filing Date
IT93MI001518A IT1264709B1 (it) 1993-07-12 1993-07-12 Derivati eparinici ad attivita' antimetastatica

Country Status (15)

Country Link
US (2) US5763421A (it)
EP (1) EP0708785B1 (it)
JP (1) JPH08512353A (it)
AT (1) ATE177433T1 (it)
AU (1) AU7345194A (it)
CA (1) CA2167059A1 (it)
DE (1) DE69417035T2 (it)
DK (1) DK0708785T3 (it)
ES (1) ES2128573T3 (it)
FI (1) FI960130A (it)
GR (1) GR3029861T3 (it)
IL (1) IL110287A0 (it)
IT (1) IT1264709B1 (it)
WO (1) WO1995002613A2 (it)
ZA (1) ZA945005B (it)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7151099B2 (en) 1998-07-31 2006-12-19 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Use of taurolidine and/or taurultam for treatment of abdominal cancer and/or for the prevention of metastases
US8304390B2 (en) * 1997-07-31 2012-11-06 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method of treatment for preventing or reducing tumor growth in the liver of patient
US20050124608A1 (en) * 2001-04-03 2005-06-09 Redmond H. P. Treatment of cancers
US7345039B2 (en) * 1999-06-04 2008-03-18 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Enhancement of effectiveness of 5-fluorouracil in treatment of tumor metastases and cancer
US8030301B2 (en) * 1999-06-04 2011-10-04 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Treatment of cancers with methylol-containing compounds and at least one electrolyte
US7892530B2 (en) * 1999-06-04 2011-02-22 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Treatment of tumor metastases and cancer
KR20020032444A (ko) * 1999-06-30 2002-05-03 잭 허쉬 응괴 연관된 응고 인자를 억제하는 헤파린 조성물
US6641571B2 (en) 2000-01-05 2003-11-04 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Reduction of postoperative complications of cardiopulmonary bypass (CPB) surgery
IT1316986B1 (it) 2000-01-25 2003-05-26 Sigma Tau Ind Farmaceuti Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
US7781416B2 (en) 2000-01-25 2010-08-24 Sigma-Tau Research Switzerland S.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
CA2420890A1 (en) * 2000-09-08 2002-03-14 Hamilton Civic Hospitals Research Development, Inc. Antithrombotic compositions
HU230385B1 (hu) * 2001-09-12 2016-03-29 SIGMA-TAU - Research Switzerland S.A Részlegesen deszulfatált glükóz-amino-glükánok származékai mint a heparanáz enzim inhibitorai, előállításuk és alkalmazásuk, valamint ilyen származékokat tartalmazó gyógyszerkészítmények
EP2402753A1 (en) 2002-03-11 2012-01-04 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
WO2005089365A2 (en) * 2004-03-16 2005-09-29 The General Hospital Corporation Treatment and prevention of abnormal cellular proliferation
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
EP2205642B1 (en) * 2007-11-02 2016-01-27 Momenta Pharmaceuticals, Inc. Non-anticoagulant polysaccharide compositions
US8592393B2 (en) * 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US8569262B2 (en) 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US8435795B2 (en) * 2010-01-19 2013-05-07 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
BR112012026542A2 (pt) 2010-04-16 2016-07-12 Momenta Pharmaceuticals Inc abordagem seletiva de tecido
BR112012031906A2 (pt) 2010-06-17 2016-08-23 Momenta Pharmaceuticals Inc métodos e composições para modular o crescimento de cabelo e pelos.
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
US10016449B2 (en) 2013-05-28 2018-07-10 Momenta Pharmaceuticals, Inc. Pharmaceutical compositions
JP6132302B2 (ja) * 2013-05-28 2017-05-24 リーディアント・バイオサイエンシーズ・ソシエタ・アノニマＬｅａｄｉａｎｔ Ｂｉｏｓｃｉｅｎｃｅｓ Ｓ．Ａ． 抗血管新生活性を有し、抗凝血効果を有さない、ヘパラナーゼ阻害剤としての部分的に脱硫酸化されたグリコサミノグリカンの誘導体
JP2016014148A (ja) * 2015-09-10 2016-01-28 シグマ−タウ・リサーチ・スウィッツァーランド・ソシエテ・アノニム 抗血管新生活性を有し、抗凝血効果を有さない、ヘパラナーゼ阻害剤としての部分的に脱硫酸化されたグリコサミノグリカンの誘導体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1987M (fr) * 1961-08-01 1963-08-26 Evans Medical Ltd Médicament antilipémique a base d'héparine modifiée.
US3118816A (en) * 1962-04-03 1964-01-21 Abbott Lab N-succinyl heparin and process
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
DE3422518A1 (de) * 1984-06-16 1985-12-19 B. Braun Melsungen Ag, 3508 Melsungen Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen
IL85145A (en) * 1987-01-23 1994-08-26 Univ Australian Anti-metastatic pharmacological or veterinary preparations containing modified herpin with reduced anticoagulant activity
US5541166A (en) * 1987-01-23 1996-07-30 The Australian National University Sulphated polysaccharides having anti-metastatic and/or anti-inflammatory activity
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
IT1230582B (it) * 1988-10-21 1991-10-28 Opocrin S P A Lab Farmabiologi Oliogosaccaridi di dermatan solfato ed eparina aventi attivita' antiaterosclerotica
US5280016A (en) * 1991-03-29 1994-01-18 Glycomed Incorporated Non-anticoagulant heparin derivatives
CA2157388C (en) * 1993-03-01 1998-12-15 Daniel P. Witt Analogs for specific oligosaccharide-protein interactions and uses thereof

Also Published As

Publication number Publication date
WO1995002613A2 (en) 1995-01-26
ITMI931518A1 (it) 1995-01-12
DE69417035T2 (de) 1999-08-05
US6130210A (en) 2000-10-10
AU7345194A (en) 1995-02-13
DE69417035D1 (de) 1999-04-15
GR3029861T3 (en) 1999-07-30
ITMI931518A0 (it) 1993-07-12
CA2167059A1 (en) 1995-01-26
FI960130A0 (fi) 1996-01-11
FI960130A (fi) 1996-01-11
ATE177433T1 (de) 1999-03-15
DK0708785T3 (da) 1999-10-04
WO1995002613A3 (en) 1995-03-09
ES2128573T3 (es) 1999-05-16
EP0708785B1 (en) 1999-03-10
EP0708785A1 (en) 1996-05-01
IL110287A0 (en) 1994-10-21
US5763421A (en) 1998-06-09
ZA945005B (en) 1995-02-21
JPH08512353A (ja) 1996-12-24

Similar Documents

Publication Publication Date Title
IT1264709B1 (it) Derivati eparinici ad attivita' antimetastatica
UA32510A1 (uk) Клавіатура
BR8903283A (pt) Composicao de vidro cinzento neutro,e lamina de vidro
DE69725256D1 (de) Plasmavergasung und -verglasung von Aschen
AU2266297A (en) Recovery of taxanes from conifers
ATE397005T1 (de) Sialyl-lewisa und sialyl-lewisx epitope analoge
DE69016463D1 (de) Handfreie hardwaretastatur.
DE69002595T2 (de) Spiralverdichter und Montageverfahren dafür.
DE69310216D1 (de) Schraubenverdichter
BG103832A (en) Leptin as tumour cells proliferation inhibitor
IT8919964A0 (it) Proteine inibenti i ribosomi e loro derivati.
DE59105300D1 (de) Tastatur-und Anzeigenbeleuchtung.
FI935654A0 (fi) Kondenserade heterocykliska foereningar, deras framstaellning och anvaendning
BR8901106A (pt) Armacao de ferragem e esteio de janela
IT8521067A0 (it) Complesso con beta-ciclodestrina di derivati della benzensolfonilurea.
ITMI931175A0 (it) Polisaccaridi ad elevata attivita' antitrombotica e anticoagulante
DE69029051D1 (de) Cache-Speicher und verwandtes Übereinstimmungsprotokoll
DE69026046T2 (de) Kombinierte Tastatur- und Mausrechnereingabe
DE69007825T2 (de) Vertrauliche Tastatur mit Berührungseffekt und Verwendung der Tastatur.
ITTO920683A1 (it) Impiego di frammenti o/e di derivati della timosina alfa 1.
ITMI940025A0 (it) Derivati di piperazin e piperidinisossazolo
NO930712L (no) Ensilasje-additiv
BR8506858A (pt) Muleta,bengala e similar com comprimento continuamente variavel
KR950011915U (ko) 스크롤압축기의 분류판
NO884507D0 (no) Profilplate bestaaende av baerende og romavsluttende avsnitt

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970730