CY1114011T1 - Φαρμακευτικη στοματικη δοσολογικη μορφη που περιλαμβανει ενα συνδυασμο ενος οπιοειδους αγωνιστη και ενος οπιοειδους ανταγωνιστη - Google Patents
Φαρμακευτικη στοματικη δοσολογικη μορφη που περιλαμβανει ενα συνδυασμο ενος οπιοειδους αγωνιστη και ενος οπιοειδους ανταγωνιστηInfo
- Publication number
- CY1114011T1 CY1114011T1 CY20131100423T CY131100423T CY1114011T1 CY 1114011 T1 CY1114011 T1 CY 1114011T1 CY 20131100423 T CY20131100423 T CY 20131100423T CY 131100423 T CY131100423 T CY 131100423T CY 1114011 T1 CY1114011 T1 CY 1114011T1
- Authority
- CY
- Cyprus
- Prior art keywords
- opioid
- combination
- oral dosage
- opioid agonist
- dosage form
- Prior art date
Links
- 239000003402 opiate agonist Substances 0.000 title abstract 4
- 239000003401 opiate antagonist Substances 0.000 title abstract 3
- 239000006186 oral dosage form Substances 0.000 title abstract 2
- 230000000202 analgesic effect Effects 0.000 abstract 2
- 239000013066 combination product Substances 0.000 abstract 1
- 229940127555 combination product Drugs 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Peptides Or Proteins (AREA)
Abstract
Η εφεύρεση σχετίζεται με στοματικές δοσολογικές μορφές οι οποίες περιλαμβάνουν έναν συνδυασμό μιας στοματικά αναλγητικά αποτελεσματικής ποσότητας ενός οπιοειδούς αγωνιστή και ενός στοματικά δραστικού οπιοειδούς ανταγωνιστή, με τον οπιοειδή ανταγωνιστή να περιέχεται σε μια αναλογία ως προς τον οπιοειδή αγωνιστή για να παράσχει ένα προϊόν συνδυασμού το οποίο είναι αναλγητικά αποτελεσματικό όταν ο συνδυασμός χορηγείται στοματικά, αλλά ο οποίος είναι αποτρεπτικός σε ένα φυσικά εξαρτώμενο άτομο όταν χορηγείται στην ίδια δόση ή σε μια υψηλότερη δόση από τη συνήθη συνταγογραφούμενη δόση οπιοειδούς αγωνιστή.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6848097P | 1997-12-22 | 1997-12-22 | |
EP10179026A EP2266564B1 (en) | 1997-12-22 | 1998-12-22 | Pharmaceutical oral dosage form comprising a combination of an opioid agonist and an opioid antagonist |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1114011T1 true CY1114011T1 (el) | 2016-07-27 |
Family
ID=22082853
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061100804T CY1106099T1 (el) | 1997-12-22 | 2006-06-16 | Φαρμακευτικη στοματικη δοσολογικη μορφη που πepιλαμβανει ενα συνδυασμο ενος οπιοειδους αγωνιστη και ναλτρεξονης |
CY20131100423T CY1114011T1 (el) | 1997-12-22 | 2013-05-29 | Φαρμακευτικη στοματικη δοσολογικη μορφη που περιλαμβανει ενα συνδυασμο ενος οπιοειδους αγωνιστη και ενος οπιοειδους ανταγωνιστη |
CY20131100501T CY1114066T1 (el) | 1997-12-22 | 2013-06-19 | Φαρμακευτικη στοματικη δοσολογικη μορφη που περιλαμβανει εναν συνδυασμο ενος οπιοειδους αγωνιστη και οπιοειδους ανταγωνιστη |
CY2013038C CY2013038I1 (el) | 1997-12-22 | 2013-10-10 | Φαρμακευτικη στοματικη δοσολογικη μορφη που περιλαμβανει εναν συνδυασμο ενος οπιοειδους αγωνιστη και οπιοειδους ανταγωνιστη |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061100804T CY1106099T1 (el) | 1997-12-22 | 2006-06-16 | Φαρμακευτικη στοματικη δοσολογικη μορφη που πepιλαμβανει ενα συνδυασμο ενος οπιοειδους αγωνιστη και ναλτρεξονης |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20131100501T CY1114066T1 (el) | 1997-12-22 | 2013-06-19 | Φαρμακευτικη στοματικη δοσολογικη μορφη που περιλαμβανει εναν συνδυασμο ενος οπιοειδους αγωνιστη και οπιοειδους ανταγωνιστη |
CY2013038C CY2013038I1 (el) | 1997-12-22 | 2013-10-10 | Φαρμακευτικη στοματικη δοσολογικη μορφη που περιλαμβανει εναν συνδυασμο ενος οπιοειδους αγωνιστη και οπιοειδους ανταγωνιστη |
Country Status (29)
Country | Link |
---|---|
US (11) | US6277384B1 (el) |
EP (3) | EP1685839B8 (el) |
JP (5) | JP2001526228A (el) |
KR (1) | KR100417489B1 (el) |
CN (1) | CN1234362C (el) |
AT (1) | ATE323491T1 (el) |
AU (2) | AU773642C (el) |
BR (1) | BR9813827A (el) |
CA (1) | CA2314893C (el) |
CY (4) | CY1106099T1 (el) |
CZ (1) | CZ299283B6 (el) |
DE (1) | DE69834268T2 (el) |
DK (3) | DK1685839T3 (el) |
ES (3) | ES2412409T3 (el) |
HK (2) | HK1031692A1 (el) |
HU (2) | HU226730B1 (el) |
IL (2) | IL136804A (el) |
LU (1) | LU92292I2 (el) |
ME (1) | ME00527B (el) |
NO (1) | NO321625B1 (el) |
NZ (2) | NZ505193A (el) |
PL (1) | PL193273B1 (el) |
PT (3) | PT1041987E (el) |
RS (1) | RS50070B (el) |
RU (1) | RU2241458C2 (el) |
SI (3) | SI1685839T1 (el) |
TR (1) | TR200001942T2 (el) |
UA (1) | UA55507C2 (el) |
WO (1) | WO1999032119A1 (el) |
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