HRP20041234B1 - Oblik pramipeksola za doziranje jednom dnevno - Google Patents
Oblik pramipeksola za doziranje jednom dnevnoInfo
- Publication number
- HRP20041234B1 HRP20041234B1 HRP20041234AA HRP20041234A HRP20041234B1 HR P20041234 B1 HRP20041234 B1 HR P20041234B1 HR P20041234A A HRP20041234A A HR P20041234AA HR P20041234 A HRP20041234 A HR P20041234A HR P20041234 B1 HRP20041234 B1 HR P20041234B1
- Authority
- HR
- Croatia
- Prior art keywords
- pramipexole
- hours
- absorption
- reach
- approximately
- Prior art date
Links
- FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 title abstract 4
- 229960003089 pramipexole Drugs 0.000 title abstract 4
- 239000002552 dosage form Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 4
- 238000010521 absorption reaction Methods 0.000 abstract 3
- 229940098778 Dopamine receptor agonist Drugs 0.000 abstract 1
- 238000007922 dissolution test Methods 0.000 abstract 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Farmaceutska oralno primjenjiva smjesa obuhvaća terapijski učinkovitu količinu pramipeksola ili njegove farmaceutski prihvatljive soli i najmanje jedan farmaceutski prihvatljiv ekscipijent, spomenuta smjesa pokazuje najmanje jedno od (a) in vitro profil otpuštanja pri čemu se prosječno ne otapa više od oko 20% pramipeksola unutar 2 sata nakon stavljanja smjese u standardni test otapanja; i (b) in vivo apsorpcijski profil pramipeksola nakon jedne doze dane zdravoj odrasloj osobi pri čemu je vrijeme da bi se dosegla srednja vrijednost od 20% apsorpcije veće nego otprilike 2 sata i/ili je vrijeme da bi se dosegla srednja vrijednost od 40% apsorpcije veće od otprilike 4 sata. Smjesa je korisna za oralnu primjenu, ne više od jednom dnevno, subjektu koji ima stanje ili poremećaj za koji je indiciran agonist dopamin receptora.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39842702P | 2002-07-25 | 2002-07-25 | |
US39844702P | 2002-07-25 | 2002-07-25 | |
US47951403P | 2003-06-18 | 2003-06-18 | |
PCT/US2003/023522 WO2004010999A1 (en) | 2002-07-25 | 2003-07-25 | Pramipexole once-daily dosage form |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20041234A2 HRP20041234A2 (en) | 2005-04-30 |
HRP20041234B1 true HRP20041234B1 (hr) | 2013-07-31 |
Family
ID=31192088
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20041234AA HRP20041234B1 (hr) | 2002-07-25 | 2004-12-30 | Oblik pramipeksola za doziranje jednom dnevno |
Country Status (40)
Country | Link |
---|---|
US (2) | US8679533B2 (hr) |
EP (2) | EP1536792B1 (hr) |
JP (1) | JP4607584B2 (hr) |
KR (2) | KR20050025654A (hr) |
CN (1) | CN1671381B (hr) |
AP (1) | AP2223A (hr) |
AR (1) | AR040682A1 (hr) |
AU (1) | AU2003256921B2 (hr) |
BR (1) | BR0312948A (hr) |
CA (1) | CA2493629C (hr) |
CU (1) | CU23468B7 (hr) |
CY (2) | CY1114263T1 (hr) |
DE (1) | DE20321906U1 (hr) |
DK (2) | DK1536792T3 (hr) |
EA (1) | EA017595B1 (hr) |
EC (1) | ECSP055569A (hr) |
ES (2) | ES2436745T3 (hr) |
GE (1) | GEP20074047B (hr) |
HK (1) | HK1078007A1 (hr) |
HR (1) | HRP20041234B1 (hr) |
IL (1) | IL166076A0 (hr) |
IS (1) | IS7613A (hr) |
MA (1) | MA27372A1 (hr) |
ME (1) | ME00347B (hr) |
MX (1) | MXPA05000980A (hr) |
MY (1) | MY142204A (hr) |
NO (1) | NO20050481L (hr) |
NZ (1) | NZ562681A (hr) |
OA (1) | OA12889A (hr) |
PA (1) | PA8578501A1 (hr) |
PE (1) | PE20040134A1 (hr) |
PL (1) | PL375444A1 (hr) |
PT (2) | PT1536792E (hr) |
RS (1) | RS52764B (hr) |
SG (1) | SG177011A1 (hr) |
SI (2) | SI2289514T1 (hr) |
TW (1) | TWI351955B (hr) |
UY (1) | UY27913A1 (hr) |
WO (1) | WO2004010999A1 (hr) |
ZA (1) | ZA200500015B (hr) |
Families Citing this family (44)
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US20050226926A1 (en) | 2002-07-25 | 2005-10-13 | Pfizer Inc | Sustained-release tablet composition of pramipexole |
US7365086B2 (en) * | 2003-07-25 | 2008-04-29 | Synthon Ip Inc. | Pramipexole acid addition salts |
ATE486588T1 (de) * | 2004-08-13 | 2010-11-15 | Boehringer Ingelheim Int | Tablettenformulierung mit verlängerter freisetzung mit pramipexol oder einem pharmazeutisch zulässigen salz davon, herstellungsverfahren und verwendung dafür |
CA2576386A1 (en) * | 2004-08-13 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof |
WO2006038339A1 (ja) * | 2004-10-01 | 2006-04-13 | Nippon Zoki Pharmaceutical Co., Ltd. | 固形医薬製剤 |
WO2006046256A1 (en) * | 2004-10-27 | 2006-05-04 | Alembic Limited | Extended release formulation of pramipexole dihydrochloride |
US20090041844A1 (en) * | 2006-02-10 | 2009-02-12 | Boehringer Ingelheim International Gmbh | Modified Release Formulation |
WO2007090882A2 (en) * | 2006-02-10 | 2007-08-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical extended release compositions comprising pramipexole |
US20090098202A1 (en) * | 2006-02-10 | 2009-04-16 | Boehringer Ingelheim International Gmbh | Extended Release Formulation |
US8518926B2 (en) * | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
AU2007253899A1 (en) | 2006-05-16 | 2007-11-29 | Knopp Neurosciences, Inc. | Compositions of R(+) and S(-) pramipexole and methods of using the same |
US20080254118A1 (en) * | 2007-04-11 | 2008-10-16 | Hans-Werner Wernersbach | Process for preparing pramipexole dihydrochloride tablets |
US8524695B2 (en) | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
US10716798B2 (en) | 2007-02-21 | 2020-07-21 | The Regents Of The University Of Michigan | Compositions and methods for tranquilizing heart muscle |
RU2454409C2 (ru) | 2007-03-14 | 2012-06-27 | Нопп Ньюросайенсиз, Инк. | Синтез хирально очищенных замещенных бензотиазолдиаминов |
WO2008145252A1 (en) * | 2007-05-25 | 2008-12-04 | Boehringer Ingelheim International Gmbh | Pharmaceutical formulation comprising pramipexole |
WO2008150741A1 (en) * | 2007-06-04 | 2008-12-11 | Drugtech Corporation | Controlled release dopamine agonist compositions |
WO2009152041A2 (en) * | 2008-06-09 | 2009-12-17 | Supernus Pharmaceuticals, Inc. | Controlled release formulations of pramipexole |
CA2734491A1 (en) | 2008-08-19 | 2010-02-25 | Knopp Neurosciences, Inc. | Compositions and methods of using (r)-pramipexole |
WO2010115267A1 (en) * | 2009-04-09 | 2010-10-14 | Purdue Pharma | Once-daily oral ir/cr pramipexole formulation |
WO2011002891A1 (en) * | 2009-07-02 | 2011-01-06 | Supernus Pharmaceuticals, Inc. | A method of treatment of a neurological disorder |
WO2011037976A2 (en) * | 2009-09-22 | 2011-03-31 | Dr. Reddy's Laboratories Limited | Pramipexole pharmaceutical formulations |
EP2525786A2 (en) * | 2010-01-18 | 2012-11-28 | Synthon BV | Pramipexole extended release tablets |
TR201001862A1 (tr) * | 2010-03-11 | 2011-10-21 | Sanovel �La� San.Ve T�C.A.�. | Kontrollü salım gerçekleştiren pramipeksol formülasyonları. |
US20130209553A1 (en) | 2010-04-15 | 2013-08-15 | Cadila Healthcare Limited | Extended release pharmaceutical compositions of pramipexole |
AU2011256928A1 (en) | 2010-05-24 | 2012-12-20 | Lupin Limited | Extended release formulation of pramipexole |
CN102670550A (zh) * | 2011-03-14 | 2012-09-19 | 北京天衡药物研究院 | 盐酸普拉克索渗透泵型控释片 |
WO2013034173A1 (en) | 2011-09-06 | 2013-03-14 | Synthon Bv | Pramipexole extended release tablets |
CN102406626B (zh) * | 2011-12-02 | 2013-08-28 | 深圳海王药业有限公司 | 盐酸普拉克索缓释片剂及其制备方法 |
WO2013096816A1 (en) | 2011-12-22 | 2013-06-27 | Biogen Idec Ma Inc. | Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
EP2732812A1 (de) | 2012-11-15 | 2014-05-21 | Aristo Pharma GmbH | Pramipexol-Retardtablettenformulierung |
CN103058953B (zh) * | 2012-11-22 | 2015-03-25 | 刘炜 | 用于治疗神经疾病的四氢苯并噻唑衍生物 |
US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
CN105764507B (zh) | 2013-07-12 | 2019-07-19 | 诺普生物科学有限责任公司 | 治疗升高的嗜酸性粒细胞和/或嗜碱性粒细胞的水平 |
US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
AU2014306683B2 (en) | 2013-08-13 | 2017-10-12 | Knopp Biosciences Llc | Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders |
ES2871556T3 (es) | 2013-08-13 | 2021-10-29 | Knopp Biosciences Llc | Composiciones y métodos para el tratamiento de la urticaria crónica |
CN104606162B (zh) * | 2015-01-07 | 2017-03-29 | 海南康虹医药科技开发有限公司 | 一种盐酸普拉克索缓释制剂及其制备方法 |
CN104784155B (zh) * | 2015-05-15 | 2018-02-23 | 中国药科大学 | 一种盐酸普拉克索组合微丸胶囊及其制备方法 |
CN105030721B (zh) * | 2015-08-30 | 2018-05-04 | 南京康川济医药科技有限公司 | 一种含有盐酸普拉克索的口服固体组合物 |
EP3522843B1 (en) * | 2016-10-07 | 2022-09-21 | Transwell Biotech Co., Ltd. | Pramipexole transdermal delivery system and uses thereof |
WO2018115338A1 (de) * | 2016-12-21 | 2018-06-28 | Hso Herbert Schmidt Gmbh & Co. Kg | Beizlösung zum beizen von kunststoffen |
BR112019022175A2 (pt) * | 2017-04-24 | 2020-05-12 | Chase Therapeutics Corporation | Composições e método para tratamento de depressão |
US11234961B2 (en) | 2017-08-17 | 2022-02-01 | Zi-Qiang Gu | Pamoate salt of monoamine anti-Parkinson's agents, method of preparation and use thereof |
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