SG10201400973XA - Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human cd38 - Google Patents
Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human cd38Info
- Publication number
- SG10201400973XA SG10201400973XA SG10201400973XA SG10201400973XA SG10201400973XA SG 10201400973X A SG10201400973X A SG 10201400973XA SG 10201400973X A SG10201400973X A SG 10201400973XA SG 10201400973X A SG10201400973X A SG 10201400973XA SG 10201400973X A SG10201400973X A SG 10201400973XA
- Authority
- SG
- Singapore
- Prior art keywords
- human
- profiling
- generation
- antibodies specific
- therapeutic antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Diabetes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72529705P | 2005-10-12 | 2005-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201400973XA true SG10201400973XA (en) | 2014-08-28 |
Family
ID=37467440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201400973XA SG10201400973XA (en) | 2005-10-12 | 2006-10-12 | Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human cd38 |
Country Status (29)
| Country | Link |
|---|---|
| US (6) | US8088896B2 (en) |
| EP (3) | EP3284756B1 (en) |
| JP (2) | JP5362359B2 (en) |
| KR (4) | KR101512853B1 (en) |
| CN (4) | CN106434683B (en) |
| AR (2) | AR055191A1 (en) |
| AU (1) | AU2006301446B2 (en) |
| BR (1) | BRPI0618399B1 (en) |
| CA (1) | CA2625681C (en) |
| CY (1) | CY1119722T1 (en) |
| DK (1) | DK2860192T3 (en) |
| ES (1) | ES2653664T3 (en) |
| HK (2) | HK1122822A1 (en) |
| HR (1) | HRP20171978T1 (en) |
| HU (1) | HUE035250T2 (en) |
| IL (1) | IL190665B (en) |
| LT (1) | LT2860192T (en) |
| ME (1) | ME02886B (en) |
| NO (1) | NO344961B1 (en) |
| NZ (1) | NZ566915A (en) |
| PL (1) | PL2860192T3 (en) |
| PT (1) | PT2860192T (en) |
| RS (1) | RS56677B1 (en) |
| RU (1) | RU2425841C2 (en) |
| SG (1) | SG10201400973XA (en) |
| SI (1) | SI2860192T1 (en) |
| TW (1) | TWI428444B (en) |
| WO (1) | WO2007042309A2 (en) |
| ZA (1) | ZA200803208B (en) |
Families Citing this family (111)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9200061B2 (en) * | 2004-02-06 | 2015-12-01 | Morpho Sys AG | Generation and profiling of fully human HuCAL gold®-derived therapeutic antibodies specific for human CD3i |
| AU2006301446B2 (en) | 2005-10-12 | 2012-06-07 | Morphosys Ag | Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human CD38 |
| PE20090368A1 (en) | 2007-06-19 | 2009-04-28 | Boehringer Ingelheim Int | ANTI-IGF ANTIBODIES |
| PE20120259A1 (en) | 2007-08-09 | 2012-04-04 | Boehringer Ingelheim Int | ANTI-CD37 ANTIBODIES |
| NZ592151A (en) | 2008-12-12 | 2012-10-26 | Boehringer Ingelheim Int | Anti-igf antibodies |
| US20100291106A1 (en) * | 2009-05-06 | 2010-11-18 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c3b |
| KR101912957B1 (en) * | 2010-09-27 | 2018-10-29 | 모르포시스 아게 | Anti-cd38 antibody and lenalidomide or bortezomib for the treatment of multiple myeloma and nhl |
| JOP20210044A1 (en) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | Anti-cd38 antibodies |
| US9238689B2 (en) | 2011-07-15 | 2016-01-19 | Morpho Sys AG | Antibodies that are cross-reactive for macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D-DT) |
| US20130122005A1 (en) | 2011-10-27 | 2013-05-16 | Paul Adam | Anticancer combination therapy |
| EP3559049A4 (en) | 2011-10-28 | 2019-12-04 | Teva Pharmaceuticals Australia Pty Ltd | Polypeptide constructs and uses thereof |
| US9051365B2 (en) | 2011-12-21 | 2015-06-09 | Novartis Ag | Antibodies that bind factor P |
| AU2013253581B2 (en) | 2012-04-23 | 2019-05-16 | Genefrontier Corporation | Anti-human CD69 antibody, and use thereof for medical purposes |
| PT2900232T (en) | 2012-09-25 | 2018-02-09 | Morphosys Ag | Combinations and uses thereof |
| EP2914302B1 (en) | 2012-11-05 | 2017-01-04 | MorphoSys AG | Radiolabelled antibody and uses thereof |
| CA2890862C (en) * | 2012-11-09 | 2021-10-12 | Genefrontier Corporation | Anti-adam28 antibody for treating cancer |
| US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
| EP3620473A1 (en) | 2013-01-14 | 2020-03-11 | Xencor, Inc. | Novel heterodimeric proteins |
| US20140255413A1 (en) | 2013-03-07 | 2014-09-11 | Boehringer Ingelheim International Gmbh | Combination therapy for neoplasia treatment |
| PL2968555T3 (en) * | 2013-03-13 | 2020-11-16 | Sanofi | Compositions comprising anti-cd38 antibodies and carfilzomib |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| AU2013388126B2 (en) * | 2013-04-29 | 2019-03-07 | Teva Pharmaceuticals Australia Pty Ltd. | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2b |
| US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
| JP5892117B2 (en) * | 2013-07-17 | 2016-03-23 | 横河電機株式会社 | Field device and communication system |
| CN103513040B (en) * | 2013-10-16 | 2015-03-11 | 常晓天 | Application of protein CD38 to preparation of rheumatoid arthritis diagnosing marker |
| US9603927B2 (en) | 2014-02-28 | 2017-03-28 | Janssen Biotech, Inc. | Combination therapies with anti-CD38 antibodies |
| US9732154B2 (en) | 2014-02-28 | 2017-08-15 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia |
| UA119167C2 (en) | 2014-03-28 | 2019-05-10 | Зенкор, Інк. | Bispecific antibodies that bind to cd38 and cd3 |
| UA119352C2 (en) | 2014-05-01 | 2019-06-10 | Тева Фармасьютикалз Острейліа Пті Лтд | Combination of lenalidomide or pomalidomide and cd38 antibody-attenuated interferon-alpha constructs, and the use thereof |
| TWI645230B (en) | 2014-08-03 | 2018-12-21 | 帕戈技術股份有限公司 | Wearable camera systems and apparatus and method for attaching camera systems or other electronic devices to wearable articles |
| MY192918A (en) | 2014-09-09 | 2022-09-15 | Janssen Biotech Inc | Combination therapies with anti-cd38 antibodies |
| KR102639037B1 (en) | 2014-10-29 | 2024-02-20 | 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 | INTERFERON α2b VARIANTS |
| US11773166B2 (en) | 2014-11-04 | 2023-10-03 | Ichnos Sciences SA | CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production |
| MA40894A (en) * | 2014-11-04 | 2017-09-12 | Glenmark Pharmaceuticals Sa | HETERODIMERIC IMMUNOGLOBULINS RE-TARGET CD3 / CD38 T-LYMPHOCYTES AND THEIR PRODUCTION PROCESSES |
| EP3223845B1 (en) | 2014-11-26 | 2021-05-19 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cd20 |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| CN107406512A (en) | 2014-11-26 | 2017-11-28 | Xencor公司 | With reference to CD3 and CD38 heterodimeric antibodies |
| EP3227338A4 (en) | 2014-12-04 | 2018-05-16 | Janssen Biotech, Inc. | Anti-cd38 antibodies for treatment of acute myeloid leukemia |
| AU2016230182B2 (en) | 2015-03-06 | 2019-04-04 | Genefrontier Corporation | Anti-human membrane-type ADAM28 antibody |
| EP3280443B1 (en) | 2015-04-08 | 2022-08-24 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind cd38 |
| US10533057B2 (en) | 2015-05-13 | 2020-01-14 | Morphosys Ag | Treatment for multiple myeloma (MM) |
| AU2016264725B2 (en) | 2015-05-20 | 2021-05-27 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of light chain amyloidosis and other CD38-positive hematological malignancies |
| JP6816038B2 (en) | 2015-06-22 | 2021-01-20 | ヤンセン バイオテツク，インコーポレーテツド | Combination therapy for hematological malignancies with anti-CD38 antibody and survivin inhibitor |
| US20170044265A1 (en) | 2015-06-24 | 2017-02-16 | Janssen Biotech, Inc. | Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38 |
| AU2016281717B2 (en) | 2015-06-24 | 2022-07-28 | Janssen Biotech, Inc. | Immune modulation and treatment of solid tumors with antibodies that specifically bind CD38 |
| US10781261B2 (en) | 2015-11-03 | 2020-09-22 | Janssen Biotech, Inc. | Subcutaneous formulations of anti-CD38 antibodies and their uses |
| MA53356B1 (en) | 2015-11-03 | 2022-05-31 | Janssen Biotech Inc | Subcutaneous anti-cd38 antibody formulations and uses thereof |
| KR20180085800A (en) | 2015-12-07 | 2018-07-27 | 젠코어 인코포레이티드 | CD3 and heterodimeric antibodies that bind to PSMA |
| JP7362250B2 (en) | 2016-03-04 | 2023-10-17 | モルフォシス・アーゲー | Clinical evaluation of M protein response in multiple myeloma |
| KR102405278B1 (en) | 2016-04-22 | 2022-06-07 | 악셀레론 파마 인코포레이티드 | ALK7 binding proteins and uses thereof |
| MA45255A (en) | 2016-06-14 | 2019-04-17 | Xencor Inc | BISPECIFIC CONTROL POINT INHIBITORS ANTIBODIES |
| EP3474895A1 (en) | 2016-06-28 | 2019-05-01 | UMC Utrecht Holding B.V. | TREATMENT OF IgE-MEDIATED DISEASES WITH ANTIBODIES THAT SPECIFICALLY BIND CD38 |
| EP3487506A1 (en) | 2016-07-20 | 2019-05-29 | Hybrigenics SA | Combinations of inecalcitol with an anti-cd38 agent and their uses for treating cancer |
| JOP20190009A1 (en) | 2016-09-21 | 2019-01-27 | Alx Oncology Inc | Antibodies against signal-regulatory protein alpha and methods of use |
| CN110167964B (en) | 2016-11-02 | 2023-12-01 | 百时美施贵宝公司 | Combination of bispecific antibodies and immunopharmaceuticals against BCMA and CD3 for the treatment of multiple myeloma |
| EP3360898A1 (en) | 2017-02-14 | 2018-08-15 | Boehringer Ingelheim International GmbH | Bispecific anti-tnf-related apoptosis-inducing ligand receptor 2 and anti-cadherin 17 binding molecules for the treatment of cancer |
| AU2018280868A1 (en) | 2017-06-08 | 2020-01-02 | Black Belt Therapeutics Limited | CD38 modulating antibody |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | Multispecific molecules that bind to bcma and uses thereof |
| US11542338B2 (en) | 2017-08-16 | 2023-01-03 | Black Belt Therapeutics Limited | CD38 modulating antibody |
| US11236173B2 (en) | 2017-08-16 | 2022-02-01 | Black Belt Therapeutics Limited | CD38 antibody |
| JP2020533362A (en) | 2017-09-13 | 2020-11-19 | テネオバイオ， インコーポレイテッド | Heavy chain antibody that binds to ect enzyme |
| EP3692066A2 (en) | 2017-09-14 | 2020-08-12 | GlaxoSmithKline Intellectual Property Development Limited | Combination treatment for cancer |
| CA3079963A1 (en) | 2017-10-25 | 2019-05-02 | Acceleron Pharma Inc. | Alk7 binding proteins and uses thereof |
| CA3079242A1 (en) | 2017-10-31 | 2019-05-09 | Janssen Biotech, Inc. | Methods of treating high risk multiple myeloma |
| KR20200076732A (en) | 2017-11-03 | 2020-06-29 | 소렌토 쎄라퓨틱스, 인코포레이티드 | CD38-directed chimeric antigen receptor construct |
| CA3085572A1 (en) * | 2017-12-14 | 2019-06-20 | Abl Bio Inc. | Bispecific antibody to a-syn/igf1r and use thereof |
| CN110144008B (en) * | 2018-02-12 | 2021-03-19 | 杭州尚健生物技术有限公司 | CD38 protein antibody and application thereof |
| BR112020018927A2 (en) | 2018-03-21 | 2021-01-05 | ALX Oncology Inc. | ANTIBODIES AGAINST ALPHA SIGN REGULATORY PROTEIN AND METHODS OF USE |
| EP3793606A4 (en) | 2018-05-16 | 2022-08-31 | Janssen Biotech, Inc. | Methods of treating cancers and enhancing efficacy of t cell redirecting therapeutics |
| EP3569618A1 (en) | 2018-05-19 | 2019-11-20 | Boehringer Ingelheim International GmbH | Antagonizing cd73 antibody |
| TW202016151A (en) | 2018-06-09 | 2020-05-01 | 德商百靈佳殷格翰國際股份有限公司 | Multi-specific binding proteins for cancer treatment |
| EP3810655A4 (en) * | 2018-06-20 | 2022-03-16 | Sorrento Therapeutics, Inc. | Variant antibody that binds cd38 |
| MA53123A (en) | 2018-07-13 | 2021-05-19 | Genmab As | TROGOCYTOSIS MEDIATION THERAPY USING CD38 ANTIBODIES |
| MA53122A (en) | 2018-07-13 | 2021-05-19 | Genmab As | CD38 ANTIBODY VARIANTS AND THEIR USES |
| CA3111651A1 (en) | 2018-09-11 | 2020-03-19 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-cd38 antibody, antigen-binding fragment thereof, and pharmaceutical use |
| CN109293773B (en) * | 2018-09-25 | 2020-09-04 | 上海邦耀生物科技有限公司 | Antibodies, chimeric antigen receptors and drugs targeting CD38 protein |
| JP2022512722A (en) | 2018-10-17 | 2022-02-07 | ヤンセン バイオテツク，インコーポレーテツド | Methods of Providing Subcutaneous Administration of Anti-CD38 Antibodies |
| BR112021000173A2 (en) | 2018-10-26 | 2021-05-04 | Teneobio, Inc. | heavy chain antibodies with binding to cd38 |
| SG11202104092UA (en) | 2018-11-13 | 2021-05-28 | Janssen Biotech Inc | Control of trace metals during production of anti-cd38 antibodies |
| SG11202104012QA (en) | 2018-12-14 | 2021-05-28 | Morphosys Ag | Antibody formulations |
| AU2020211728A1 (en) * | 2019-01-23 | 2021-08-12 | Encefa | CD31 competitors and uses thereof |
| AU2020242228A1 (en) | 2019-03-15 | 2021-07-22 | Morphosys Ag | Anti-CD38 antibodies and pharmaceutical compositions thereof for the treatment of autoantibody-mediated autoimmune disease |
| AU2020299600A1 (en) * | 2019-07-03 | 2022-01-06 | Crystal Bioscience Inc. | Anti-CD38 antibody and methods of use thereof |
| CN114786713A (en) * | 2019-09-18 | 2022-07-22 | 动量制药公司 | Compositions and methods related to engineered Fc antigen binding domain constructs targeting CD38 |
| TW202128756A (en) | 2019-10-02 | 2021-08-01 | 德商百靈佳殷格翰國際股份有限公司 | Multi-specific binding proteins for cancer treatment |
| GB201916150D0 (en) | 2019-11-06 | 2019-12-18 | Univ Of Ireland Galway | Treatment of multiple myeloma |
| JPWO2021112196A1 (en) * | 2019-12-05 | 2021-06-10 | ||
| EP4077391A1 (en) | 2019-12-18 | 2022-10-26 | Teneofour, Inc. | Heavy chain antibodies binding to cd38 |
| MX2022008050A (en) | 2020-01-16 | 2022-07-27 | Genmab As | Formulations of cd38 antibodies and uses thereof. |
| US11919956B2 (en) | 2020-05-14 | 2024-03-05 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3 |
| TW202214303A (en) | 2020-05-19 | 2022-04-16 | 德商百靈佳殷格翰國際股份有限公司 | Binding molecules for the treatment of cancer |
| WO2022002065A1 (en) * | 2020-06-30 | 2022-01-06 | 百奥泰生物制药股份有限公司 | Anti-cd40 antibody or antigen-binding fragment and use thereof |
| CN111808193B (en) * | 2020-06-30 | 2022-04-05 | 源道隆（苏州）医学科技有限公司 | Nanobody capable of binding human CD38 and application thereof |
| IL300666A (en) | 2020-08-19 | 2023-04-01 | Xencor Inc | Anti-cd28 compositions |
| JP2023546228A (en) | 2020-10-21 | 2023-11-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Bispecific anti-VEGF and anti-TrkB binding molecules for the treatment of ocular diseases |
| AU2022208200A1 (en) | 2021-01-14 | 2023-07-20 | Morphosys Ag | Anti-cd38 antibodies and their uses |
| US20220275090A1 (en) | 2021-02-22 | 2022-09-01 | Janssen Biotech, Inc. | Combination Therapies with Anti-CD38 Antibodies and PARP or Adenosine Receptor Inhibitors |
| TW202302642A (en) | 2021-03-01 | 2023-01-16 | 德商莫菲西斯公司 | Anti-cd38 antibodies for use in the treatment of antibody-mediated transplant rejection |
| WO2022192403A1 (en) | 2021-03-09 | 2022-09-15 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cldn6 |
| EP4305065A1 (en) | 2021-03-10 | 2024-01-17 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and gpc3 |
| TW202317625A (en) | 2021-06-17 | 2023-05-01 | 德商百靈佳殷格翰國際股份有限公司 | Novel tri-specific binding molecules |
| WO2022271987A1 (en) | 2021-06-23 | 2022-12-29 | TeneoFour, Inc. | Anti-cd38 antibodies and epitopes of same |
| TW202321303A (en) | 2021-07-19 | 2023-06-01 | 德商莫菲西斯公司 | Treatment of anti-pla2r-autoantibody-mediated membranous nephropathy |
| IL310372A (en) | 2021-07-28 | 2024-03-01 | Genentech Inc | Il15/il15r alpha heterodimeric fc-fusion proteins for the treatment of blood cancers |
| US20230136301A1 (en) | 2021-11-03 | 2023-05-04 | Janssen Biotech, Inc. | Corticosteriod Reduction in Treatment with Anti-CD38 Antibody |
| WO2023143547A1 (en) * | 2022-01-30 | 2023-08-03 | 百奥泰生物制药股份有限公司 | Anti-cd28 antibody and use thereof |
| WO2023144303A1 (en) | 2022-01-31 | 2023-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Cd38 as a biomarker and biotarget in t-cell lymphomas |
| WO2023240135A2 (en) | 2022-06-07 | 2023-12-14 | Actinium Pharmaceuticals, Inc. | Bifunctional chelators and conjugates |
| US20240052065A1 (en) | 2022-07-15 | 2024-02-15 | Boehringer Ingelheim International Gmbh | Binding molecules for the treatment of cancer |
| WO2024094660A1 (en) | 2022-10-31 | 2024-05-10 | Genmab A/S | Cd38 antibodies and uses thereof |
| WO2024095173A1 (en) | 2022-11-02 | 2024-05-10 | Janssen Biotech, Inc. | Methods of treating cancers |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| WO1987004154A1 (en) * | 1986-01-03 | 1987-07-16 | The University Of Melbourne | Melphalan derivatives |
| SU1595902A1 (en) * | 1988-06-30 | 1990-09-30 | Всесоюзный онкологический научный центр АМН СССР | Strain of mus musculus l hybrid cultivable cells for producing monoclonal antibodies to atigen cd38 |
| US5156951A (en) * | 1989-07-13 | 1992-10-20 | Becton Dickinson And Company | Detecting immunological changes in HIV infected patient samples |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| GB9022543D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Antibody production |
| AU6123894A (en) | 1993-01-29 | 1994-08-15 | Board Of Trustees Of The Leland Stanford Junior University | Modulation of physiological responses of lymphocytes by cd38 or antibodies thereto |
| US6555324B1 (en) | 1993-11-04 | 2003-04-29 | Becton Dickinson & Company | Method to distinguish hematopoietic progenitor cells |
| US20020164788A1 (en) * | 1994-12-02 | 2002-11-07 | The Wellcome Foundation Limited | Humanized antibodies to CD38 |
| GB9424449D0 (en) * | 1994-12-02 | 1995-01-18 | Wellcome Found | Antibodies |
| RU2205874C2 (en) | 1995-05-11 | 2003-06-10 | Апплайд Резеч Системз Арс Холдинг Н.В. | Nucleotide sequence able to inhibit il-6 activity, plasmid vector for transfection into mammalian cells, nucleotide sequence used in therapy, pharmaceutical composition (variants) |
| ES2176484T3 (en) | 1995-08-18 | 2002-12-01 | Morphosys Ag | PROTEIN BANKS / (POLI) PEPTIDES. |
| US5594116A (en) | 1995-11-08 | 1997-01-14 | Promega Corporation | Tryptase polyclonal antibody and purification method for use in human tryptase immunoassay |
| WO1998016245A1 (en) * | 1996-10-15 | 1998-04-23 | Shionogi & Co., Ltd. | Method of autoantibody assay |
| AU770718B2 (en) | 1998-06-05 | 2004-02-26 | Mayo Foundation For Medical Education And Research | Use of genetically engineered antibodies to CD38 to treat multiple myeloma |
| US7223397B1 (en) * | 1999-01-07 | 2007-05-29 | Research Development Foundation | Potentiation of anti-CD38-Immunotoxin cytotoxicity |
| GB9903664D0 (en) | 1999-02-17 | 1999-04-14 | Isis Innovation | Adjuvant and cell maturation agent |
| JP2000316578A (en) | 1999-05-12 | 2000-11-21 | Bml Inc | Detection of diabetes development risk factor |
| IL142025A0 (en) | 1999-07-20 | 2002-03-10 | Morphosys Ag | Novel methods for displaying (poly) peptides/proteins on bacteriophage particles via disulfide bonds |
| US7442776B2 (en) * | 1999-10-08 | 2008-10-28 | Young David S F | Cancerous disease modifying antibodies |
| US20020028488A1 (en) | 2000-06-19 | 2002-03-07 | Sujay Singh | Transgenic avian species for making human and chimeric antibodies |
| EP1174440A1 (en) | 2000-07-19 | 2002-01-23 | U-BISys B.V. | A selectively-expressed epitope on the human CD38 molecule detected by a phage display library-derived human scFv antibody fragment |
| CA2424643A1 (en) | 2000-10-17 | 2002-04-25 | Trudeau Institute, Inc. | Cd38 modulated chemotaxis |
| US20070042436A1 (en) | 2000-10-17 | 2007-02-22 | Lund Frances E | CD38 modulated chemotaxis |
| US6892140B1 (en) | 2000-11-27 | 2005-05-10 | Enteron, Inc. | Immunogenic cancer peptides and uses thereof |
| US7361343B2 (en) * | 2003-01-21 | 2008-04-22 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD63 |
| AU2002246733B2 (en) | 2000-12-19 | 2007-09-20 | Altor Bioscience Corporation | Transgenic animals comprising a humanized immune system |
| US20040081981A1 (en) | 2001-01-31 | 2004-04-29 | Toru Egashira | Method of detecting risk factor for onset of diabetes |
| ATE484522T1 (en) | 2001-04-24 | 2010-10-15 | Bayer Corp | HUMAN ANTIBODIES TO TIMP-1 |
| US7084257B2 (en) | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
| WO2003033538A1 (en) | 2001-10-15 | 2003-04-24 | Kirin Beer Kabushiki Kaisha | Anti-hla-dr antibody |
| AR038568A1 (en) | 2002-02-20 | 2005-01-19 | Hoffmann La Roche | ANTI-A BETA ANTIBODIES AND ITS USE |
| US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| AU2003241103A1 (en) | 2002-04-23 | 2003-11-10 | Umberto Dianzani | Compositions containing anti-hiv peptides and methods of use |
| ATE328906T1 (en) * | 2002-06-28 | 2006-06-15 | Domantis Ltd | DUAL-SPECIFIC LIGANDS WITH INCREASED HALF-LIFE |
| ITMI20021527A1 (en) | 2002-07-11 | 2004-01-12 | Consiglio Nazionale Ricerche | C5 COMPONENT ANTIBODIES OF COMPLEMENT AND THEIR USE |
| US7393531B2 (en) * | 2003-01-21 | 2008-07-01 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of MCSP |
| EP1689435A4 (en) | 2003-10-22 | 2007-10-03 | Univ Rochester | Anti-thymocyte antiserum and use thereof to trigger b cell apoptosis |
| EP1720907B1 (en) * | 2004-02-06 | 2015-04-08 | MorphoSys AG | Anti-cd38 human antibodies and uses therefor |
| CA2555185C (en) | 2004-02-06 | 2020-03-24 | Morphosys Ag | Anti-cd38 human antibodies and uses therefor |
| US9200061B2 (en) | 2004-02-06 | 2015-12-01 | Morpho Sys AG | Generation and profiling of fully human HuCAL gold®-derived therapeutic antibodies specific for human CD3i |
| WO2006125640A2 (en) * | 2005-05-24 | 2006-11-30 | Morphosys Ag | Generation and profiling of fully human hucal gold®-derived therapeutic antibodies specific for human cd38 |
| ES2331891T3 (en) | 2004-02-13 | 2010-01-19 | Boehringer Ingelheim Pharmaceuticals, Inc. | PROCESSING VALUES OF CD38 AND USES OF THE SAME. |
| SI2567976T1 (en) | 2005-03-23 | 2017-11-30 | Genmab A/S | Antibodies against CD38 for treatment of multiple myeloma |
| JP2008535853A (en) | 2005-04-07 | 2008-09-04 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド | Cancer-related genes |
| AU2006301446B2 (en) | 2005-10-12 | 2012-06-07 | Morphosys Ag | Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human CD38 |
| GB0603683D0 (en) * | 2006-02-23 | 2006-04-05 | Novartis Ag | Organic compounds |
| EP1914242A1 (en) | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| CN101883846A (en) | 2007-10-01 | 2010-11-10 | 科德克希思公司 | Ketoreductase polypeptides for the production of azetidinone |
| AU2010308030B2 (en) | 2009-10-12 | 2014-05-29 | Pfizer Inc. | Cancer treatment |
| KR101912957B1 (en) * | 2010-09-27 | 2018-10-29 | 모르포시스 아게 | Anti-cd38 antibody and lenalidomide or bortezomib for the treatment of multiple myeloma and nhl |
| JOP20210044A1 (en) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | Anti-cd38 antibodies |
| PT2900232T (en) * | 2012-09-25 | 2018-02-09 | Morphosys Ag | Combinations and uses thereof |
| EP2914302B1 (en) * | 2012-11-05 | 2017-01-04 | MorphoSys AG | Radiolabelled antibody and uses thereof |
| US11920830B1 (en) | 2022-11-11 | 2024-03-05 | Russell Dwayne Mcnally | Tool and method for cleaning and draining a water heater |
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