GB9718972D0
(en)
|
1996-09-25 |
1997-11-12 |
Zeneca Ltd |
Chemical compounds
|
IL128994A
(en)
|
1996-09-25 |
2004-12-15 |
Zeneca Ltd |
History of quinoline and naphthyridine and their salts, processes for their preparation, pharmaceutical preparations containing them and their use as medicines
|
CO4950519A1
(es)
*
|
1997-02-13 |
2000-09-01 |
Novartis Ag |
Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
|
JP4959049B2
(ja)
|
1997-08-22 |
2012-06-20 |
アストラゼネカ・ユーケイ・リミテッド |
血管新生阻害剤としてのオキシインドリルキナゾリン誘導体
|
PT1107964E
(pt)
|
1998-08-11 |
2010-06-11 |
Novartis Ag |
Derivados de isoquinolina com actividade inibidora da angiogénese
|
EP1105136B1
(en)
*
|
1998-08-13 |
2007-08-29 |
Novartis AG |
Method for treating ocular neovascular diseases
|
PT1165085E
(pt)
|
1999-03-30 |
2006-10-31 |
Novartis Ag |
Derivados de ftalazina para tratar doencas inflamatorias
|
AR025068A1
(es)
*
|
1999-08-10 |
2002-11-06 |
Bayer Corp |
Pirazinas sustituidas y piridazinas fusionadas, composicion farmaceutica que las comprenden, uso de dichos compuestos para la manufactura de un medicamentocon actividad inhibidora de angiogenesis
|
US6271233B1
(en)
|
1999-08-10 |
2001-08-07 |
Ciba Vision Corporation |
Method for treating ocular neovascular diseases
|
DOP2000000070A
(es)
*
|
1999-09-28 |
2002-02-28 |
Bayer Healthcare Llc |
Piridinas y piridacinas sustituidas con actividad de inhibición de angiogénesis
|
US6689883B1
(en)
|
1999-09-28 |
2004-02-10 |
Bayer Pharmaceuticals Corporation |
Substituted pyridines and pyridazines with angiogenesis inhibiting activity
|
EP1676845B1
(en)
|
1999-11-05 |
2008-06-11 |
AstraZeneca AB |
New quinazoline derivatives
|
DE19963607B4
(de)
*
|
1999-12-23 |
2005-12-15 |
Schering Ag |
Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen
|
DE60110749T2
(de)
|
2000-02-09 |
2006-02-02 |
Novartis Ag |
Pyridinderivative als angiogenese- und/oder vegf-rezeptor-tyrosinkinase-inhibitoren
|
US7087608B2
(en)
|
2000-03-03 |
2006-08-08 |
Robert Charles Atkins |
Use of PDGF receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy
|
NZ521421A
(en)
|
2000-04-07 |
2004-09-24 |
Astrazeneca Ab |
Quinazoline compounds
|
US7977333B2
(en)
|
2000-04-20 |
2011-07-12 |
Bayer Healthcare Llc |
Substituted pyridines and pyridazines with angiogenesis inhibiting activity
|
AU784231B2
(en)
*
|
2000-06-23 |
2006-02-23 |
Schering Aktiengesellschaft |
Combinations and compositions which interfere with VEGF/VEGF and angiopoietin/tie receptor function and their use (II)
|
EP1166799A1
(en)
*
|
2000-06-28 |
2002-01-02 |
Schering Aktiengesellschaft |
Combinations and compositions which interfere with VEGF/VEGF and angiopoietin/Tie receptor function and their use (II)
|
EP1166798A1
(en)
*
|
2000-06-23 |
2002-01-02 |
Schering Aktiengesellschaft |
Combinations and compositions which interfere with VEGF/VEGF and angiopoietin/ Tie receptor function and their use
|
AU2001279938B2
(en)
*
|
2000-08-09 |
2007-01-25 |
Astrazeneca Ab |
Indole, azaindole and indazole derivatives having VEGF inhibiting activity
|
US6903101B1
(en)
|
2000-08-10 |
2005-06-07 |
Bayer Pharmaceuticals Corporation |
Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity
|
DE60126997T2
(de)
|
2000-10-20 |
2007-10-25 |
Eisai R&D Management Co., Ltd. |
Stickstoff-enthaltende aromatische ringverbindungen zur behandlung von tumorerkrankungen
|
BR0115062A
(pt)
*
|
2000-10-30 |
2004-02-17 |
Kudos Pharm Ltd |
Derivados de ftalazinona
|
AU2002223684A1
(en)
*
|
2000-11-22 |
2002-06-03 |
Novartis Pharma Gmbh |
Combination comprising an agent decreasing vegf activity and an agent decreasing egf activity
|
US7096566B2
(en)
*
|
2001-01-09 |
2006-08-29 |
Black & Decker Inc. |
Method for making an encapsulated coil structure
|
US7814641B2
(en)
|
2001-01-09 |
2010-10-19 |
Black & Decker Inc. |
Method of forming a power tool
|
EP2269603B1
(en)
|
2001-02-19 |
2015-05-20 |
Novartis AG |
Treatment of breast tumors with a rapamycin derivative in combination with exemestane
|
GB0111078D0
(en)
*
|
2001-05-04 |
2001-06-27 |
Novartis Ag |
Organic compounds
|
HUP0400038A3
(en)
|
2001-05-16 |
2007-05-29 |
Novartis Ag |
Combination comprising n-{5-[4-{-methyl-piperazino-methyl)-benzoylamino]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent
|
TWI315982B
(en)
|
2001-07-19 |
2009-10-21 |
Novartis Ag |
Combinations comprising epothilones and pharmaceutical uses thereof
|
US20030073692A1
(en)
*
|
2001-08-07 |
2003-04-17 |
Pharmacia & Upjohn S.P.A. |
Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them
|
EP1712234B1
(en)
*
|
2001-09-12 |
2009-01-28 |
Novartis AG |
Use of 4-Pyridylmethylphthalazines for Renal Cancer Treatment
|
PL367349A1
(en)
*
|
2001-09-12 |
2005-02-21 |
Novartis Ag |
Use of 4-pyridylmethylphthalazines for cancer treatment
|
RU2320344C2
(ru)
*
|
2001-09-12 |
2008-03-27 |
Новартис Аг |
Применение 4-пиридилметилфталазинов для лечения рака
|
US20040266779A1
(en)
*
|
2001-09-27 |
2004-12-30 |
Anderson Kenneth C. |
Use of c-kit inhibitors for the treatment of myeloma
|
RU2333754C2
(ru)
*
|
2001-10-25 |
2008-09-20 |
Новартис Аг |
Композиции, содержащие избирательный ингибитор циклооксигеназы-2
|
AU2002364102A1
(en)
*
|
2001-12-21 |
2003-07-30 |
Bayer Pharmaceuticals Corporation |
Anti-angiogenesis combination therapies comprising pyridazine or pyridine derivatives
|
KR100965519B1
(ko)
|
2001-12-27 |
2010-06-23 |
세라밴스 인코포레이티드 |
단백질 키나제 억제제로서 유용한 인돌리논 유도체
|
US20030171375A1
(en)
*
|
2002-02-13 |
2003-09-11 |
Brazzell Romulus Kimbro |
Method for treating ocular neovascular diseases
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
US20050209237A1
(en)
*
|
2002-04-30 |
2005-09-22 |
Brazzell Romulus K |
Method for decreasing capillary permeability in the retina
|
CA2483594C
(en)
|
2002-05-16 |
2011-02-15 |
Novartis Ag |
Use of edg receptor binding agents in cancer
|
BR0312283A
(pt)
*
|
2002-06-28 |
2005-04-12 |
Novartis Ag |
Combinação compreendendo um agente de alquilação e um agente redutor da atividade de vegf
|
US7195876B2
(en)
*
|
2002-08-09 |
2007-03-27 |
Theravance, Inc. |
Oncokinase fusion polypeptides associated with hyperproliferative and related disorders, nucleic acids encoding the same and methods for detecting and identifying the same
|
HRP20050281A2
(en)
*
|
2002-09-24 |
2006-07-31 |
Novartis Ag |
Use of 4-pyridylmethyl-phthalazine derivatives for the manufacture of a medicament for the treatment of myelodysplastic syndromes
|
GB0223341D0
(en)
*
|
2002-10-08 |
2002-11-13 |
Groningen Acad Ziekenhuis |
Organic compounds
|
AU2003271712A1
(en)
*
|
2002-10-10 |
2004-05-04 |
Novartis Ag |
Treatment of amm
|
US7268137B2
(en)
|
2002-11-07 |
2007-09-11 |
Campochiaro Peter A |
Ocular therapy
|
JP2006507319A
(ja)
*
|
2002-11-12 |
2006-03-02 |
ノバルティス アクチエンゲゼルシャフト |
中皮腫の処置
|
US7094785B1
(en)
|
2002-12-18 |
2006-08-22 |
Cornell Research Foundation, Inc. |
Method of treating polycythemia vera
|
AU2003286373A1
(en)
*
|
2002-12-20 |
2004-07-14 |
Dana-Farber Cancer Institute Inc. |
Treatment of von hippel lindau disease
|
EP1738752A1
(en)
*
|
2002-12-27 |
2007-01-03 |
Schering Aktiengesellschaft |
Pharmaceutical combinations comprising cis-retine acid
|
ES2527185T3
(es)
|
2003-03-07 |
2015-01-21 |
Santen Pharmaceutical Co., Ltd |
Nuevos compuestos que tienen un grupo 4-piridilalquiltio como sustituyente
|
US20050043233A1
(en)
|
2003-04-29 |
2005-02-24 |
Boehringer Ingelheim International Gmbh |
Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
|
US20040242886A1
(en)
*
|
2003-04-30 |
2004-12-02 |
Sandeep Gupta |
Monocyclic diazodioxide based Bcl-2 protein antagonists related applications
|
MY150088A
(en)
|
2003-05-19 |
2013-11-29 |
Irm Llc |
Immunosuppressant compounds and compositions
|
EP2644195A1
(en)
|
2003-05-19 |
2013-10-02 |
Irm Llc |
Immunosuppressant Compounds and Compositions
|
PL1648998T3
(pl)
|
2003-07-18 |
2015-03-31 |
Amgen Inc |
Specyficzne czynniki wiążące czynnik wzrostu hepatocytów
|
CN100450998C
(zh)
|
2003-11-11 |
2009-01-14 |
卫材R&D管理有限公司 |
脲衍生物的制备方法
|
BRPI0416680A
(pt)
|
2003-11-18 |
2007-02-13 |
Novartis Ag |
inibidores da forma mutante de kit
|
WO2005058341A2
(en)
*
|
2003-12-11 |
2005-06-30 |
Theravance, Inc. |
Compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases
|
PL1717229T3
(pl)
|
2004-02-17 |
2011-11-30 |
Santen Pharmaceutical Co Ltd |
Nowy cykliczny związek mający grupę 4-pirydyloalkilotiolową z wprowadzoną do niej (nie)podstawioną grupą aminową
|
EP1568368A1
(en)
*
|
2004-02-26 |
2005-08-31 |
Schering Aktiengesellschaft |
Pharmaceutical combination comprising a CDK inhibitor and a VEGF receptor inhibitor
|
FR2868780B1
(fr)
*
|
2004-04-13 |
2008-10-17 |
Sanofi Synthelabo |
Derives de la 1-amino-phthalazine, leur preparation et leur application en therapeutique
|
WO2006002422A2
(en)
|
2004-06-24 |
2006-01-05 |
Novartis Vaccines And Diagnostics Inc. |
Compounds for immunopotentiation
|
GB0512324D0
(en)
|
2005-06-16 |
2005-07-27 |
Novartis Ag |
Organic compounds
|
US8772269B2
(en)
|
2004-09-13 |
2014-07-08 |
Eisai R&D Management Co., Ltd. |
Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
|
WO2006030941A1
(ja)
|
2004-09-13 |
2006-03-23 |
Eisai R & D Management Co., Ltd. |
スルホンアミド含有化合物の血管新生阻害物質との併用
|
PE20060664A1
(es)
*
|
2004-09-15 |
2006-08-04 |
Novartis Ag |
Amidas biciclicas como inhibidores de cinasa
|
EP1797881B1
(en)
|
2004-09-17 |
2009-04-15 |
Eisai R&D Management Co., Ltd. |
Medicinal composition with improved stability and reduced gelation properties
|
ES2325344B1
(es)
*
|
2004-11-02 |
2010-06-09 |
Univ Madrid Autonoma |
Inhibidores de angiogenesis multifuncionales y multivalentes.
|
MX2007006230A
(es)
|
2004-11-30 |
2007-07-25 |
Amgen Inc |
Quinolinas y analogos de quinazolinas y su uso como medicamentos para tratar cancer.
|
ES2351613T3
(es)
*
|
2005-03-03 |
2011-02-08 |
Santen Pharmaceutical Co., Ltd. |
Nuevo compuesto cíclico que tiene un grupo quinolilalquiltio.
|
US20060216288A1
(en)
*
|
2005-03-22 |
2006-09-28 |
Amgen Inc |
Combinations for the treatment of cancer
|
US7906511B2
(en)
|
2005-03-31 |
2011-03-15 |
Santen Pharmaceutical Co., Ltd. |
Cyclic compound having pyrimidinylalkylthio group
|
WO2006113172A1
(en)
*
|
2005-04-13 |
2006-10-26 |
Novartis Ag |
Use of vascular endothelial growth factor receptor inhibitors for the treatment of gastrointestinal, genitourinary, lymphoid and pulmonary cancers
|
MX2007013741A
(es)
|
2005-05-02 |
2008-01-21 |
Novartis Ag |
Uso de derivados de pirimidilaminobenzamida para el tratamiento de mastocitosis sistemica.
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
EP1731154A1
(en)
*
|
2005-06-07 |
2006-12-13 |
Schering Aktiengesellschaft |
Immediate-release and high-drug-load pharmaceutical formulations of micronised (4-chlorophenyl)|4-(4-pyridylmethyl)pht halazin-1-yl| and salts thereof
|
EP1731153A1
(en)
*
|
2005-06-07 |
2006-12-13 |
Schering Aktiengesellschaft |
Immediate-release and high-drug-load pharmaceutical formulations of non-micronised (4-chlorophenyl)¬4-(4-pyridylmethyl)phthalazin-1-yl| and salts thereof
|
WO2007015578A1
(ja)
|
2005-08-02 |
2007-02-08 |
Eisai R & D Management Co., Ltd. |
血管新生阻害物質の効果を検定する方法
|
GB0517205D0
(en)
*
|
2005-08-22 |
2005-09-28 |
Novartis Ag |
Organic compounds
|
US7915410B2
(en)
*
|
2005-09-09 |
2011-03-29 |
Bristol-Myers Squibb Company |
Acyclic IKur inhibitors
|
US20080255149A1
(en)
|
2005-09-27 |
2008-10-16 |
Novartis Ag |
Carboxyamine Compounds and Methods of Use Thereof
|
UA96139C2
(uk)
|
2005-11-08 |
2011-10-10 |
Дженентек, Інк. |
Антитіло до нейропіліну-1 (nrp1)
|
CA2629245C
(en)
|
2005-11-21 |
2016-07-12 |
Novartis Ag |
Neuroendocrine tumor treatment
|
US20080108664A1
(en)
|
2005-12-23 |
2008-05-08 |
Liu Belle B |
Solid-state form of AMG 706 and pharmaceutical compositions thereof
|
US7989461B2
(en)
|
2005-12-23 |
2011-08-02 |
Amgen Inc. |
Substituted quinazolinamine compounds for the treatment of cancer
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
AR059066A1
(es)
|
2006-01-27 |
2008-03-12 |
Amgen Inc |
Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf)
|
DE602007010734D1
(de)
*
|
2006-02-10 |
2011-01-05 |
Amgen Inc |
Hydratformen von amg706
|
PE20070978A1
(es)
*
|
2006-02-14 |
2007-11-15 |
Novartis Ag |
COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
|
WO2007124252A2
(en)
|
2006-04-05 |
2007-11-01 |
Novartis Ag |
Combinations of therapeutic agents for treating cancer
|
AR060358A1
(es)
*
|
2006-04-06 |
2008-06-11 |
Novartis Vaccines & Diagnostic |
Quinazolinas para la inhibicion de pdk 1
|
US8777120B2
(en)
*
|
2006-04-15 |
2014-07-15 |
International Business Machines Corporation |
Hydronic radiant flooring heating system
|
PE20110235A1
(es)
|
2006-05-04 |
2011-04-14 |
Boehringer Ingelheim Int |
Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
|
CA2649792A1
(en)
|
2006-05-09 |
2007-11-15 |
Novartis Ag |
Combination comprising an iron chelator and an anti-neoplastic agent and use thereof
|
RS20080525A
(en)
|
2006-05-09 |
2009-09-08 |
Pfizer Products Inc., |
Cycloalkylamino acid derivatives and pharmaceutical compositions thereof
|
CN101443009A
(zh)
|
2006-05-18 |
2009-05-27 |
卫材R&D管理有限公司 |
针对甲状腺癌的抗肿瘤剂
|
GB0610925D0
(en)
*
|
2006-06-02 |
2006-07-12 |
Novartis Ag |
Use of vascular endothelial growth factor receptor inhibitors for the treatment of cancer
|
GB0612721D0
(en)
|
2006-06-27 |
2006-08-09 |
Novartis Ag |
Organic compounds
|
US8217177B2
(en)
|
2006-07-14 |
2012-07-10 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
PE20080403A1
(es)
|
2006-07-14 |
2008-04-25 |
Amgen Inc |
Derivados heterociclicos fusionados y metodos de uso
|
TW200817409A
(en)
|
2006-08-04 |
2008-04-16 |
Takeda Pharmaceutical |
Fused heterocyclic derivative and use thereof
|
US8865737B2
(en)
|
2006-08-28 |
2014-10-21 |
Eisai R&D Management Co., Ltd. |
Antitumor agent for undifferentiated gastric cancer
|
DE602007013441D1
(de)
|
2006-09-29 |
2011-05-05 |
Novartis Ag |
Pyrazolopyrimidine als pi3k-lipidkinasehemmer
|
JP5528806B2
(ja)
|
2006-10-12 |
2014-06-25 |
アステックス、セラピューティックス、リミテッド |
複合薬剤
|
JP5528807B2
(ja)
|
2006-10-12 |
2014-06-25 |
アステックス、セラピューティックス、リミテッド |
複合薬剤
|
CA2672438A1
(en)
|
2006-12-20 |
2008-07-03 |
Amgen Inc. |
Substituted heterocycles and methods of use
|
CA2673652A1
(en)
|
2007-01-09 |
2008-07-17 |
Amgen Inc. |
Bis-aryl amide derivatives and methods of use
|
EP2119707B1
(en)
|
2007-01-29 |
2015-01-14 |
Eisai R&D Management Co., Ltd. |
Composition for treatment of undifferentiated-type of gastric cancer
|
JP5216341B2
(ja)
|
2007-01-29 |
2013-06-19 |
参天製薬株式会社 |
血管新生阻害活性を有する新規オキサジアゾール誘導体およびチアジアゾール誘導体
|
AR065335A1
(es)
|
2007-02-15 |
2009-06-03 |
Novartis Ag |
Combinaciones de agentes terapeuticos para el tratamiento de cancer
|
US8314087B2
(en)
|
2007-02-16 |
2012-11-20 |
Amgen Inc. |
Nitrogen-containing heterocyclyl ketones and methods of use
|
CL2008001626A1
(es)
|
2007-06-05 |
2009-06-05 |
Takeda Pharmaceuticals Co |
Compuestos derivados de heterociclos fusionados, agente farmaceutico que los comprende y su uso en la profilaxis y tratamiento del cancer.
|
US20090023727A1
(en)
*
|
2007-07-05 |
2009-01-22 |
Muhammad Hashim Javaid |
Phthalazinone derivatives
|
BRPI0815368A2
(pt)
|
2007-08-21 |
2015-02-10 |
Amgen Inc |
"proteinas c-fms humanas a antigeno"
|
JP5270553B2
(ja)
|
2007-08-23 |
2013-08-21 |
武田薬品工業株式会社 |
複素環化合物およびその用途
|
CN101116664B
(zh)
*
|
2007-08-28 |
2010-05-19 |
山东省科学院生物研究所 |
化合物1-(4-氯苯胺基)-4-(4-甲基吡啶基)-2,3-二氮杂萘的应用
|
AU2008325608B2
(en)
|
2007-11-09 |
2013-03-14 |
Eisai R & D Management Co., Ltd. |
Combination of anti-angiogenic substance and anti-tumor platinum complex
|
WO2009080694A1
(en)
|
2007-12-20 |
2009-07-02 |
Novartis Ag |
Thiazole derivatives used as pi 3 kinase inhibitors
|
MX2010010502A
(es)
|
2008-03-26 |
2010-10-26 |
Novartis Ag |
Inhibidores de desacetilasas b a base de hidroxamato.
|
UY32030A
(es)
|
2008-08-06 |
2010-03-26 |
Boehringer Ingelheim Int |
"tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
|
EP2326326B1
(en)
|
2008-08-15 |
2019-10-09 |
Boehringer Ingelheim International GmbH |
Dpp-4 inhibitors for use for the treatment of wound healing in diabetic patients
|
EP2344161B1
(en)
|
2008-10-16 |
2018-12-19 |
Celator Pharmaceuticals, Inc. |
Combinations of a liposomal water-soluble camptothecin with cetuximab or bevacizumab
|
JP5579619B2
(ja)
|
2008-12-01 |
2014-08-27 |
武田薬品工業株式会社 |
複素環化合物およびその用途
|
JO3101B1
(ar)
|
2008-12-02 |
2017-09-20 |
Takeda Pharmaceuticals Co |
مشتقات بنزوثيازول كعوامل مضادة للسرطان
|
CN103204794A
(zh)
|
2008-12-18 |
2013-07-17 |
诺瓦提斯公司 |
新的盐
|
JP2012512884A
(ja)
|
2008-12-18 |
2012-06-07 |
ノバルティス アーゲー |
1−(4−{1−[(e)−4−シクロヘキシル−3−トリフルオロメチル−ベンジルオキシイミノ]−エチル}−2−エチル−ベンジル)−アゼチジン−3−カルボン酸の新規の多形相
|
IL253845B
(en)
|
2008-12-18 |
2022-08-01 |
Novartis Ag |
Hemifumarate salt of 1- [4- [1- ( 4 -cyclohexyl-3 -trifluoromethyl-benzyloxyimino ) -ethyl] -2 -ethyl-benzyl] -a zetidine-3-carboxylic acid
|
EP2382216A1
(en)
|
2008-12-23 |
2011-11-02 |
Boehringer Ingelheim International GmbH |
Salt forms of organic compound
|
AR074990A1
(es)
|
2009-01-07 |
2011-03-02 |
Boehringer Ingelheim Int |
Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
|
EP2391366B1
(en)
|
2009-01-29 |
2012-11-28 |
Novartis AG |
Substituted benzimidazoles for the treatment of astrocytomas
|
AR075204A1
(es)
|
2009-01-29 |
2011-03-16 |
Boehringer Ingelheim Int |
Inhibidores de dpp-4 y composiciones farmaceuticas que los comprenden, utiles para tratar enfermedades metabolicas en pacientes pediatricos, particularmente diabetes mellitus tipo 2
|
AU2010212823B2
(en)
|
2009-02-13 |
2016-01-28 |
Boehringer Ingelheim International Gmbh |
Antidiabetic medications comprising a DPP-4 inhibitor (linagliptin) optionally in combination with other antidiabetics
|
WO2010108503A1
(en)
|
2009-03-24 |
2010-09-30 |
Life & Brain Gmbh |
Promotion of neuronal integration in neural stem cell grafts
|
US8530492B2
(en)
|
2009-04-17 |
2013-09-10 |
Nektar Therapeutics |
Oligomer-protein tyrosine kinase inhibitor conjugates
|
PT2445903E
(pt)
|
2009-06-26 |
2014-07-08 |
Novartis Ag |
Derivados de imidazolidin-2-ona 1,3-dissubstituídos como inibidores de cyp17
|
US8293753B2
(en)
|
2009-07-02 |
2012-10-23 |
Novartis Ag |
Substituted 2-carboxamide cycloamino ureas
|
US8389526B2
(en)
|
2009-08-07 |
2013-03-05 |
Novartis Ag |
3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
|
AU2010283806A1
(en)
|
2009-08-12 |
2012-03-01 |
Novartis Ag |
Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation
|
SG10201404886PA
(en)
|
2009-08-17 |
2014-10-30 |
Intellikine Llc |
Heterocyclic compounds and uses thereof
|
IN2012DN01453A
(forum.php)
|
2009-08-20 |
2015-06-05 |
Novartis Ag |
|
US20120149661A1
(en)
|
2009-08-26 |
2012-06-14 |
Novartis Ag |
Tetra-substituted heteroaryl compounds and their use as mdm2 and/or mdm4 modulators
|
US20120165310A1
(en)
|
2009-09-10 |
2012-06-28 |
Novartis Ag |
Ether derivatives of bicyclic heteroaryls
|
CN107028924A
(zh)
|
2009-10-02 |
2017-08-11 |
勃林格殷格翰国际有限公司 |
包含bi‑1356和二甲双胍的药物组合物
|
PE20121471A1
(es)
|
2009-11-04 |
2012-11-01 |
Novartis Ag |
Derivados de sulfonamida heterociclicos utiles como inhibidores de mek
|
US20120289501A1
(en)
|
2009-11-25 |
2012-11-15 |
Novartis Ag |
Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls
|
EP2504002B1
(en)
|
2009-11-27 |
2019-10-09 |
Boehringer Ingelheim International GmbH |
Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
|
BR112012013735A2
(pt)
|
2009-12-08 |
2019-09-24 |
Novartis Ag |
derivados heterocícilicos de sulfonamida
|
US8440693B2
(en)
|
2009-12-22 |
2013-05-14 |
Novartis Ag |
Substituted isoquinolinones and quinazolinones
|
CU24130B1
(es)
|
2009-12-22 |
2015-09-29 |
Novartis Ag |
Isoquinolinonas y quinazolinonas sustituidas
|
WO2011113947A1
(en)
|
2010-03-18 |
2011-09-22 |
Boehringer Ingelheim International Gmbh |
Combination of a gpr119 agonist and the dpp-iv inhibitor linagliptin for use in the treatment of diabetes and related conditions
|
PT2566469T
(pt)
|
2010-05-05 |
2023-01-10 |
Boehringer Ingelheim Int |
Terapia de combinação
|
EP2582680A1
(en)
|
2010-06-17 |
2013-04-24 |
Novartis AG |
Biphenyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives
|
EP2582681A1
(en)
|
2010-06-17 |
2013-04-24 |
Novartis AG |
Piperidinyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives
|
WO2011161217A2
(en)
|
2010-06-23 |
2011-12-29 |
Palacký University in Olomouc |
Targeting of vegfr2
|
JP5843855B2
(ja)
|
2010-06-24 |
2016-01-13 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
糖尿病療法
|
CN102958523B
(zh)
|
2010-06-25 |
2014-11-19 |
卫材R&D管理有限公司 |
使用具有激酶抑制作用的组合的抗肿瘤剂
|
EP2591004A1
(en)
|
2010-07-09 |
2013-05-15 |
F.Hoffmann-La Roche Ag |
Anti-neuropilin antibodies and methods of use
|
AR082418A1
(es)
|
2010-08-02 |
2012-12-05 |
Novartis Ag |
Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
|
CN103108871B
(zh)
|
2010-09-16 |
2014-09-10 |
诺华股份有限公司 |
17α-羟化酶/C17,20-裂合酶抑制剂
|
AR083878A1
(es)
|
2010-11-15 |
2013-03-27 |
Boehringer Ingelheim Int |
Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
|
US20120128665A1
(en)
|
2010-11-18 |
2012-05-24 |
Synta Pharmaceuticals Corp. |
Preselection of subjects for therapeutic treatment based on hypoxic status
|
WO2012068487A1
(en)
|
2010-11-18 |
2012-05-24 |
Synta Pharmaceuticals Corp. |
Preselection of subjects for therapeutic treatment with oxygen sensitive agents based on hypoxic status
|
UY33883A
(es)
|
2011-01-31 |
2012-08-31 |
Novartis Ag |
Novedosos derivados heterocíclicos
|
US20130324526A1
(en)
|
2011-02-10 |
2013-12-05 |
Novartis Ag |
[1,2,4] triazolo [4,3-b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
|
JP5808826B2
(ja)
|
2011-02-23 |
2015-11-10 |
インテリカイン, エルエルシー |
複素環化合物およびその使用
|
JP2014507465A
(ja)
|
2011-03-08 |
2014-03-27 |
ノバルティス アーゲー |
フルオロフェニル二環式ヘテロアリール化合物
|
DK2937349T3
(en)
|
2011-03-23 |
2017-02-20 |
Amgen Inc |
CONDENSED TRICYCLIC DUAL INHIBITORS OF CDK 4/6 AND FLT3
|
MX2013009931A
(es)
|
2011-04-18 |
2013-10-01 |
Eisai R&D Man Co Ltd |
Agentes terapeuticos contra tumores.
|
ES2656218T3
(es)
|
2011-04-28 |
2018-02-26 |
Novartis Ag |
Inhibidores de 17 alfa-hidroxilasa/C17,20-liasa
|
ES2841809T3
(es)
|
2011-06-03 |
2021-07-09 |
Eisai R&D Man Co Ltd |
Biomarcadores para pronosticar y evaluar el grado de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib
|
MX2013014398A
(es)
|
2011-06-09 |
2014-03-21 |
Novartis Ag |
Derivados de sulfonamida heterociclicos.
|
BR112013032273B1
(pt)
*
|
2011-06-16 |
2020-11-17 |
Korea Research Institute Of Chemical Technology |
Compostos derivados de 1,3-dioxoindeno, seus usos, métodos de preparação dos mesmos e composições farmacêutica
|
WO2012175487A1
(en)
|
2011-06-20 |
2012-12-27 |
Novartis Ag |
Cyclohexyl isoquinolinone compounds
|
EP2721008B1
(en)
|
2011-06-20 |
2015-04-29 |
Novartis AG |
Hydroxy substituted isoquinolinone derivatives as p53 (mdm2 or mdm4) inhibitors
|
DK2731947T3
(en)
|
2011-07-15 |
2019-04-23 |
Boehringer Ingelheim Int |
SUBSTITUTED DIMERIC QUINAZOLINE DERIVATIVE, PREPARATION AND USE thereof IN PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF TYPE I AND TYPE II DIABETES
|
WO2013025939A2
(en)
|
2011-08-16 |
2013-02-21 |
Indiana University Research And Technology Corporation |
Compounds and methods for treating cancer by inhibiting the urokinase receptor
|
EP2758043A4
(en)
|
2011-08-17 |
2016-02-24 |
Dennis M Brown |
COMPOSITIONS AND METHODS FOR INCREASING THE THERAPEUTIC UTILITY OF SUBOPTIMALLY APPLIED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED HEXITOLS SUCH AS DIBROMODULCITOL
|
BR112014006223A8
(pt)
|
2011-09-15 |
2018-01-09 |
Novartis Ag |
3-(quinolin-6-iltio)-[1,2,4-triazol[4,3-a] piradinas 6-substituídas, seus usos, composições farmacêuticas, e combinação
|
ES2587533T3
(es)
|
2011-10-28 |
2016-10-25 |
Novartis Ag |
Derivados de purina y su uso en el tratamiento de enfermedades
|
EP2785717B1
(en)
|
2011-11-29 |
2016-01-13 |
Novartis AG |
Pyrazolopyrrolidine compounds
|
EA201491260A1
(ru)
|
2011-12-23 |
2014-11-28 |
Новартис Аг |
Соединения и композиции для ингибирования взаимодействия bcl2 с партнерами по связыванию
|
BR112014015274A8
(pt)
|
2011-12-23 |
2017-06-13 |
Novartis Ag |
compostos e composições para inibição da interação de bcl2 com parceiros de ligação
|
EA201491264A1
(ru)
|
2011-12-23 |
2014-11-28 |
Новартис Аг |
Соединения для ингибирования взаимодействия bcl-2 с партнерами по связыванию
|
KR20140107575A
(ko)
|
2011-12-23 |
2014-09-04 |
노파르티스 아게 |
Bcl2와 결합 파트너의 상호작용을 억제하기 위한 화합물
|
CA2859873A1
(en)
|
2011-12-23 |
2013-06-27 |
Novartis Ag |
Compounds for inhibiting the interaction of bcl2 with binding partners
|
US20130172244A1
(en)
|
2011-12-29 |
2013-07-04 |
Thomas Klein |
Subcutaneous therapeutic use of dpp-4 inhibitor
|
UY34591A
(es)
|
2012-01-26 |
2013-09-02 |
Novartis Ag |
Compuestos de imidazopirrolidinona
|
AR090263A1
(es)
|
2012-03-08 |
2014-10-29 |
Hoffmann La Roche |
Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
|
JP2015512425A
(ja)
|
2012-04-03 |
2015-04-27 |
ノバルティス アーゲー |
チロシンキナーゼ阻害剤との組合せ製品及びそれらの使用
|
EP2849754B1
(en)
|
2012-05-14 |
2022-09-14 |
Boehringer Ingelheim International GmbH |
Linagliptin, a xanthine derivative as dpp-4 inhibitor, for use in the treatment of sirs and/or sepsis
|
WO2013171167A1
(en)
|
2012-05-14 |
2013-11-21 |
Boehringer Ingelheim International Gmbh |
A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
|
EP2849756A1
(en)
|
2012-05-16 |
2015-03-25 |
Novartis AG |
Dosage regimen for a pi-3 kinase inhibitor
|
US9365576B2
(en)
|
2012-05-24 |
2016-06-14 |
Novartis Ag |
Pyrrolopyrrolidinone compounds
|
JP6374862B2
(ja)
|
2012-05-24 |
2018-08-15 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
自己免疫性糖尿病、特に、ladaの治療に使用するためのdpp−4阻害剤としてのキサンチン誘導体
|
WO2013174767A1
(en)
|
2012-05-24 |
2013-11-28 |
Boehringer Ingelheim International Gmbh |
A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
|
MX367055B
(es)
|
2012-06-26 |
2019-08-02 |
Del Mar Pharmaceuticals |
El uso de una composición que comprende dianhidrogalactitol, diacetildianhidrogalactitol, y dibromodulcitol, y análogos o derivados de cada uno para el tratamiento de malignidades resistentes a inhibidores de tirosina cinasa.
|
WO2014036022A1
(en)
|
2012-08-29 |
2014-03-06 |
Amgen Inc. |
Quinazolinone compounds and derivatives thereof
|
WO2014092514A1
(ko)
|
2012-12-14 |
2014-06-19 |
한국화학연구원 |
신규한 화합물, 이의 약학적으로 허용가능한 염 또는 이의 광학 이성질체, 이의 제조방법 및 이를 유효성분으로 함유하는 바이러스성 질환의 예방 또는 치료용 약학적 조성물
|
JPWO2014098176A1
(ja)
|
2012-12-21 |
2017-01-12 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
キノリン誘導体のアモルファス及びその製造方法
|
US9556180B2
(en)
|
2013-01-22 |
2017-01-31 |
Novartis Ag |
Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction
|
EP2948451B1
(en)
|
2013-01-22 |
2017-07-12 |
Novartis AG |
Substituted purinone compounds
|
WO2014124860A1
(en)
|
2013-02-14 |
2014-08-21 |
Boehringer Ingelheim International Gmbh |
Specific pde4b-inhibitors for the treatment of diabetes mellitus
|
WO2014151147A1
(en)
|
2013-03-15 |
2014-09-25 |
Intellikine, Llc |
Combination of kinase inhibitors and uses thereof
|
EP2968344A1
(en)
|
2013-03-15 |
2016-01-20 |
Boehringer Ingelheim International GmbH |
Use of linagliptin in cardio- and renoprotective antidiabetic therapy
|
WO2014155268A2
(en)
|
2013-03-25 |
2014-10-02 |
Novartis Ag |
Fgf-r tyrosine kinase activity inhibitors - use in diseases associated with lack of or reduced snf5 activity
|
US11491154B2
(en)
|
2013-04-08 |
2022-11-08 |
Dennis M. Brown |
Therapeutic benefit of suboptimally administered chemical compounds
|
NZ714049A
(en)
|
2013-05-14 |
2020-05-29 |
Eisai R&D Man Co Ltd |
Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
|
WO2015022664A1
(en)
|
2013-08-14 |
2015-02-19 |
Novartis Ag |
Compounds and compositions as inhibitors of mek
|
US9227969B2
(en)
|
2013-08-14 |
2016-01-05 |
Novartis Ag |
Compounds and compositions as inhibitors of MEK
|
WO2015022663A1
(en)
|
2013-08-14 |
2015-02-19 |
Novartis Ag |
Compounds and compositions as inhibitors of mek
|
WO2015084804A1
(en)
|
2013-12-03 |
2015-06-11 |
Novartis Ag |
Combination of mdm2 inhibitor and braf inhibitor and their use
|
HUE057092T2
(hu)
|
2013-12-06 |
2022-04-28 |
Novartis Ag |
Alfa-izoformára szelektív foszfatidilinozitol-3-kináz-inhibitor adagolási rendje
|
KR20170036037A
(ko)
|
2014-07-31 |
2017-03-31 |
노파르티스 아게 |
조합 요법
|
RS63559B1
(sr)
|
2014-08-28 |
2022-10-31 |
Eisai R&D Man Co Ltd |
Derivat hinolina velike čistoće i postupak za njegovu proizvodnju
|
US20170340733A1
(en)
|
2014-12-19 |
2017-11-30 |
Novartis Ag |
Combination therapies
|
EP3242934B1
(en)
|
2015-01-08 |
2021-08-18 |
The Board of Trustees of the Leland Stanford Junior University |
Factors and cells that provide for induction of bone, bone marrow, and cartilage
|
US20180093956A1
(en)
*
|
2015-02-06 |
2018-04-05 |
Abbvie Inc. |
Substituted phthalazines
|
SG11201706630UA
(en)
|
2015-02-25 |
2017-09-28 |
Eisai R&D Man Co Ltd |
Method for suppressing bitterness of quinoline derivative
|
KR20240064733A
(ko)
|
2015-03-04 |
2024-05-13 |
머크 샤프 앤드 돔 코포레이션 |
암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
|
BR112017018908A2
(pt)
|
2015-03-10 |
2018-04-17 |
Aduro Biotech, Inc. |
composições e métodos para ativar a sinalização dependente do "estimulador do gene de interferon
|
SG11201710198YA
(en)
|
2015-06-16 |
2018-01-30 |
Eisai R&D Man Co Ltd |
Anticancer agent
|
ES2887426T3
(es)
|
2015-08-20 |
2021-12-22 |
Eisai R&D Man Co Ltd |
Lenvatinib combinado con etopósido e ifosfamida para su uso en el tratamiento de un tumor
|
US20180280370A1
(en)
|
2015-11-02 |
2018-10-04 |
Novartis Ag |
Dosage regimen for a phosphatidylinositol 3-kinase inhibitor
|
CN109310697A
(zh)
|
2016-06-10 |
2019-02-05 |
勃林格殷格翰国际有限公司 |
利格列汀和二甲双胍的组合
|
WO2018009466A1
(en)
|
2016-07-05 |
2018-01-11 |
Aduro Biotech, Inc. |
Locked nucleic acid cyclic dinucleotide compounds and uses thereof
|
WO2018060833A1
(en)
|
2016-09-27 |
2018-04-05 |
Novartis Ag |
Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
|
WO2018119183A2
(en)
|
2016-12-22 |
2018-06-28 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
CA3044658A1
(en)
|
2017-02-08 |
2018-08-16 |
Eisai R&D Management Co., Ltd. |
Tumor-treating pharmaceutical composition
|
UY37695A
(es)
|
2017-04-28 |
2018-11-30 |
Novartis Ag |
Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
|
RU2019134940A
(ru)
|
2017-05-16 |
2021-06-16 |
Эйсай Ар Энд Ди Менеджмент Ко., Лтд. |
Лечение гепатоцеллюлярной карциномы
|
JOP20190272A1
(ar)
|
2017-05-22 |
2019-11-21 |
Amgen Inc |
مثبطات kras g12c وطرق لاستخدامها
|
JP7150823B2
(ja)
|
2017-09-08 |
2022-10-11 |
アムジエン・インコーポレーテツド |
KRas G12Cの阻害剤及びそれを使用する方法
|
US12023353B2
(en)
|
2017-10-18 |
2024-07-02 |
Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus |
Methods and compounds for improved immune cell therapy
|
JP7021356B2
(ja)
|
2017-12-21 |
2022-02-16 |
ヘフェイ インスティテューツ オブ フィジカル サイエンス, チャイニーズ アカデミー オブ サイエンシーズ |
ピリミジン誘導体系キナーゼ阻害剤類
|
JP7361722B2
(ja)
|
2018-05-04 |
2023-10-16 |
アムジエン・インコーポレーテツド |
Kras g12c阻害剤及び同一物の使用方法
|
WO2019213516A1
(en)
|
2018-05-04 |
2019-11-07 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
WO2019217691A1
(en)
|
2018-05-10 |
2019-11-14 |
Amgen Inc. |
Kras g12c inhibitors for the treatment of cancer
|
ES2938987T3
(es)
|
2018-06-01 |
2023-04-18 |
Amgen Inc |
Inhibidores de KRAS G12c y métodos de uso de los mismos
|
WO2019241157A1
(en)
|
2018-06-11 |
2019-12-19 |
Amgen Inc. |
Kras g12c inhibitors for treating cancer
|
US11285156B2
(en)
|
2018-06-12 |
2022-03-29 |
Amgen Inc. |
Substituted piperazines as KRAS G12C inhibitors
|
MX2021000555A
(es)
|
2018-07-17 |
2021-03-29 |
Boehringer Ingelheim Int |
Tratamiento antidiabetico cardiovascular seguro.
|
KR20210035227A
(ko)
|
2018-07-17 |
2021-03-31 |
베링거 인겔하임 인터내셔날 게엠베하 |
심장 안전성 및 신장 안전성 항당뇨 치료법
|
JP7516029B2
(ja)
|
2018-11-16 |
2024-07-16 |
アムジエン・インコーポレーテツド |
Kras g12c阻害剤化合物の重要な中間体の改良合成法
|
JP7377679B2
(ja)
|
2018-11-19 |
2023-11-10 |
アムジエン・インコーポレーテツド |
がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法
|
WO2020106640A1
(en)
|
2018-11-19 |
2020-05-28 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
WO2020132649A1
(en)
|
2018-12-20 |
2020-06-25 |
Amgen Inc. |
Heteroaryl amides useful as kif18a inhibitors
|
MX2021007157A
(es)
|
2018-12-20 |
2021-08-16 |
Amgen Inc |
Heteroarilamidas utiles como inhibidores de kif18a.
|
MA54550A
(fr)
|
2018-12-20 |
2022-03-30 |
Amgen Inc |
Inhibiteurs de kif18a
|
WO2020132648A1
(en)
|
2018-12-20 |
2020-06-25 |
Amgen Inc. |
Kif18a inhibitors
|
US20230148450A9
(en)
|
2019-03-01 |
2023-05-11 |
Revolution Medicines, Inc. |
Bicyclic heteroaryl compounds and uses thereof
|
CA3130083A1
(en)
|
2019-03-01 |
2020-09-10 |
Revolution Medicines, Inc. |
Bicyclic heterocyclyl compounds and uses thereof
|
CN114173774A
(zh)
*
|
2019-05-14 |
2022-03-11 |
斯克里普斯研究院 |
用于治疗神经退行性和代谢性疾患的化合物
|
EP3738593A1
(en)
|
2019-05-14 |
2020-11-18 |
Amgen, Inc |
Dosing of kras inhibitor for treatment of cancers
|
BR112021023277A2
(pt)
|
2019-05-21 |
2022-01-04 |
Amgen Inc |
Formas em estado sólido
|
JP7640521B2
(ja)
|
2019-08-02 |
2025-03-05 |
アムジエン・インコーポレーテツド |
Kif18a阻害剤として有用なヘテロアリールアミド
|
AU2020325115A1
(en)
|
2019-08-02 |
2022-03-17 |
Amgen Inc. |
Pyridine derivatives as KIF18A inhibitors
|
US20220289724A1
(en)
|
2019-08-02 |
2022-09-15 |
Amgen Inc. |
Kif18a inhibitors
|
CA3147272A1
(en)
|
2019-08-02 |
2021-02-11 |
Amgen Inc. |
Kif18a inhibitors
|
WO2021081212A1
(en)
|
2019-10-24 |
2021-04-29 |
Amgen Inc. |
Pyridopyrimidine derivatives useful as kras g12c and kras g12d inhibitors in the treatment of cancer
|
US11566007B2
(en)
|
2019-11-04 |
2023-01-31 |
Revolution Medicines, Inc. |
Ras inhibitors
|
BR112022008535A2
(pt)
|
2019-11-04 |
2022-08-09 |
Revolution Medicines Inc |
Composto, composição farmacêutica, métodos para tratar câncer e um distúrbio relativo à proteína ras
|
PH12022550973A1
(en)
|
2019-11-04 |
2023-09-25 |
Revolution Medicines Inc |
Ras inhibitors
|
EP4055017A1
(en)
|
2019-11-08 |
2022-09-14 |
Revolution Medicines, Inc. |
Bicyclic heteroaryl compounds and uses thereof
|
TWI882037B
(zh)
|
2019-11-14 |
2025-05-01 |
美商安進公司 |
Kras g12c抑制劑化合物之改善的合成
|
CA3161156A1
(en)
|
2019-11-14 |
2021-05-20 |
Amgen Inc. |
Improved synthesis of kras g12c inhibitor compound
|
US20220395553A1
(en)
|
2019-11-14 |
2022-12-15 |
Cohbar, Inc. |
Cxcr4 antagonist peptides
|
JP2023505100A
(ja)
|
2019-11-27 |
2023-02-08 |
レボリューション メディシンズ インコーポレイテッド |
共有ras阻害剤及びその使用
|
IL294484A
(en)
|
2020-01-07 |
2022-09-01 |
Revolution Medicines Inc |
Shp2 inhibitor dosing and methods of treating cancer
|
CA3176727A1
(en)
|
2020-04-20 |
2021-10-28 |
Novartis Ag |
Antiviral 1,3-di-oxo-indene compounds
|
CA3176618A1
(en)
|
2020-04-20 |
2021-10-28 |
Novartis Ag |
Antiviral 1,3-di-oxo-indene compounds
|
CA3183032A1
(en)
|
2020-06-18 |
2021-12-23 |
Mallika Singh |
Methods for delaying, preventing, and treating acquired resistance to ras inhibitors
|
US20250195521A1
(en)
|
2020-09-03 |
2025-06-19 |
Revolution Medicines, Inc. |
Use of sos1 inhibitors to treat malignancies with shp2 mutations
|
CN116457358A
(zh)
|
2020-09-15 |
2023-07-18 |
锐新医药公司 |
作为ras抑制剂以治疗癌症的吲哚衍生物
|
US20240051956A1
(en)
|
2020-12-22 |
2024-02-15 |
Qilu Regor Therapeutics Inc. |
Sos1 inhibitors and uses thereof
|
JP2024505256A
(ja)
*
|
2021-01-28 |
2024-02-05 |
ユニバーシティ オブ フロリダ リサーチファウンデーション インコーポレイティッド |
神経変性、変性及び代謝性障害の処置のための化合物並びにその使用
|
CR20230570A
(es)
|
2021-05-05 |
2024-01-22 |
Revolution Medicines Inc |
Inhibidores de ras
|
TW202309053A
(zh)
|
2021-05-05 |
2023-03-01 |
美商銳新醫藥公司 |
Ras抑制劑
|
JP2024516450A
(ja)
|
2021-05-05 |
2024-04-15 |
レボリューション メディシンズ インコーポレイテッド |
共有結合性ras阻害剤及びその使用
|
WO2022271679A1
(en)
*
|
2021-06-21 |
2022-12-29 |
Mirati Therapeutics, Inc. |
Sos1 inhibitors
|
AR127308A1
(es)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
Inhibidores ras
|
US20250282782A1
(en)
|
2021-12-17 |
2025-09-11 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
KR20230098078A
(ko)
*
|
2021-12-24 |
2023-07-03 |
제일약품주식회사 |
신규한 바이사이클릭 헤테로사이클릴 화합물 및 이의 용도
|
EP4227307A1
(en)
|
2022-02-11 |
2023-08-16 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
WO2023172940A1
(en)
|
2022-03-08 |
2023-09-14 |
Revolution Medicines, Inc. |
Methods for treating immune refractory lung cancer
|
WO2023240263A1
(en)
|
2022-06-10 |
2023-12-14 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|
CN120359029A
(zh)
|
2022-10-14 |
2025-07-22 |
黑钻治疗公司 |
使用异喹啉或6-氮杂-喹啉衍生物治疗癌症的方法
|
TW202504611A
(zh)
|
2023-03-30 |
2025-02-01 |
美商銳新醫藥公司 |
用於誘導ras gtp水解之組合物及其用途
|
WO2024211712A1
(en)
|
2023-04-07 |
2024-10-10 |
Revolution Medicines, Inc. |
Condensed macrocyclic compounds as ras inhibitors
|
WO2024211663A1
(en)
|
2023-04-07 |
2024-10-10 |
Revolution Medicines, Inc. |
Condensed macrocyclic compounds as ras inhibitors
|
TW202446388A
(zh)
|
2023-04-14 |
2024-12-01 |
美商銳新醫藥公司 |
Ras抑制劑之結晶形式、含有其之組合物及其使用方法
|
WO2024216048A1
(en)
|
2023-04-14 |
2024-10-17 |
Revolution Medicines, Inc. |
Crystalline forms of ras inhibitors, compositions containing the same, and methods of use thereof
|
TW202508595A
(zh)
|
2023-05-04 |
2025-03-01 |
美商銳新醫藥公司 |
用於ras相關疾病或病症之組合療法
|
US20250049810A1
(en)
|
2023-08-07 |
2025-02-13 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
WO2025080946A2
(en)
|
2023-10-12 |
2025-04-17 |
Revolution Medicines, Inc. |
Ras inhibitors
|
WO2025137507A1
(en)
|
2023-12-22 |
2025-06-26 |
Regor Pharmaceuticals, Inc. |
Sos1 inhibitors and uses thereof
|
WO2025171296A1
(en)
|
2024-02-09 |
2025-08-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|