RU98102392A - Производные дифенилметиленпиперидина - Google Patents
Производные дифенилметиленпиперидинаInfo
- Publication number
- RU98102392A RU98102392A RU98102392/04A RU98102392A RU98102392A RU 98102392 A RU98102392 A RU 98102392A RU 98102392/04 A RU98102392/04 A RU 98102392/04A RU 98102392 A RU98102392 A RU 98102392A RU 98102392 A RU98102392 A RU 98102392A
- Authority
- RU
- Russia
- Prior art keywords
- piperidine
- diphenylmethylene
- derivative
- diphenylmethylene piperidine
- pharmaceutically acceptable
- Prior art date
Links
- ZFDDWBKSMIWSBN-UHFFFAOYSA-N 2-benzhydrylidenepiperidine Chemical class N1CCCCC1=C(C=1C=CC=CC=1)C1=CC=CC=C1 ZFDDWBKSMIWSBN-UHFFFAOYSA-N 0.000 title claims 8
- 150000003839 salts Chemical class 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 206010061920 Psychotic disease Diseases 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 2
- CLASDMKBOIFHNY-UHFFFAOYSA-N 2-methylidenepiperidine Chemical compound C=C1CCCCN1 CLASDMKBOIFHNY-UHFFFAOYSA-N 0.000 claims 1
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- 239000003210 dopamine receptor blocking agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Claims (7)
1. Производное дифенилметиленпиперидина формулы
где n равно 1 или 2, или его фармацевтически приемлемая соль.
где n равно 1 или 2, или его фармацевтически приемлемая соль.
2. Производное дифенилметиленпиперидина по п. 1, в котором оба атома фтора находятся в пара-положении бензольных колец.
3. Производное дифенилметиленпиперидина по п. 1 или 2, имеющее формулу
или его фармацевтически приемлемая соль.
или его фармацевтически приемлемая соль.
4. Производное дифенилметиленпиперидина по любому из пп. 1-3 для применения в терапии, в особенности для применения в качестве антагониста допамина для лечения или профилактики психотических расстройств.
5. Фармацевтическая композиция, содержащая производное дифенилметиленпиперидина по любому из пп. 1-3 и фармацевтически приемлемые добавки.
6. Способ получения производного дифенилметиленпиперидина по любому из пп. 1-3, в котором проводят конденсацию 4-бис(2-, 3- или 4-фторфенил)метиленпиперидина или его соли с 1-(4-гало-1-оксобутил)пирролидином (n = 1) или с 1-(4-гало-1-оксобутил)пиперидином (n = 2), где гало представляет подходящий атом галогена, такой как хлор, бром или иод, после чего полученное соединение необязательно превращают в фармацевтически приемлемую соль.
7. Применение производного дифенилметиленпиперидина по любому из пп. 1-3 для производства медикамента для лечения или профилактики психотических расстройств.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95201910 | 1995-07-12 | ||
| EP95201910.7 | 1995-07-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU98102392A true RU98102392A (ru) | 1999-12-20 |
| RU2162846C2 RU2162846C2 (ru) | 2001-02-10 |
Family
ID=8220478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU98102392/04A RU2162846C2 (ru) | 1995-07-12 | 1996-07-09 | Производные дифенилметиленпиперидина или их фармацевтически приемлемые соли, способ их получения и фармацевтическая композиция |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5935974A (ru) |
| EP (1) | EP0842170B1 (ru) |
| JP (1) | JPH11508907A (ru) |
| KR (1) | KR19990028807A (ru) |
| CN (1) | CN1091108C (ru) |
| AR (1) | AR003966A1 (ru) |
| AT (1) | ATE199150T1 (ru) |
| AU (1) | AU699370B2 (ru) |
| BR (1) | BR9609330A (ru) |
| CA (1) | CA2226851A1 (ru) |
| CZ (1) | CZ288909B6 (ru) |
| DE (1) | DE69611788T2 (ru) |
| DK (1) | DK0842170T3 (ru) |
| ES (1) | ES2156287T3 (ru) |
| GR (1) | GR3035849T3 (ru) |
| HK (1) | HK1010818A1 (ru) |
| HU (1) | HUP9802762A3 (ru) |
| IL (1) | IL118768A (ru) |
| NO (1) | NO309765B1 (ru) |
| NZ (1) | NZ315318A (ru) |
| PL (1) | PL183837B1 (ru) |
| PT (1) | PT842170E (ru) |
| RU (1) | RU2162846C2 (ru) |
| TR (1) | TR199800027T1 (ru) |
| TW (1) | TW419477B (ru) |
| WO (1) | WO1997003065A1 (ru) |
| ZA (1) | ZA965691B (ru) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2198172C2 (ru) * | 1997-10-07 | 2003-02-10 | Акцо Нобель Н.В. | Замещенные производные пиперидина и фармацевтическая композиция |
| AU2517499A (en) * | 1998-01-09 | 1999-07-26 | Akzo Nobel N.V. | Use of diphenylmethylene piperidine derivatives in the manufacture of a medicament for the treatment of movement disorders |
| WO1999034801A1 (en) * | 1998-01-09 | 1999-07-15 | Akzo Nobel N.V. | Use of diphenylmethylene piperidine derivatives in the manufacture of a medicament for the treatment of depression |
| AU5473400A (en) | 1999-06-11 | 2001-01-02 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| US6358979B1 (en) | 1999-06-11 | 2002-03-19 | Merck & Co., Inc. | N-cyclopentyl modulators of chemokine receptor activity |
| WO2000076513A1 (en) | 1999-06-11 | 2000-12-21 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| WO2000076514A1 (en) | 1999-06-11 | 2000-12-21 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| AU5328500A (en) * | 1999-06-11 | 2001-01-02 | Merck & Co., Inc. | N-cyclopentyl modulators of chemokine receptor activity |
| AU5469400A (en) | 1999-06-11 | 2001-01-02 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| KR20010113007A (ko) * | 2000-06-15 | 2001-12-24 | 주정호 | 항암제로서 유용한 ｎ-치환된 피페리디닐우레아 유도체 및그의 제조방법 |
| TW200303304A (en) * | 2002-02-18 | 2003-09-01 | Astrazeneca Ab | Chemical compounds |
| US6770659B2 (en) * | 2002-08-26 | 2004-08-03 | Sk Corporation | Benzoyl piperidine compounds |
| MXPA05006427A (es) * | 2002-12-18 | 2005-09-08 | Fmc Corp | Piperidinas y piridinas (arilmetilo sustituido)-n-4-(metilo disustituido). |
| SE0400208D0 (sv) * | 2004-02-02 | 2004-02-02 | Astrazeneca Ab | Chemical compounds |
| TW200812582A (en) * | 2006-04-06 | 2008-03-16 | Astrazeneca Ab | Medicaments |
| SG11201701315VA (en) | 2014-08-28 | 2017-03-30 | Asceneuron Sa | Glycosidase inhibitors |
| EP3389658B1 (en) * | 2015-12-18 | 2020-11-25 | Merck Sharp & Dohme Corp. | Glycosidase inhibitors and uses thereof |
| CA3012624A1 (en) | 2016-02-25 | 2017-08-31 | Asceneuron S.A. | Glycosidase inhibitors |
| US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
| KR20180132060A (ko) | 2016-02-25 | 2018-12-11 | 아셰뉴론 에스아 | 피페라진 유도체의 산 부가 염 |
| CN108884077A (zh) | 2016-02-25 | 2018-11-23 | 阿森纽荣股份公司 | 糖苷酶抑制剂 |
| EP3672959A1 (en) | 2017-08-24 | 2020-07-01 | Asceneuron SA | Linear glycosidase inhibitors |
| WO2020039028A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Tetrahydro-benzoazepine glycosidase inhibitors |
| US11731972B2 (en) | 2018-08-22 | 2023-08-22 | Asceneuron Sa | Spiro compounds as glycosidase inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US450780A (en) * | 1891-04-21 | Steam-engine | ||
| US4180583A (en) * | 1972-01-28 | 1979-12-25 | Richardson-Merrell Inc. | Olefinic 4-substituted piperidino derivatives as therapeutics |
| US3922276A (en) * | 1974-12-11 | 1975-11-25 | Robins Co Inc A H | 1-Substituted-4-benzylidenepiperidines |
| US4666905A (en) * | 1983-06-02 | 1987-05-19 | Warner-Lambert Company | Diphenylmethylene piperidines compositions and methods for their use |
| US4540780A (en) * | 1983-06-02 | 1985-09-10 | Warner-Lambert Company | Diphenylmethylene piperidines |
-
1996
- 1996-07-01 IL IL11876896A patent/IL118768A/xx not_active IP Right Cessation
- 1996-07-04 ZA ZA965691A patent/ZA965691B/xx unknown
- 1996-07-09 ES ES96927006T patent/ES2156287T3/es not_active Expired - Lifetime
- 1996-07-09 CN CN96195461A patent/CN1091108C/zh not_active Expired - Fee Related
- 1996-07-09 TR TR1998/00027T patent/TR199800027T1/xx unknown
- 1996-07-09 DK DK96927006T patent/DK0842170T3/da active
- 1996-07-09 JP JP9505516A patent/JPH11508907A/ja active Pending
- 1996-07-09 US US08/983,059 patent/US5935974A/en not_active Expired - Fee Related
- 1996-07-09 PT PT96927006T patent/PT842170E/pt unknown
- 1996-07-09 CZ CZ199883A patent/CZ288909B6/cs not_active IP Right Cessation
- 1996-07-09 PL PL96324451A patent/PL183837B1/pl unknown
- 1996-07-09 BR BR9609330A patent/BR9609330A/pt active Search and Examination
- 1996-07-09 KR KR1019980700107A patent/KR19990028807A/ko not_active Application Discontinuation
- 1996-07-09 NZ NZ315318A patent/NZ315318A/en unknown
- 1996-07-09 EP EP96927006A patent/EP0842170B1/en not_active Expired - Lifetime
- 1996-07-09 HU HU9802762A patent/HUP9802762A3/hu unknown
- 1996-07-09 AU AU66993/96A patent/AU699370B2/en not_active Ceased
- 1996-07-09 CA CA002226851A patent/CA2226851A1/en not_active Abandoned
- 1996-07-09 DE DE69611788T patent/DE69611788T2/de not_active Expired - Fee Related
- 1996-07-09 AT AT96927006T patent/ATE199150T1/de not_active IP Right Cessation
- 1996-07-09 WO PCT/EP1996/003099 patent/WO1997003065A1/en not_active Application Discontinuation
- 1996-07-09 RU RU98102392/04A patent/RU2162846C2/ru not_active IP Right Cessation
- 1996-07-12 AR ARP960103567A patent/AR003966A1/es active IP Right Grant
- 1996-07-29 TW TW085109218A patent/TW419477B/zh not_active IP Right Cessation
-
1998
- 1998-01-09 NO NO980109A patent/NO309765B1/no unknown
- 1998-11-13 HK HK98111967A patent/HK1010818A1/xx not_active IP Right Cessation
-
2001
- 2001-05-11 GR GR20010400699T patent/GR3035849T3/el not_active IP Right Cessation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU98102392A (ru) | Производные дифенилметиленпиперидина | |
| BR0210122A (pt) | Composto ou um sal farmaceuticamente aceitável do mesmo, método para o tratamento ou prevenção de uma doença, uso do composto ou de seu sal, e, método para preparar o mesmo | |
| ES2160949T3 (es) | Derivados de fenilen-sulfonamida sustituidos en meta. | |
| NO950774L (no) | Fremgangsmåte for inhibering av bentap og nedsettelse av serumkolesterol | |
| ES8505519A1 (es) | Un procedimiento para la preparacion de 14-fluoromorfinanos utiles como analgesicos, narcoticos y-o agentes anorexicos. | |
| RU93058555A (ru) | Производные хинуклидина, способ их получения, фармацевтическая композиция, способ лечения или профилактики | |
| BR0213242A (pt) | Composto ou um seu sal ou solvato, composto e seus sais de adição de ácido fisiologicamente aceitáveis, composição farmacêutica, método de tratamento de um ou mais distúrbios, uso de um composto, e, processo de preparação de um composto | |
| NO20045434L (no) | En kombinasjon av en NMDA-antagonist og acetylkolinesteraseinhibitorer for behandlingen av Alzheimers sykdom | |
| EA200400589A1 (ru) | Высокоселективные ингибиторы обратного захвата норэпинефрина и способы их применения | |
| RU96119781A (ru) | Применение 2-фенил-3-ароилбензотиофенов для снижения уровня холестерина в сыворотке, фармацевтическая композиция | |
| BR0209468A (pt) | Composto ou sais ou solvatos deste farmaceuticamente aceitáveis, composição farmacêutica, uso de um composto, e, método de tratamento de uma doença ou condição mediada pelo hppar | |
| KR950016745A (ko) | 생리증상의 치료방법 및 이를 위한 조성물 | |
| AR021355A1 (es) | Derivados de quinolina. procedimiento para su preparacion, composicion farmaceutica que los comprende, y el uso de los mismos para la fabricacion de unmedicamento | |
| NO306345B1 (no) | Piperidin-derivater med PAF antagonist-aktivitet, anvendelse derav og farmasöytisk blanding | |
| NO304113B1 (no) | Krystallinsk tiagabinhydrokloridmonohydrat, farmas°ytisk preparat som omfatter det, og anvendelse derav for fremstilling av et medikament | |
| BRPI0411936A (pt) | composto, processo para a sua preparação, composição farmacêutica que comprende o mesmo, utilização de um composto, métodos para o tratamento e profilaxia de distúrbios do sistema nervoso central, alimentares e obesidade | |
| RU2003118411A (ru) | Кристаллические производные 1-метилкарбапенема | |
| PT97395A (pt) | Processo para a preparacao de 2,9-di-substituidas-4h-pirido{1,2-a}-pirimidin-4-onas e de composicoes farmaceuticas que os contem | |
| ES2154669T3 (es) | Uso de 2-fenil-3-aroilbenzotiofenos para la preparacion de un medicamento para la inhibicion de la degradacion del cartilago. | |
| DK0669912T3 (da) | N-(3-Piperidinylcarbonyl)-beta-alaninderivater som PAF-antagonister | |
| RU92016595A (ru) | Замещенные тиазолильные и замещенные пиридинильные производные, фармацевтическая композиция и способ их получения | |
| DE3483798D1 (de) | Dihydrodibenzocycloheptylidenethylamin-derivate. | |
| DE60035429D1 (de) | Verwendung von sulfodehydroabietinsäure zur behandlung entzündlicher darmerkrankungen | |
| DE69315699T2 (de) | Inhibitoren gegen die aggregation von blutplättchen | |
| IS3659A7 (is) | Ný aðferð við að framleiða útskipt 4-fenýl-4-píperídínkarboxamíð sem hefur bæði staðbundin deyfandi og kvalastillandi áhrif |