US6228879B1
(en)
*
|
1997-10-16 |
2001-05-08 |
The Children's Medical Center |
Methods and compositions for inhibition of angiogenesis
|
US6429221B1
(en)
|
1994-12-30 |
2002-08-06 |
Celgene Corporation |
Substituted imides
|
HU228769B1
(en)
*
|
1996-07-24 |
2013-05-28 |
Celgene Corp |
Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
|
US5635517B1
(en)
*
|
1996-07-24 |
1999-06-29 |
Celgene Corp |
Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
|
US7629360B2
(en)
*
|
1999-05-07 |
2009-12-08 |
Celgene Corporation |
Methods for the treatment of cachexia and graft v. host disease
|
US6458810B1
(en)
|
2000-11-14 |
2002-10-01 |
George Muller |
Pharmaceutically active isoindoline derivatives
|
DE60130799T2
(de)
*
|
2000-11-30 |
2008-07-17 |
Children's Medical Center Corp., Boston |
Synthese von 4-aminothalidomid enantiomeren
|
US20030045552A1
(en)
*
|
2000-12-27 |
2003-03-06 |
Robarge Michael J. |
Isoindole-imide compounds, compositions, and uses thereof
|
DE10137163A1
(de)
*
|
2001-07-30 |
2003-02-13 |
Bayer Ag |
Substituierte Isoindole und ihre Verwendung
|
ATE428419T1
(de)
*
|
2001-08-06 |
2009-05-15 |
Childrens Medical Center |
Antiangiogenese wirkung von stickstoffsubstituierten thalidomid-analoga
|
EP2317307B1
(en)
|
2002-02-14 |
2013-11-20 |
Ajinomoto Co., Inc. |
Method of analyzing amino- and/or imino-functional compounds, and analytical reagent
|
US7498171B2
(en)
|
2002-04-12 |
2009-03-03 |
Anthrogenesis Corporation |
Modulation of stem and progenitor cell differentiation, assays, and uses thereof
|
US20050148034A1
(en)
*
|
2002-04-12 |
2005-07-07 |
Hariri Robert J. |
Methods for identification of modulators of angiogenesis, compounds discovered thereby, and methods of treatment using the compounds
|
KR100822149B1
(ko)
*
|
2002-05-17 |
2008-04-15 |
셀진 코포레이션 |
암 및 기타 질병의 치료 및 관리를 위해 면역 조절화합물을 이용하는 방법 및 조성물
|
AU2006202316B2
(en)
*
|
2002-05-17 |
2008-04-10 |
Celgene Corporation |
Methods and compositions using immunomodulatory compounds for treatment and management of cancers and other diseases
|
USRE48890E1
(en)
|
2002-05-17 |
2022-01-11 |
Celgene Corporation |
Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation
|
US7968569B2
(en)
|
2002-05-17 |
2011-06-28 |
Celgene Corporation |
Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
|
US7393862B2
(en)
|
2002-05-17 |
2008-07-01 |
Celgene Corporation |
Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
|
US7323479B2
(en)
*
|
2002-05-17 |
2008-01-29 |
Celgene Corporation |
Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
|
US8404716B2
(en)
|
2002-10-15 |
2013-03-26 |
Celgene Corporation |
Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
|
EP1900369A1
(en)
|
2002-10-15 |
2008-03-19 |
Celgene Corporation |
Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of myelodysplastic syndromes
|
US11116782B2
(en)
|
2002-10-15 |
2021-09-14 |
Celgene Corporation |
Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
|
US7189740B2
(en)
*
|
2002-10-15 |
2007-03-13 |
Celgene Corporation |
Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes
|
US8404717B2
(en)
*
|
2002-10-15 |
2013-03-26 |
Celgene Corporation |
Methods of treating myelodysplastic syndromes using lenalidomide
|
US20050203142A1
(en)
*
|
2002-10-24 |
2005-09-15 |
Zeldis Jerome B. |
Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
|
NZ540028A
(en)
*
|
2002-10-24 |
2009-07-31 |
Celgene Corp |
Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
|
US8034831B2
(en)
|
2002-11-06 |
2011-10-11 |
Celgene Corporation |
Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
|
US7563810B2
(en)
*
|
2002-11-06 |
2009-07-21 |
Celgene Corporation |
Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
|
AU2003298775B2
(en)
*
|
2002-11-26 |
2008-07-17 |
Anthrogenesis Corporation |
Cytotherapeutics, cytotherapeutic units and methods for treatments using them
|
KR20050100615A
(ko)
*
|
2003-01-14 |
2005-10-19 |
싸이토키네틱스, 인코포레이티드 |
화합물, 조성물 및 방법
|
CA2515594A1
(en)
*
|
2003-02-13 |
2004-08-26 |
Anthrogenesis Corporation |
Use of umbilical cord blood to treat individuals having a disease, disorder or condition
|
US7320992B2
(en)
*
|
2003-08-25 |
2008-01-22 |
Amgen Inc. |
Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
|
UA83504C2
(en)
*
|
2003-09-04 |
2008-07-25 |
Селджин Корпорейшн |
Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
|
EP1663223B1
(en)
*
|
2003-09-17 |
2014-01-01 |
The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services |
Thalidomide analogs as tnf-alpha modulators
|
US8952895B2
(en)
|
2011-06-03 |
2015-02-10 |
Apple Inc. |
Motion-based device operations
|
US7612096B2
(en)
*
|
2003-10-23 |
2009-11-03 |
Celgene Corporation |
Methods for treatment, modification and management of radiculopathy using 1-oxo-2-(2,6-dioxopiperidin-3yl)-4-aminoisoindoline
|
US20050100529A1
(en)
*
|
2003-11-06 |
2005-05-12 |
Zeldis Jerome B. |
Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders
|
BRPI0416275A
(pt)
*
|
2003-11-06 |
2007-01-23 |
Celgene Corp |
métodos de tratar, controlar ou prevenir um cáncer especìfico e uma doença associada com angiogênese indesejada
|
AU2004296765B2
(en)
*
|
2003-12-02 |
2011-03-24 |
Celgene Corporation |
Methods and compositions for the treatment and management of hemoglobinopathy and anemia
|
US20050143344A1
(en)
*
|
2003-12-30 |
2005-06-30 |
Zeldis Jerome B. |
Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases
|
EP2505200A1
(en)
*
|
2004-03-22 |
2012-10-03 |
Celgene Corporation |
Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of scleroderma
|
US20050222209A1
(en)
*
|
2004-04-01 |
2005-10-06 |
Zeldis Jerome B |
Methods and compositions for the treatment, prevention or management of dysfunctional sleep and dysfunctional sleep associated with disease
|
US20080199422A1
(en)
*
|
2004-04-14 |
2008-08-21 |
Celgene Corporation |
Method for the Treatment of Myelodysplastic Syndromes Using 1-Oxo-2-(2,6-Dioxopiperidin-3-Yl-)-4-Methylisoindoline
|
ZA200609226B
(en)
*
|
2004-04-23 |
2008-06-25 |
Celgene Corp |
Methods of using and compositions comprising immuno-modulatory compounds for the treatment and management of pulmonary hypertension
|
JP2005336157A
(ja)
*
|
2004-04-30 |
2005-12-08 |
Arigen Inc |
光学活性サリドマイドおよびその誘導体の製造法
|
BRPI0418798A
(pt)
*
|
2004-05-05 |
2007-10-16 |
Celgene Corp |
métodos de tratamento ou prevenção, e de controle, de uma doença mieloproliferativa, de redução ou prevenção de um efeito adverso, de aumento da eficácia terapêutica de um tratamento de doença mieloproliferativa, composição farmacêutica, e, kit
|
WO2006009726A2
(en)
|
2004-06-17 |
2006-01-26 |
Cytokinetics, Inc. |
Substituted urea derivatives for treating cardiac diseases
|
US7176222B2
(en)
|
2004-07-27 |
2007-02-13 |
Cytokinetics, Inc. |
Syntheses of ureas
|
EP2479172B1
(en)
*
|
2004-09-03 |
2013-10-09 |
Celgene Corporation |
Processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines
|
CA2585423A1
(en)
*
|
2004-10-28 |
2006-05-11 |
Celgene Corporation |
Methods and compositions using pde4 modulators for treatment and management of central nervous system injury
|
CN101098694A
(zh)
*
|
2004-11-12 |
2008-01-02 |
细胞基因公司 |
使用免疫调节化合物治疗和控制寄生性疾病的方法和组合物
|
AU2005309733A1
(en)
*
|
2004-11-23 |
2006-06-01 |
Celgene Corporation |
Methods and compositions using immunomodulatory compounds for treatment and management of central nervous system injury
|
US20060270707A1
(en)
*
|
2005-05-24 |
2006-11-30 |
Zeldis Jerome B |
Methods and compositions using 4-[(cyclopropanecarbonylamino)methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione for the treatment or prevention of cutaneous lupus
|
WO2007005807A2
(en)
*
|
2005-06-30 |
2007-01-11 |
Anthrogenesis Corporation |
Repair of tympanic membrane using placenta derived collagen biofabric
|
EP2380887B1
(en)
*
|
2005-06-30 |
2013-08-07 |
Celgene Corporation |
Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds
|
US7928280B2
(en)
*
|
2005-07-13 |
2011-04-19 |
Anthrogenesis Corporation |
Treatment of leg ulcers using placenta derived collagen biofabric
|
EP1919365A2
(en)
*
|
2005-07-13 |
2008-05-14 |
Anthrogenesis Corporation |
Ocular plug formed from placenta derived collagen biofabric
|
US7538223B2
(en)
|
2005-08-04 |
2009-05-26 |
Cytokinetics, Inc. |
Compounds, compositions and methods
|
JP5578785B2
(ja)
*
|
2005-08-31 |
2014-08-27 |
セルジーン コーポレイション |
イソインドール−イミド化合物及びそれを含有する組成物及びそれの使用法
|
SI1928492T1
(sl)
*
|
2005-09-01 |
2011-09-30 |
Celgene Corp |
Imunoloĺ ka uporaba imunomodulatornih spojin za cepivo in protiinfekcijsko bolezensko terapijo
|
US20070066512A1
(en)
|
2005-09-12 |
2007-03-22 |
Dominique Verhelle |
Methods and compositions using immunomodulatory compounds for the treatment of disorders associated with low plasma leptin levels
|
CN1939922B
(zh)
*
|
2005-09-27 |
2010-10-13 |
天津和美生物技术有限公司 |
可抑制细胞释放肿瘤坏死因子的5H-噻吩[3,4-c]吡咯-4,6-二酮衍生物
|
PE20070771A1
(es)
*
|
2005-10-13 |
2007-08-11 |
Anthrogenesis Corp |
Inmunomodulacion mediante el uso de celulas madres de la placenta
|
JP5301284B2
(ja)
*
|
2005-12-15 |
2013-09-25 |
サイトキネティクス・インコーポレーテッド |
特定の化学物質、組成物および方法
|
US20070197505A1
(en)
*
|
2005-12-15 |
2007-08-23 |
Morgan Bradley P |
Certain chemical entities, compositions and methods
|
US7825120B2
(en)
*
|
2005-12-15 |
2010-11-02 |
Cytokinetics, Inc. |
Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
|
US20070208000A1
(en)
*
|
2005-12-15 |
2007-09-06 |
Morgan Bradley P |
Certain chemical entities, compositions and methods
|
US7718657B2
(en)
*
|
2005-12-16 |
2010-05-18 |
Cytokinetics, Inc. |
Certain indanyl urea modulators of the cardiac sarcomere
|
WO2007078839A2
(en)
*
|
2005-12-19 |
2007-07-12 |
Cytokinetics, Inc. |
Compounds, compositions and methods
|
US20070155791A1
(en)
*
|
2005-12-29 |
2007-07-05 |
Zeldis Jerome B |
Methods for treating cutaneous lupus using aminoisoindoline compounds
|
KR20080097190A
(ko)
|
2005-12-29 |
2008-11-04 |
안트로제네시스 코포레이션 |
태반 줄기세포의 수집과 보존을 위한 개선된 조성물과 이조성물의 이용 방법
|
ES2671355T3
(es)
|
2005-12-29 |
2018-06-06 |
Anthrogenesis Corporation |
Poblaciones de células madre placentarias
|
US8247582B2
(en)
*
|
2006-02-07 |
2012-08-21 |
Battelle Memorial Institute |
Esters of 5-hydroxymethylfurfural and methods for their preparation
|
US20080064876A1
(en)
*
|
2006-05-16 |
2008-03-13 |
Muller George W |
Process for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
|
TW200806625A
(en)
*
|
2006-05-26 |
2008-02-01 |
Astrazeneca Ab |
Therapeutic compounds
|
EP2049119A2
(en)
*
|
2006-06-29 |
2009-04-22 |
Astex Therapeutics Limited |
Pharmaceutical combinations of 1-cyclopropyl-3-[3-(5-morphoolin-4-ylmethyl-1h-benzoimidazol-2-yl)-1h-1-pyrazol-4-yl]-urea
|
CL2007002218A1
(es)
*
|
2006-08-03 |
2008-03-14 |
Celgene Corp Soc Organizada Ba |
Uso de 3-(4-amino-1-oxo-1,3-dihidro-isoindol-2-il)-piperidina 2,6-diona para la preparacion de un medicamento util para el tratamiento de linfoma de celula de capa.
|
US7993918B2
(en)
|
2006-08-04 |
2011-08-09 |
Anthrogenesis Corporation |
Tumor suppression using placental stem cells
|
US8105634B2
(en)
*
|
2006-08-15 |
2012-01-31 |
Anthrogenesis Corporation |
Umbilical cord biomaterial for medical use
|
AU2007290407A1
(en)
*
|
2006-08-30 |
2008-03-06 |
Celgene Corporation |
5-substituted isoindoline compounds
|
RU2448101C2
(ru)
*
|
2006-08-30 |
2012-04-20 |
Селджин Корпорейшн |
5-замещенные изоиндолиновые соединения
|
US8877780B2
(en)
*
|
2006-08-30 |
2014-11-04 |
Celgene Corporation |
5-substituted isoindoline compounds
|
CA2663376C
(en)
*
|
2006-09-15 |
2015-01-06 |
Celgene Corporation |
N-methylaminomethyl isoindole compounds and compositions comprising and methods of using the same
|
US20080131522A1
(en)
*
|
2006-10-03 |
2008-06-05 |
Qing Liu |
Use of placental biomaterial for ocular surgery
|
WO2008060377A2
(en)
|
2006-10-04 |
2008-05-22 |
Anthrogenesis Corporation |
Placental or umbilical cord tissue compositions
|
ZA200902485B
(en)
|
2006-10-06 |
2010-07-28 |
Anthrogenesis Corp |
Native (telopeptide) placental collagen compositions
|
CA2677397C
(en)
|
2007-02-12 |
2016-04-05 |
Anthrogenesis Corporation |
Treatment of inflammatory diseases using placental stem cells
|
CN101688177A
(zh)
*
|
2007-02-12 |
2010-03-31 |
人类起源公司 |
来自贴壁胎盘干细胞的肝细胞和软骨细胞;以及cd34+、cd45-胎盘干细胞富集的细胞群
|
CA2681633C
(en)
*
|
2007-03-20 |
2018-01-09 |
Celgene Corporation |
4'-o-substituted isoindoline derivatives and compositions comprising and methods of using the same
|
US20100172830A1
(en)
*
|
2007-03-29 |
2010-07-08 |
Cellx Inc. |
Extraembryonic Tissue cells and method of use thereof
|
US7893045B2
(en)
|
2007-08-07 |
2011-02-22 |
Celgene Corporation |
Methods for treating lymphomas in certain patient populations and screening patients for said therapy
|
NZ584425A
(en)
|
2007-09-26 |
2012-03-30 |
Celgene Corp |
6-, 7-, or 8-substituted quinazolinone derivatives and compositions comprising and methods of using the same
|
KR101645311B1
(ko)
*
|
2007-09-26 |
2016-08-03 |
안트로제네시스 코포레이션 |
인간 태반 관류액으로부터의 혈관형성 세포
|
KR20190132556A
(ko)
|
2007-09-28 |
2019-11-27 |
안트로제네시스 코포레이션 |
인간 태반 관류액 및 인간 태반-유래 중간체 천연 킬러 세포를 사용한 종양 억제 방법
|
CN101909694A
(zh)
*
|
2007-11-07 |
2010-12-08 |
人类起源公司 |
脐带血在治疗早产并发症中的用途
|
EP2219627A2
(en)
*
|
2007-11-08 |
2010-08-25 |
Celgene Corporation |
Use of immunomodulatory compounds for the treatment of disorders associated with endothelial dysfunction
|
WO2009073146A2
(en)
*
|
2007-11-29 |
2009-06-11 |
Celgene Corporation |
Use of immunomodulatory compounds for the treatment of transverse myelitis, multiple sclerosis, and other disorders
|
US7964354B2
(en)
*
|
2007-12-20 |
2011-06-21 |
Celgene Corporation |
Use of micro-RNA as a biomarker of immunomodulatory drug activity
|
CN101977603A
(zh)
*
|
2008-01-29 |
2011-02-16 |
细胞基因公司 |
使用免疫调节化合物来调节cd59水平的方法
|
WO2009105256A2
(en)
*
|
2008-02-20 |
2009-08-27 |
Celgene Corporation |
Method of treating cancer by administering an immunomodulatory compound in combination with a cd40 antibody or cd40 ligand
|
PE20110400A1
(es)
*
|
2008-08-20 |
2011-06-22 |
Anthrogenesis Corp |
Composiciones mejoradas de celulas y metodos para preparar las mismas
|
WO2010021715A1
(en)
*
|
2008-08-20 |
2010-02-25 |
Anthrogenesis Corporation |
Treatment of stroke using isolated placental cells
|
CA2965883C
(en)
*
|
2008-08-22 |
2020-05-12 |
Anthrogenesis Corporation |
Methods and compositions for treatment of bone defects with placental cell populations
|
SI2358697T1
(sl)
|
2008-10-29 |
2016-02-29 |
Celgene Corporation |
Spojine izoindolina za uporabo pri zdravljenju raka
|
KR20110086176A
(ko)
*
|
2008-11-19 |
2011-07-27 |
안트로제네시스 코포레이션 |
양막 유래 부착성 세포
|
BRPI0921999B8
(pt)
*
|
2008-11-21 |
2021-05-25 |
Anthrogenesis Corp |
uso de uma quantidade terapeuticamente eficaz de células tronco placentárias
|
US20110319411A1
(en)
*
|
2008-12-08 |
2011-12-29 |
Sirtis Pharmaceuticals, Inc. |
Isoindolinone and related analogs as sirtuin modulators
|
RU2742171C2
(ru)
|
2009-03-25 |
2021-02-02 |
Антродженезис Корпорейшн |
Супрессия опухолей с использованием полученных из плаценты человека промежуточных естественных киллерных клеток и иммуномодулирующих соединений
|
EP2436387B1
(en)
|
2009-05-25 |
2018-07-25 |
Celgene Corporation |
Pharmaceutical composition comprising crbn for use in treating a disease of the cerebral cortex
|
CN101580501B
(zh)
|
2009-06-01 |
2011-03-09 |
南京卡文迪许生物工程技术有限公司 |
3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮的合成方法及其中间体
|
WO2011084968A1
(en)
|
2010-01-05 |
2011-07-14 |
Celgene Corporation |
A combination of an immunomodulatory compound and an artemisinin or a derivative thereof for treating cancer
|
WO2011094181A1
(en)
*
|
2010-01-26 |
2011-08-04 |
Anthrogenesis Corporation |
Treatment of bone-related cancers using placental stem cells
|
WO2011100380A1
(en)
|
2010-02-11 |
2011-08-18 |
Celgene Corporation |
Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
|
JP6097684B2
(ja)
|
2010-04-07 |
2017-03-15 |
アントフロゲネシス コーポレーション |
胎盤幹細胞を用いる血管形成
|
JP5937060B2
(ja)
|
2010-04-07 |
2016-06-22 |
セルジーン コーポレイション |
呼吸器ウイルス感染症の治療方法
|
JP2013523823A
(ja)
|
2010-04-08 |
2013-06-17 |
アントフロゲネシス コーポレーション |
胎盤幹細胞を用いるサルコイドーシスの治療
|
CN103097520B
(zh)
|
2010-07-13 |
2017-12-05 |
人类起源公司 |
产生自然杀伤细胞的方法
|
US20140031325A1
(en)
|
2010-12-06 |
2014-01-30 |
Celgene Corporation |
Combination therapy with lenalidomide and a cdk inhibitor for treating multiple myeloma
|
US8969315B2
(en)
|
2010-12-31 |
2015-03-03 |
Anthrogenesis Corporation |
Enhancement of placental stem cell potency using modulatory RNA molecules
|
SI2683708T1
(en)
|
2011-03-11 |
2018-05-31 |
Celgene Corporation |
3- (5-AMINO-2-METHYL-4-OXO-4H-QUINASOLIN-3-YL) -PYPERIDIN-2,6-DION, AND THEIR PHARMACEUTICAL COMPOSITION AND TYPES OF USE
|
US9090585B2
(en)
|
2011-03-28 |
2015-07-28 |
Deuterx, Llc |
2,6-dioxo-3-deutero-piperdin-3-yl-isoindoline compounds
|
WO2012145309A1
(en)
|
2011-04-18 |
2012-10-26 |
Celgene Corporation |
Biomarkers for the treatment of multiple myeloma
|
CA2834535A1
(en)
|
2011-04-29 |
2012-11-01 |
Celgene Corporation |
Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
|
EP2714059B1
(en)
|
2011-06-01 |
2018-10-03 |
Celularity, Inc. |
Treatment of pain using placental stem cells
|
US8927725B2
(en)
|
2011-12-02 |
2015-01-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Thio compounds
|
KR20150029678A
(ko)
|
2012-06-06 |
2015-03-18 |
바이오노르 이뮤노 에이에스 |
백신
|
WO2014004990A2
(en)
|
2012-06-29 |
2014-01-03 |
Celgene Corporation |
Methods for determining drug efficacy using cereblon-associated proteins
|
US9587281B2
(en)
|
2012-08-14 |
2017-03-07 |
Celgene Corporation |
Cereblon isoforms and their use as biomarkers for therapeutic treatment
|
AU2013204922B2
(en)
|
2012-12-20 |
2015-05-14 |
Celgene Corporation |
Chimeric antigen receptors
|
WO2014110558A1
(en)
|
2013-01-14 |
2014-07-17 |
Deuterx, Llc |
3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives
|
EP3622960A1
(en)
|
2013-02-05 |
2020-03-18 |
Celularity, Inc. |
Natural killer cells from placenta
|
WO2014152833A1
(en)
|
2013-03-14 |
2014-09-25 |
Deuterx, Llc |
3-(substituted-4-oxo-quinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives
|
AU2014240083C1
(en)
|
2013-03-15 |
2019-10-24 |
Celgene Corporation |
Modified T lymphocytes
|
WO2015007337A1
(en)
|
2013-07-19 |
2015-01-22 |
Bionor Immuno As |
Method for the vaccination against hiv
|
CN103396397A
(zh)
*
|
2013-08-14 |
2013-11-20 |
中国人民解放军军事医学科学院毒物药物研究所 |
来那度胺衍生物及其作为药物的用途
|
CN103421061A
(zh)
*
|
2013-08-14 |
2013-12-04 |
中国药科大学 |
来那度胺衍生物、其制法及其医药用途
|
JP2017501145A
(ja)
*
|
2013-12-23 |
2017-01-12 |
ノージン ビーブイ |
Ccr9調節因子として有用な化合物
|
RU2020139890A
(ru)
*
|
2014-04-14 |
2022-01-18 |
Арвинас Оперэйшнз, Инк. |
Имидные модуляторы протеолиза и способы их применения
|
US10092555B2
(en)
|
2014-06-27 |
2018-10-09 |
Celgene Corporation |
Compositions and methods for inducing conformational changes in cereblon and other E3 ubiquitin ligases
|
EP3166633A1
(en)
|
2014-07-11 |
2017-05-17 |
Bionor Immuno AS |
Method for reducing and/or delaying pathological effects of human immunodeficiency virus i (hiv) or for reducing the risk of developing acquired immunodeficiency syndrome (aids)
|
WO2016029004A1
(en)
|
2014-08-22 |
2016-02-25 |
Celgene Corporation |
Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies
|
KR102191256B1
(ko)
*
|
2014-10-30 |
2020-12-15 |
강푸 바이오파마슈티칼즈 리미티드 |
이소인돌린 유도체, 이의 중간체, 제조방법, 약물 조성물 및 응용
|
WO2016105518A1
(en)
|
2014-12-23 |
2016-06-30 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
US9694084B2
(en)
|
2014-12-23 |
2017-07-04 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
BR112017015497A2
(pt)
|
2015-01-20 |
2018-01-30 |
Arvinas, Inc. |
composto, e, composição
|
US20170327469A1
(en)
|
2015-01-20 |
2017-11-16 |
Arvinas, Inc. |
Compounds and methods for the targeted degradation of androgen receptor
|
JP2018515603A
(ja)
|
2015-05-04 |
2018-06-14 |
ビオノル・イムノ・アクシェセルスカプBionor Immuno AS |
Hivワクチン用の投薬レジメン
|
WO2016197114A1
(en)
|
2015-06-05 |
2016-12-08 |
Arvinas, Inc. |
Tank-binding kinase-1 protacs and associated methods of use
|
US10001483B2
(en)
|
2015-06-26 |
2018-06-19 |
Celgene Corporation |
Methods for the treatment of Kaposi's sarcoma or KSHV-induced lymphoma using immunomodulatory compounds, and uses of biomarkers
|
US9809603B1
(en)
|
2015-08-18 |
2017-11-07 |
Deuterx, Llc |
Deuterium-enriched isoindolinonyl-piperidinonyl conjugates and oxoquinazolin-3(4H)-yl-piperidinonyl conjugates and methods of treating medical disorders using same
|
EP3337476A4
(en)
|
2015-08-19 |
2019-09-04 |
Arvinas, Inc. |
COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF PROTEINS CONTAINING BROMODOMAIN
|
BR112018006025B1
(pt)
*
|
2015-09-29 |
2023-12-05 |
Kangpu Biopharmaceuticals, Ltd |
Composição farmacêutica e aplicação da mesma
|
WO2017117118A1
(en)
|
2015-12-28 |
2017-07-06 |
Celgene Corporation |
Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases
|
EP3440082A1
(en)
*
|
2016-04-06 |
2019-02-13 |
The Regents of The University of Michigan |
Monofunctional intermediates for ligand-dependent target protein degradation
|
MX2018012174A
(es)
*
|
2016-04-06 |
2019-07-08 |
Univ Michigan Regents |
Degradantes de proteina homologa de proteina murina de cromosoma diminuto doble (mdm2).
|
JP7072519B2
(ja)
*
|
2016-04-12 |
2022-05-20 |
ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン |
Betタンパク質分解剤
|
CN109562107A
(zh)
|
2016-05-10 |
2019-04-02 |
C4医药公司 |
用于靶蛋白降解的杂环降解决定子体
|
EP3454862A4
(en)
|
2016-05-10 |
2020-02-12 |
C4 Therapeutics, Inc. |
SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN REDUCTION
|
WO2017197046A1
(en)
|
2016-05-10 |
2017-11-16 |
C4 Therapeutics, Inc. |
C3-carbon linked glutarimide degronimers for target protein degradation
|
FI3660004T3
(fi)
|
2016-10-11 |
2023-05-04 |
Arvinas Operations Inc |
Yhdisteitä ja menetelmiä androgeenireseptorin kohdennettuun hajotukseen
|
KR102570992B1
(ko)
|
2016-11-01 |
2023-08-28 |
아비나스 오퍼레이션스, 인코포레이티드 |
타우(Tau)-단백질 표적화 프로탁(PROTAC) 및 관련 사용 방법
|
BR112019011200B1
(pt)
|
2016-12-01 |
2021-12-28 |
Arvinas Operations, Inc |
Derivados de tetrahidronaftaleno e tetrahidroisoquinolina como degradadores do receptor de estrogênio
|
WO2018102786A1
(en)
|
2016-12-03 |
2018-06-07 |
Juno Therapeutics, Inc. |
Methods for modulation of car-t cells
|
KR20190104528A
(ko)
|
2016-12-03 |
2019-09-10 |
주노 쎄러퓨티크스 인코퍼레이티드 |
Car-t 세포들 투여를 결정하는 방법
|
EP3527210B1
(en)
|
2016-12-16 |
2021-06-09 |
Kangpu Biopharmaceuticals, Ltd. |
Combined composition comprising a benzoheterocyclic compound and an androgen receptor pathway modulator and uses thereof
|
US10806737B2
(en)
|
2016-12-23 |
2020-10-20 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of fetal liver kinase polypeptides
|
WO2018119448A1
(en)
|
2016-12-23 |
2018-06-28 |
Arvinas, Inc. |
Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides
|
WO2018119441A1
(en)
|
2016-12-23 |
2018-06-28 |
Arvinas, Inc. |
Egfr proteolysis targeting chimeric molecules and associated methods of use
|
US11191741B2
(en)
|
2016-12-24 |
2021-12-07 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide
|
BR112019015312A2
(pt)
|
2017-01-26 |
2020-03-10 |
Arvinas Operations, Inc. |
Moduladores da proteólise pelo receptor de estrogênio e métodos de uso associados
|
ES2899372T3
(es)
*
|
2017-02-13 |
2022-03-11 |
Kangpu Biopharmaceuticals Ltd |
Combinación de tratamiento del cáncer de próstata, composición farmacéutica y método de tratamiento
|
WO2018204427A1
(en)
|
2017-05-01 |
2018-11-08 |
Juno Therapeutics, Inc. |
Combination of a cell therapy and an immunomodulatory compound
|
US10093647B1
(en)
|
2017-05-26 |
2018-10-09 |
Celgene Corporation |
Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione dihydrate, compositions and methods of use thereof
|
AU2018275894A1
(en)
|
2017-06-02 |
2019-12-12 |
Juno Therapeutics, Inc. |
Articles of manufacture and methods for treatment using adoptive cell therapy
|
EP3641762A4
(en)
|
2017-06-20 |
2021-03-10 |
C4 Therapeutics, Inc. |
N / O BONDED DEGRONS AND DEGRONIMERS FOR PROTEIN DEGRADATION
|
EP3644721A1
(en)
|
2017-06-29 |
2020-05-06 |
Juno Therapeutics, Inc. |
Mouse model for assessing toxicities associated with immunotherapies
|
CN109422751B
(zh)
*
|
2017-09-03 |
2022-04-22 |
上海美志医药科技有限公司 |
一类具有降解酪氨酸蛋白激酶jak3活性的化合物
|
CN118108706A
(zh)
|
2017-09-04 |
2024-05-31 |
C4医药公司 |
戊二酰亚胺
|
CN118206529A
(zh)
|
2017-09-04 |
2024-06-18 |
C4医药公司 |
二氢苯并咪唑酮
|
EP3679028A1
(en)
|
2017-09-04 |
2020-07-15 |
C4 Therapeutics, Inc. |
Dihydroquinolinones
|
US10093648B1
(en)
|
2017-09-22 |
2018-10-09 |
Celgene Corporation |
Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione hemihydrate, compositions and methods of use thereof
|
US10093649B1
(en)
|
2017-09-22 |
2018-10-09 |
Celgene Corporation |
Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione monohydrate, compositions and methods of use thereof
|
WO2019067792A1
(en)
|
2017-09-28 |
2019-04-04 |
Celularity, Inc. |
TUMOR CONTROL WITH INTERMEDIATE NATURAL KILLER CELLS DERIVED FROM HUMAN PLACENTA (PINK) IN COMBINATION WITH ANTIBODY
|
WO2019089858A2
(en)
|
2017-11-01 |
2019-05-09 |
Juno Therapeutics, Inc. |
Methods of assessing or monitoring a response to a cell therapy
|
KR20200074997A
(ko)
|
2017-11-01 |
2020-06-25 |
주노 쎄러퓨티크스 인코퍼레이티드 |
B-세포 성숙 항원에 특이적인 항체 및 키메릭 항원 수용체
|
WO2019099868A2
(en)
|
2017-11-16 |
2019-05-23 |
C4 Therapeutics, Inc. |
Degraders and degrons for targeted protein degradation
|
WO2019099926A1
(en)
|
2017-11-17 |
2019-05-23 |
Arvinas, Inc. |
Compounds and methods for the targeted degradation of interleukin-1 receptor-associated kinase 4 polypeptides
|
US20210198372A1
(en)
|
2017-12-01 |
2021-07-01 |
Juno Therapeutics, Inc. |
Methods for dosing and for modulation of genetically engineered cells
|
CN112204048A
(zh)
|
2017-12-15 |
2021-01-08 |
朱诺治疗学股份有限公司 |
抗cct5结合分子及其使用方法
|
HUE063099T2
(hu)
|
2018-01-25 |
2023-12-28 |
Fujimoto Co Ltd |
Tiofénszármazék és alkalmazása
|
JP2021512153A
(ja)
|
2018-01-26 |
2021-05-13 |
イエール ユニバーシティ |
タンパク質分解のイミド系モジュレーターおよび使用方法
|
EP3755718A1
(en)
|
2018-02-21 |
2020-12-30 |
Celgene Corporation |
Bcma-binding antibodies and uses thereof
|
JP2021519337A
(ja)
|
2018-03-26 |
2021-08-10 |
シー4 セラピューティクス, インコーポレイテッド |
Ikarosの分解のためのセレブロン結合剤
|
BR112020020307A2
(pt)
|
2018-04-04 |
2021-01-12 |
Arvinas Operations, Inc. |
Moduladores de proteólise e métodos de uso associados
|
CN112312904A
(zh)
|
2018-04-16 |
2021-02-02 |
C4医药公司 |
螺环化合物
|
HUE064340T2
(hu)
|
2018-04-23 |
2024-03-28 |
Celgene Corp |
Szubsztituált 4-aminoizoindolin-1,3-dion-származékok és alkalmazásuk limfóma kezelésére
|
EP3578561A1
(en)
|
2018-06-04 |
2019-12-11 |
F. Hoffmann-La Roche AG |
Spiro compounds
|
US11530219B2
(en)
|
2018-06-29 |
2022-12-20 |
Dana-Farber Cancer Institute, Inc. |
Ligands to cereblon (CRBN)
|
WO2020051235A1
(en)
*
|
2018-09-04 |
2020-03-12 |
C4 Therapeutics, Inc. |
Compounds for the degradation of brd9 or mth1
|
CN113573719A
(zh)
|
2018-11-08 |
2021-10-29 |
朱诺治疗学股份有限公司 |
治疗和t细胞调节的方法和组合
|
CN113423701A
(zh)
*
|
2018-11-13 |
2021-09-21 |
拜欧斯瑞克斯公司 |
取代的异吲哚啉酮
|
JP2022513062A
(ja)
|
2018-11-16 |
2022-02-07 |
ジュノー セラピューティクス インコーポレイテッド |
B細胞悪性腫瘍を処置するために、操作されたt細胞を投薬する方法
|
EP3886875B1
(en)
|
2018-11-30 |
2024-05-08 |
Juno Therapeutics, Inc. |
Methods for treatment using adoptive cell therapy
|
CN109293631B
(zh)
*
|
2018-11-30 |
2020-05-08 |
常州制药厂有限公司 |
3-氨基-n-(2,6-二氧代-3-哌啶基)-邻苯二甲酰亚胺化合物的制备方法
|
CA3123303A1
(en)
|
2019-01-29 |
2020-08-06 |
Juno Therapeutics, Inc. |
Antibodies and chimeric antigen receptors specific for receptor tyrosine kinase like orphan receptor 1 (ror1)
|
WO2020227183A1
(en)
*
|
2019-05-03 |
2020-11-12 |
Dynamic Biologics Inc. |
Lenalidomide prodrugs, polymeric conjugates, and formulations thereof, and their uses for the treatment of multiple myeloma
|
CN114502543A
(zh)
|
2019-05-24 |
2022-05-13 |
拜欧斯瑞克斯公司 |
靶向蛋白化合物、其药物组合物及治疗应用
|
WO2020243379A1
(en)
|
2019-05-31 |
2020-12-03 |
Celgene Corporation |
Substituted 1-oxo-isoindoline-5-carboxamide compounds, compositions thereof, and methods of treatment therewith
|
EP4041231A1
(en)
*
|
2019-10-09 |
2022-08-17 |
Monte Rosa Therapeutics AG |
Isoindolinone compounds
|
MX2022005839A
(es)
|
2019-11-19 |
2022-06-09 |
Bristol Myers Squibb Co |
Compuestos utiles como inhibidores de la proteina helios.
|
CN118059104A
(zh)
|
2019-12-19 |
2024-05-24 |
阿尔维纳斯运营股份有限公司 |
用于雄激素受体的靶向降解的化合物和方法
|
JP2024504932A
(ja)
|
2021-01-13 |
2024-02-02 |
モンテ ローザ セラピューティクス, インコーポレイテッド |
イソインドリノン化合物
|
CN112876414B
(zh)
*
|
2021-01-29 |
2022-09-09 |
河南大学 |
一种基于多胺修饰的萘酰亚胺缀合物、其制备方法及应用
|
EP4313047A1
(en)
*
|
2021-03-22 |
2024-02-07 |
Monte Rosa Therapeutics, Inc. |
Pharmaceutical compositions for use in the prevention and treatment of a disease or disorder caused by or associated with one or more premature termination codons
|
AR125298A1
(es)
|
2021-04-06 |
2023-07-05 |
Bristol Myers Squibb Co |
Compuestos de oxoisoindolina sustituidos con piridinilo
|
WO2022236339A1
(en)
*
|
2021-05-07 |
2022-11-10 |
Kymera Therapeutics, Inc. |
Deuterated irak degraders and uses thereof
|
CN115504963A
(zh)
*
|
2021-06-22 |
2022-12-23 |
苏州开拓药业股份有限公司 |
一种c-Myc蛋白降解剂
|
WO2023081224A1
(en)
*
|
2021-11-03 |
2023-05-11 |
St. Jude Children's Research Hospital, Inc. |
Substituted n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4- yl)methyl)benzamide analogs as modulators of cereblon protein
|
CN114656374A
(zh)
*
|
2022-02-22 |
2022-06-24 |
营口兴福化工有限公司 |
2,4-二氯-3-氰基-5-氟苯甲酸合成方法
|
WO2023250400A1
(en)
|
2022-06-22 |
2023-12-28 |
Juno Therapeutics, Inc. |
Treatment methods for second line therapy of cd19-targeted car t cells
|
KR20240001072A
(ko)
*
|
2022-06-24 |
2024-01-03 |
주식회사 아이비스바이오 |
신규한 포말리도마이드 유도체 및 이의 제조방법
|
US11957759B1
(en)
|
2022-09-07 |
2024-04-16 |
Arvinas Operations, Inc. |
Rapidly accelerated fibrosarcoma (RAF) degrading compounds and associated methods of use
|
WO2024097905A1
(en)
|
2022-11-02 |
2024-05-10 |
Celgene Corporation |
Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy
|
KR20240066904A
(ko)
*
|
2022-11-08 |
2024-05-16 |
주식회사 온코드바이오 |
아릴시클로알킬아마이드 구조를 갖는 이소인돌리논 유도체 및 이의 용도
|