DE69005251T2 - Sulfatierte Glykosaminoglykuronane mit antithrombotischer Wirkung. - Google Patents
Sulfatierte Glykosaminoglykuronane mit antithrombotischer Wirkung.Info
- Publication number
- DE69005251T2 DE69005251T2 DE90202449T DE69005251T DE69005251T2 DE 69005251 T2 DE69005251 T2 DE 69005251T2 DE 90202449 T DE90202449 T DE 90202449T DE 69005251 T DE69005251 T DE 69005251T DE 69005251 T2 DE69005251 T2 DE 69005251T2
- Authority
- DE
- Germany
- Prior art keywords
- content
- sulphate
- sulphated
- glycosaminoglykuronans
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP89202494 | 1989-10-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69005251D1 DE69005251D1 (de) | 1994-01-27 |
DE69005251T2 true DE69005251T2 (de) | 1994-05-05 |
Family
ID=8202480
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE90202449T Expired - Lifetime DE69005251T2 (de) | 1989-10-04 | 1990-09-17 | Sulfatierte Glykosaminoglykuronane mit antithrombotischer Wirkung. |
Country Status (16)
Country | Link |
---|---|
US (1) | US5164377A (de) |
EP (1) | EP0421508B1 (de) |
JP (1) | JP2655746B2 (de) |
KR (1) | KR0184260B1 (de) |
AT (1) | ATE98656T1 (de) |
AU (1) | AU637143B2 (de) |
CA (1) | CA2026036C (de) |
DE (1) | DE69005251T2 (de) |
DK (1) | DK0421508T3 (de) |
ES (1) | ES2062307T3 (de) |
FI (1) | FI101152B (de) |
IE (1) | IE64121B1 (de) |
MX (1) | MX9203786A (de) |
NZ (1) | NZ235440A (de) |
PT (1) | PT95511B (de) |
ZA (1) | ZA907495B (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8826448D0 (en) * | 1988-11-11 | 1988-12-14 | Thrombosis Res Inst | Improvements in/relating to organic compounds |
KR950704362A (ko) * | 1993-09-30 | 1995-11-20 | 야마야 구따루 | 항혈전제 |
WO1999003893A1 (en) | 1997-07-16 | 1999-01-28 | Akzo Nobel N.V. | Process for the production of heparin |
JP4915888B2 (ja) * | 2001-08-01 | 2012-04-11 | 株式会社ジャパンエコロジーシンキング | 豚皮抽出物よりのデルマタン硫酸の製造方法 |
FR2847256B1 (fr) * | 2002-11-15 | 2005-04-08 | Biochimie Appliquee Soc | Nouveau procede d'obtention d'acide chondroitine sulfurique et ses utilisations |
KR100786174B1 (ko) * | 2005-07-06 | 2007-12-17 | 건양대학교산학협력단 | 돈족유래의 글리코스아미노글리칸을 포함하는 식품 조성물 및 이의 추출방법 |
US20110036133A1 (en) * | 2008-04-18 | 2011-02-17 | N. V. Organon | Purification of protein hydrolysate and the result and products |
WO2022015794A1 (en) | 2020-07-14 | 2022-01-20 | Optimvia, Llc | Methods for synthesizing non-anticoagulant heparan sulfate |
WO2021007429A1 (en) | 2019-07-09 | 2021-01-14 | Optimvia Llc | Methods for synthesizing anticoagulant polysaccharides |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE136572C (de) * | 1902-12-05 | |||
CH460248A (fr) * | 1963-02-21 | 1968-07-31 | Joseph Malgouzou Guy Louis | Procédé de traitement de tissus animaux, en vue de la séparation de polysaccharides acides contenus dans ces tissus |
US3887703A (en) * | 1967-03-24 | 1975-06-03 | Oreal | Mucopolysaccharides, their preparation and use in cosmetic and pharmaceutical compositions |
DE2426586A1 (de) * | 1973-06-14 | 1975-01-09 | Opocrin Srl | Verfahren zur herstellung von glukuronil-glukosamin-glykan-sulfaten mit antilipaemischer wirkung |
JPS5151509A (de) * | 1974-10-28 | 1976-05-07 | Seikagaku Kogyo Co Ltd | |
IT1075117B (it) * | 1977-02-14 | 1985-04-22 | Fedeli Gianfranco | Complesso polisaccaridico arterioso,processo per la sua preparazione e suo impiego in terapia umana |
IT1158896B (it) * | 1977-08-10 | 1987-02-25 | Hepar Chimie Sa | Esuronil esosaminoglicano solfato naturale, procedimento per la sua preparazione e impieghi terapeutici relativi |
SE7811306L (sv) * | 1978-11-01 | 1980-05-02 | Rothman Gunnvor | Antikoagulationsmedel samt sett for dess framstellning |
DE3265781D1 (en) * | 1981-05-21 | 1985-10-03 | Akzo Nv | New anti-thromboticum based on polysacharides, method for its preparation and pharmaceutical compositions |
DE3244214A1 (de) * | 1982-11-30 | 1984-05-30 | B. Braun Melsungen Ag, 3508 Melsungen | Verfahren zur reinigung und fraktionierung von heparin |
FR2538404B1 (de) * | 1982-12-28 | 1985-08-23 | Anic Spa | |
US4745098A (en) * | 1984-02-24 | 1988-05-17 | The Regents Of The University Of California | Compositions and method for improving wound healing |
FR2572080B1 (fr) * | 1984-10-18 | 1987-06-26 | Dropic | Procede de preparation de compositions de mucopolysaccharides dotees d'une activite antithrombotique elevee, les compositions obtenues et leur application en tant que medicaments |
IT1208509B (it) * | 1985-03-13 | 1989-07-10 | Mediolanum Farmaceutici Srl | Processo per la produzione di eparan solfato e dermatan solfato naturali sostanzialmente puri eloro impiego farmaceutico. |
FR2584728B1 (fr) * | 1985-07-12 | 1987-11-20 | Choay Sa | Procede de sulfatation de glycosaminoglycanes et de leurs fragments |
EP0209924A1 (de) * | 1985-07-12 | 1987-01-28 | Akzo N.V. | Antithrombotikum auf Basis von Glykosaminoglykan, Verfahren zu dessen Herstellung und pharmazeutische Zusammensetzung |
AU7852687A (en) * | 1986-08-21 | 1988-03-08 | University Of Texas System, The | Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness or metastatic profusion |
IT1213384B (it) * | 1986-11-24 | 1989-12-20 | Lab Derivati Organici Mediolan | Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare. |
IT1217458B (it) * | 1988-05-02 | 1990-03-22 | Crinos Ind Farmacoriologica S | Sulfoamino derivati di condroitin solfati,del dermatan solfato e dell' acido ialuronico e loro proprieta' farmacologiche |
-
1990
- 1990-09-17 DE DE90202449T patent/DE69005251T2/de not_active Expired - Lifetime
- 1990-09-17 EP EP90202449A patent/EP0421508B1/de not_active Expired - Lifetime
- 1990-09-17 DK DK90202449.6T patent/DK0421508T3/da active
- 1990-09-17 IE IE336690A patent/IE64121B1/en not_active IP Right Cessation
- 1990-09-17 AT AT90202449T patent/ATE98656T1/de not_active IP Right Cessation
- 1990-09-17 ES ES90202449T patent/ES2062307T3/es not_active Expired - Lifetime
- 1990-09-19 ZA ZA907495A patent/ZA907495B/xx unknown
- 1990-09-24 CA CA002026036A patent/CA2026036C/en not_active Expired - Lifetime
- 1990-09-25 NZ NZ235440A patent/NZ235440A/en unknown
- 1990-09-26 AU AU63238/90A patent/AU637143B2/en not_active Expired
- 1990-09-29 KR KR1019900015875A patent/KR0184260B1/ko not_active IP Right Cessation
- 1990-10-01 FI FI904828A patent/FI101152B/fi active IP Right Grant
- 1990-10-03 US US07/592,152 patent/US5164377A/en not_active Expired - Lifetime
- 1990-10-04 JP JP2267507A patent/JP2655746B2/ja not_active Expired - Lifetime
- 1990-10-04 PT PT95511A patent/PT95511B/pt not_active IP Right Cessation
-
1992
- 1992-06-29 MX MX9203786A patent/MX9203786A/es unknown
Also Published As
Publication number | Publication date |
---|---|
NZ235440A (en) | 1992-07-28 |
PT95511B (pt) | 1997-07-31 |
AU6323890A (en) | 1991-04-11 |
JPH03167127A (ja) | 1991-07-19 |
ES2062307T3 (es) | 1994-12-16 |
EP0421508B1 (de) | 1993-12-15 |
IE903366A1 (en) | 1991-04-10 |
DE69005251D1 (de) | 1994-01-27 |
US5164377A (en) | 1992-11-17 |
JP2655746B2 (ja) | 1997-09-24 |
KR0184260B1 (ko) | 1999-05-01 |
EP0421508A2 (de) | 1991-04-10 |
FI101152B (fi) | 1998-04-30 |
ZA907495B (en) | 1991-07-31 |
MX9203786A (es) | 1992-07-01 |
PT95511A (pt) | 1991-08-14 |
EP0421508A3 (en) | 1991-07-24 |
AU637143B2 (en) | 1993-05-20 |
ATE98656T1 (de) | 1994-01-15 |
FI904828A0 (fi) | 1990-10-01 |
DK0421508T3 (da) | 1994-04-11 |
CA2026036A1 (en) | 1991-04-05 |
CA2026036C (en) | 2000-08-01 |
KR910007532A (ko) | 1991-05-30 |
IE64121B1 (en) | 1995-07-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: AKZO NOBEL N.V., ARNHEIM/ARNHEM, NL |
|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: N.V. ORGANON, OSS, NL |