CY1119722T1 - Δημιουργια και περιγραφη πληρως ανθρωπινων θεραπευτικων αντισωματων λαμβανομενων μεσω hucal gold ειδικων για ανθρωπινό cd38 - Google Patents
Δημιουργια και περιγραφη πληρως ανθρωπινων θεραπευτικων αντισωματων λαμβανομενων μεσω hucal gold ειδικων για ανθρωπινό cd38Info
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- CY1119722T1 CY1119722T1 CY20171101331T CY171101331T CY1119722T1 CY 1119722 T1 CY1119722 T1 CY 1119722T1 CY 20171101331 T CY20171101331 T CY 20171101331T CY 171101331 T CY171101331 T CY 171101331T CY 1119722 T1 CY1119722 T1 CY 1119722T1
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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Abstract
Η εφεύρεση παρέχει ένα ανθρώπινο αντίσωμα, το οποίο είναι ειδικό για CD38. Το αντίσωμα της εφεύρεσης έχει την ικανότητα να προσδένεται σε CD38 που προέρχεται από χοίρους μινιατούρες και να επάγει, μέσω διασταυρούμενης σύνδεσης, ειδική θανάτωση κυττάρων, ειδικότερα κυττάρων όγκου, που εκφράζουν CD38. Η εφεύρεση περαιτέρω παρέχει χρήσεις αυτού του αντισώματος για τη θεραπευτική αγωγή διαφόρων διαταραχών και καταστάσεων που σχετίζονται με ανεπιθύμητη παρουσία CD38+ κυττάρων, οι οποίες περιλαμβάνουν αιματολογικές και φλεγμονώδεις ασθένειες. Η εφεύρεση, επίσης, παρέχει διαγνωστικές συνθέσεις και μεθόδους με βάση την ανίχνευση της παρουσίας CD38 σε έναν ιστό ή ένα κύτταρο που προέρχεται από χοίρο μινιατούρα που έρχεται σε επαφή με το αντίσωμα της εφεύρεσης.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72529705P | 2005-10-12 | 2005-10-12 | |
EP06806243A EP1945671A2 (en) | 2005-10-12 | 2006-10-12 | Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human cd38 |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1119722T1 true CY1119722T1 (el) | 2018-06-27 |
Family
ID=37467440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171101331T CY1119722T1 (el) | 2005-10-12 | 2017-12-19 | Δημιουργια και περιγραφη πληρως ανθρωπινων θεραπευτικων αντισωματων λαμβανομενων μεσω hucal gold ειδικων για ανθρωπινό cd38 |
Country Status (29)
Country | Link |
---|---|
US (6) | US8088896B2 (el) |
EP (3) | EP1945671A2 (el) |
JP (2) | JP5362359B2 (el) |
KR (4) | KR20150139636A (el) |
CN (4) | CN103554260A (el) |
AR (2) | AR055191A1 (el) |
AU (1) | AU2006301446B2 (el) |
BR (1) | BRPI0618399B1 (el) |
CA (1) | CA2625681C (el) |
CY (1) | CY1119722T1 (el) |
DK (1) | DK2860192T3 (el) |
ES (1) | ES2653664T3 (el) |
HK (2) | HK1122822A1 (el) |
HR (1) | HRP20171978T1 (el) |
HU (1) | HUE035250T2 (el) |
IL (1) | IL190665B (el) |
LT (1) | LT2860192T (el) |
ME (1) | ME02886B (el) |
NO (1) | NO344961B1 (el) |
NZ (1) | NZ566915A (el) |
PL (1) | PL2860192T3 (el) |
PT (1) | PT2860192T (el) |
RS (1) | RS56677B1 (el) |
RU (1) | RU2425841C2 (el) |
SG (1) | SG10201400973XA (el) |
SI (1) | SI2860192T1 (el) |
TW (1) | TWI428444B (el) |
WO (1) | WO2007042309A2 (el) |
ZA (1) | ZA200803208B (el) |
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