CY1114066T1 - Φαρμακευτικη στοματικη δοσολογικη μορφη που περιλαμβανει εναν συνδυασμο ενος οπιοειδους αγωνιστη και οπιοειδους ανταγωνιστη - Google Patents

Φαρμακευτικη στοματικη δοσολογικη μορφη που περιλαμβανει εναν συνδυασμο ενος οπιοειδους αγωνιστη και οπιοειδους ανταγωνιστη

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Publication number
CY1114066T1
CY1114066T1 CY20131100501T CY131100501T CY1114066T1 CY 1114066 T1 CY1114066 T1 CY 1114066T1 CY 20131100501 T CY20131100501 T CY 20131100501T CY 131100501 T CY131100501 T CY 131100501T CY 1114066 T1 CY1114066 T1 CY 1114066T1
Authority
CY
Cyprus
Prior art keywords
combination
opioid
oral dosage
opioid antagonist
opioid agonist
Prior art date
Application number
CY20131100501T
Other languages
English (en)
Inventor
Robert F Kaiko
Robert D Colucci
Original Assignee
Euro-Celtique S.A.
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22082853&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1114066(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro-Celtique S.A. filed Critical Euro-Celtique S.A.
Publication of CY1114066T1 publication Critical patent/CY1114066T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Η εφεύρεση εστιάζεται εν μέρει σε στοματικές δοσολογικές μορφές οι οποίες περιλαμβάνουν έναν συνδυασμό μιας στοματικά αναλγητικώς αποτελεσματικής ποσότητας ενός οπιοειδούς αγωνιστή και ενός στοματικά δραστικού οπιοειδούς ανταγωνιστή, με τον οπιοειδή ανταγωνιστή να περιέχεται σε μια αναλογία ως προς τον οπιοειδή αγωνιστή ώστε να παράσχει ένα προϊόν συνδυασμού το οποίο είναι αναλγητικά αποτελεσματικό όταν ο συνδυασμός χορηγείται στοματικά, αλλά ο οποίος είναι αποτρεπτικός σε ένα φυσικά εξαρτώμενο άτομο. Κατά προτίμηση, η ποσότητα του οπιοειδούς ανταγωνιστή που περιέχεται στο προϊόν συνδυασμού παρέχει τουλάχιστον μια ήπια αρνητική «αποτρεπτική» εμπειρία σε φυσικά εξαρτημένους τοξικομανείς (π.χ. σύνδρομο αιφνίδιας αποχής).
CY20131100501T 1997-12-22 2013-06-19 Φαρμακευτικη στοματικη δοσολογικη μορφη που περιλαμβανει εναν συνδυασμο ενος οπιοειδους αγωνιστη και οπιοειδους ανταγωνιστη CY1114066T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6848097P 1997-12-22 1997-12-22
EP06111805.5A EP1685839B8 (en) 1997-12-22 1998-12-22 Pharmaceutical oral dosage form comprising a combination of an opioid agonist and opioid antagonist

Publications (1)

Publication Number Publication Date
CY1114066T1 true CY1114066T1 (el) 2016-07-27

Family

ID=22082853

Family Applications (4)

Application Number Title Priority Date Filing Date
CY20061100804T CY1106099T1 (el) 1997-12-22 2006-06-16 Φαρμακευτικη στοματικη δοσολογικη μορφη που πepιλαμβανει ενα συνδυασμο ενος οπιοειδους αγωνιστη και ναλτρεξονης
CY20131100423T CY1114011T1 (el) 1997-12-22 2013-05-29 Φαρμακευτικη στοματικη δοσολογικη μορφη που περιλαμβανει ενα συνδυασμο ενος οπιοειδους αγωνιστη και ενος οπιοειδους ανταγωνιστη
CY20131100501T CY1114066T1 (el) 1997-12-22 2013-06-19 Φαρμακευτικη στοματικη δοσολογικη μορφη που περιλαμβανει εναν συνδυασμο ενος οπιοειδους αγωνιστη και οπιοειδους ανταγωνιστη
CY2013038C CY2013038I1 (el) 1997-12-22 2013-10-10 Φαρμακευτικη στοματικη δοσολογικη μορφη που περιλαμβανει εναν συνδυασμο ενος οπιοειδους αγωνιστη και οπιοειδους ανταγωνιστη

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CY20061100804T CY1106099T1 (el) 1997-12-22 2006-06-16 Φαρμακευτικη στοματικη δοσολογικη μορφη που πepιλαμβανει ενα συνδυασμο ενος οπιοειδους αγωνιστη και ναλτρεξονης
CY20131100423T CY1114011T1 (el) 1997-12-22 2013-05-29 Φαρμακευτικη στοματικη δοσολογικη μορφη που περιλαμβανει ενα συνδυασμο ενος οπιοειδους αγωνιστη και ενος οπιοειδους ανταγωνιστη

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY2013038C CY2013038I1 (el) 1997-12-22 2013-10-10 Φαρμακευτικη στοματικη δοσολογικη μορφη που περιλαμβανει εναν συνδυασμο ενος οπιοειδους αγωνιστη και οπιοειδους ανταγωνιστη

Country Status (29)

Country Link
US (11) US6277384B1 (el)
EP (3) EP1041987B1 (el)
JP (5) JP2001526228A (el)
KR (1) KR100417489B1 (el)
CN (1) CN1234362C (el)
AT (1) ATE323491T1 (el)
AU (2) AU773642C (el)
BR (1) BR9813827A (el)
CA (1) CA2314893C (el)
CY (4) CY1106099T1 (el)
CZ (1) CZ299283B6 (el)
DE (1) DE69834268T2 (el)
DK (3) DK1041987T3 (el)
ES (3) ES2412409T3 (el)
HK (2) HK1031692A1 (el)
HU (2) HU226730B1 (el)
IL (2) IL136804A (el)
LU (1) LU92292I2 (el)
ME (1) ME00527B (el)
NO (1) NO321625B1 (el)
NZ (2) NZ505193A (el)
PL (1) PL193273B1 (el)
PT (3) PT1041987E (el)
RS (1) RS50070B (el)
RU (1) RU2241458C2 (el)
SI (3) SI1685839T1 (el)
TR (1) TR200001942T2 (el)
UA (1) UA55507C2 (el)
WO (1) WO1999032119A1 (el)

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