IT1232939B - Eparan solfato caratterizzato da elevata attivita' antitrombotica, elevata biodisponibilita', assenza di attivita' anticoagulante; suo processo di estrazione da organi e da tessuti e relative composizioni farmaceutiche - Google Patents

Eparan solfato caratterizzato da elevata attivita' antitrombotica, elevata biodisponibilita', assenza di attivita' anticoagulante; suo processo di estrazione da organi e da tessuti e relative composizioni farmaceutiche

Info

Publication number
IT1232939B
IT1232939B IT8722544A IT2254487A IT1232939B IT 1232939 B IT1232939 B IT 1232939B IT 8722544 A IT8722544 A IT 8722544A IT 2254487 A IT2254487 A IT 2254487A IT 1232939 B IT1232939 B IT 1232939B
Authority
IT
Italy
Prior art keywords
activity
eparan
agulant
fabrics
organs
Prior art date
Application number
IT8722544A
Other languages
English (en)
Other versions
IT8722544A0 (it
Inventor
Giuseppe Mascellani
Pietro Bianchini
Original Assignee
Opocrin Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Opocrin Spa filed Critical Opocrin Spa
Priority to IT8722544A priority Critical patent/IT1232939B/it
Publication of IT8722544A0 publication Critical patent/IT8722544A0/it
Priority to EP88909474A priority patent/EP0386053B1/en
Priority to PCT/EP1988/000967 priority patent/WO1989004328A1/en
Priority to AU26179/88A priority patent/AU2617988A/en
Priority to AT88909474T priority patent/ATE100112T1/de
Priority to DE88909474T priority patent/DE3887159D1/de
Priority to ES8803350A priority patent/ES2012563A6/es
Application granted granted Critical
Publication of IT1232939B publication Critical patent/IT1232939B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT8722544A 1987-11-06 1987-11-06 Eparan solfato caratterizzato da elevata attivita' antitrombotica, elevata biodisponibilita', assenza di attivita' anticoagulante; suo processo di estrazione da organi e da tessuti e relative composizioni farmaceutiche IT1232939B (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT8722544A IT1232939B (it) 1987-11-06 1987-11-06 Eparan solfato caratterizzato da elevata attivita' antitrombotica, elevata biodisponibilita', assenza di attivita' anticoagulante; suo processo di estrazione da organi e da tessuti e relative composizioni farmaceutiche
EP88909474A EP0386053B1 (en) 1987-11-06 1988-10-27 Non-anticoagulant heparan sulfate, process for extraction from organs, and pharmaceutical compositions thereof
PCT/EP1988/000967 WO1989004328A1 (en) 1987-11-06 1988-10-27 Non-anticoagulant heparan sulfate, process for extraction from organs, and pharmaceutical compositions thereof
AU26179/88A AU2617988A (en) 1987-11-06 1988-10-27 Non-anticoagulant heparan sulfate, process for extraction from organs, and pharmaceutical compositions thereof
AT88909474T ATE100112T1 (de) 1987-11-06 1988-10-27 Nichtanticoagulierendes heparansulfat, verfahren zu seiner extraktion aus organen und pharmazeutische zubereitungen davon.
DE88909474T DE3887159D1 (de) 1987-11-06 1988-10-27 Nichtanticoagulierendes heparansulfat, verfahren zu seiner extraktion aus organen und pharmazeutische zubereitungen davon.
ES8803350A ES2012563A6 (es) 1987-11-06 1988-11-03 Un procedimiento pra la extraccion de sulfato de heparano de organos y tejidos de animales.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8722544A IT1232939B (it) 1987-11-06 1987-11-06 Eparan solfato caratterizzato da elevata attivita' antitrombotica, elevata biodisponibilita', assenza di attivita' anticoagulante; suo processo di estrazione da organi e da tessuti e relative composizioni farmaceutiche

Publications (2)

Publication Number Publication Date
IT8722544A0 IT8722544A0 (it) 1987-11-06
IT1232939B true IT1232939B (it) 1992-03-10

Family

ID=11197660

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8722544A IT1232939B (it) 1987-11-06 1987-11-06 Eparan solfato caratterizzato da elevata attivita' antitrombotica, elevata biodisponibilita', assenza di attivita' anticoagulante; suo processo di estrazione da organi e da tessuti e relative composizioni farmaceutiche

Country Status (6)

Country Link
EP (1) EP0386053B1 (it)
AU (1) AU2617988A (it)
DE (1) DE3887159D1 (it)
ES (1) ES2012563A6 (it)
IT (1) IT1232939B (it)
WO (1) WO1989004328A1 (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010110654A1 (en) * 2009-03-24 2010-09-30 Van Hessen Bv Method for preparation of heparin from mucosa
CN102212149B (zh) * 2011-06-15 2012-11-28 天津宝迪农业科技股份有限公司 利用猪肺提取肝素钠粗品的制备工艺
US9758819B2 (en) 2012-10-12 2017-09-12 Nantpharma, Llc PCR assay for animal origin of heparin
CN103539869B (zh) * 2013-10-11 2015-11-18 浙江凯胜畜产品加工有限公司 一种提高粗肝素钠提取工艺酶解效率的方法
CN103772529A (zh) * 2013-12-20 2014-05-07 河北常山生化药业股份有限公司 一种膜分离制备肝素钠工艺
CN103772530A (zh) * 2014-01-20 2014-05-07 江苏集贤绿色化学科技研究院有限公司 一种酶解法提取分离肝素钠的方法
RU2612813C1 (ru) * 2015-12-07 2017-03-13 Павел Андреевич Канаев Способ получения гепарина
CN105504098B (zh) * 2016-01-08 2018-03-16 东营天东制药有限公司 一种从十二指肠中提取硫酸乙酰肝素的工艺
WO2018165656A1 (en) 2017-03-10 2018-09-13 The University Of North Carolina At Chapel Hill Short-acting heparin-based anticoagulant compounds and methods
US11993627B2 (en) 2017-07-03 2024-05-28 The University Of North Carolina At Chapel Hill Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides
WO2019090203A1 (en) * 2017-11-03 2019-05-09 The University Of North Carolina At Chapel Hill Sulfated oligosaccharides having anti-inflammatory activity
JP2021528421A (ja) 2018-06-20 2021-10-21 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｎｏｒｔｈ Ｃａｒｏｌｉｎａ Ａｔ Ｃｈａｐｅｌ Ｈｉｌｌ 細胞保護の方法と組成物
CN113896813A (zh) * 2021-11-26 2022-01-07 重庆望业药物研究有限公司 一种高纯度硫酸乙酰肝素的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1208509B (it) * 1985-03-13 1989-07-10 Mediolanum Farmaceutici Srl Processo per la produzione di eparan solfato e dermatan solfato naturali sostanzialmente puri eloro impiego farmaceutico.

Also Published As

Publication number Publication date
ES2012563A6 (es) 1990-04-01
DE3887159D1 (de) 1994-02-24
IT8722544A0 (it) 1987-11-06
WO1989004328A1 (en) 1989-05-18
EP0386053B1 (en) 1994-01-12
EP0386053A1 (en) 1990-09-12
AU2617988A (en) 1989-06-01

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19941129