ATE98656T1 - Sulfatierte glykosaminoglykuronane mit antithrombotischer wirkung. - Google Patents
Sulfatierte glykosaminoglykuronane mit antithrombotischer wirkung.Info
- Publication number
- ATE98656T1 ATE98656T1 AT90202449T AT90202449T ATE98656T1 AT E98656 T1 ATE98656 T1 AT E98656T1 AT 90202449 T AT90202449 T AT 90202449T AT 90202449 T AT90202449 T AT 90202449T AT E98656 T1 ATE98656 T1 AT E98656T1
- Authority
- AT
- Austria
- Prior art keywords
- content
- sulphate
- sulphated
- activity
- glycosaminoglycuronans
- Prior art date
Links
- 230000002785 anti-thrombosis Effects 0.000 title abstract 2
- FPJHWYCPAOPVIV-VOZMEZHOSA-N (2R,3S,4R,5R,6R)-6-[(2R,3R,4R,5R,6R)-5-acetamido-2-(hydroxymethyl)-6-methoxy-3-sulfooxyoxan-4-yl]oxy-4,5-dihydroxy-3-methoxyoxane-2-carboxylic acid Chemical class CO[C@@H]1O[C@H](CO)[C@H](OS(O)(=O)=O)[C@H](O[C@@H]2O[C@H]([C@@H](OC)[C@H](O)[C@H]2O)C(O)=O)[C@H]1NC(C)=O FPJHWYCPAOPVIV-VOZMEZHOSA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 229920001287 Chondroitin sulfate Chemical class 0.000 abstract 2
- 229920000045 Dermatan sulfate Polymers 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 102000004411 Antithrombin III Human genes 0.000 abstract 1
- 108090000935 Antithrombin III Proteins 0.000 abstract 1
- 229920002971 Heparan sulfate Chemical class 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 230000001858 anti-Xa Effects 0.000 abstract 1
- 239000004019 antithrombin Substances 0.000 abstract 1
- 229960005348 antithrombin iii Drugs 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Polymers & Plastics (AREA)
- Animal Behavior & Ethology (AREA)
- Materials Engineering (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP89202494 | 1989-10-04 | ||
| EP90202449A EP0421508B1 (de) | 1989-10-04 | 1990-09-17 | Sulfatierte Glykosaminoglykuronane mit antithrombotischer Wirkung. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE98656T1 true ATE98656T1 (de) | 1994-01-15 |
Family
ID=8202480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90202449T ATE98656T1 (de) | 1989-10-04 | 1990-09-17 | Sulfatierte glykosaminoglykuronane mit antithrombotischer wirkung. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5164377A (de) |
| EP (1) | EP0421508B1 (de) |
| JP (1) | JP2655746B2 (de) |
| KR (1) | KR0184260B1 (de) |
| AT (1) | ATE98656T1 (de) |
| AU (1) | AU637143B2 (de) |
| CA (1) | CA2026036C (de) |
| DE (1) | DE69005251T2 (de) |
| DK (1) | DK0421508T3 (de) |
| ES (1) | ES2062307T3 (de) |
| FI (1) | FI101152B (de) |
| IE (1) | IE64121B1 (de) |
| MX (1) | MX9203786A (de) |
| NZ (1) | NZ235440A (de) |
| PT (1) | PT95511B (de) |
| ZA (1) | ZA907495B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8826448D0 (en) * | 1988-11-11 | 1988-12-14 | Thrombosis Res Inst | Improvements in/relating to organic compounds |
| JP3813169B2 (ja) * | 1993-09-30 | 2006-08-23 | 生化学工業株式会社 | 抗血栓剤 |
| JP4455680B2 (ja) * | 1997-07-16 | 2010-04-21 | ナームローゼ・フエンノートチヤツプ・オルガノン | ヘパリンの製造方法 |
| JP4915888B2 (ja) * | 2001-08-01 | 2012-04-11 | 株式会社ジャパンエコロジーシンキング | 豚皮抽出物よりのデルマタン硫酸の製造方法 |
| FR2847256B1 (fr) * | 2002-11-15 | 2005-04-08 | Biochimie Appliquee Soc | Nouveau procede d'obtention d'acide chondroitine sulfurique et ses utilisations |
| KR100786174B1 (ko) * | 2005-07-06 | 2007-12-17 | 건양대학교산학협력단 | 돈족유래의 글리코스아미노글리칸을 포함하는 식품 조성물 및 이의 추출방법 |
| US20110036133A1 (en) * | 2008-04-18 | 2011-02-17 | N. V. Organon | Purification of protein hydrolysate and the result and products |
| WO2022015794A1 (en) | 2020-07-14 | 2022-01-20 | Optimvia, Llc | Methods for synthesizing non-anticoagulant heparan sulfate |
| CN114616340A (zh) | 2019-07-09 | 2022-06-10 | 奥普蒂姆维亚有限公司 | 合成抗凝血多糖的方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE136572C (de) * | 1902-12-05 | |||
| CH460248A (fr) * | 1963-02-21 | 1968-07-31 | Joseph Malgouzou Guy Louis | Procédé de traitement de tissus animaux, en vue de la séparation de polysaccharides acides contenus dans ces tissus |
| US3887703A (en) * | 1967-03-24 | 1975-06-03 | Oreal | Mucopolysaccharides, their preparation and use in cosmetic and pharmaceutical compositions |
| DE2426586A1 (de) * | 1973-06-14 | 1975-01-09 | Opocrin Srl | Verfahren zur herstellung von glukuronil-glukosamin-glykan-sulfaten mit antilipaemischer wirkung |
| JPS5151509A (de) * | 1974-10-28 | 1976-05-07 | Seikagaku Kogyo Co Ltd | |
| IT1075117B (it) * | 1977-02-14 | 1985-04-22 | Fedeli Gianfranco | Complesso polisaccaridico arterioso,processo per la sua preparazione e suo impiego in terapia umana |
| IT1158896B (it) * | 1977-08-10 | 1987-02-25 | Hepar Chimie Sa | Esuronil esosaminoglicano solfato naturale, procedimento per la sua preparazione e impieghi terapeutici relativi |
| SE7811306L (sv) * | 1978-11-01 | 1980-05-02 | Rothman Gunnvor | Antikoagulationsmedel samt sett for dess framstellning |
| ATE15142T1 (de) * | 1981-05-21 | 1985-09-15 | Akzo Nv | Antithrombotikum auf basis von polysacchariden, verfahren zur dessen herstellung und medizinale zusammensetzungen. |
| DE3244214A1 (de) * | 1982-11-30 | 1984-05-30 | B. Braun Melsungen Ag, 3508 Melsungen | Verfahren zur reinigung und fraktionierung von heparin |
| FR2538404B1 (de) * | 1982-12-28 | 1985-08-23 | Anic Spa | |
| US4745098A (en) * | 1984-02-24 | 1988-05-17 | The Regents Of The University Of California | Compositions and method for improving wound healing |
| FR2572080B1 (fr) * | 1984-10-18 | 1987-06-26 | Dropic | Procede de preparation de compositions de mucopolysaccharides dotees d'une activite antithrombotique elevee, les compositions obtenues et leur application en tant que medicaments |
| IT1208509B (it) * | 1985-03-13 | 1989-07-10 | Mediolanum Farmaceutici Srl | Processo per la produzione di eparan solfato e dermatan solfato naturali sostanzialmente puri eloro impiego farmaceutico. |
| FR2584728B1 (fr) * | 1985-07-12 | 1987-11-20 | Choay Sa | Procede de sulfatation de glycosaminoglycanes et de leurs fragments |
| EP0209924A1 (de) * | 1985-07-12 | 1987-01-28 | Akzo N.V. | Antithrombotikum auf Basis von Glykosaminoglykan, Verfahren zu dessen Herstellung und pharmazeutische Zusammensetzung |
| WO1988001280A1 (en) * | 1986-08-21 | 1988-02-25 | Board Of Regents, The University Of Texas System | Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness or metastatic profusion |
| IT1213384B (it) * | 1986-11-24 | 1989-12-20 | Lab Derivati Organici Mediolan | Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare. |
| IT1217458B (it) * | 1988-05-02 | 1990-03-22 | Crinos Ind Farmacoriologica S | Sulfoamino derivati di condroitin solfati,del dermatan solfato e dell' acido ialuronico e loro proprieta' farmacologiche |
-
1990
- 1990-09-17 EP EP90202449A patent/EP0421508B1/de not_active Expired - Lifetime
- 1990-09-17 AT AT90202449T patent/ATE98656T1/de not_active IP Right Cessation
- 1990-09-17 IE IE336690A patent/IE64121B1/en not_active IP Right Cessation
- 1990-09-17 ES ES90202449T patent/ES2062307T3/es not_active Expired - Lifetime
- 1990-09-17 DK DK90202449.6T patent/DK0421508T3/da active
- 1990-09-17 DE DE90202449T patent/DE69005251T2/de not_active Expired - Lifetime
- 1990-09-19 ZA ZA907495A patent/ZA907495B/xx unknown
- 1990-09-24 CA CA002026036A patent/CA2026036C/en not_active Expired - Lifetime
- 1990-09-25 NZ NZ235440A patent/NZ235440A/en unknown
- 1990-09-26 AU AU63238/90A patent/AU637143B2/en not_active Expired
- 1990-09-29 KR KR1019900015875A patent/KR0184260B1/ko not_active Expired - Lifetime
- 1990-10-01 FI FI904828A patent/FI101152B/fi active IP Right Grant
- 1990-10-03 US US07/592,152 patent/US5164377A/en not_active Expired - Lifetime
- 1990-10-04 JP JP2267507A patent/JP2655746B2/ja not_active Expired - Lifetime
- 1990-10-04 PT PT95511A patent/PT95511B/pt not_active IP Right Cessation
-
1992
- 1992-06-29 MX MX9203786A patent/MX9203786A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE64121B1 (en) | 1995-07-12 |
| EP0421508B1 (de) | 1993-12-15 |
| CA2026036A1 (en) | 1991-04-05 |
| ES2062307T3 (es) | 1994-12-16 |
| DE69005251T2 (de) | 1994-05-05 |
| PT95511A (pt) | 1991-08-14 |
| KR910007532A (ko) | 1991-05-30 |
| JP2655746B2 (ja) | 1997-09-24 |
| PT95511B (pt) | 1997-07-31 |
| KR0184260B1 (ko) | 1999-05-01 |
| AU637143B2 (en) | 1993-05-20 |
| ZA907495B (en) | 1991-07-31 |
| EP0421508A3 (en) | 1991-07-24 |
| CA2026036C (en) | 2000-08-01 |
| MX9203786A (es) | 1992-07-01 |
| FI101152B (fi) | 1998-04-30 |
| DK0421508T3 (da) | 1994-04-11 |
| EP0421508A2 (de) | 1991-04-10 |
| FI904828A0 (fi) | 1990-10-01 |
| DE69005251D1 (de) | 1994-01-27 |
| NZ235440A (en) | 1992-07-28 |
| JPH03167127A (ja) | 1991-07-19 |
| IE903366A1 (en) | 1991-04-10 |
| US5164377A (en) | 1992-11-17 |
| AU6323890A (en) | 1991-04-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |