CS221906B2 - Method of preparation of the 3-/alkylthio,alkylsulphinyl or alkylsulphonyl/-4-chinolone - Google Patents

Method of preparation of the 3-/alkylthio,alkylsulphinyl or alkylsulphonyl/-4-chinolone Download PDF

Info

Publication number
CS221906B2
CS221906B2 CS802156A CS215680A CS221906B2 CS 221906 B2 CS221906 B2 CS 221906B2 CS 802156 A CS802156 A CS 802156A CS 215680 A CS215680 A CS 215680A CS 221906 B2 CS221906 B2 CS 221906B2
Authority
CS
Czechoslovakia
Prior art keywords
hydrogen
formula
alkyl
methyl
compound
Prior art date
Application number
CS802156A
Other languages
Czech (cs)
English (en)
Inventor
Roy V Davies
James Fraser
Kenneth J Nichol
Raymond Parkinson
David B Yates
Original Assignee
Sim Malcolm F
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sim Malcolm F filed Critical Sim Malcolm F
Publication of CS221906B2 publication Critical patent/CS221906B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CS802156A 1979-03-27 1980-03-27 Method of preparation of the 3-/alkylthio,alkylsulphinyl or alkylsulphonyl/-4-chinolone CS221906B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7910558 1979-03-27
GB7939505 1979-11-15

Publications (1)

Publication Number Publication Date
CS221906B2 true CS221906B2 (en) 1983-04-29

Family

ID=26271029

Family Applications (1)

Application Number Title Priority Date Filing Date
CS802156A CS221906B2 (en) 1979-03-27 1980-03-27 Method of preparation of the 3-/alkylthio,alkylsulphinyl or alkylsulphonyl/-4-chinolone

Country Status (34)

Country Link
US (1) US4302460A (fr)
KR (1) KR840001612B1 (fr)
AT (1) AT379390B (fr)
AU (1) AU536616B2 (fr)
BG (2) BG37993A3 (fr)
CA (1) CA1151652A (fr)
CH (1) CH644366A5 (fr)
CS (1) CS221906B2 (fr)
DD (1) DD149608A5 (fr)
DE (2) DE3051205C2 (fr)
DK (1) DK151252C (fr)
EG (1) EG16606A (fr)
FI (1) FI77026C (fr)
FR (2) FR2452484A1 (fr)
GR (1) GR68007B (fr)
HK (1) HK94986A (fr)
HU (1) HU179845B (fr)
IE (1) IE49562B1 (fr)
IL (1) IL59710A (fr)
IT (1) IT1188916B (fr)
KE (1) KE3649D (fr)
LU (1) LU82295A1 (fr)
MX (1) MX6816E (fr)
MY (1) MY8600668A (fr)
NL (1) NL191306C (fr)
NO (1) NO156787C (fr)
NZ (1) NZ193167A (fr)
PH (1) PH16758A (fr)
PL (1) PL124037B1 (fr)
PT (1) PT71006A (fr)
RO (1) RO79397A (fr)
SE (1) SE455422B (fr)
SG (1) SG60886G (fr)
YU (1) YU42332B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE51542B1 (en) * 1980-09-26 1987-01-07 Boots Co Ltd Therapeutic agents
PT79031B (en) * 1983-08-20 1986-08-22 Boots Co Plc Therapeutic agents
US4552884A (en) * 1984-01-13 1985-11-12 The Boots Company Plc Method of treating heart disease
EP0172004B1 (fr) * 1984-08-15 1990-03-21 The Boots Company PLC Quinolinones, procédé pour leur préparation et compositions pharmaceutiques les contenant
GB8515207D0 (en) * 1985-06-15 1985-07-17 Boots Co Plc Therapeutic agents
GB8515209D0 (en) * 1985-06-15 1985-07-17 Boots Co Plc Therapeutic agents
GB8627698D0 (en) * 1986-11-20 1986-12-17 Boots Co Plc Therapeutic agents
GB8726950D0 (en) * 1987-11-18 1987-12-23 Boots Co Plc Chemical process
GB8804016D0 (en) * 1988-02-22 1988-03-23 Boots Co Plc Therapeutic agents
GB8918952D0 (en) * 1989-08-19 1989-10-04 Boots Co Plc Therapeutic agents
FR2680511B1 (fr) * 1991-08-20 1995-05-19 Roussel Uclaf Derives n-substitues de la quinoleine, leur procede de preparation, intermediaires obtenus, leur application comme medicaments et les compositions les renfermant.
IL100555A (en) * 1991-02-07 2000-08-31 Hoechst Marion Roussel Inc N-substituted quinoline derivatives their preparation their use for the preparation of medicaments and the pharmaceutical compositions containing them
FR2684671B1 (fr) * 1991-11-20 1995-05-19 Roussel Uclaf Nouveaux derives de la quinoleine, leur procede de preparation et intermediaires et leur application a titre de medicaments.
FR2672597B1 (fr) * 1991-02-07 1995-05-19 Roussel Uclaf Nouveaux derives n-substitues de la quinoleine, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
WO2000007595A1 (fr) * 1998-08-03 2000-02-17 Basf Corporation Utilisation de pyridinones pour traiter les dysfonctionnements sexuels
US6307050B1 (en) * 2000-08-29 2001-10-23 R. T. Alamo Venture I Llc Method of synthesizing flosequinan from 4-fluoroanthranilic acid
US6562838B2 (en) * 2001-01-26 2003-05-13 R. T. Alamo Ventures I, L.L.C. Treatment of cardiovascular disease with quinolinone enantiomers
US6458804B1 (en) 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US6649764B2 (en) * 2001-10-25 2003-11-18 R. T. Alamo Ventures I, Llc Stereospecific enrichment of heterocyclic enantiomers
US6730790B2 (en) * 2002-03-01 2004-05-04 R.T. Alamo Ventures I. Llc Chlorinated heterocyclic compounds and methods of synthesis

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3178348A (en) * 1961-02-08 1965-04-13 Norwich Pharma Co Hypotensive quinolines
GB1066919A (en) 1964-04-03 1967-04-26 Hoffmann La Roche Novel benzyl amine derivatives
DE1770482A1 (de) * 1968-05-22 1971-11-11 Basf Ag Verfahren zur Herstellung von 2,4-Dioxychinolinen
US3798219A (en) * 1971-10-18 1974-03-19 Warner Lambert Co 3-(methylsulfinyl)cinnolinones and their derivatives
US3772301A (en) * 1971-11-22 1973-11-13 Warner Lambert Co (4-substituted)4-(methylsulfinyl)methylcarbostyrils
CH607848A5 (fr) * 1974-06-04 1978-11-30 Bayer Ag
GB1488411A (en) * 1975-01-16 1977-10-12 Wyeth John & Brother Ltd 3,4-dihydro-4-arylquinolin-4-ol derivatives
US4127574A (en) * 1976-03-01 1978-11-28 Sandoz, Inc. 4-Hydroxy-3-sulfonyl-quinolin-2(1H)-ones
US4124587A (en) * 1976-03-01 1978-11-07 Sandoz, Inc. 4-Hydroxy-3-sulfinyl-quinolin-2(1H)-ones
DE2616991A1 (de) 1976-04-17 1977-10-27 Bayer Ag Heterocyclisch-substituierte schwefelhaltige dihydropyridine, mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2616995A1 (de) 1976-04-17 1977-10-27 Bayer Ag 1.4-dihydropyridine mit schwefelhaltigen substituenten mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2639257A1 (de) 1976-09-01 1978-03-02 Bayer Ag Aminoalkylidenamino-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2639498A1 (de) 1976-09-02 1978-03-09 Bayer Ag Neue schwefelhaltige amino-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2641746C2 (de) 1976-09-16 1986-11-06 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridin-Zuckerderivate, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2658183A1 (de) 1976-12-22 1978-07-06 Bayer Ag In 2-position substituierte 1,4- dihydropyridin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2658804A1 (de) 1976-12-24 1978-07-06 Bayer Ag Kreislaufbeeinflussende mittel
US4177278A (en) * 1977-04-05 1979-12-04 Bayer Aktiengesellschaft 2-Alkyleneaminodihydropyridines compounds, their production and their medicinal use
DE2715182A1 (de) 1977-04-05 1978-10-19 Bayer Ag 2-alkylenaminodihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS5424882A (en) * 1977-07-22 1979-02-24 Yamanouchi Pharmaceut Co Ltd Novel heterocyclic compounds and their preparation
DE2747513A1 (de) 1977-10-22 1979-05-03 Bayer Ag Dihydropyridine mit schwefelhaltigen estergruppierungen

Also Published As

Publication number Publication date
FR2468367B1 (fr) 1983-09-30
DD149608A5 (de) 1981-07-22
KE3649D (en) 1986-08-01
ATA161880A (de) 1985-05-15
NL191306B (nl) 1994-12-16
PH16758A (en) 1984-02-15
AU536616B2 (en) 1984-05-17
YU42332B (en) 1988-08-31
NL8001771A (nl) 1980-09-30
IE49562B1 (en) 1985-10-30
GR68007B (fr) 1981-10-26
LU82295A1 (fr) 1981-04-17
SE8002345L (sv) 1980-11-14
CH644366A5 (fr) 1984-07-31
NO156787B (no) 1987-08-17
YU84980A (en) 1983-09-30
US4302460A (en) 1981-11-24
BG37836A3 (en) 1985-08-15
RO79397A (fr) 1982-06-25
NO800881L (no) 1980-09-29
NO156787C (no) 1987-11-25
IE800567L (en) 1980-09-27
NZ193167A (en) 1984-08-24
IT8048262A0 (it) 1980-03-26
FI77026B (fi) 1988-09-30
HK94986A (en) 1986-12-12
AT379390B (de) 1985-12-27
AU5670280A (en) 1980-10-02
MX6816E (es) 1986-08-05
HU179845B (en) 1982-12-28
PL124037B1 (en) 1982-12-31
KR840001612B1 (ko) 1984-10-11
DK130180A (da) 1980-09-28
DK151252C (da) 1988-05-16
IT8048262A1 (it) 1981-09-26
DE3051205C2 (de) 1991-01-24
FR2452484A1 (fr) 1980-10-24
IT1188916B (it) 1988-01-28
PL223050A1 (fr) 1981-01-30
NL191306C (nl) 1995-05-16
CA1151652A (fr) 1983-08-09
IL59710A (en) 1984-01-31
MY8600668A (en) 1986-12-31
SG60886G (en) 1987-03-27
SE455422B (sv) 1988-07-11
FI77026C (fi) 1989-01-10
DE3011994C2 (fr) 1991-06-27
KR830001898A (ko) 1983-05-19
EG16606A (en) 1989-01-30
DK151252B (da) 1987-11-16
PT71006A (en) 1980-04-01
FI800923A (fi) 1980-09-28
FR2468367A1 (fr) 1981-05-08
FR2452484B1 (fr) 1983-08-12
BG37993A3 (en) 1985-09-16
DE3011994A1 (de) 1980-10-16

Similar Documents

Publication Publication Date Title
CS221906B2 (en) Method of preparation of the 3-/alkylthio,alkylsulphinyl or alkylsulphonyl/-4-chinolone
JP6629218B2 (ja) Ｎ−ベンジルトリプタンスリン誘導体、ならびにその調製方法および利用
CA3120880A1 (fr) Compose agoniste de recepteur thrb son procede de preparation et son utilisation
HU217080B (hu) Új eljárás imidazo[4,5-c]kinolin-4-amin-származékok előállítására
CS390691A3 (en) Olefinic 1h-imidazo-(4,5-c)quinolin-4-amines
CZ291368B6 (cs) Způsob a meziprodukty pro přípravu 1H- imidazo[4,5-c]chinolin-4-aminu
JPH05222048A (ja) 水溶性カンプトテシン誘導体
EP0269378A1 (fr) Dérivé de la quinazolinone et procédés pour sa préparation
CZ9302005A3 (en) Azaquinoxalines, process of their preparation and their use
NO321536B1 (no) 3<alfa>-Hydroksy-3<beta>-metoksymetyl-21-heterocyklisk substituerte steroider med bedovende aktivitet
JPS6340792B2 (fr)
PL178591B1 (pl) Nowe związki, fluorowane pochodne 17beta-podstawionego 4-aza-5alfa-androstan-3-onu oraz kompozycja farmaceutyczna
JPS62142198A (ja) 新規中間体
JPS6383095A (ja) ４−置換６−アルキリデンアンドロステン−３，１７−ジオン誘導体およびその製造方法
KR830000026B1 (ko) 트리사이클릭 오르토-융합된 헤테로사이클릭 화합물의 제조방법
JP4231107B2 (ja) 抗ウイルス作用を有する置換キノリン誘導体
JP3860618B2 (ja) 置換キノリン誘導体、それらの製造方法およびそれらの使用
US4390541A (en) Quinolone derivatives and their use in a method of controlling an immediate hypersensitivity disease
HU196188B (en) Process for preparing new quinazolindione-derivatives and medical compounds containing them
DK152674B (da) Analogifremgangsmaade til fremstilling af 3-metyltiometyl-4-oxo-quinolonderivater
JP2744224B2 (ja) ビス−アザ−二環式抗不安薬の製法
GB2171995A (en) Pharmaceutically active 8-heteroarylthio-5, 6, 7, 8-tetrahydroquinolines
EP0136198A1 (fr) Dérivés de triazolo pyrimidine, leur procédé de préparation et leur application thérapeutique en tant que toni-cardiaques
JPH0114235B2 (fr)
JPS6229585A (ja) エーテル化若しくはエステル化しうるジヒドロキシ基により位置２で置換された４―ｏｈキノリンカルボン酸の新規の誘導体、その製造方法、及び医薬としてのその使用