FI960130A - Hepariinijohdannaiset, joilla on etäpesäkkeitä vastustava vaikutus - Google Patents

Hepariinijohdannaiset, joilla on etäpesäkkeitä vastustava vaikutus Download PDF

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Publication number
FI960130A
FI960130A FI960130A FI960130A FI960130A FI 960130 A FI960130 A FI 960130A FI 960130 A FI960130 A FI 960130A FI 960130 A FI960130 A FI 960130A FI 960130 A FI960130 A FI 960130A
Authority
FI
Finland
Prior art keywords
heparin derivatives
daltons
metastatic effect
acylated
molecular weights
Prior art date
Application number
FI960130A
Other languages
English (en)
Swedish (sv)
Other versions
FI960130A0 (fi
Inventor
Patrizia Caretto
Teresa Sciambata
Flavio Leoni
Gianni Gromo
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Publication of FI960130A publication Critical patent/FI960130A/fi
Publication of FI960130A0 publication Critical patent/FI960130A0/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
FI960130A 1993-07-12 1996-01-11 Hepariinijohdannaiset, joilla on etäpesäkkeitä vastustava vaikutus FI960130A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT93MI001518A IT1264709B1 (it) 1993-07-12 1993-07-12 Derivati eparinici ad attivita' antimetastatica
PCT/EP1994/002133 WO1995002613A2 (en) 1993-07-12 1994-06-30 Heparin derivatives having antimetastatic activity

Publications (2)

Publication Number Publication Date
FI960130A true FI960130A (fi) 1996-01-11
FI960130A0 FI960130A0 (fi) 1996-01-11

Family

ID=11366579

Family Applications (1)

Application Number Title Priority Date Filing Date
FI960130A FI960130A0 (fi) 1993-07-12 1996-01-11 Hepariinijohdannaiset, joilla on etäpesäkkeitä vastustava vaikutus

Country Status (15)

Country Link
US (2) US5763421A (fi)
EP (1) EP0708785B1 (fi)
JP (1) JPH08512353A (fi)
AT (1) ATE177433T1 (fi)
AU (1) AU7345194A (fi)
CA (1) CA2167059A1 (fi)
DE (1) DE69417035T2 (fi)
DK (1) DK0708785T3 (fi)
ES (1) ES2128573T3 (fi)
FI (1) FI960130A0 (fi)
GR (1) GR3029861T3 (fi)
IL (1) IL110287A0 (fi)
IT (1) IT1264709B1 (fi)
WO (1) WO1995002613A2 (fi)
ZA (1) ZA945005B (fi)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050124608A1 (en) * 2001-04-03 2005-06-09 Redmond H. P. Treatment of cancers
US7151099B2 (en) 1998-07-31 2006-12-19 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Use of taurolidine and/or taurultam for treatment of abdominal cancer and/or for the prevention of metastases
US8304390B2 (en) * 1997-07-31 2012-11-06 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method of treatment for preventing or reducing tumor growth in the liver of patient
US8030301B2 (en) * 1999-06-04 2011-10-04 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Treatment of cancers with methylol-containing compounds and at least one electrolyte
US7892530B2 (en) * 1999-06-04 2011-02-22 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Treatment of tumor metastases and cancer
US7345039B2 (en) * 1999-06-04 2008-03-18 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Enhancement of effectiveness of 5-fluorouracil in treatment of tumor metastases and cancer
WO2001002443A1 (en) * 1999-06-30 2001-01-11 Hamilton Civic Hospitals Research Development, Inc Heparin compositions that inhibit clot associated coagulation factors
US6641571B2 (en) 2000-01-05 2003-11-04 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Reduction of postoperative complications of cardiopulmonary bypass (CPB) surgery
US7781416B2 (en) 2000-01-25 2010-08-24 Sigma-Tau Research Switzerland S.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
IT1316986B1 (it) 2000-01-25 2003-05-26 Sigma Tau Ind Farmaceuti Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
PL363047A1 (en) * 2000-09-08 2004-11-15 Hamilton Civic Hospitals Research Development Inc. Antithrombotic compositions
PT1427427E (pt) * 2001-09-12 2011-09-13 Sigma Tau Res Switzerland Sa Derivados de glicosaminoglicanos parcialmente dessulfatados como inibidores da heparanase, dotados de actividade antiangiogénica e destituídos de efeito anticoagulante
JP4828795B2 (ja) 2002-03-11 2011-11-30 モメンタ ファーマシューティカルズ インコーポレイテッド 硫酸化多糖類の分析
US7538096B2 (en) * 2004-03-16 2009-05-26 The General Hospital Corporation Treatment and prevention of abnormal cellular proliferation
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
US8569262B2 (en) * 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
EP2205642B1 (en) * 2007-11-02 2016-01-27 Momenta Pharmaceuticals, Inc. Non-anticoagulant polysaccharide compositions
US8592393B2 (en) 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US8435795B2 (en) * 2010-01-19 2013-05-07 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
EP2558506B1 (en) 2010-04-16 2019-06-26 Momenta Pharmaceuticals, Inc. Tissue targeting
US10017585B2 (en) 2010-06-17 2018-07-10 Momenta Pharmaceuticals, Inc. Methods and compositions for promoting hair growth
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
AU2014274377A1 (en) 2013-05-28 2015-11-12 Momenta Pharmaceuticals, Inc. Pharmaceutical compositions
JP6132302B2 (ja) * 2013-05-28 2017-05-24 リーディアント・バイオサイエンシーズ・ソシエタ・アノニマＬｅａｄｉａｎｔ Ｂｉｏｓｃｉｅｎｃｅｓ Ｓ．Ａ． 抗血管新生活性を有し、抗凝血効果を有さない、ヘパラナーゼ阻害剤としての部分的に脱硫酸化されたグリコサミノグリカンの誘導体
JP2016014148A (ja) * 2015-09-10 2016-01-28 シグマ−タウ・リサーチ・スウィッツァーランド・ソシエテ・アノニム 抗血管新生活性を有し、抗凝血効果を有さない、ヘパラナーゼ阻害剤としての部分的に脱硫酸化されたグリコサミノグリカンの誘導体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1987M (fr) * 1961-08-01 1963-08-26 Evans Medical Ltd Médicament antilipémique a base d'héparine modifiée.
US3118816A (en) * 1962-04-03 1964-01-21 Abbott Lab N-succinyl heparin and process
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
DE3422518A1 (de) * 1984-06-16 1985-12-19 B. Braun Melsungen Ag, 3508 Melsungen Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen
IL85145A (en) * 1987-01-23 1994-08-26 Univ Australian Anti-metastatic pharmacological or veterinary preparations containing modified herpin with reduced anticoagulant activity
US5541166A (en) * 1987-01-23 1996-07-30 The Australian National University Sulphated polysaccharides having anti-metastatic and/or anti-inflammatory activity
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
IT1230582B (it) * 1988-10-21 1991-10-28 Opocrin S P A Lab Farmabiologi Oliogosaccaridi di dermatan solfato ed eparina aventi attivita' antiaterosclerotica
US5280016A (en) * 1991-03-29 1994-01-18 Glycomed Incorporated Non-anticoagulant heparin derivatives
DE69418322D1 (de) * 1993-03-01 1999-06-10 Glycan Pharm Inc Analoge für spezifische oligosaccharid-protein-wechselwirkungen und ihre verwendungen

Also Published As

Publication number Publication date
AU7345194A (en) 1995-02-13
ZA945005B (en) 1995-02-21
ATE177433T1 (de) 1999-03-15
DE69417035D1 (de) 1999-04-15
WO1995002613A3 (en) 1995-03-09
DK0708785T3 (da) 1999-10-04
US6130210A (en) 2000-10-10
ITMI931518A0 (it) 1993-07-12
ITMI931518A1 (it) 1995-01-12
IL110287A0 (en) 1994-10-21
US5763421A (en) 1998-06-09
JPH08512353A (ja) 1996-12-24
EP0708785B1 (en) 1999-03-10
CA2167059A1 (en) 1995-01-26
IT1264709B1 (it) 1996-10-04
DE69417035T2 (de) 1999-08-05
WO1995002613A2 (en) 1995-01-26
FI960130A0 (fi) 1996-01-11
GR3029861T3 (en) 1999-07-30
EP0708785A1 (en) 1996-05-01
ES2128573T3 (es) 1999-05-16

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