CZ291904B6 - Způsob výroby proteinového hydrolyzátového prostředku, tento prostředek a jeho použití - Google Patents
Způsob výroby proteinového hydrolyzátového prostředku, tento prostředek a jeho použití Download PDFInfo
- Publication number
- CZ291904B6 CZ291904B6 CZ19973997A CZ399797A CZ291904B6 CZ 291904 B6 CZ291904 B6 CZ 291904B6 CZ 19973997 A CZ19973997 A CZ 19973997A CZ 399797 A CZ399797 A CZ 399797A CZ 291904 B6 CZ291904 B6 CZ 291904B6
- Authority
- CZ
- Czechia
- Prior art keywords
- lactobacillus
- protein hydrolyzate
- atcc
- deposited under
- cow
- Prior art date
Links
- 239000003531 protein hydrolysate Substances 0.000 title claims abstract description 27
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 241000186660 Lactobacillus Species 0.000 claims abstract description 61
- 229940039696 lactobacillus Drugs 0.000 claims abstract description 44
- 241000894006 Bacteria Species 0.000 claims abstract description 31
- 239000006041 probiotic Substances 0.000 claims abstract description 20
- 235000018291 probiotics Nutrition 0.000 claims abstract description 20
- 206010020751 Hypersensitivity Diseases 0.000 claims abstract description 18
- 230000000529 probiotic effect Effects 0.000 claims abstract description 18
- 235000013305 food Nutrition 0.000 claims abstract description 16
- 238000011282 treatment Methods 0.000 claims abstract description 16
- 235000020247 cow milk Nutrition 0.000 claims abstract description 15
- 230000002496 gastric effect Effects 0.000 claims abstract description 15
- 239000003814 drug Substances 0.000 claims abstract description 14
- 201000010859 Milk allergy Diseases 0.000 claims abstract description 13
- 230000004888 barrier function Effects 0.000 claims abstract description 8
- 210000001035 gastrointestinal tract Anatomy 0.000 claims abstract description 8
- 210000000936 intestine Anatomy 0.000 claims abstract description 4
- 230000008105 immune reaction Effects 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims description 58
- 102000004190 Enzymes Human genes 0.000 claims description 19
- 108090000790 Enzymes Proteins 0.000 claims description 19
- 229940088598 enzyme Drugs 0.000 claims description 19
- 239000000427 antigen Substances 0.000 claims description 15
- 108091007433 antigens Proteins 0.000 claims description 15
- 102000036639 antigens Human genes 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
- 102000057297 Pepsin A Human genes 0.000 claims description 14
- 108090000284 Pepsin A Proteins 0.000 claims description 14
- 102000004142 Trypsin Human genes 0.000 claims description 14
- 108090000631 Trypsin Proteins 0.000 claims description 14
- 229940111202 pepsin Drugs 0.000 claims description 14
- 239000012588 trypsin Substances 0.000 claims description 14
- 230000001580 bacterial effect Effects 0.000 claims description 13
- 208000009793 Milk Hypersensitivity Diseases 0.000 claims description 12
- 108091005804 Peptidases Proteins 0.000 claims description 12
- 239000000853 adhesive Substances 0.000 claims description 12
- 230000001070 adhesive effect Effects 0.000 claims description 12
- 235000018102 proteins Nutrition 0.000 claims description 11
- 102000004169 proteins and genes Human genes 0.000 claims description 11
- 108090000623 proteins and genes Proteins 0.000 claims description 11
- 230000028993 immune response Effects 0.000 claims description 9
- 102000014171 Milk Proteins Human genes 0.000 claims description 5
- 108010011756 Milk Proteins Proteins 0.000 claims description 5
- 230000001737 promoting effect Effects 0.000 claims description 5
- 230000003614 tolerogenic effect Effects 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 6
- 238000006243 chemical reaction Methods 0.000 abstract description 5
- 208000026935 allergic disease Diseases 0.000 abstract description 4
- 230000009885 systemic effect Effects 0.000 abstract description 4
- 239000013566 allergen Substances 0.000 abstract description 3
- 230000007815 allergy Effects 0.000 abstract description 3
- 230000015556 catabolic process Effects 0.000 abstract description 3
- 238000006731 degradation reaction Methods 0.000 abstract description 3
- 230000035945 sensitivity Effects 0.000 abstract description 2
- 206010020772 Hypertension Diseases 0.000 abstract 2
- 230000001631 hypertensive effect Effects 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 1
- 208000013403 hyperactivity Diseases 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 239000005018 casein Substances 0.000 description 55
- 102000011632 Caseins Human genes 0.000 description 31
- 108010076119 Caseins Proteins 0.000 description 31
- 235000021240 caseins Nutrition 0.000 description 31
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 30
- 238000012360 testing method Methods 0.000 description 17
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 16
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 16
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 15
- 206010012438 Dermatitis atopic Diseases 0.000 description 11
- 201000008937 atopic dermatitis Diseases 0.000 description 11
- 102000004388 Interleukin-4 Human genes 0.000 description 9
- 108090000978 Interleukin-4 Proteins 0.000 description 9
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 description 9
- 102000015395 alpha 1-Antitrypsin Human genes 0.000 description 9
- 229940024142 alpha 1-antitrypsin Drugs 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 9
- 206010003645 Atopy Diseases 0.000 description 8
- 239000012980 RPMI-1640 medium Substances 0.000 description 7
- 239000005862 Whey Substances 0.000 description 7
- 102000007544 Whey Proteins Human genes 0.000 description 7
- 108010046377 Whey Proteins Proteins 0.000 description 7
- 208000010668 atopic eczema Diseases 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- 238000006460 hydrolysis reaction Methods 0.000 description 7
- 241000283690 Bos taurus Species 0.000 description 6
- 102000035195 Peptidases Human genes 0.000 description 6
- 230000007062 hydrolysis Effects 0.000 description 6
- 239000003226 mitogen Substances 0.000 description 6
- 201000004624 Dermatitis Diseases 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000000968 intestinal effect Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- 208000004262 Food Hypersensitivity Diseases 0.000 description 4
- 108010047620 Phytohemagglutinins Proteins 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 210000003608 fece Anatomy 0.000 description 4
- 235000020932 food allergy Nutrition 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- 230000003301 hydrolyzing effect Effects 0.000 description 4
- 210000004698 lymphocyte Anatomy 0.000 description 4
- 230000001885 phytohemagglutinin Effects 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 102000004127 Cytokines Human genes 0.000 description 3
- 108090000695 Cytokines Proteins 0.000 description 3
- 238000008157 ELISA kit Methods 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000002009 allergenic effect Effects 0.000 description 3
- 239000003246 corticosteroid Substances 0.000 description 3
- 230000016396 cytokine production Effects 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 230000009610 hypersensitivity Effects 0.000 description 3
- 230000000813 microbial effect Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- 210000001835 viscera Anatomy 0.000 description 3
- 101710081722 Antitrypsin Proteins 0.000 description 2
- 206010003445 Ascites Diseases 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 102000002322 Egg Proteins Human genes 0.000 description 2
- 108010000912 Egg Proteins Proteins 0.000 description 2
- 206010016946 Food allergy Diseases 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 108010009736 Protein Hydrolysates Proteins 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000009285 allergic inflammation Effects 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000001475 anti-trypsic effect Effects 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000000890 antigenic effect Effects 0.000 description 2
- 229960001334 corticosteroids Drugs 0.000 description 2
- 230000007123 defense Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 230000007071 enzymatic hydrolysis Effects 0.000 description 2
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000012894 fetal calf serum Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000005847 immunogenicity Effects 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000017307 interleukin-4 production Effects 0.000 description 2
- 210000004347 intestinal mucosa Anatomy 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 230000004682 mucosal barrier function Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- 235000004252 protein component Nutrition 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 230000020192 tolerance induction in gut-associated lymphoid tissue Effects 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 239000002753 trypsin inhibitor Substances 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 208000012657 Atopic disease Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 101001002709 Homo sapiens Interleukin-4 Proteins 0.000 description 1
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- 206010024438 Lichenification Diseases 0.000 description 1
- 238000000585 Mann–Whitney U test Methods 0.000 description 1
- 235000008540 Mucuna pruriens var utilis Nutrition 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 108010019160 Pancreatin Proteins 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940021722 caseins Drugs 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 235000006986 cowitch Nutrition 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000003413 degradative effect Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 239000012997 ficoll-paque Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 229960004931 histamine dihydrochloride Drugs 0.000 description 1
- PPZMYIBUHIPZOS-UHFFFAOYSA-N histamine dihydrochloride Chemical compound Cl.Cl.NCCC1=CN=CN1 PPZMYIBUHIPZOS-UHFFFAOYSA-N 0.000 description 1
- 102000055229 human IL4 Human genes 0.000 description 1
- 102000057041 human TNF Human genes 0.000 description 1
- 235000020256 human milk Nutrition 0.000 description 1
- 210000004251 human milk Anatomy 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940099472 immunoglobulin a Drugs 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 244000005706 microflora Species 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 229940055695 pancreatin Drugs 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 235000019371 penicillin G benzathine Nutrition 0.000 description 1
- 229940056360 penicillin g Drugs 0.000 description 1
- 210000004976 peripheral blood cell Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000007065 protein hydrolysis Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/018—Hydrolysed proteins; Derivatives thereof from animals from milk
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
- A23J3/343—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins
- A23J3/344—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins of casein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Dairy Products (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI952926A FI104465B (fi) | 1995-06-14 | 1995-06-14 | Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CZ399797A3 CZ399797A3 (cs) | 1998-06-17 |
| CZ291904B6 true CZ291904B6 (cs) | 2003-06-18 |
Family
ID=8543602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ19973997A CZ291904B6 (cs) | 1995-06-14 | 1996-06-12 | Způsob výroby proteinového hydrolyzátového prostředku, tento prostředek a jeho použití |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US6506380B1 (https=) |
| EP (1) | EP0833649B2 (https=) |
| JP (1) | JP3983804B2 (https=) |
| KR (1) | KR100494741B1 (https=) |
| CN (1) | CN1154506C (https=) |
| AR (1) | AR003960A1 (https=) |
| AT (1) | ATE230606T1 (https=) |
| BG (1) | BG63153B1 (https=) |
| BR (1) | BR9607827A (https=) |
| CA (1) | CA2224320C (https=) |
| CZ (1) | CZ291904B6 (https=) |
| DE (1) | DE69625690T3 (https=) |
| DK (1) | DK0833649T4 (https=) |
| EE (1) | EE03424B1 (https=) |
| ES (1) | ES2191103T5 (https=) |
| FI (1) | FI104465B (https=) |
| IL (1) | IL122577A0 (https=) |
| MX (1) | MX9710109A (https=) |
| MY (1) | MY113912A (https=) |
| NO (1) | NO321504B1 (https=) |
| NZ (1) | NZ310478A (https=) |
| PL (1) | PL185123B1 (https=) |
| RO (1) | RO120243B1 (https=) |
| SK (1) | SK284245B6 (https=) |
| WO (1) | WO1997000078A1 (https=) |
| ZA (1) | ZA965088B (https=) |
Families Citing this family (171)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI104465B (fi) * | 1995-06-14 | 2000-02-15 | Valio Oy | Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö |
| JP2002502430A (ja) * | 1997-06-03 | 2002-01-22 | ガネデン バイオテック,インコーポレイテッド | Sidsに関連する細菌感染を処置するための共生乳酸細菌 |
| ES2341217T3 (es) | 1999-01-19 | 2010-06-17 | Maxygen, Inc. | Recombinacion de acidos nucleicos mediada por oligonucleotidos. |
| ES2296635T3 (es) | 1999-08-05 | 2008-05-01 | Societe Des Produits Nestle S.A. | Bifidobacteria capaz de prevenir la diarrea. |
| ES2321797T3 (es) | 1999-08-05 | 2009-06-12 | Societe Des Produits Nestle S.A. | Bifidobacterias que previenen la diarrea causada por bacterias patogenicas. |
| WO2001057534A2 (en) * | 2000-02-04 | 2001-08-09 | Bioseek | Compositions and methods for reducing autoimmunity |
| FI110668B (fi) * | 2000-06-20 | 2003-03-14 | Aboatech Ab Oy | Probioottien käyttö atooppisten sairauksien primaariseen ehkäisyyn |
| IL154284A0 (en) * | 2000-09-25 | 2003-09-17 | Nestle Sa | Lactic acid bacteria capable of reducing an individual's tendency to develop allergic reactions |
| BRPI0114400B8 (pt) | 2000-10-06 | 2021-05-25 | Nestle Sa | uso de bactéria de ácido lático probiótica para equilibrar o sistema imunológico da pele |
| FI109602B (fi) * | 2001-01-25 | 2002-09-13 | Valio Oy | Probioottiyhdistelmä |
| EP1228707A1 (en) * | 2001-02-01 | 2002-08-07 | Campina Melkunie B.V. | Use of alpha-lactalbumin as prebiotic agent |
| EA006429B1 (ru) * | 2001-03-09 | 2005-12-29 | Сосьете Де Продюи Нестле С.А. | Композиция для предупреждения или восстановления возрастных функциональных дефицитов у млекопитающих и способ ее применения |
| JP2003137804A (ja) * | 2001-10-31 | 2003-05-14 | Morinaga Milk Ind Co Ltd | インターロイキン−18誘導剤 |
| EP1364586A1 (en) * | 2002-05-24 | 2003-11-26 | Nestec S.A. | Probiotics and oral tolerance |
| ES2540926T3 (es) | 2002-06-04 | 2015-07-14 | Dsm Ip Assets B.V. | Hidrolizado de proteínas rico en tripéptidos |
| DK1565547T4 (da) | 2002-06-28 | 2013-01-14 | Biosearch S A | Probiotiske stammer, en fremgangsmåde til selektion deraf, præparater deraf samt anvendelse deraf |
| EP1384483A1 (en) * | 2002-07-23 | 2004-01-28 | Nestec S.A. | Probiotics for treatment of irritable bowel disease (IBS) through improvement of gut neuromuscular function |
| US7105336B2 (en) * | 2002-10-07 | 2006-09-12 | Biogaia Ab | Selection and use of lactic acid bacteria for reducing inflammation caused by Helicobacter |
| US20040208863A1 (en) * | 2003-01-30 | 2004-10-21 | James Versalovic | Anti-inflammatory activity from lactic acid bacteria |
| CN1863463B (zh) | 2003-06-23 | 2011-05-04 | 雀巢技术公司 | 用于促进肠道屏障成熟的营养组合物 |
| KR101225918B1 (ko) | 2004-02-25 | 2013-01-24 | 파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 | 신규한 바실루스 투링기엔시스 결정 폴리펩티드,폴리뉴클레오티드, 및 이의 조성물 |
| US20050265946A1 (en) * | 2004-05-28 | 2005-12-01 | Kao Corporation | Elastase inhibitor |
| US7862808B2 (en) * | 2004-07-01 | 2011-01-04 | Mead Johnson Nutrition Company | Method for preventing or treating respiratory infections and acute otitis media in infants using Lactobacillus rhamnosus LGG and Bifidobacterium lactis Bb-12 |
| AU2006233918B2 (en) | 2005-04-13 | 2012-06-21 | Nestec S.A. | Infant formula with probiotics |
| US20060233762A1 (en) * | 2005-04-15 | 2006-10-19 | Mcmahon Robert J | Method for treating or preventing systemic inflammation in formula-fed infants |
| US7303745B2 (en) | 2005-04-15 | 2007-12-04 | Bristol-Myers Squibb Company | Method for preventing or treating the development of respiratory allergies |
| WO2007054587A1 (en) * | 2005-11-14 | 2007-05-18 | Nestec S.A. | Oral tolerance promotion with glycated proteins |
| ES2381211T3 (es) | 2006-02-15 | 2012-05-24 | Nestec S.A. | Uso del Bifidobacterium longum para prevenir y tratar inflamaciones |
| RU2448720C2 (ru) | 2006-03-07 | 2012-04-27 | Нестек С.А. | Синбиотическая смесь |
| CN101460067B (zh) * | 2006-06-15 | 2012-09-26 | 雀巢产品技术援助有限公司 | 诱导对卵蛋白的耐受 |
| CN105796607A (zh) * | 2007-02-28 | 2016-07-27 | Mjn 美国控股有限责任公司 | 用于儿童或婴幼儿的含有灭活益生菌的产品 |
| EP1974743A1 (en) | 2007-03-28 | 2008-10-01 | Nestec S.A. | Probiotics to Improve Gut Microbiota |
| EP1974735A1 (en) | 2007-03-28 | 2008-10-01 | Nestec S.A. | Reduction of risk of diarrhoea |
| EP1974734A1 (en) † | 2007-03-28 | 2008-10-01 | Nestec S.A. | Probiotics for reduction of risk of obesity |
| CN101273737B (zh) * | 2007-03-28 | 2011-08-24 | 哈尔滨正方科技有限公司 | 一种在常温下保持高活菌数的发酵乳饮料的制备方法 |
| JP2010536385A (ja) | 2007-08-24 | 2010-12-02 | コデクシス, インコーポレイテッド | (r)−3−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド |
| EP2072052A1 (en) | 2007-12-17 | 2009-06-24 | Nestec S.A. | Prevention of opportunistic infections in immune-compromised subjects |
| KR20100120169A (ko) | 2008-01-24 | 2010-11-12 | 네스텍 소시에테아노님 | 영양 성분을 담고 있는 캡슐 및 이 캡슐로부터 영양액을 전달하는 방법 |
| PL2244734T3 (pl) | 2008-02-01 | 2017-01-31 | Murdoch Childrens Research Institute | Sposób indukcji tolerancji na alergen |
| ES2658837T3 (es) | 2008-03-14 | 2018-03-12 | Nestec S.A. | Mezcla simbiótica |
| EP2127661A1 (en) | 2008-05-27 | 2009-12-02 | Nestec S.A. | Probiotics to improve gut microbiotica |
| DK3023494T3 (en) | 2008-06-13 | 2019-02-25 | Codexis Inc | PROCEDURE FOR SYNTHESIS OF POLYNUCLEOTIDE VARIETIES |
| US20090312196A1 (en) | 2008-06-13 | 2009-12-17 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
| MX2010014500A (es) | 2008-06-24 | 2011-05-30 | Codexis Inc | Procedimientos biocataliticos para la preparacion de compuestos de prolina biciclica fusionada sustancialmente estereomericamente puros. |
| EP2147678A1 (en) | 2008-07-21 | 2010-01-27 | Nestec S.A. | Probiotics to increase IgA secretion in infants born by caesarean section |
| RU2392001C2 (ru) * | 2008-08-04 | 2010-06-20 | Государственное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" | Способ лечения желтушных форм вирусного гепатита а у детей с пищевой аллергией |
| EP2329013B1 (en) | 2008-08-27 | 2015-10-28 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| HUE052297T2 (hu) | 2009-01-08 | 2021-04-28 | Codexis Inc | Transzamináz polipeptidek |
| BRPI1013886A2 (pt) | 2009-03-17 | 2016-10-11 | Codexis Inc | variantes de endoglucanases, polinucleotídeos e usos a elas relacionados |
| CA2757040C (en) | 2009-03-31 | 2016-02-09 | Codexis, Inc. | Improved endoglucanases |
| BRPI1012922A2 (pt) | 2009-06-16 | 2016-10-11 | Codexis Inc | polipeptídeo de b-glicosidase variante, vetor de expressão, célula hospedeira, método de produção de polipeptídeo de b-glicosidase variante, composição enzimática, método de conversão de um substrato de biomassa em açucar fermentável e método de produção de álcool |
| SG177331A1 (en) | 2009-06-22 | 2012-02-28 | Codexis Inc | Ketoreductase-mediated stereoselective route to alpha chloroalcohols |
| US8614081B2 (en) | 2009-07-23 | 2013-12-24 | Codexis, Inc. | Nitrilase biocatalysts |
| CN102905557A (zh) | 2009-08-18 | 2013-01-30 | 雀巢产品技术援助有限公司 | 包含长双歧杆菌菌株并且特别是在婴儿和儿童中减少食物过敏症状的营养组合物 |
| CN102695427B (zh) | 2009-08-18 | 2016-04-13 | 雀巢产品技术援助有限公司 | 包含乳球菌属菌株并且特别是在婴儿和儿童中减少过敏症状的营养组合物 |
| ES2575560T3 (es) | 2009-08-19 | 2016-06-29 | Codexis, Inc. | Polipéptidos cetorreductasa para preparar fenilefrina |
| WO2011028708A1 (en) | 2009-09-04 | 2011-03-10 | Codexis, Inc. | Variant cbh2 cellulases and related polynucleotides |
| EP2295535A1 (en) * | 2009-09-11 | 2011-03-16 | Mead Johnson Nutrition Company | Probiotic material |
| DK3301208T3 (da) | 2009-09-18 | 2020-12-14 | Codexis Inc | Reduceret codon-mutagenese |
| MX2012006016A (es) | 2009-11-25 | 2012-06-25 | Codexis Inc | Variantes de beta-glucosidasa recombinante para produccion de azucares solubles de biomasa celulosica. |
| BR112012012192A2 (pt) | 2009-11-25 | 2017-07-04 | Codexis Inc | b-glicosidades variantes recombinantes thermoascus aurantiacus para produção de açúcares fermentáveis a partir da biomassa celulósica |
| EP2509429A1 (en) | 2009-12-08 | 2012-10-17 | Nestec S.A. | Infant formula with probiotics and milk fat globule membrane components |
| CN102884178B (zh) | 2009-12-08 | 2014-12-03 | 科德克希思公司 | 拉唑化合物的合成 |
| MX2012007681A (es) | 2009-12-31 | 2013-01-29 | Pioneer Hi Bred Int | Ingenieria de resistencia de plantas a enfermedades causadas por patogenos. |
| HUE026367T2 (en) | 2010-05-04 | 2016-06-28 | Codexis Inc | Biocatalysts for ezetimibe synthesis |
| WO2011143274A1 (en) | 2010-05-10 | 2011-11-17 | Perseid Therapeutics | Polypeptide inhibitors of vla4 |
| WO2011150313A1 (en) | 2010-05-28 | 2011-12-01 | Codexis, Inc. | Pentose fermentation by a recombinant microorganism |
| HUE038434T2 (hu) | 2010-06-17 | 2018-10-29 | Codexis Inc | Biokatalizátorok és módszerek (S)-3(1-aminoetil)-fenol szintéziséhez |
| US8574878B2 (en) | 2010-06-28 | 2013-11-05 | Behnaz Behrouzian | Fatty alcohol forming acyl reductases (FARs) and methods of use thereof |
| CA2803952C (en) | 2010-06-30 | 2020-03-24 | Codexis, Inc. | Highly stable beta-class carbonic anhydrases useful in carbon capture systems |
| US9006460B2 (en) | 2010-08-16 | 2015-04-14 | Cardiome International Ag | Process for preparing aminocyclohexyl ether compounds |
| CA2807702C (en) | 2010-08-20 | 2018-07-24 | Codexis, Inc. | Use of glycoside hydrolase 61 family proteins in processing of cellulose |
| EP2649187B1 (en) | 2010-12-08 | 2017-11-22 | Codexis, Inc. | Biocatalysts and methods for the synthesis of armodafinil |
| EE05750B1 (et) | 2011-02-25 | 2015-06-15 | OÜ Tervisliku Piima Biotehnoloogiate Arenduskeskus | Isoleeritud mikroorganismi tüvi Lactobacillus gasseri MCC2 DSM 23882 ning selle kasutamine |
| US8663962B2 (en) | 2011-03-30 | 2014-03-04 | Codexis, Inc. | Pentose fermentation by a recombinant microorganism |
| HUE038800T2 (hu) | 2011-04-13 | 2018-11-28 | Codexis Inc | Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására |
| UA111078C2 (uk) * | 2011-05-03 | 2016-03-25 | Нестек С.А. | Гідролізат білкового субстрату і спосіб його виготовлення |
| US8778652B2 (en) | 2011-06-30 | 2014-07-15 | Codexis, Inc. | Pentose fermentation by a recombinant microorganism |
| EP2748317B1 (en) | 2011-08-22 | 2017-04-19 | Codexis, Inc. | Gh61 glycoside hydrolase protein variants and cofactors that enhance gh61 activity |
| WO2013036861A1 (en) | 2011-09-08 | 2013-03-14 | Codexis, Inc | Biocatalysts and methods for the synthesis of substituted lactams |
| WO2013048661A1 (en) | 2011-09-30 | 2013-04-04 | Codexis, Inc. | Fungal proteases |
| WO2013052101A1 (en) * | 2011-10-03 | 2013-04-11 | Kelly Foods Corporation | Probiotic composition for pets and method of providing the same |
| US20130089638A1 (en) * | 2011-10-11 | 2013-04-11 | Mead Johnson Nutrition Company | Compositions Comprising Maltotriose And Methods Of Using Same To Inhibit Damage Caused By Dehydration Processes |
| IN2014CN04470A (https=) | 2011-11-18 | 2015-09-04 | Codexis Inc | |
| BR112014015030A2 (pt) | 2011-12-20 | 2017-06-13 | Codexis Inc | variantes da endoflucanase 1b (eg1b) |
| CN104508126B (zh) | 2012-03-23 | 2017-06-30 | 科德克希思公司 | 用于合成色胺和色胺类似物的衍生物的生物催化剂和方法 |
| US20130251829A1 (en) * | 2012-03-23 | 2013-09-26 | Mead Johnson Nutrition Company | Probiotic derived non-viable material for infection prevention and treatment |
| SG11201407295YA (en) | 2012-05-08 | 2014-12-30 | Codexis Inc | Biocatalysts and methods for hydroxylation of chemical compounds |
| HUE036947T2 (hu) | 2012-05-11 | 2018-08-28 | Codexis Inc | Átalakított iminreduktázok és eljárások keton- és aminvegyületek reduktív aminálására |
| US8980578B2 (en) | 2012-06-11 | 2015-03-17 | Codexis, Inc. | Fungal beta-xylosidase variants |
| EP2922953A4 (en) | 2012-11-20 | 2016-11-09 | Shell Int Research | PENTOSEFERMENTATION BY A RECOMBINANT MICROORGANISM |
| US9738915B2 (en) | 2012-12-07 | 2017-08-22 | Merck Sharp & Dohme Corp. | Biocatalytic transamination process |
| SG11201504752YA (en) | 2012-12-21 | 2015-07-30 | Codexis Inc | Engineered biocatalysts and methods for synthesizing chiral amines |
| EP2946006B1 (en) | 2013-01-18 | 2019-04-10 | Codexis, Inc. | Engineered biocatalysts useful for carbapenem synthesis |
| US9617573B2 (en) | 2013-02-28 | 2017-04-11 | Codexis, Inc. | Engineered transaminase polypeptides for industrial biocatalysis |
| CN103355405A (zh) * | 2013-04-07 | 2013-10-23 | 苏州旭优食品科技有限公司 | 一种低过敏性含乳制品的加工工艺 |
| NZ713396A (en) | 2013-04-18 | 2020-06-26 | Codexis Inc | Engineered phenylalanine ammonia lyase polypeptides |
| CN106232619B (zh) | 2013-11-13 | 2022-09-09 | 科德克希思公司 | 工程化的亚胺还原酶和用于酮和胺化合物的还原胺化的方法 |
| WO2015161019A1 (en) | 2014-04-16 | 2015-10-22 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| US9708587B2 (en) | 2014-07-09 | 2017-07-18 | Codexis, Inc. | P450-BM3 variants with improved activity |
| MA41020A (fr) | 2014-11-25 | 2017-10-03 | Evelo Biosciences Inc | Compositions probiotiques et prébiotiques, et leurs procédés d'utilisation pour la modulation du microbiome |
| US10370648B2 (en) | 2014-11-25 | 2019-08-06 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
| LT3237621T (lt) | 2014-12-22 | 2023-09-25 | Codexis, Inc. | Žmogaus alfa-galaktozidazės variantai |
| WO2016130412A1 (en) | 2015-02-10 | 2016-08-18 | Codexis, Inc. | Ketoreductase polypeptides for the synthesis of chiral compounds |
| CN107531762A (zh) | 2015-05-07 | 2018-01-02 | 科德克希思公司 | 青霉素g酰化酶 |
| US9683220B2 (en) | 2015-07-07 | 2017-06-20 | Codexis, Inc. | P450-BM3 variants with improved activity |
| US10724025B2 (en) | 2016-05-05 | 2020-07-28 | Codexis, Inc. | Penicillin-G acylases |
| WO2017213758A1 (en) | 2016-06-09 | 2017-12-14 | Codexis, Inc. | Biocatalysts and methods for hydroxylation of chemical compounds |
| MX2018015534A (es) | 2016-06-15 | 2019-03-14 | Codexis Inc | Beta-glucosidasas dise?adas y metodos de glucosilacion. |
| IL264686B2 (en) | 2016-08-26 | 2024-07-01 | Codexis Inc | Engineered imine reductases and methods for reversible amination of ketone and amine compounds |
| EP3565893A4 (en) | 2017-01-05 | 2020-12-09 | Codexis, Inc. | PENICILLIN G ACYLASES |
| CA3175070A1 (en) | 2017-02-03 | 2018-08-09 | Codexis, Inc. | Engineered glycosyltransferases and steviol glycoside glucosylation methods |
| MX2019009615A (es) | 2017-02-13 | 2019-10-14 | Codexis Inc | Polipeptidos dise?ados de fenilalanina amonio liasa. |
| MA48475A (fr) | 2017-04-24 | 2020-03-04 | Tesaro Inc | Procédés de fabrication de niraparib |
| CN110831618B (zh) | 2017-04-27 | 2023-08-25 | 科德克希思公司 | 酮还原酶多肽及多核苷酸 |
| ES2887078T3 (es) | 2017-05-08 | 2021-12-21 | Codexis Inc | Variantes de ligasa diseñadas |
| EP3638688A4 (en) | 2017-06-14 | 2021-07-07 | Codexis, Inc. | MODIFIED TRANSAMINASE POLYPEPTIDES INTENDED FOR INDUSTRIAL BIOCATALYSIS |
| CN117737045A (zh) | 2017-06-27 | 2024-03-22 | 科德克希思公司 | 青霉素g酰化酶 |
| KR20250028535A (ko) | 2017-06-30 | 2025-02-28 | 코덱시스, 인코포레이티드 | T7 rna 폴리머라제 변이체 |
| EP3645712A4 (en) | 2017-06-30 | 2021-07-07 | Codexis, Inc. | T7 RNA POLYMERASE VARIANTS |
| EP3706780A4 (en) | 2017-11-07 | 2021-12-22 | Codexis, Inc. | TRANSGLUTAMINASE VARIANTS |
| JP2021506252A (ja) | 2017-12-13 | 2021-02-22 | コデクシス, インコーポレイテッド | アミドカップリングのためのカルボキシエステラーゼポリペプチド |
| CN111465688A (zh) | 2017-12-13 | 2020-07-28 | 葛兰素史密斯克莱知识产权发展有限公司 | 羧酸酯酶催化剂 |
| US10900055B2 (en) | 2018-06-12 | 2021-01-26 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| IL279884B2 (en) | 2018-07-09 | 2026-04-01 | Codexis Inc | Engineered pantothenate kinase variant enzymes |
| EP3821015A4 (en) | 2018-07-09 | 2022-07-13 | Codexis, Inc. | GENETIC DEOXYRIBOSE PHOSPHATE ALDOLASES |
| AU2019302423B2 (en) | 2018-07-09 | 2024-11-21 | Codexis, Inc. | Engineered purine nucleoside phosphorylase variant enzymes |
| SG11202012138XA (en) | 2018-07-09 | 2021-01-28 | Codexis Inc | Engineered galactose oxidase variant enzymes |
| EP3821026A4 (en) | 2018-07-09 | 2022-06-01 | Codexis, Inc. | MANIPULATED ENZYME VARIANTS OF PHOSPHOPENTOMUTASE |
| JP2021531749A (ja) | 2018-07-12 | 2021-11-25 | コデクシス, インコーポレイテッド | 操作されたフェニルアラニンアンモニアリアーゼポリペプチド |
| WO2020028039A1 (en) | 2018-07-30 | 2020-02-06 | Codexis, Inc. | Engineered glycosyltransferases and steviol glycoside glucosylation methods |
| AU2019373208A1 (en) | 2018-10-29 | 2021-05-13 | Codexis, Inc. | Engineered DNA polymerase variants |
| CA3122524A1 (en) | 2018-12-14 | 2020-06-18 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| AU2019403323B2 (en) | 2018-12-20 | 2026-02-26 | Codexis, Inc. | Human alpha-galactosidase variants |
| CA3126671A1 (en) | 2019-01-15 | 2020-07-23 | Codexis, Inc. | Engineered transaminase polypeptides |
| CN114096662B (zh) | 2019-05-01 | 2025-04-15 | 科德克希思公司 | 工程化葡萄糖脱氢酶和用于酮和胺化合物的还原胺化的方法 |
| EP3963057A4 (en) | 2019-05-01 | 2023-06-14 | Codexis, Inc. | MANIPULATED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS |
| AU2020299358A1 (en) | 2019-07-02 | 2021-12-23 | Codexis, Inc. | Engineered acetate kinase variant enzymes |
| WO2021003132A1 (en) | 2019-07-02 | 2021-01-07 | Codexis, Inc. | Engineered sucrose phosphorylase variant enzymes |
| US20230173066A1 (en) | 2019-07-23 | 2023-06-08 | Frieslandcampina Nederland B.V. | Nutritional composition comprising milk fat and immunoglobulin |
| EP4501403A3 (en) | 2019-08-30 | 2025-05-14 | Société des Produits Nestlé S.A. | Engineered lipase variants |
| US12012620B2 (en) | 2019-09-12 | 2024-06-18 | Codexis, Inc. | Peroxidase activity towards 10-acetyl-3,7-dihydroxyphenoxazine |
| CN114746745B (zh) | 2019-10-02 | 2025-06-17 | 美国雅培糖尿病护理公司 | 通过蛋白质开关检测分析物 |
| CN121780457A (zh) | 2019-11-26 | 2026-04-03 | 科德克希思公司 | 用于化学化合物的羟基化的生物催化剂和方法 |
| JP2023507575A (ja) | 2019-12-20 | 2023-02-24 | コデクシス, インコーポレイテッド | 操作された酸性アルファ-グルコシダーゼバリアント |
| JP2023512683A (ja) | 2020-02-04 | 2023-03-28 | コデクシス, インコーポレイテッド | 操作されたロイシンデカルボキシラーゼ |
| EP4133064A4 (en) | 2020-04-10 | 2024-07-24 | Codexis, Inc. | Engineered transaminase polypeptides |
| JP7747337B2 (ja) | 2020-04-10 | 2025-10-01 | コデクシス, インコーポレイテッド | 速度論的光学分割のためのカルボキシエステラーゼポリペプチド |
| CN116897205A (zh) | 2020-08-28 | 2023-10-17 | 科德克希思公司 | 工程化淀粉酶变体 |
| AU2021334371A1 (en) | 2020-08-28 | 2023-03-09 | Codexis, Inc. | Engineered protease variants |
| US20220186231A1 (en) | 2020-12-11 | 2022-06-16 | Willow Biosciences, Inc. | Recombinant acyl activating enzyme (aae) genes for enhanced biosynthesis of cannabinoids and cannabinoid precursors |
| WO2022133289A2 (en) | 2020-12-18 | 2022-06-23 | Codexis, Inc. | Engineered uridine phosphorylase variant enzymes |
| EP4314262A1 (en) | 2021-04-02 | 2024-02-07 | Codexis, Inc. | Engineered guanylate kinase variant enzymes |
| US12180483B2 (en) | 2021-04-02 | 2024-12-31 | Codexis, Inc. | Engineered cyclic GMP-AMP synthase (cGAS) variant enzymes |
| IL305919A (en) | 2021-04-02 | 2023-11-01 | Codexis Inc | Engineered adenylate kinase variant enzymes |
| CA3215105A1 (en) | 2021-04-02 | 2022-10-06 | Codexis, Inc. | Engineered acetate kinase variant enzymes |
| CA3220735A1 (en) | 2021-05-21 | 2022-11-24 | Codexis, Inc. | Engineered methionine gamma lyase variants |
| CA3227215A1 (en) | 2021-07-30 | 2023-02-02 | Trish Choudhary | Recombinant prenyltransferase polypeptides engineered for enhanced biosynthesis of cannabinoids |
| EP4388088A1 (en) | 2021-08-19 | 2024-06-26 | Willow Biosciences, Inc. | Recombinant olivetolic acid cyclase polypeptides engineered for enhanced biosynthesis of cannabinoids |
| US12129495B2 (en) | 2021-10-15 | 2024-10-29 | Codexis, Inc. | Engineered DNA polymerase variants |
| CA3234383A1 (en) | 2021-10-15 | 2023-04-27 | Codexis, Inc. | Engineered terminal deoxynucleotidyl transferase variants |
| WO2023069921A1 (en) | 2021-10-19 | 2023-04-27 | Epimeron Usa, Inc. | Recombinant thca synthase polypeptides engineered for enhanced biosynthesis of cannabinoids |
| JP2024540358A (ja) | 2021-11-01 | 2024-10-31 | シンティス バイオ,インコーポレイティド | 工学操作ロイシン脱炭酸酵素 |
| JP2025510621A (ja) | 2022-03-31 | 2025-04-15 | 青島清原化合物有限公司 | モノアミン酸化酵素及びその応用 |
| WO2024040020A1 (en) | 2022-08-15 | 2024-02-22 | Absci Corporation | Quantitative affinity activity specific cell enrichment |
| CN120981566A (zh) | 2023-01-12 | 2025-11-18 | 诺华股份有限公司 | 工程化酮还原酶多肽 |
| WO2025061911A1 (en) | 2023-09-22 | 2025-03-27 | Glaxosmithkline Intellectual Property Development Limited | Methods of producing nucleotide triphosphates (ntps) |
| WO2025144700A1 (en) | 2023-12-27 | 2025-07-03 | Absci Corporation | Nanobody library screening using bacterial surface display |
| WO2025235589A1 (en) | 2024-05-08 | 2025-11-13 | Codexis, Inc. | Dna polymerase variants |
| WO2025242702A1 (en) | 2024-05-23 | 2025-11-27 | Glaxosmithkline Intellectual Property Development Limited | Enzymatic process for producing n-acetyl galactosamine clusters |
| CN121450551A (zh) * | 2026-01-07 | 2026-02-03 | 善恩康生物科技(苏州)有限公司 | 具有抗炎活性的沙棘源益生菌及其在肠炎治疗中的应用和产品 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3886288A (en) * | 1970-06-15 | 1975-05-27 | Swift & Co | Cheese manufacture using highly active proteolytic enzymes |
| JPS5279086A (en) | 1975-12-25 | 1977-07-02 | Nippon Soda Co Ltd | Preparation of antibiotic tunicamycin |
| JPS5279083A (en) * | 1975-12-26 | 1977-07-02 | Morinaga Milk Industry Co Ltd | Production of protein decomposed substance not having bitterness and antigen property |
| JPS6041751B2 (ja) | 1976-06-22 | 1985-09-18 | ジエコ−株式会社 | デジタル電子時計 |
| JPS548785A (en) | 1977-06-21 | 1979-01-23 | Kikkoman Corp | Preparation of protein hydrolyzate |
| US4839281A (en) † | 1985-04-17 | 1989-06-13 | New England Medical Center Hospitals, Inc. | Lactobacillus strains and methods of selection |
| DK589785A (da) * | 1985-12-18 | 1987-06-19 | Samuelsson Ernst Gunnar | Peptidpraeparat, fremgangsmaade til fremstilling deraf samt anvendelse af peptidpraeparatet |
| ATE84680T1 (de) † | 1987-12-23 | 1993-02-15 | Nestle Sa | Verfahren zur herstellung eines molkeeiweisshydrolysates und eines hypoallergenen nahrungsmittels. |
| DD281540A5 (de) * | 1988-08-08 | 1990-08-15 | Berlin Chemie Veb | Verfahren zur herstellung von nutritiva |
| ES2063882T5 (es) † | 1989-10-02 | 2001-12-01 | Novartis Nutrition Ag | Hidrolizados de proteinas. |
| JP3071877B2 (ja) † | 1991-06-27 | 2000-07-31 | 財団法人糧食研究会 | 経口寛容誘導能を有する低アレルゲン性酵素分解ペプチド組成物 |
| US5952034A (en) * | 1991-10-12 | 1999-09-14 | The Regents Of The University Of California | Increasing the digestibility of food proteins by thioredoxin reduction |
| ATE161181T1 (de) * | 1992-07-06 | 1998-01-15 | Nestle Sa | Lactobacillus acidophilus enthaltende antigastritis-mittel |
| FI94089C (fi) | 1992-12-10 | 1995-07-25 | Valio Oy | Menetelmä allergiaa aiheuttavien yhdisteiden poistamiseksi proteiinipitoisista koostumuksista |
| RU2031586C1 (ru) | 1993-02-05 | 1995-03-27 | Тамара Георгиевна Извекова | Биологически активный кисломолочный продукт "ацидолакт-наринэ" и способ его получения |
| GB9312369D0 (en) | 1993-06-16 | 1993-07-28 | Sandoz Nutrition Ltd | Organic compounds |
| WO1995014485A1 (en) | 1993-11-23 | 1995-06-01 | Kabushiki Kaisha Wado Doctors Group | Intestinal flora improver composition, and apparatus and system for producing the same |
| FI104465B (fi) * | 1995-06-14 | 2000-02-15 | Valio Oy | Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö |
-
1995
- 1995-06-14 FI FI952926A patent/FI104465B/fi not_active IP Right Cessation
-
1996
- 1996-06-11 MY MYPI96002357A patent/MY113912A/en unknown
- 1996-06-12 CZ CZ19973997A patent/CZ291904B6/cs not_active IP Right Cessation
- 1996-06-12 SK SK1715-97A patent/SK284245B6/sk not_active IP Right Cessation
- 1996-06-12 KR KR1019970709383A patent/KR100494741B1/ko not_active Expired - Lifetime
- 1996-06-12 DE DE69625690T patent/DE69625690T3/de not_active Expired - Lifetime
- 1996-06-12 PL PL96324010A patent/PL185123B1/pl unknown
- 1996-06-12 RO RO97-02328A patent/RO120243B1/ro unknown
- 1996-06-12 US US08/973,963 patent/US6506380B1/en not_active Expired - Lifetime
- 1996-06-12 BR BR9607827-8A patent/BR9607827A/pt not_active Application Discontinuation
- 1996-06-12 NZ NZ310478A patent/NZ310478A/xx not_active IP Right Cessation
- 1996-06-12 WO PCT/FI1996/000350 patent/WO1997000078A1/en not_active Ceased
- 1996-06-12 CA CA2224320A patent/CA2224320C/en not_active Expired - Lifetime
- 1996-06-12 DK DK96918707T patent/DK0833649T4/da active
- 1996-06-12 AT AT96918707T patent/ATE230606T1/de active
- 1996-06-12 EE EE9700339A patent/EE03424B1/xx unknown
- 1996-06-12 ES ES96918707T patent/ES2191103T5/es not_active Expired - Lifetime
- 1996-06-12 JP JP50267197A patent/JP3983804B2/ja not_active Expired - Lifetime
- 1996-06-12 IL IL12257796A patent/IL122577A0/xx not_active IP Right Cessation
- 1996-06-12 EP EP96918707A patent/EP0833649B2/en not_active Expired - Lifetime
- 1996-06-12 CN CNB961947527A patent/CN1154506C/zh not_active Expired - Lifetime
- 1996-06-13 AR ARP960103134A patent/AR003960A1/es unknown
- 1996-06-14 ZA ZA965088A patent/ZA965088B/xx unknown
-
1997
- 1997-12-11 MX MX9710109A patent/MX9710109A/es unknown
- 1997-12-11 NO NO19975832A patent/NO321504B1/no not_active IP Right Cessation
- 1997-12-23 BG BG102144A patent/BG63153B1/bg unknown
-
2002
- 2002-12-18 US US10/321,661 patent/US7172756B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CZ291904B6 (cs) | Způsob výroby proteinového hydrolyzátového prostředku, tento prostředek a jeho použití | |
| Sashihara et al. | An analysis of the effectiveness of heat-killed lactic acid bacteria in alleviating allergic diseases | |
| Tlaskalová-Hogenová et al. | Mucosal immunity: its role in defense and allergy | |
| JP4520531B2 (ja) | 乳児仙痛を低減するための選択された乳酸菌の使用 | |
| RU2294366C2 (ru) | Трансформированные молочно-кислые бактерии, снижающие склонность к проявлению аллергических реакций, и их применение | |
| EP1229930A1 (en) | Compositions and methods for treatment of allergic disorders | |
| WO2007125566A2 (en) | Use of probiotics in the prevention and treatment of allergic conjunctivitis | |
| KR20040023755A (ko) | 알레르기 치료에 있어서 일부 락토바실러스 균주들의새로운 용도 | |
| CN112218547A (zh) | 含有特定β-乳球蛋白肽的配方物 | |
| US6506388B1 (en) | Immunomodulator, immunomodulator food | |
| JPH04342533A (ja) | IgA産生促進剤 | |
| RU2174012C2 (ru) | Способы профилактики или лечения аллергии | |
| Britti et al. | Regulation of immune response at intestinal and peripheral sites by probiotics | |
| Masuda et al. | TLR ligands of Lactobacillus sakei LK-117 isolated from seed mash for brewing sake are potent inducers of IL-12 | |
| AU710126C (en) | Methods of preventing or treating allergies | |
| HK1010081B (en) | Methods of preventing or treating allergies | |
| Kirjavainen et al. | Probiotics and the management of food allergy | |
| Johansson | Early gut microbiota in relation to cytokine responses and allergic disease | |
| Barletta et al. | Probiotic VSL# 3-induced TGF-ß ameliorates food allergy inflammation in a mouse model of peanut sensitization through the induction of regulatory T cells in the gut mucosa |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD00 | Pending as of 2000-06-30 in czech republic | ||
| MK4A | Patent expired |
Effective date: 20160612 |