US6228879B1
(en)
*
|
1997-10-16 |
2001-05-08 |
The Children's Medical Center |
Methods and compositions for inhibition of angiogenesis
|
US6429221B1
(en)
|
1994-12-30 |
2002-08-06 |
Celgene Corporation |
Substituted imides
|
HU228769B1
(en)
*
|
1996-07-24 |
2013-05-28 |
Celgene Corp |
Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
|
US5635517B1
(en)
*
|
1996-07-24 |
1999-06-29 |
Celgene Corp |
Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
|
US7629360B2
(en)
*
|
1999-05-07 |
2009-12-08 |
Celgene Corporation |
Methods for the treatment of cachexia and graft v. host disease
|
US6458810B1
(en)
|
2000-11-14 |
2002-10-01 |
George Muller |
Pharmaceutically active isoindoline derivatives
|
PT1353672E
(pt)
*
|
2000-11-30 |
2008-01-11 |
Childrens Medical Center |
Síntese da 4-amino talidomida enantiómeros
|
US20030045552A1
(en)
*
|
2000-12-27 |
2003-03-06 |
Robarge Michael J. |
Isoindole-imide compounds, compositions, and uses thereof
|
DE10137163A1
(de)
*
|
2001-07-30 |
2003-02-13 |
Bayer Ag |
Substituierte Isoindole und ihre Verwendung
|
WO2003014315A2
(en)
*
|
2001-08-06 |
2003-02-20 |
The Children's Medical Center Corporation |
Synthesis and anti-tumor activity of nitrogen substituted thalidomide analogs
|
WO2003069328A1
(fr)
|
2002-02-14 |
2003-08-21 |
Ajinomoto Co., Inc. |
Procede d'analyse aminofonctionnelle et reactif analytique
|
US7498171B2
(en)
|
2002-04-12 |
2009-03-03 |
Anthrogenesis Corporation |
Modulation of stem and progenitor cell differentiation, assays, and uses thereof
|
EP1496878A4
(en)
*
|
2002-04-12 |
2007-12-26 |
Celgene Corp |
TECHNIQUES FOR IDENTIFYING ANGIOGENESIS MODULATORS, COMPOUNDS DISCOVERED BY THESE TECHNIQUES AND TREATMENT TECHNIQUES USING THESE COMPOUNDS
|
US7323479B2
(en)
*
|
2002-05-17 |
2008-01-29 |
Celgene Corporation |
Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
|
USRE48890E1
(en)
|
2002-05-17 |
2022-01-11 |
Celgene Corporation |
Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation
|
US7393862B2
(en)
|
2002-05-17 |
2008-07-01 |
Celgene Corporation |
Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
|
US7968569B2
(en)
|
2002-05-17 |
2011-06-28 |
Celgene Corporation |
Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
|
AU2006202316B2
(en)
*
|
2002-05-17 |
2008-04-10 |
Celgene Corporation |
Methods and compositions using immunomodulatory compounds for treatment and management of cancers and other diseases
|
DE60331537D1
(de)
|
2002-05-17 |
2010-04-15 |
Celgene Corp |
Kombinationen zur behandlung von multiplem myelom
|
US7189740B2
(en)
*
|
2002-10-15 |
2007-03-13 |
Celgene Corporation |
Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes
|
US11116782B2
(en)
|
2002-10-15 |
2021-09-14 |
Celgene Corporation |
Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
|
US8404717B2
(en)
*
|
2002-10-15 |
2013-03-26 |
Celgene Corporation |
Methods of treating myelodysplastic syndromes using lenalidomide
|
US8404716B2
(en)
|
2002-10-15 |
2013-03-26 |
Celgene Corporation |
Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
|
EP1900369A1
(en)
|
2002-10-15 |
2008-03-19 |
Celgene Corporation |
Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of myelodysplastic syndromes
|
CN101108185A
(zh)
*
|
2002-10-24 |
2008-01-23 |
细胞基因公司 |
用于治疗、改变和控制疼痛的包含免疫调节化合物的组合物
|
US20050203142A1
(en)
*
|
2002-10-24 |
2005-09-15 |
Zeldis Jerome B. |
Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
|
US8034831B2
(en)
|
2002-11-06 |
2011-10-11 |
Celgene Corporation |
Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
|
US7563810B2
(en)
*
|
2002-11-06 |
2009-07-21 |
Celgene Corporation |
Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
|
CN1717177A
(zh)
*
|
2002-11-26 |
2006-01-04 |
人类起源公司 |
细胞治疗剂、细胞治疗单元及其用于治疗的方法
|
ATE552236T1
(de)
*
|
2003-01-14 |
2012-04-15 |
Cytokinetics Inc |
Verbindungen, zusammensetzungen und verfahren zur behandlung von herzinsuffizienz
|
NZ542127A
(en)
*
|
2003-02-13 |
2008-04-30 |
Anthrogenesis Corp |
Use of umbilical cord blood to treat individuals having a disease, disorder or condition
|
US7320992B2
(en)
*
|
2003-08-25 |
2008-01-22 |
Amgen Inc. |
Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
|
UA83504C2
(en)
*
|
2003-09-04 |
2008-07-25 |
Селджин Корпорейшн |
Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
|
US8952895B2
(en)
|
2011-06-03 |
2015-02-10 |
Apple Inc. |
Motion-based device operations
|
JP4943845B2
(ja)
|
2003-09-17 |
2012-05-30 |
ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンティッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ |
サリドマイド類似体
|
US7612096B2
(en)
*
|
2003-10-23 |
2009-11-03 |
Celgene Corporation |
Methods for treatment, modification and management of radiculopathy using 1-oxo-2-(2,6-dioxopiperidin-3yl)-4-aminoisoindoline
|
US20050100529A1
(en)
*
|
2003-11-06 |
2005-05-12 |
Zeldis Jerome B. |
Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders
|
BRPI0416275A
(pt)
*
|
2003-11-06 |
2007-01-23 |
Celgene Corp |
métodos de tratar, controlar ou prevenir um cáncer especìfico e uma doença associada com angiogênese indesejada
|
NZ548049A
(en)
*
|
2003-12-02 |
2009-01-31 |
Celgene Corp |
Methods and compositions for the treatment and management of hemoglobinopathy and anemia
|
US20050143344A1
(en)
*
|
2003-12-30 |
2005-06-30 |
Zeldis Jerome B. |
Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases
|
MXPA06010699A
(es)
*
|
2004-03-22 |
2006-12-15 |
Celgene Corp |
Metodos de usos y composiciones que contienen compuestos inmunomoduladores para el tratamiento y manejo de enfermedades o alteraciones de la piel.
|
US20050222209A1
(en)
*
|
2004-04-01 |
2005-10-06 |
Zeldis Jerome B |
Methods and compositions for the treatment, prevention or management of dysfunctional sleep and dysfunctional sleep associated with disease
|
MXPA06011798A
(es)
*
|
2004-04-14 |
2007-01-16 |
Celgene Corp |
Metodos de uso y composiciones que comprenden compuestos inmunomoduladores para el tratamiento y manejo de sindromes mielodisplasticos.
|
CA2563810A1
(en)
*
|
2004-04-23 |
2005-11-10 |
Celgene Corporation |
Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of pulmonary hypertension
|
JP2005336157A
(ja)
*
|
2004-04-30 |
2005-12-08 |
Arigen Inc |
光学活性サリドマイドおよびその誘導体の製造法
|
EP1746995A4
(en)
*
|
2004-05-05 |
2010-03-31 |
Celgene Corp |
METHOD OF USE AND COMPOSITIONS COMPRISING IMMUNOMODULATORY COMPOUNDS FOR THE TREATMENT AND MANAGEMENT OF MYELOPROLIFERATIVE DISEASES
|
PL1765327T3
(pl)
*
|
2004-06-17 |
2015-01-30 |
Cytokinetics Inc |
Związki, kompozycje i sposoby
|
US7176222B2
(en)
|
2004-07-27 |
2007-02-13 |
Cytokinetics, Inc. |
Syntheses of ureas
|
EP1797068B1
(en)
*
|
2004-09-03 |
2013-10-09 |
Celgene Corporation |
Processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines
|
MX2007005040A
(es)
*
|
2004-10-28 |
2007-06-19 |
Celgene Corp |
Metodos y composiciones usando moduladores de pde4 para el tratamiento y manejo de lesion al sistema nervioso central.
|
MX2007005570A
(es)
*
|
2004-11-12 |
2007-07-09 |
Celgene Corp |
Metodos y composiciones que usan compuestos inmunomoduladores para el tratamiento y manejo de padecimientos parasiticos.
|
CN101102771A
(zh)
*
|
2004-11-23 |
2008-01-09 |
细胞基因公司 |
用免疫调节化合物治疗和控制中枢神经系统损伤的方法和组合物
|
US20060270707A1
(en)
*
|
2005-05-24 |
2006-11-30 |
Zeldis Jerome B |
Methods and compositions using 4-[(cyclopropanecarbonylamino)methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione for the treatment or prevention of cutaneous lupus
|
US20070038298A1
(en)
*
|
2005-06-30 |
2007-02-15 |
Sulner Joseph W |
Repair of tympanic membrane using placenta derived collagen biofabric
|
WO2007005972A1
(en)
*
|
2005-06-30 |
2007-01-11 |
Celgene Corporation |
Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds
|
WO2007009062A2
(en)
*
|
2005-07-13 |
2007-01-18 |
Anthrogenesis Corporation |
Treatment of leg ulcers using placenta derived collagen biofabric
|
EP1919365A2
(en)
*
|
2005-07-13 |
2008-05-14 |
Anthrogenesis Corporation |
Ocular plug formed from placenta derived collagen biofabric
|
US7538223B2
(en)
|
2005-08-04 |
2009-05-26 |
Cytokinetics, Inc. |
Compounds, compositions and methods
|
MX2008002765A
(es)
*
|
2005-08-31 |
2008-04-07 |
Celgene Corp |
Compuestos de isoindol-imida y composiciones que la comprenden y metodos para usar los mismos.
|
SI1928492T1
(sl)
|
2005-09-01 |
2011-09-30 |
Celgene Corp |
Imunoloĺ ka uporaba imunomodulatornih spojin za cepivo in protiinfekcijsko bolezensko terapijo
|
US20070066512A1
(en)
*
|
2005-09-12 |
2007-03-22 |
Dominique Verhelle |
Methods and compositions using immunomodulatory compounds for the treatment of disorders associated with low plasma leptin levels
|
CN1939922B
(zh)
*
|
2005-09-27 |
2010-10-13 |
天津和美生物技术有限公司 |
可抑制细胞释放肿瘤坏死因子的5H-噻吩[3,4-c]吡咯-4,6-二酮衍生物
|
SI1957633T1
(sl)
|
2005-10-13 |
2014-04-30 |
Anthrogenesis Corporation |
Imunomodulacija z uporabo matičnih celic iz placente
|
TW200808321A
(en)
*
|
2005-12-15 |
2008-02-16 |
Cytokinetics Inc |
Certain chemical entities, compositions and methods
|
US20070208000A1
(en)
*
|
2005-12-15 |
2007-09-06 |
Morgan Bradley P |
Certain chemical entities, compositions and methods
|
WO2007075377A2
(en)
*
|
2005-12-15 |
2007-07-05 |
Cytokinetics, Inc. |
Certain chemical entities, compositions and methods
|
US7825120B2
(en)
*
|
2005-12-15 |
2010-11-02 |
Cytokinetics, Inc. |
Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
|
US7718657B2
(en)
*
|
2005-12-16 |
2010-05-18 |
Cytokinetics, Inc. |
Certain indanyl urea modulators of the cardiac sarcomere
|
EP1962852B1
(en)
*
|
2005-12-19 |
2017-01-25 |
Cytokinetics, Inc. |
Compounds, compositions and methods
|
AU2006332680A1
(en)
*
|
2005-12-29 |
2007-07-12 |
Anthrogenesis Corporation |
Improved composition for collecting and preserving placental stem cells and methods of using the composition
|
CN103525758B
(zh)
|
2005-12-29 |
2018-02-13 |
人类起源公司 |
胎盘干细胞群
|
US20070155791A1
(en)
*
|
2005-12-29 |
2007-07-05 |
Zeldis Jerome B |
Methods for treating cutaneous lupus using aminoisoindoline compounds
|
WO2007092569A1
(en)
*
|
2006-02-07 |
2007-08-16 |
Battelle Memorial Institute |
Esters of 5 -hydroxymethylfurfural and methods for their preparation
|
US20080064876A1
(en)
*
|
2006-05-16 |
2008-03-13 |
Muller George W |
Process for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
|
TW200806625A
(en)
*
|
2006-05-26 |
2008-02-01 |
Astrazeneca Ab |
Therapeutic compounds
|
EP2049119A2
(en)
*
|
2006-06-29 |
2009-04-22 |
Astex Therapeutics Limited |
Pharmaceutical combinations of 1-cyclopropyl-3-[3-(5-morphoolin-4-ylmethyl-1h-benzoimidazol-2-yl)-1h-1-pyrazol-4-yl]-urea
|
CL2007002218A1
(es)
*
|
2006-08-03 |
2008-03-14 |
Celgene Corp Soc Organizada Ba |
Uso de 3-(4-amino-1-oxo-1,3-dihidro-isoindol-2-il)-piperidina 2,6-diona para la preparacion de un medicamento util para el tratamiento de linfoma de celula de capa.
|
US7993918B2
(en)
|
2006-08-04 |
2011-08-09 |
Anthrogenesis Corporation |
Tumor suppression using placental stem cells
|
WO2008021391A1
(en)
*
|
2006-08-15 |
2008-02-21 |
Anthrogenesis Corporation |
Umbilical cord biomaterial for medical use
|
US8877780B2
(en)
*
|
2006-08-30 |
2014-11-04 |
Celgene Corporation |
5-substituted isoindoline compounds
|
RU2448101C2
(ru)
*
|
2006-08-30 |
2012-04-20 |
Селджин Корпорейшн |
5-замещенные изоиндолиновые соединения
|
MX2009001989A
(es)
*
|
2006-08-30 |
2009-03-09 |
Celgene Corp |
Compuestos de isoindolina 5-substituidos.
|
JP5567339B2
(ja)
*
|
2006-09-15 |
2014-08-06 |
セルジーン コーポレイション |
N−メチルアミノメチルイソインドール化合物、それを含む組成物、及びその使用方法
|
US20080131522A1
(en)
*
|
2006-10-03 |
2008-06-05 |
Qing Liu |
Use of placental biomaterial for ocular surgery
|
US8071135B2
(en)
|
2006-10-04 |
2011-12-06 |
Anthrogenesis Corporation |
Placental tissue compositions
|
ES2516698T3
(es)
|
2006-10-06 |
2014-10-31 |
Anthrogenesis Corporation |
Composiciones de colágeno placentario (telopéptido) nativo
|
WO2008100498A2
(en)
|
2007-02-12 |
2008-08-21 |
Anthrogenesis Corporation |
Treatment of inflammatory diseases using placental stem cells
|
KR20090109127A
(ko)
*
|
2007-02-12 |
2009-10-19 |
안트로제네시스 코포레이션 |
부착성 태반 줄기세포에서 유래한 간세포와 연골세포 및 cd34+, cd45- 태반 줄기세포가 농축된 세포군
|
WO2008115516A2
(en)
*
|
2007-03-20 |
2008-09-25 |
Celgene Corporation |
4'-o-substituted isoindoline derivatives and compositions comprising and methods of using the same
|
US20100172830A1
(en)
*
|
2007-03-29 |
2010-07-08 |
Cellx Inc. |
Extraembryonic Tissue cells and method of use thereof
|
US7893045B2
(en)
|
2007-08-07 |
2011-02-22 |
Celgene Corporation |
Methods for treating lymphomas in certain patient populations and screening patients for said therapy
|
CN101952272B
(zh)
|
2007-09-26 |
2014-08-27 |
细胞基因公司 |
6-、7-或8-取代的喹唑啉酮衍生物、含有它的组合物及其使用方法
|
JP5703493B2
(ja)
*
|
2007-09-26 |
2015-04-22 |
アンスロジェネシス コーポレーション |
ヒト胎盤灌流液由来の血管形成細胞
|
AU2008307633C1
(en)
|
2007-09-28 |
2015-04-30 |
Celularity Inc. |
Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
|
KR20210056449A
(ko)
*
|
2007-11-07 |
2021-05-18 |
안트로제네시스 코포레이션 |
조산 합병증의 치료에 있어서의 제대혈의 용도
|
MX2010005009A
(es)
*
|
2007-11-08 |
2010-05-27 |
Celgene Corp |
Uso de compuestos inmunomoduladores para el tratamiento de trastornos asociados con disfunciones endoteliales.
|
US20090155207A1
(en)
*
|
2007-11-29 |
2009-06-18 |
Hariri Robert J |
Use of Immunomodulatory Compounds for the Treatment of Transverse Myelitis, Multiple Sclerosis, and Other Disorders
|
WO2009085234A2
(en)
|
2007-12-20 |
2009-07-09 |
Signal Pharmaceuticals, Inc. |
Use of micro-rna as a biomarker of immunomodulatory drug activity
|
CA2712724A1
(en)
*
|
2008-01-29 |
2009-08-06 |
Celgene Corporation |
Use of lenalidomide or pomalidomide for treating a disease associated with cd59 deficiency
|
US20090232796A1
(en)
*
|
2008-02-20 |
2009-09-17 |
Corral Laura G |
Method of treating cancer by administering an immunomodulatory compound in combination with a cd40 antibody or cd40 ligand
|
EP3539380A3
(en)
*
|
2008-08-20 |
2019-12-18 |
Celularity, Inc. |
Improved cell composition and methods of making the same
|
CA2734237C
(en)
*
|
2008-08-20 |
2019-07-02 |
Anthrogenesis Corporation |
Treatment of stroke using isolated placental cells
|
US8728805B2
(en)
*
|
2008-08-22 |
2014-05-20 |
Anthrogenesis Corporation |
Methods and compositions for treatment of bone defects with placental cell populations
|
RU2527952C2
(ru)
|
2008-10-29 |
2014-09-10 |
Селджин Корпорейшн |
Изоиндолиновые соединения для применения при лечении рака
|
RU2562154C2
(ru)
|
2008-11-19 |
2015-09-10 |
Антродженезис Корпорейшн |
Амниотические адгезивные клетки
|
DK2375907T3
(da)
*
|
2008-11-21 |
2019-06-11 |
Celularity Inc |
Behandling af sygdomme, lidelser eller tilstande i lungerne under anvendelse af placentaceller
|
US20110319411A1
(en)
*
|
2008-12-08 |
2011-12-29 |
Sirtis Pharmaceuticals, Inc. |
Isoindolinone and related analogs as sirtuin modulators
|
EP3489352A1
(en)
|
2009-03-25 |
2019-05-29 |
Celularity, Inc. |
Tumor suppression using human placenta-derived intermediate natural killer cells and immunomodulatory compounds
|
EP2436387B1
(en)
|
2009-05-25 |
2018-07-25 |
Celgene Corporation |
Pharmaceutical composition comprising crbn for use in treating a disease of the cerebral cortex
|
CN101580501B
(zh)
|
2009-06-01 |
2011-03-09 |
南京卡文迪许生物工程技术有限公司 |
3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮的合成方法及其中间体
|
EP2851070A1
(en)
|
2010-01-05 |
2015-03-25 |
Celgene Corporation |
A combination of lenalidomide and artesunate/artemisone for treating cancer
|
CA2787992A1
(en)
*
|
2010-01-26 |
2011-08-04 |
Anthrogenesis Corporation |
Treatment of bone-related cancers using placental stem cells
|
RU2567753C2
(ru)
|
2010-02-11 |
2015-11-10 |
Селджин Корпорейшн |
Производные арилметокси изоиндолина и композиции, включающие их, и способы их применения
|
WO2011127117A1
(en)
|
2010-04-07 |
2011-10-13 |
Anthrogenesis Corporation |
Angiogenesis using placental stem cells
|
EP2555769B1
(en)
|
2010-04-07 |
2022-01-12 |
Amgen (Europe) GmbH |
Methods for treating respiratory viral infection
|
CA2795401A1
(en)
|
2010-04-08 |
2011-10-13 |
Anthrogenesis Corporation |
Treatment of sarcoidosis using placental stem cells
|
KR20210063457A
(ko)
|
2010-07-13 |
2021-06-01 |
안트로제네시스 코포레이션 |
천연 킬러 세포의 생성 방법
|
WO2012078492A1
(en)
|
2010-12-06 |
2012-06-14 |
Celgene Corporation |
A combination therapy with lenalidomide and a cdk inhibitor for treating multiple myeloma
|
EP2658557A1
(en)
|
2010-12-31 |
2013-11-06 |
Anthrogenesis Corporation |
Enhancement of placental stem cell potency using modulatory rna molecules
|
NO2683708T3
(US20030045552A1-20030306-C00032.png)
|
2011-03-11 |
2018-03-31 |
|
|
US9090585B2
(en)
|
2011-03-28 |
2015-07-28 |
Deuterx, Llc |
2,6-dioxo-3-deutero-piperdin-3-yl-isoindoline compounds
|
WO2012145309A1
(en)
|
2011-04-18 |
2012-10-26 |
Celgene Corporation |
Biomarkers for the treatment of multiple myeloma
|
CA2834535A1
(en)
|
2011-04-29 |
2012-11-01 |
Celgene Corporation |
Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
|
EP3443968A1
(en)
|
2011-06-01 |
2019-02-20 |
Celularity, Inc. |
Treatment of pain using placental stem cells
|
US8927725B2
(en)
|
2011-12-02 |
2015-01-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Thio compounds
|
CN104717974A
(zh)
|
2012-06-06 |
2015-06-17 |
比奥诺尔免疫有限公司 |
疫苗
|
ES2872967T3
(es)
|
2012-06-29 |
2021-11-03 |
Celgene Corp |
Métodos para determinar la eficacia de fármacos usando IKZF3 (AIOLOS)
|
US9587281B2
(en)
|
2012-08-14 |
2017-03-07 |
Celgene Corporation |
Cereblon isoforms and their use as biomarkers for therapeutic treatment
|
AU2013204922B2
(en)
|
2012-12-20 |
2015-05-14 |
Celgene Corporation |
Chimeric antigen receptors
|
US9540340B2
(en)
|
2013-01-14 |
2017-01-10 |
Deuterx, Llc |
3-(5-substituted-4-oxoquinazolin-3(4H)-yl)-3-deutero-piperidine-2,6-dione derivatives and compositions comprising and methods of using the same
|
EP3622960A1
(en)
|
2013-02-05 |
2020-03-18 |
Celularity, Inc. |
Natural killer cells from placenta
|
AU2014236597A1
(en)
|
2013-03-14 |
2015-09-24 |
Deuterx, Llc |
3-(substituted-4-oxo-quinazolin-3(4H)-yl)-3-deutero-piperidine-2,6-dione derivatives
|
EP2970372B1
(en)
|
2013-03-15 |
2020-09-30 |
Celgene Corporation |
Modified t lymphocytes
|
WO2015007337A1
(en)
|
2013-07-19 |
2015-01-22 |
Bionor Immuno As |
Method for the vaccination against hiv
|
CN103421061A
(zh)
*
|
2013-08-14 |
2013-12-04 |
中国药科大学 |
来那度胺衍生物、其制法及其医药用途
|
CN103396397A
(zh)
*
|
2013-08-14 |
2013-11-20 |
中国人民解放军军事医学科学院毒物药物研究所 |
来那度胺衍生物及其作为药物的用途
|
JP2017501145A
(ja)
*
|
2013-12-23 |
2017-01-12 |
ノージン ビーブイ |
Ccr9調節因子として有用な化合物
|
KR20210132233A
(ko)
*
|
2014-04-14 |
2021-11-03 |
아비나스 오퍼레이션스, 인코포레이티드 |
단백질분해의 이미드-기초된 조절인자 및 연관된 이용 방법
|
EP3160486B1
(en)
|
2014-06-27 |
2020-11-18 |
Celgene Corporation |
Compositions and methods for inducing conformational changes in cereblon other e3 ubiquitin ligases
|
JP2017523166A
(ja)
|
2014-07-11 |
2017-08-17 |
ビオノール イミュノ エーエスBionor Immuno As |
ヒト免疫不全ウイルスi(hiv)の病理学的影響を減少及び/若しくは遅延させるか又は後天性免疫不全症候群(aids)を発症するリスクを低減させる方法
|
BR112017003620A2
(pt)
|
2014-08-22 |
2017-12-05 |
Celgene Corp |
métodos de tratamento de mieloma múltiplo com compostos imunomoduladores em combinação com anticorpos
|
RU2695521C9
(ru)
*
|
2014-10-30 |
2019-08-19 |
Канпу Биофармасьютикалс, Лтд. |
Производное изоиндолина, промежуточный продукт, способ получения, фармацевтическая композиция и ее применение
|
US9694084B2
(en)
|
2014-12-23 |
2017-07-04 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
JP6815318B2
(ja)
*
|
2014-12-23 |
2021-01-20 |
ダナ−ファーバー キャンサー インスティテュート,インコーポレイテッド |
二官能性分子によって標的化タンパク質分解を誘導する方法
|
JP6817962B2
(ja)
|
2015-01-20 |
2021-01-20 |
アルビナス・オペレーションズ・インコーポレイテッドArvinas Operations, Inc. |
ターゲティングされたアンドロゲン受容体分解のための化合物および方法
|
US20170327469A1
(en)
|
2015-01-20 |
2017-11-16 |
Arvinas, Inc. |
Compounds and methods for the targeted degradation of androgen receptor
|
WO2016177833A1
(en)
|
2015-05-04 |
2016-11-10 |
Bionor Immuno As |
Dosage regimen for hiv vaccine
|
EP3302482A4
(en)
|
2015-06-05 |
2018-12-19 |
Arvinas, Inc. |
Tank-binding kinase-1 protacs and associated methods of use
|
JP2018527302A
(ja)
|
2015-06-26 |
2018-09-20 |
セルジーン コーポレイション |
免疫調節化合物を用いたカポジ肉腫またはkshv誘発性リンパ腫の治療方法、及びバイオマーカーの使用
|
US9809603B1
(en)
|
2015-08-18 |
2017-11-07 |
Deuterx, Llc |
Deuterium-enriched isoindolinonyl-piperidinonyl conjugates and oxoquinazolin-3(4H)-yl-piperidinonyl conjugates and methods of treating medical disorders using same
|
US10772962B2
(en)
|
2015-08-19 |
2020-09-15 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of bromodomain-containing proteins
|
NZ742001A
(en)
*
|
2015-09-29 |
2019-06-28 |
Kangpu Biopharmaceuticals Ltd |
Pharmaceutical composition and application thereof comprising a benzoheterocyclic compound
|
US10830762B2
(en)
|
2015-12-28 |
2020-11-10 |
Celgene Corporation |
Compositions and methods for inducing conformational changes in cereblon and other E3 ubiquitin ligases
|
SG11201808728QA
(en)
*
|
2016-04-06 |
2018-11-29 |
Univ Michigan Regents |
Mdm2 protein degraders
|
JP7001614B2
(ja)
*
|
2016-04-06 |
2022-02-03 |
ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン |
リガンド依存性の標的タンパク質分解のための単官能性中間体
|
US10633386B2
(en)
*
|
2016-04-12 |
2020-04-28 |
The Regents Of The University Of Michigan |
BET protein degraders
|
WO2017197055A1
(en)
|
2016-05-10 |
2017-11-16 |
C4 Therapeutics, Inc. |
Heterocyclic degronimers for target protein degradation
|
CN109641874A
(zh)
|
2016-05-10 |
2019-04-16 |
C4医药公司 |
用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
|
EP3454862A4
(en)
|
2016-05-10 |
2020-02-12 |
C4 Therapeutics, Inc. |
SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN REDUCTION
|
SI3660004T1
(sl)
|
2016-10-11 |
2023-08-31 |
Arvinas Operations, Inc. |
Spojine in postopki za ciljno razgradnjo androgenskih receptorjev
|
JP7286539B2
(ja)
|
2016-11-01 |
2023-06-05 |
アルビナス・オペレーションズ・インコーポレイテッド |
タウタンパク質標的化protac、および関連使用方法
|
AU2017366693B2
(en)
|
2016-12-01 |
2021-04-01 |
Arvinas Operations, Inc. |
Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders
|
US20190358262A1
(en)
|
2016-12-03 |
2019-11-28 |
Juno Therapeutics, Inc. |
Methods for modulation of car-t cells
|
EP4279136A3
(en)
|
2016-12-03 |
2024-03-20 |
Juno Therapeutics, Inc. |
Methods for determining car-t cells dosing
|
JP7048106B2
(ja)
|
2016-12-16 |
2022-04-05 |
カンプ・バイオファーマスーティカルズ、リミテッド |
組み合わせ、その用途及び処置方法
|
US10806737B2
(en)
|
2016-12-23 |
2020-10-20 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of fetal liver kinase polypeptides
|
KR20190101406A
(ko)
|
2016-12-23 |
2019-08-30 |
아비나스 오퍼레이션스, 인코포레이티드 |
Egfr 단백질분해 표적화 키메라 분자 및 관련 사용 방법
|
CN117510491A
(zh)
|
2016-12-23 |
2024-02-06 |
阿尔维纳斯运营股份有限公司 |
用于迅速加速性纤维肉瘤多肽的靶向降解的化合物和方法
|
US11191741B2
(en)
|
2016-12-24 |
2021-12-07 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide
|
MX2019008934A
(es)
|
2017-01-26 |
2019-11-05 |
Arvinas Operations Inc |
Moduladores de la proteolisis del receptor de estrogeno y métodos asociados de uso,.
|
JP6773915B2
(ja)
*
|
2017-02-13 |
2020-10-21 |
カング バイオファーマシューティカルズ リミテッド |
前立腺癌を治療する組み合わせ、薬物組成物および治療方法
|
AU2018263887A1
(en)
|
2017-05-01 |
2019-11-21 |
Juno Therapeutics, Inc. |
Combination of a cell therapy and an immunomodulatory compound
|
US10093647B1
(en)
|
2017-05-26 |
2018-10-09 |
Celgene Corporation |
Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione dihydrate, compositions and methods of use thereof
|
JP2020522489A
(ja)
|
2017-06-02 |
2020-07-30 |
ジュノー セラピューティクス インコーポレイテッド |
養子細胞療法を用いる処置のための製造物品および方法
|
CN110769822A
(zh)
|
2017-06-20 |
2020-02-07 |
C4医药公司 |
用于蛋白降解的n/o-连接的降解决定子和降解决定子体
|
WO2019006427A1
(en)
|
2017-06-29 |
2019-01-03 |
Juno Therapeutics, Inc. |
WALL MODEL FOR ASSESSING TOXICITIES ASSOCIATED WITH IMMUNOTHERAPIES
|
CN109422751B
(zh)
*
|
2017-09-03 |
2022-04-22 |
上海美志医药科技有限公司 |
一类具有降解酪氨酸蛋白激酶jak3活性的化合物
|
CN111315735B
(zh)
|
2017-09-04 |
2024-03-08 |
C4医药公司 |
二氢苯并咪唑酮
|
WO2019043208A1
(en)
|
2017-09-04 |
2019-03-07 |
F. Hoffmann-La Roche Ag |
DIHYDROQUINOLINONES
|
WO2019043214A1
(en)
|
2017-09-04 |
2019-03-07 |
F. Hoffmann-La Roche Ag |
glutarimide
|
US10093649B1
(en)
|
2017-09-22 |
2018-10-09 |
Celgene Corporation |
Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione monohydrate, compositions and methods of use thereof
|
US10093648B1
(en)
|
2017-09-22 |
2018-10-09 |
Celgene Corporation |
Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione hemihydrate, compositions and methods of use thereof
|
US20200246393A1
(en)
|
2017-09-28 |
2020-08-06 |
Celularity, Inc. |
Tumor suppression using human placenta-derived intermediate natural killer (pink) cells in combination with an antibody
|
JP7256197B2
(ja)
|
2017-11-01 |
2023-04-11 |
ジュノー セラピューティクス インコーポレイテッド |
B細胞成熟抗原に特異的な抗体およびキメラ抗原受容体
|
WO2019089858A2
(en)
|
2017-11-01 |
2019-05-09 |
Juno Therapeutics, Inc. |
Methods of assessing or monitoring a response to a cell therapy
|
WO2019099868A2
(en)
|
2017-11-16 |
2019-05-23 |
C4 Therapeutics, Inc. |
Degraders and degrons for targeted protein degradation
|
WO2019099926A1
(en)
|
2017-11-17 |
2019-05-23 |
Arvinas, Inc. |
Compounds and methods for the targeted degradation of interleukin-1 receptor-associated kinase 4 polypeptides
|
EP3716980A1
(en)
|
2017-12-01 |
2020-10-07 |
Juno Therapeutics, Inc. |
Methods for dosing and for modulation of genetically engineered cells
|
MA51184A
(fr)
|
2017-12-15 |
2020-10-21 |
Juno Therapeutics Inc |
Molécules de liaison à l'anti-cct5 et procédés d'utilisation associés
|
AU2019211910B2
(en)
*
|
2018-01-25 |
2022-09-22 |
Fujimoto Co., Ltd |
Thiophene derivative and use thereof
|
EP3743066A4
(en)
|
2018-01-26 |
2021-09-08 |
Yale University |
IMIDE BASED MODULATORS OF PROTEOLYSIS AND METHOD OF USE
|
JP2021514193A
(ja)
|
2018-02-21 |
2021-06-10 |
セルジーン コーポレイション |
Bcma結合抗体及びその使用
|
WO2019191112A1
(en)
|
2018-03-26 |
2019-10-03 |
C4 Therapeutics, Inc. |
Cereblon binders for the degradation of ikaros
|
CA3095494C
(en)
|
2018-04-04 |
2023-11-07 |
Arvinas Operations, Inc. |
Modulators of proteolysis and associated methods of use
|
WO2019204354A1
(en)
|
2018-04-16 |
2019-10-24 |
C4 Therapeutics, Inc. |
Spirocyclic compounds
|
CA3096404A1
(en)
|
2018-04-23 |
2019-10-31 |
Celgene Corporation |
Substituted 4-aminoisoindoline-1,3-dione compounds and their use for treating lymphoma
|
EP3578561A1
(en)
|
2018-06-04 |
2019-12-11 |
F. Hoffmann-La Roche AG |
Spiro compounds
|
AU2019294835A1
(en)
*
|
2018-06-29 |
2020-12-17 |
Dana-Farber Cancer Institute, Inc. |
Ligands to cereblon (CRBN)
|
WO2020051235A1
(en)
*
|
2018-09-04 |
2020-03-12 |
C4 Therapeutics, Inc. |
Compounds for the degradation of brd9 or mth1
|
CA3117978A1
(en)
|
2018-11-08 |
2020-05-14 |
Juno Therapeutics, Inc. |
Methods and combinations for treatment and t cell modulation
|
US10844039B2
(en)
*
|
2018-11-13 |
2020-11-24 |
Biotheryx, Inc. |
Substituted isoindolinones
|
AU2019381827A1
(en)
|
2018-11-16 |
2021-06-10 |
Juno Therapeutics, Inc. |
Methods of dosing engineered T cells for the treatment of B cell malignancies
|
JP2022513685A
(ja)
|
2018-11-30 |
2022-02-09 |
ジュノー セラピューティクス インコーポレイテッド |
養子細胞療法を用いた処置のための方法
|
CN109293631B
(zh)
*
|
2018-11-30 |
2020-05-08 |
常州制药厂有限公司 |
3-氨基-n-(2,6-二氧代-3-哌啶基)-邻苯二甲酰亚胺化合物的制备方法
|
CN113365660A
(zh)
|
2019-01-29 |
2021-09-07 |
朱诺治疗学股份有限公司 |
对受体酪氨酸激酶样孤儿受体1(ror1)具特异性的抗体及嵌合抗原受体
|
US20230248696A1
(en)
*
|
2019-05-03 |
2023-08-10 |
Dynamic Biologics Inc. |
Lenalidomide prodrugs, polymeric conjugates, and formulations thereof, and their uses for the treatment of multiple myeloma
|
WO2020242960A1
(en)
*
|
2019-05-24 |
2020-12-03 |
Biotheryx, Inc. |
Compounds targeting proteins and pharmaceutical compositions thereof, and their therapeutic applications
|
PE20220569A1
(es)
|
2019-05-31 |
2022-04-20 |
Celgene Corp |
Compuestos de 1-oxo-isoindolin-5-carboxamida sustituida, composiciones de estos y metodos de tratamiento con dichos compuestos
|
JP2022551185A
(ja)
*
|
2019-10-09 |
2022-12-07 |
モンテ ローザ セラピューティクス アーゲー |
イソインドリノン化合物
|
CN114728950A
(zh)
|
2019-11-19 |
2022-07-08 |
百时美施贵宝公司 |
可作为helios蛋白质抑制剂的化合物
|
CN115175901B
(zh)
|
2019-12-19 |
2024-03-22 |
阿尔维纳斯运营股份有限公司 |
用于雄激素受体的靶向降解的化合物和方法
|
CA3208313A1
(en)
|
2021-01-13 |
2022-07-21 |
Monte Rosa Therapeutics Ag |
Isoindolinone compounds
|
CN112876414B
(zh)
*
|
2021-01-29 |
2022-09-09 |
河南大学 |
一种基于多胺修饰的萘酰亚胺缀合物、其制备方法及应用
|
WO2022200857A1
(en)
*
|
2021-03-22 |
2022-09-29 |
Monte Rosa Therapeutics Ag |
Pharmaceutical compositions for use in the prevention and treatment of a disease or disorder caused by or associated with one or more premature termination codons
|
CA3214244A1
(en)
|
2021-04-06 |
2022-10-13 |
Yan Chen |
Pyridinyl substituted oxoisoindoline compounds
|
WO2022236339A1
(en)
*
|
2021-05-07 |
2022-11-10 |
Kymera Therapeutics, Inc. |
Deuterated irak degraders and uses thereof
|
CN115504963A
(zh)
*
|
2021-06-22 |
2022-12-23 |
苏州开拓药业股份有限公司 |
一种c-Myc蛋白降解剂
|
WO2023081224A1
(en)
*
|
2021-11-03 |
2023-05-11 |
St. Jude Children's Research Hospital, Inc. |
Substituted n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4- yl)methyl)benzamide analogs as modulators of cereblon protein
|
CN114656374A
(zh)
*
|
2022-02-22 |
2022-06-24 |
营口兴福化工有限公司 |
2,4-二氯-3-氰基-5-氟苯甲酸合成方法
|
WO2023250400A1
(en)
|
2022-06-22 |
2023-12-28 |
Juno Therapeutics, Inc. |
Treatment methods for second line therapy of cd19-targeted car t cells
|
KR20240001072A
(ko)
*
|
2022-06-24 |
2024-01-03 |
주식회사 아이비스바이오 |
신규한 포말리도마이드 유도체 및 이의 제조방법
|
WO2024054591A1
(en)
|
2022-09-07 |
2024-03-14 |
Arvinas Operations, Inc. |
Rapidly accelerated fibrosarcoma (raf) degrading compounds and associated methods of use
|
WO2024097905A1
(en)
|
2022-11-02 |
2024-05-10 |
Celgene Corporation |
Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy
|
KR20240066904A
(ko)
*
|
2022-11-08 |
2024-05-16 |
주식회사 온코드바이오 |
아릴시클로알킬아마이드 구조를 갖는 이소인돌리논 유도체 및 이의 용도
|