CZ303656B6 - Lécivo pro lécení ocního onemocnení - Google Patents
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- CZ303656B6 CZ303656B6 CZ20100386A CZ2010386A CZ303656B6 CZ 303656 B6 CZ303656 B6 CZ 303656B6 CZ 20100386 A CZ20100386 A CZ 20100386A CZ 2010386 A CZ2010386 A CZ 2010386A CZ 303656 B6 CZ303656 B6 CZ 303656B6
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Classifications
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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Landscapes
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| CZ303656B6 true CZ303656B6 (cs) | 2013-01-30 |
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| CZ20100386A CZ303656B6 (cs) | 1999-06-08 | 2000-05-23 | Lécivo pro lécení ocního onemocnení |
| CZ20014387A CZ302689B6 (cs) | 1999-06-08 | 2000-05-23 | Izolovaná molekula nukleové kyseliny, fúzní polypeptid jí kódovaný, vektor s jejím obsahem, systém vektor-hostitel pro produkci fúzního polypeptidu a zpusob jeho prípravy, antagonista dimerního VEGF a použití |
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| CZ20014387A CZ302689B6 (cs) | 1999-06-08 | 2000-05-23 | Izolovaná molekula nukleové kyseliny, fúzní polypeptid jí kódovaný, vektor s jejím obsahem, systém vektor-hostitel pro produkci fúzního polypeptidu a zpusob jeho prípravy, antagonista dimerního VEGF a použití |
Country Status (32)
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Families Citing this family (106)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6710174B2 (en) | 2001-09-13 | 2004-03-23 | Isis Pharmaceuticals, Inc. | Antisense inhibition of vascular endothelial growth factor receptor-1 expression |
| US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
| US7087411B2 (en) * | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| US7070959B1 (en) | 1999-06-08 | 2006-07-04 | Regeneron Pharmaceuticals, Inc. | Modified chimeric polypeptides with improved pharmacokinetic properties |
| US6833349B2 (en) * | 1999-06-08 | 2004-12-21 | Regeneron Pharmaceuticals, Inc. | Methods of treating inflammatory skin diseases |
| US7396664B2 (en) | 1999-06-08 | 2008-07-08 | Regeneron Pharmaceuticals, Inc. | VEGF-binding fusion proteins and nucleic acids encoding the same |
| CA2435503C (en) | 2001-01-19 | 2011-02-22 | Ludwig Institute For Cancer Research | Flt4(vegfr-3) as a target for tumor imaging and anti-tumor therapy |
| US6734017B2 (en) | 2001-09-28 | 2004-05-11 | Isis Pharmaceuticals, Inc. | Antisense modulation of vascular endothelial growth factor receptor-2 expression |
| EP2301564A1 (en) | 2002-05-04 | 2011-03-30 | Acorda Therapeutics, Inc. | Compositions and methods for promoting neuronal outgrowth |
| DK1608685T3 (da) * | 2003-03-28 | 2007-06-11 | Regeneron Pharma | VEGF antagonister til behandlingen af diabetes |
| AU2004247026B2 (en) | 2003-05-16 | 2009-09-24 | Acorda Therapeutics, Inc. | Proteoglycan degrading mutants for treatment of CNS |
| US7959914B2 (en) | 2003-05-16 | 2011-06-14 | Acorda Therapeutics, Inc. | Methods of reducing extravasation of inflammatory cells |
| MXPA05012306A (es) * | 2003-05-16 | 2006-04-18 | Acorda Therapeutics Inc | Proteinas de fusion para el tratamiento del snc. |
| EP1626989A2 (en) * | 2003-05-28 | 2006-02-22 | Regeneron Pharmaceuticals, Inc. | Method of treating corneal transplant rejection by using vegf antagonists |
| US7186699B2 (en) | 2003-06-03 | 2007-03-06 | Cell Genesys, Inc. | Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes |
| AU2004247095A1 (en) | 2003-06-06 | 2004-12-23 | Regeneron Pharmaceuticals, Inc. | Use of VEGF inhibitors for tumor regression |
| US7399612B2 (en) | 2003-06-30 | 2008-07-15 | Regeneron Pharmaceuticals, Inc. | VEGF-binding fusion proteins and nucleic acids encoding the same |
| AR046510A1 (es) * | 2003-07-25 | 2005-12-14 | Regeneron Pharma | Composicion de un antagonista de vegf y un agente anti-proliferativo |
| CA2534197A1 (en) * | 2003-08-06 | 2005-02-24 | Thomas Jefferson University | Use of a vegf antagonist in combination with radiation therapy |
| ES2411504T3 (es) | 2004-05-18 | 2013-07-05 | Acorda Therapeutics, Inc. | Métodos de purificación de condroitinasa y formulaciones estables de la misma |
| PL1767546T3 (pl) * | 2004-06-08 | 2012-07-31 | Chengdu Kanghong Biotechnologies Co Ltd | Hamujące angiogenezę białka chimeryczne i ich zastosowanie |
| AU2005254058A1 (en) * | 2004-06-10 | 2005-12-29 | Regeneron Pharmaceuticals, Inc. | Use of VEGF inhibitors for the treatment of human cancer |
| JP2008503481A (ja) * | 2004-06-18 | 2008-02-07 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 悪性胸膜滲出液の処置のためのｖｅｇｆインヒビターの投与および使用の方法 |
| CN1997386B (zh) | 2004-07-30 | 2012-05-30 | 瑞泽恩制药公司 | 通过阻断vegf介导的活性来治疗i型糖尿病的方法 |
| WO2006031689A2 (en) | 2004-09-13 | 2006-03-23 | Genzyme Corporation | Multimeric constructs |
| FR2878749B1 (fr) * | 2004-12-03 | 2007-12-21 | Aventis Pharma Sa | Combinaisons antitumorales contenant en agent inhibiteur de vegt et du 5fu ou un de ses derives |
| WO2006088650A2 (en) * | 2005-02-02 | 2006-08-24 | Regeneron Pharmaceuticals, Inc. | Method of treating eye injury with local administration of a vegf inhibitor |
| PL1861116T3 (pl) | 2005-03-25 | 2016-02-29 | Regeneron Pharma | Formulacje antagonistów VEGF |
| CA2623635C (en) | 2005-09-26 | 2013-04-02 | Acorda Therapeutics, Inc. | Compositions and methods of using chondroitinase abci mutants |
| WO2007070671A2 (en) † | 2005-12-16 | 2007-06-21 | Regeneron Pharmaceuticals, Inc. | Therapeutic methods for inhibiting tumor growth with dll4 antagonists |
| FR2895258B1 (fr) | 2005-12-22 | 2008-03-21 | Aventis Pharma Sa | Combinaison comprenant de la combretastatine et des agents anticancereux |
| US8216575B2 (en) | 2006-03-31 | 2012-07-10 | Chengdu Kanghong Biotechnologies Co., Ltd. | Inhibition of neovascularization with a soluble chimeric protein comprising VEGF FLT-1 and KDR domains |
| CN100502945C (zh) * | 2006-03-31 | 2009-06-24 | 成都康弘生物科技有限公司 | Vegf受体融合蛋白在治疗眼睛疾病中的应用 |
| US7608261B2 (en) | 2006-06-16 | 2009-10-27 | Regeneron Pharmacuticals, Inc. | VEGF antagonist formulations suitable for intravitreal administration |
| HUE028379T2 (en) | 2006-09-29 | 2016-12-28 | Oncomed Pharm Inc | Preparations and procedures for the diagnosis and treatment of cancer |
| CA3086902C (en) | 2006-10-10 | 2021-11-09 | Acorda Therapeutics, Inc. | Compositions and methods of using chondroitinase abci mutants |
| FR2918279B1 (fr) * | 2007-07-05 | 2010-10-22 | Aventis Pharma Sa | Combinaisons antitumorales contenant un agent inhibiteur de vegf et de l'irinotecan |
| CN101575379B (zh) * | 2008-05-09 | 2012-05-30 | 上海抗体药物国家工程研究中心有限公司 | 可溶性vegfr双功能融合受体、其制备方法及用途 |
| CN102272148A (zh) | 2008-11-03 | 2011-12-07 | 分子组合公司 | 抑制vegf-a受体相互作用的结合蛋白 |
| CN101838329A (zh) | 2009-03-18 | 2010-09-22 | 嘉和生物药业有限公司 | 抗血管新生融合蛋白 |
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| TWI510246B (zh) * | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質 |
| HUE035554T2 (en) | 2010-08-06 | 2018-05-02 | Genzyme Corp | VEGF antagonist compositions and their uses |
| US20140080153A1 (en) * | 2011-01-07 | 2014-03-20 | Chugai Seiyaku Kabushiki Kaisha | Method for improving physical properties of antibody |
| CA2824422A1 (en) | 2011-01-13 | 2012-07-19 | Regeneron Pharmaceuticals, Inc. | Use of a vegf antagonist to treat angiogenic eye disorders |
| JO3283B1 (ar) | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
| KR101397088B1 (ko) | 2011-06-10 | 2014-05-19 | 강원대학교산학협력단 | 암세포 증식 억제와 혈관신생 억제를 위한 융합 단백질 및 이를 포함한 항암 조성물 |
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