ES2012563A6 - Un procedimiento pra la extraccion de sulfato de heparano de organos y tejidos de animales. - Google Patents
Un procedimiento pra la extraccion de sulfato de heparano de organos y tejidos de animales.Info
- Publication number
- ES2012563A6 ES2012563A6 ES8803350A ES8803350A ES2012563A6 ES 2012563 A6 ES2012563 A6 ES 2012563A6 ES 8803350 A ES8803350 A ES 8803350A ES 8803350 A ES8803350 A ES 8803350A ES 2012563 A6 ES2012563 A6 ES 2012563A6
- Authority
- ES
- Spain
- Prior art keywords
- heparan sulfate
- extraction
- organs
- pharmaceutical compositions
- anticoagulant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229920002971 Heparan sulfate Polymers 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000000605 extraction Methods 0.000 title abstract 2
- 239000003146 anticoagulant agent Substances 0.000 title 1
- 229940127219 anticoagulant drug Drugs 0.000 title 1
- 210000000056 organ Anatomy 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229920005989 resin Polymers 0.000 abstract 2
- 239000011347 resin Substances 0.000 abstract 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 210000001557 animal structure Anatomy 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- 210000004877 mucosa Anatomy 0.000 abstract 1
- 230000014508 negative regulation of coagulation Effects 0.000 abstract 1
- 210000000496 pancreas Anatomy 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000000952 spleen Anatomy 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
UN PROCEDIMIENTO PARA LA EXTRACCION DE SULFATO DE HEPARANO DE ORGANOS Y TEJIDOS DE ANIMALES TALES COMO EL BAZO, EL PANCREAS, EL RIÑON Y LAS MUCOSAS. EL PROCEDIMIENTO CONSISTE EN PREPARAR UN COMPLEJO DE SULFATO DE HEPARANO CON RESINAS BASICAS MACROPOROSAS, DESCOMPLEJAR CON SALES DE FUERZA IONICA APROPIADA Y PURIFICAR SOBRE RESINAS. EL SULFATO DE HEPARANO OBTENIDO PRESENTA BAJO CONTENIDO DE AZUFRE, UNA RELACION SO3C/-COOC INFERIOR A 1, UNA ACTIVIDAD ANTITROMBOTICA IGUAL O SUPERIOR A LA DE LA HEPARINA Y PRACTICAMENTE NINGUNA ACTIVIDAD ANTICOAGULANTE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8722544A IT1232939B (it) | 1987-11-06 | 1987-11-06 | Eparan solfato caratterizzato da elevata attivita' antitrombotica, elevata biodisponibilita', assenza di attivita' anticoagulante; suo processo di estrazione da organi e da tessuti e relative composizioni farmaceutiche |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2012563A6 true ES2012563A6 (es) | 1990-04-01 |
Family
ID=11197660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8803350A Expired - Lifetime ES2012563A6 (es) | 1987-11-06 | 1988-11-03 | Un procedimiento pra la extraccion de sulfato de heparano de organos y tejidos de animales. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0386053B1 (es) |
| AU (1) | AU2617988A (es) |
| DE (1) | DE3887159D1 (es) |
| ES (1) | ES2012563A6 (es) |
| IT (1) | IT1232939B (es) |
| WO (1) | WO1989004328A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010110654A1 (en) * | 2009-03-24 | 2010-09-30 | Van Hessen Bv | Method for preparation of heparin from mucosa |
| CN102212149B (zh) * | 2011-06-15 | 2012-11-28 | 天津宝迪农业科技股份有限公司 | 利用猪肺提取肝素钠粗品的制备工艺 |
| US9758819B2 (en) * | 2012-10-12 | 2017-09-12 | Nantpharma, Llc | PCR assay for animal origin of heparin |
| CN103539869B (zh) * | 2013-10-11 | 2015-11-18 | 浙江凯胜畜产品加工有限公司 | 一种提高粗肝素钠提取工艺酶解效率的方法 |
| CN103772529A (zh) * | 2013-12-20 | 2014-05-07 | 河北常山生化药业股份有限公司 | 一种膜分离制备肝素钠工艺 |
| CN103772530A (zh) * | 2014-01-20 | 2014-05-07 | 江苏集贤绿色化学科技研究院有限公司 | 一种酶解法提取分离肝素钠的方法 |
| RU2612813C1 (ru) * | 2015-12-07 | 2017-03-13 | Павел Андреевич Канаев | Способ получения гепарина |
| CN105504098B (zh) * | 2016-01-08 | 2018-03-16 | 东营天东制药有限公司 | 一种从十二指肠中提取硫酸乙酰肝素的工艺 |
| CN110446511B (zh) | 2017-03-10 | 2024-04-02 | 北卡罗来纳大学查珀尔希尔分校 | 短效的基于肝素的抗凝血剂化合物和方法 |
| US11993627B2 (en) | 2017-07-03 | 2024-05-28 | The University Of North Carolina At Chapel Hill | Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides |
| CN111601603A (zh) * | 2017-11-03 | 2020-08-28 | 北卡罗来纳大学查珀尔希尔分校 | 具有抗炎活性的硫酸化寡糖 |
| EP3810152A4 (en) | 2018-06-20 | 2022-04-27 | The University of North Carolina at Chapel Hill | CELLULAR PROTECTION METHODS AND COMPOSITIONS |
| CN113896813A (zh) * | 2021-11-26 | 2022-01-07 | 重庆望业药物研究有限公司 | 一种高纯度硫酸乙酰肝素的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1208509B (it) * | 1985-03-13 | 1989-07-10 | Mediolanum Farmaceutici Srl | Processo per la produzione di eparan solfato e dermatan solfato naturali sostanzialmente puri eloro impiego farmaceutico. |
-
1987
- 1987-11-06 IT IT8722544A patent/IT1232939B/it active
-
1988
- 1988-10-27 AU AU26179/88A patent/AU2617988A/en not_active Abandoned
- 1988-10-27 WO PCT/EP1988/000967 patent/WO1989004328A1/en active IP Right Grant
- 1988-10-27 DE DE88909474T patent/DE3887159D1/de not_active Expired - Lifetime
- 1988-10-27 EP EP88909474A patent/EP0386053B1/en not_active Expired - Lifetime
- 1988-11-03 ES ES8803350A patent/ES2012563A6/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1989004328A1 (en) | 1989-05-18 |
| EP0386053B1 (en) | 1994-01-12 |
| IT8722544A0 (it) | 1987-11-06 |
| EP0386053A1 (en) | 1990-09-12 |
| DE3887159D1 (de) | 1994-02-24 |
| IT1232939B (it) | 1992-03-10 |
| AU2617988A (en) | 1989-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SA6 | Expiration date (snapshot 920101) |
Free format text: 2008-11-03 |