FI861020A - Foerfarande foer framstaellning av naturligt heparansulfat och dermatansulfat i vaesentligen ren form. - Google Patents

Foerfarande foer framstaellning av naturligt heparansulfat och dermatansulfat i vaesentligen ren form. Download PDF

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Publication number
FI861020A
FI861020A FI861020A FI861020A FI861020A FI 861020 A FI861020 A FI 861020A FI 861020 A FI861020 A FI 861020A FI 861020 A FI861020 A FI 861020A FI 861020 A FI861020 A FI 861020A
Authority
FI
Finland
Prior art keywords
sulphate
vaesentligen
naturligt
heparansulfat
dermatansulfat
Prior art date
Application number
FI861020A
Other languages
English (en)
Other versions
FI82700B (fi
FI82700C (fi
FI861020A0 (fi
Inventor
Rinaldo Del Bono
Ambrosi Luigi De
Piergiuseppe Pagella
Gianni Ferrari
Original Assignee
Mediolanum Farmaceutici Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediolanum Farmaceutici Srl filed Critical Mediolanum Farmaceutici Srl
Publication of FI861020A0 publication Critical patent/FI861020A0/fi
Publication of FI861020A publication Critical patent/FI861020A/fi
Publication of FI82700B publication Critical patent/FI82700B/fi
Application granted granted Critical
Publication of FI82700C publication Critical patent/FI82700C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0066—Isolation or extraction of proteoglycans from organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
FI861020A 1985-03-13 1986-03-12 Foerfarande foer framstaellning av naturligt heparansulfat och dermatansulfat i vaesentligen ren form. FI82700C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1988585 1985-03-13
IT8519885A IT1208509B (it) 1985-03-13 1985-03-13 Processo per la produzione di eparan solfato e dermatan solfato naturali sostanzialmente puri eloro impiego farmaceutico.

Publications (4)

Publication Number Publication Date
FI861020A0 FI861020A0 (fi) 1986-03-12
FI861020A true FI861020A (fi) 1986-09-14
FI82700B FI82700B (fi) 1990-12-31
FI82700C FI82700C (fi) 1991-04-10

Family

ID=11162062

Family Applications (1)

Application Number Title Priority Date Filing Date
FI861020A FI82700C (fi) 1985-03-13 1986-03-12 Foerfarande foer framstaellning av naturligt heparansulfat och dermatansulfat i vaesentligen ren form.

Country Status (20)

Country Link
US (1) US4783447A (fi)
EP (1) EP0199033B1 (fi)
JP (1) JPS61218601A (fi)
KR (1) KR910006809B1 (fi)
AT (1) ATE99702T1 (fi)
AU (1) AU582221B2 (fi)
CA (1) CA1286286C (fi)
DE (1) DE3689493T2 (fi)
DK (1) DK113886A (fi)
ES (1) ES8705894A1 (fi)
FI (1) FI82700C (fi)
GR (1) GR860677B (fi)
IN (1) IN163616B (fi)
IT (1) IT1208509B (fi)
NO (1) NO166187C (fi)
NZ (1) NZ215435A (fi)
PH (2) PH22370A (fi)
PT (1) PT82198B (fi)
YU (1) YU46303B (fi)
ZA (1) ZA861855B (fi)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1189085B (it) * 1986-03-25 1988-01-28 Mediolanum Farmaceutici Srl Processo per la preparazione di dermatan solfato ad alta purezza e composizioni farmaceutiche che lo contengono
US5707604A (en) * 1986-11-18 1998-01-13 Access Pharmaceuticals, Inc. Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles
DE3639561A1 (de) * 1986-11-20 1988-06-01 Baumann Hanno Verfahren zur herstellung von nicht-thrombogenen substraten
IT1232939B (it) * 1987-11-06 1992-03-10 Opocrin Spa Eparan solfato caratterizzato da elevata attivita' antitrombotica, elevata biodisponibilita', assenza di attivita' anticoagulante; suo processo di estrazione da organi e da tessuti e relative composizioni farmaceutiche
AU630359B2 (en) * 1988-06-03 1992-10-29 Italfarmaco S.P.A. Glycosaminoglycan salts, processes for the preparation thereof and pharmaceutical compositions containing them
ATE98656T1 (de) * 1989-10-04 1994-01-15 Akzo Nv Sulfatierte glykosaminoglykuronane mit antithrombotischer wirkung.
EP0493533A4 (en) * 1989-10-27 1992-10-28 Case Western Reserve University Inhibition of cell growth by keratan sulfate, chondroitin sulfate, dermatan sulfate and other glycans
IT1240615B (it) * 1990-04-03 1993-12-17 Mediolanum Farmaceutici Spa Impiego del dermatan solfato nella prevenzione e terapia dell'invecchiamento cerebrale e degli stati di deficit funzionale del sistema nervoso centrale
WO1991015217A1 (en) * 1990-04-06 1991-10-17 Washington University Anticoagulant oligosaccharides
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
US5705178A (en) * 1991-05-31 1998-01-06 Gliatech, Inc. Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
FR2691066B1 (fr) * 1992-05-15 1995-06-09 Sanofi Elf Utilisation de glycosaminoglycanes exogenes, de leurs analogues ainsi que de leurs fragments, fractions et derives, pour la preparation de medicaments destines au traitement de thrombopenies.
IT1256236B (it) * 1992-12-23 1995-11-29 Mediolanum Farmaceutici Srl Oligosaccaridi aventi attivita' biologica e procedimento per la loro preparazione di glicosaminoglicani
PL177245B1 (pl) * 1993-09-30 1999-10-29 Seikagaku Kogyo Co Ltd Środek przeciwzakrzepowy
US6106866A (en) * 1995-07-31 2000-08-22 Access Pharmaceuticals, Inc. In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites
IT1296581B1 (it) * 1997-11-28 1999-07-14 Istituto Scient Di Chimica E B Materiali polimerici non trombogenici e ad esaltata compatibilita' con fluidi e tessuti organici
KR20020032444A (ko) * 1999-06-30 2002-05-03 잭 허쉬 응괴 연관된 응고 인자를 억제하는 헤파린 조성물
JP2004507562A (ja) * 2000-09-08 2004-03-11 ハミルトン　シビック　ホスピタルズ　リサーチ　ディベロップメント　インコーポレイテッド 抗血栓性組成物
CN107098989A (zh) * 2017-04-27 2017-08-29 甘肃省金羚集团药业有限公司 一种肝素钠的制备方法
CN114478832B (zh) * 2022-02-14 2023-03-03 河北常山生化药业股份有限公司 从肝素钠副产物中提纯四种多糖类产品的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3179566A (en) * 1963-05-16 1965-04-20 Canada Packers Ltd Purification of heparin
JPS5318520B2 (fi) * 1972-07-05 1978-06-15
AR207237A1 (es) * 1974-02-25 1976-09-22 Thomas A Procedimiento para obtener extractos biologicos estables liofilizados solubles constituidos por complejos proteicos termorresistentes
US4243582A (en) * 1979-04-26 1981-01-06 Monsanto Company Novel glycoproteins from bovine cartilage
JPS58171403A (ja) * 1982-04-01 1983-10-08 Eisai Co Ltd ヘパラン硫酸の精製法
IT1189298B (it) * 1982-06-18 1988-02-04 Manetti & Roberts Italo Brit Procedimento per produrre i glicosa minoglicani dermatansolfato ed eparan-solfato sostanzialmente puri e loro impiego farmaceutico
FR2555993B1 (fr) * 1983-12-06 1986-11-07 Anic Spa Chitosanes 6-sulfates et procede pour leur preparation
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
IT1163772B (it) * 1983-07-13 1987-04-08 Baldacci Lab Spa Oligosaccaridi eterogenei complessabili ed alfa-idosani ad attivita' terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche

Also Published As

Publication number Publication date
JPS61218601A (ja) 1986-09-29
GR860677B (en) 1986-07-14
PT82198B (pt) 1988-02-17
FI82700B (fi) 1990-12-31
NO860940L (no) 1986-09-15
ES552898A0 (es) 1987-05-16
YU37586A (en) 1988-04-30
FI82700C (fi) 1991-04-10
KR910006809B1 (ko) 1991-09-02
FI861020A0 (fi) 1986-03-12
IN163616B (fi) 1988-10-15
DE3689493D1 (de) 1994-02-17
NO166187C (no) 1991-06-12
YU46303B (sh) 1993-05-28
KR860007278A (ko) 1986-10-10
DK113886A (da) 1986-09-14
US4783447A (en) 1988-11-08
EP0199033A3 (en) 1988-03-30
ES8705894A1 (es) 1987-05-16
NO166187B (no) 1991-03-04
EP0199033A2 (en) 1986-10-29
DE3689493T2 (de) 1994-04-28
NZ215435A (en) 1989-01-06
JPH0238601B2 (fi) 1990-08-31
IT8519885A0 (it) 1985-03-13
AU582221B2 (en) 1989-03-16
PH22370A (en) 1988-08-12
CA1286286C (en) 1991-07-16
AU5472786A (en) 1986-09-18
PH25136A (en) 1991-02-19
DK113886D0 (da) 1986-03-12
PT82198A (en) 1986-04-01
EP0199033B1 (en) 1994-01-05
IT1208509B (it) 1989-07-10
ZA861855B (en) 1986-10-29
ATE99702T1 (de) 1994-01-15

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Owner name: MEDIOLANUM FARMACEUTICI S.R.L.