CY1114263T1 - Δοσολογικη μορφη πραμιπεξολης χορηγουμενη μια φορα την ημερα - Google Patents
Δοσολογικη μορφη πραμιπεξολης χορηγουμενη μια φορα την ημεραInfo
- Publication number
- CY1114263T1 CY1114263T1 CY20131100643T CY131100643T CY1114263T1 CY 1114263 T1 CY1114263 T1 CY 1114263T1 CY 20131100643 T CY20131100643 T CY 20131100643T CY 131100643 T CY131100643 T CY 131100643T CY 1114263 T1 CY1114263 T1 CY 1114263T1
- Authority
- CY
- Cyprus
- Prior art keywords
- composition
- hours
- pramipexole
- absorption
- day
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Μια χορηγούμενη από το στόμα φαρμακευτική σύνθεση η οποία περιλαμβάνει μια θεραπευτικά αποτελεσματική ποσότητα πραμιπεξόλης ή ένα φαρμακευτικά αποδεκτό άλας αυτής και τουλάχιστον ένα φαρμακευτικά αποδεκτό έκδοχο, με την εν λόγω σύνθεση να επιδεικνύει τουλάχιστον ένα από τα: (α) προφίλ αποδέσμευσης στο δοκιμαστικό σωλήνα στο οποίο κατά μέσο όρο δε διαλύεται περισσότερο από 20% πραμιπεξόλης μέσα σε δυο ώρες από την τοποθέτηση της σύνθεσης σε μια πρότυπη δοκιμή διάλυσης· και (β) προφίλ απορρόφησης της πραμιπεξόλης εσωσωματικά μετά τη χορήγηση μιας δόσης σε υγιείς ενήλικες ανθρώπους, στο οποίο ο χρόνος για να επιτευχθεί ένας μέσος όρος 20% απορρόφησης είναι μεγαλύτερος από περίπου 2 ώρες και/ή ο χρόνος για να επιτευχθεί ένας μέσος όρος 40% απορρόφησης είναι μεγαλύτερος από περίπου 4 ώρες. Η σύνθεση είναι χρήσιμη για χορήγηση από το στόμα, όχι περισσότερο από μια φορά την ημέρα, σε ένα άτομο που έχει μια κατάσταση ή διαταραχή για την οποία ενδείκνυται ένας αγωνιστής του υποδοχέα της ντοπαμίνης.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39842702P | 2002-07-25 | 2002-07-25 | |
US39844702P | 2002-07-25 | 2002-07-25 | |
US47951403P | 2003-06-18 | 2003-06-18 | |
EP10174089.2A EP2289514B9 (en) | 2002-07-25 | 2003-07-25 | Pramipexole once daily dosage form |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1114263T1 true CY1114263T1 (el) | 2016-08-31 |
Family
ID=31192088
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20131100643T CY1114263T1 (el) | 2002-07-25 | 2013-07-26 | Δοσολογικη μορφη πραμιπεξολης χορηγουμενη μια φορα την ημερα |
CY20131100969T CY1114566T1 (el) | 2002-07-25 | 2013-11-01 | Δοσολογικη μορφη πραμιπεξολης χορηγουμενη μια φορα την ημερα |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20131100969T CY1114566T1 (el) | 2002-07-25 | 2013-11-01 | Δοσολογικη μορφη πραμιπεξολης χορηγουμενη μια φορα την ημερα |
Country Status (40)
Country | Link |
---|---|
US (2) | US8679533B2 (el) |
EP (2) | EP1536792B1 (el) |
JP (1) | JP4607584B2 (el) |
KR (2) | KR101066374B1 (el) |
CN (1) | CN1671381B (el) |
AP (1) | AP2223A (el) |
AR (1) | AR040682A1 (el) |
AU (1) | AU2003256921B2 (el) |
BR (1) | BR0312948A (el) |
CA (1) | CA2493629C (el) |
CU (1) | CU23468B7 (el) |
CY (2) | CY1114263T1 (el) |
DE (1) | DE20321906U1 (el) |
DK (2) | DK2289514T5 (el) |
EA (1) | EA017595B1 (el) |
EC (1) | ECSP055569A (el) |
ES (2) | ES2436745T3 (el) |
GE (1) | GEP20074047B (el) |
HK (1) | HK1078007A1 (el) |
HR (1) | HRP20041234B1 (el) |
IL (1) | IL166076A0 (el) |
IS (1) | IS7613A (el) |
MA (1) | MA27372A1 (el) |
ME (1) | ME00347B (el) |
MX (1) | MXPA05000980A (el) |
MY (1) | MY142204A (el) |
NO (1) | NO20050481L (el) |
NZ (1) | NZ562681A (el) |
OA (1) | OA12889A (el) |
PA (1) | PA8578501A1 (el) |
PE (1) | PE20040134A1 (el) |
PL (1) | PL375444A1 (el) |
PT (2) | PT1536792E (el) |
RS (1) | RS52764B (el) |
SG (1) | SG177011A1 (el) |
SI (2) | SI1536792T1 (el) |
TW (1) | TWI351955B (el) |
UY (1) | UY27913A1 (el) |
WO (1) | WO2004010999A1 (el) |
ZA (1) | ZA200500015B (el) |
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ES2813674T3 (es) | 2013-08-13 | 2021-03-24 | Knopp Biosciences Llc | Composiciones y métodos para el tratamiento de trastornos de células plasmáticas y trastornos prolinfocíticos de células b |
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