RU98102392A - Производные дифенилметиленпиперидина - Google Patents
Производные дифенилметиленпиперидинаInfo
- Publication number
- RU98102392A RU98102392A RU98102392/04A RU98102392A RU98102392A RU 98102392 A RU98102392 A RU 98102392A RU 98102392/04 A RU98102392/04 A RU 98102392/04A RU 98102392 A RU98102392 A RU 98102392A RU 98102392 A RU98102392 A RU 98102392A
- Authority
- RU
- Russia
- Prior art keywords
- piperidine
- diphenylmethylene
- derivative
- diphenylmethylene piperidine
- pharmaceutically acceptable
- Prior art date
Links
- ZFDDWBKSMIWSBN-UHFFFAOYSA-N 2-benzhydrylidenepiperidine Chemical class N1CCCCC1=C(C=1C=CC=CC=1)C1=CC=CC=C1 ZFDDWBKSMIWSBN-UHFFFAOYSA-N 0.000 title claims 8
- 150000003839 salts Chemical class 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 206010061920 Psychotic disease Diseases 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 2
- CLASDMKBOIFHNY-UHFFFAOYSA-N 2-methylidenepiperidine Chemical compound C=C1CCCCN1 CLASDMKBOIFHNY-UHFFFAOYSA-N 0.000 claims 1
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- 239000003210 dopamine receptor blocking agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Claims (7)
1. Производное дифенилметиленпиперидина формулы
где n равно 1 или 2, или его фармацевтически приемлемая соль.
где n равно 1 или 2, или его фармацевтически приемлемая соль.
2. Производное дифенилметиленпиперидина по п. 1, в котором оба атома фтора находятся в пара-положении бензольных колец.
3. Производное дифенилметиленпиперидина по п. 1 или 2, имеющее формулу
или его фармацевтически приемлемая соль.
или его фармацевтически приемлемая соль.
4. Производное дифенилметиленпиперидина по любому из пп. 1-3 для применения в терапии, в особенности для применения в качестве антагониста допамина для лечения или профилактики психотических расстройств.
5. Фармацевтическая композиция, содержащая производное дифенилметиленпиперидина по любому из пп. 1-3 и фармацевтически приемлемые добавки.
6. Способ получения производного дифенилметиленпиперидина по любому из пп. 1-3, в котором проводят конденсацию 4-бис(2-, 3- или 4-фторфенил)метиленпиперидина или его соли с 1-(4-гало-1-оксобутил)пирролидином (n = 1) или с 1-(4-гало-1-оксобутил)пиперидином (n = 2), где гало представляет подходящий атом галогена, такой как хлор, бром или иод, после чего полученное соединение необязательно превращают в фармацевтически приемлемую соль.
7. Применение производного дифенилметиленпиперидина по любому из пп. 1-3 для производства медикамента для лечения или профилактики психотических расстройств.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95201910 | 1995-07-12 | ||
| EP95201910.7 | 1995-07-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU98102392A true RU98102392A (ru) | 1999-12-20 |
| RU2162846C2 RU2162846C2 (ru) | 2001-02-10 |
Family
ID=8220478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU98102392/04A RU2162846C2 (ru) | 1995-07-12 | 1996-07-09 | Производные дифенилметиленпиперидина или их фармацевтически приемлемые соли, способ их получения и фармацевтическая композиция |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5935974A (ru) |
| EP (1) | EP0842170B1 (ru) |
| JP (1) | JPH11508907A (ru) |
| KR (1) | KR19990028807A (ru) |
| CN (1) | CN1091108C (ru) |
| AR (1) | AR003966A1 (ru) |
| AT (1) | ATE199150T1 (ru) |
| AU (1) | AU699370B2 (ru) |
| BR (1) | BR9609330A (ru) |
| CA (1) | CA2226851A1 (ru) |
| CZ (1) | CZ288909B6 (ru) |
| DE (1) | DE69611788T2 (ru) |
| DK (1) | DK0842170T3 (ru) |
| ES (1) | ES2156287T3 (ru) |
| GR (1) | GR3035849T3 (ru) |
| HK (1) | HK1010818A1 (ru) |
| HU (1) | HUP9802762A3 (ru) |
| IL (1) | IL118768A (ru) |
| NO (1) | NO309765B1 (ru) |
| NZ (1) | NZ315318A (ru) |
| PL (1) | PL183837B1 (ru) |
| PT (1) | PT842170E (ru) |
| RU (1) | RU2162846C2 (ru) |
| TR (1) | TR199800027T1 (ru) |
| TW (1) | TW419477B (ru) |
| WO (1) | WO1997003065A1 (ru) |
| ZA (1) | ZA965691B (ru) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0004796A3 (en) | 1997-10-07 | 2002-05-28 | Akzo Nobel Nv | Antipsychotic substituted piperidine derivatives, process for the preparation and pharmaceutical compositions containing the same |
| WO1999034801A1 (en) * | 1998-01-09 | 1999-07-15 | Akzo Nobel N.V. | Use of diphenylmethylene piperidine derivatives in the manufacture of a medicament for the treatment of depression |
| WO1999034799A1 (en) * | 1998-01-09 | 1999-07-15 | Akzo Nobel N.V. | Use of diphenylmethylene piperidine derivatives in the manufacture of a medicament for the treatment of movement disorders |
| US6358979B1 (en) | 1999-06-11 | 2002-03-19 | Merck & Co., Inc. | N-cyclopentyl modulators of chemokine receptor activity |
| US6538002B1 (en) | 1999-06-11 | 2003-03-25 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| AU5600100A (en) | 1999-06-11 | 2001-01-02 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| WO2000076973A1 (en) * | 1999-06-11 | 2000-12-21 | Merck & Co., Inc. | N-cyclopentyl modulators of chemokine receptor activity |
| WO2000076513A1 (en) | 1999-06-11 | 2000-12-21 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| AU5473400A (en) | 1999-06-11 | 2001-01-02 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| KR20010113007A (ko) * | 2000-06-15 | 2001-12-24 | 주정호 | 항암제로서 유용한 ｎ-치환된 피페리디닐우레아 유도체 및그의 제조방법 |
| TW200303304A (en) * | 2002-02-18 | 2003-09-01 | Astrazeneca Ab | Chemical compounds |
| US6770659B2 (en) * | 2002-08-26 | 2004-08-03 | Sk Corporation | Benzoyl piperidine compounds |
| AU2003296308A1 (en) * | 2002-12-18 | 2004-07-29 | Bayer Cropscience Ag | N-(substituted arylmethyl)-4-(disubstituted methyl) piperidines and pyridines |
| SE0400208D0 (sv) * | 2004-02-02 | 2004-02-02 | Astrazeneca Ab | Chemical compounds |
| TW200812582A (en) * | 2006-04-06 | 2008-03-16 | Astrazeneca Ab | Medicaments |
| BR112017003658B1 (pt) | 2014-08-28 | 2022-12-06 | Asceneuron Sa | Composto, mistura, método para inibição de uma glicosidase, e, composição farmacêutica |
| DK3389658T3 (da) | 2015-12-18 | 2021-01-11 | Merck Sharp & Dohme | Glycosidasehæmmere og anvendelser deraf |
| JP2019506430A (ja) | 2016-02-25 | 2019-03-07 | エースニューロン・ソシエテ・アノニム | グリコシダーゼ阻害剤 |
| BR112018017225A2 (pt) | 2016-02-25 | 2019-01-15 | Asceneuron Sa | sal de adição de ácido, composto, métodos para preparação de um sal de adição de ácido, para tratamento de uma tauopatia e para inibição de uma glicosidase, e, forma de dosagem oral sólida. |
| US11612599B2 (en) | 2016-02-25 | 2023-03-28 | Asceneuron Sa | Glycosidase inhibitors |
| US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
| US11213525B2 (en) | 2017-08-24 | 2022-01-04 | Asceneuron Sa | Linear glycosidase inhibitors |
| US11731972B2 (en) | 2018-08-22 | 2023-08-22 | Asceneuron Sa | Spiro compounds as glycosidase inhibitors |
| WO2020039028A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Tetrahydro-benzoazepine glycosidase inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US450780A (en) * | 1891-04-21 | Steam-engine | ||
| US4180583A (en) * | 1972-01-28 | 1979-12-25 | Richardson-Merrell Inc. | Olefinic 4-substituted piperidino derivatives as therapeutics |
| US3922276A (en) * | 1974-12-11 | 1975-11-25 | Robins Co Inc A H | 1-Substituted-4-benzylidenepiperidines |
| US4666905A (en) * | 1983-06-02 | 1987-05-19 | Warner-Lambert Company | Diphenylmethylene piperidines compositions and methods for their use |
| US4540780A (en) * | 1983-06-02 | 1985-09-10 | Warner-Lambert Company | Diphenylmethylene piperidines |
-
1996
- 1996-07-01 IL IL11876896A patent/IL118768A/xx not_active IP Right Cessation
- 1996-07-04 ZA ZA965691A patent/ZA965691B/xx unknown
- 1996-07-09 AT AT96927006T patent/ATE199150T1/de not_active IP Right Cessation
- 1996-07-09 CN CN96195461A patent/CN1091108C/zh not_active Expired - Fee Related
- 1996-07-09 KR KR1019980700107A patent/KR19990028807A/ko not_active Application Discontinuation
- 1996-07-09 JP JP9505516A patent/JPH11508907A/ja active Pending
- 1996-07-09 BR BR9609330A patent/BR9609330A/pt active Search and Examination
- 1996-07-09 ES ES96927006T patent/ES2156287T3/es not_active Expired - Lifetime
- 1996-07-09 PL PL96324451A patent/PL183837B1/pl unknown
- 1996-07-09 EP EP96927006A patent/EP0842170B1/en not_active Expired - Lifetime
- 1996-07-09 US US08/983,059 patent/US5935974A/en not_active Expired - Fee Related
- 1996-07-09 HU HU9802762A patent/HUP9802762A3/hu unknown
- 1996-07-09 WO PCT/EP1996/003099 patent/WO1997003065A1/en not_active Application Discontinuation
- 1996-07-09 CZ CZ199883A patent/CZ288909B6/cs not_active IP Right Cessation
- 1996-07-09 NZ NZ315318A patent/NZ315318A/en unknown
- 1996-07-09 PT PT96927006T patent/PT842170E/pt unknown
- 1996-07-09 DE DE69611788T patent/DE69611788T2/de not_active Expired - Fee Related
- 1996-07-09 DK DK96927006T patent/DK0842170T3/da active
- 1996-07-09 CA CA002226851A patent/CA2226851A1/en not_active Abandoned
- 1996-07-09 TR TR1998/00027T patent/TR199800027T1/xx unknown
- 1996-07-09 RU RU98102392/04A patent/RU2162846C2/ru not_active IP Right Cessation
- 1996-07-09 AU AU66993/96A patent/AU699370B2/en not_active Ceased
- 1996-07-12 AR ARP960103567A patent/AR003966A1/es active IP Right Grant
- 1996-07-29 TW TW085109218A patent/TW419477B/zh not_active IP Right Cessation
-
1998
- 1998-01-09 NO NO980109A patent/NO309765B1/no unknown
- 1998-11-13 HK HK98111967A patent/HK1010818A1/xx not_active IP Right Cessation
-
2001
- 2001-05-11 GR GR20010400699T patent/GR3035849T3/el not_active IP Right Cessation
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