KR830001898A - 치 료 제 - Google Patents

치 료 제 Download PDF

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Publication number
KR830001898A
KR830001898A KR1019800001266A KR800001266A KR830001898A KR 830001898 A KR830001898 A KR 830001898A KR 1019800001266 A KR1019800001266 A KR 1019800001266A KR 800001266 A KR800001266 A KR 800001266A KR 830001898 A KR830001898 A KR 830001898A
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KR
South Korea
Prior art keywords
structural formula
hydrogen
compound
following structural
lower alkyl
Prior art date
Application number
KR1019800001266A
Other languages
English (en)
Other versions
KR840001612B1 (ko
Inventor
빅터 데이비스 로이
프레이져 제임스
존 니콜 케네스
파킨슨 레이몬드
브리안 예이츠 데이비드
프리맨 심 말콤
Original Assignee
피터 테스터 메인, 데럭 노만 에드먼슨
더 부츠 캄파니 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 피터 테스터 메인, 데럭 노만 에드먼슨, 더 부츠 캄파니 리미티드 filed Critical 피터 테스터 메인, 데럭 노만 에드먼슨
Publication of KR830001898A publication Critical patent/KR830001898A/ko
Priority to KR1019840005181A priority Critical patent/KR840001613B1/ko
Application granted granted Critical
Publication of KR840001612B1 publication Critical patent/KR840001612B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

치료제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. (a) 다음 구조식(Ⅱ)의 화합물 또는 다음 구조식(Ⅲ)의 상응하는 일리드를 오르토포메이트 에스테르와 반응시키거나
    (b) 다음 구조식(Ⅴ)의 아크릴레이트를 폐환시키거나
    (c) R1은 수소이고 R2-R5및 n는 하기와 같은 다음 구조식(Ⅰ)의 퀴놀론 화합물을 알킬화시키거나
    (d) R1-R5는 하기와 같고 n는 0 또는 1인 구조식(Ⅰ)의 화합물을 산화시켜 n가 1 또는 2인 상응하는 퀴놀린을 얻거나
    (e) R1, R2및 n는 상기와 같고 하나 또는 그 이상의 R4-R5는 하이드록시인 다음 구조식(Ⅰ)의 퀴놀론 화합물을 알킬화하여 하나 또는 그 이상의 R3-R5가 저급알콕시인 상응하는 화합물을 얻는 것을 특징으로 하는 다음 구조식(Ⅰ)의 퀴놀론 화합물의 제조방법.
    상기 구조식에서
    n는 0, 1 또는 2이고
    R1는 하이드록시 또는 탄소수 1내지 4-알콕시카보닐로 임의 치환한 저급알킬; 알릴; 프로피닐 또는 페닐-저급알킬이고(페닐환은 하나 또는 둘의 탄소수 1내지 4-알콕시그룹으로 임의 치환된다)
    R2는 탄소수 1내지 4-알킬이고 같거나 다른 R3, R4및 (R5는 수소, 저급알킬, 저급알콕시, 저급알카노일, 할로, 트리플루오로메틸 또는 저급알킬티오이며, 단
    (a) R3, R4및 R5가 수소이고 R2가 메틸이면 R1은 하나이상의 탄소원자를 함유하고
    (b) R3및 R4가 수소이고 R5가 수소 또는 7-메틸이고 R1이 에틸이면, R2는 하나이상의 탄소를 함유하는 조건에서이며
    R6는 저급알킬 또는 페닐-저급알킬이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800001266A 1979-03-27 1980-03-26 퀴놀론 화합물의 제조방법 KR840001612B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019840005181A KR840001613B1 (ko) 1979-03-27 1984-08-25 퀴놀론 화합물의 제조방법

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB7910558 1979-03-27
GB7910558 1979-03-27
GB7939505 1979-11-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019840005181A Division KR840001613B1 (ko) 1979-03-27 1984-08-25 퀴놀론 화합물의 제조방법

Publications (2)

Publication Number Publication Date
KR830001898A true KR830001898A (ko) 1983-05-19
KR840001612B1 KR840001612B1 (ko) 1984-10-11

Family

ID=26271029

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800001266A KR840001612B1 (ko) 1979-03-27 1980-03-26 퀴놀론 화합물의 제조방법

Country Status (34)

Country Link
US (1) US4302460A (ko)
KR (1) KR840001612B1 (ko)
AT (1) AT379390B (ko)
AU (1) AU536616B2 (ko)
BG (2) BG37836A3 (ko)
CA (1) CA1151652A (ko)
CH (1) CH644366A5 (ko)
CS (1) CS221906B2 (ko)
DD (1) DD149608A5 (ko)
DE (2) DE3051205C2 (ko)
DK (1) DK151252C (ko)
EG (1) EG16606A (ko)
FI (1) FI77026C (ko)
FR (2) FR2452484A1 (ko)
GR (1) GR68007B (ko)
HK (1) HK94986A (ko)
HU (1) HU179845B (ko)
IE (1) IE49562B1 (ko)
IL (1) IL59710A (ko)
IT (1) IT1188916B (ko)
KE (1) KE3649D (ko)
LU (1) LU82295A1 (ko)
MX (1) MX6816E (ko)
MY (1) MY8600668A (ko)
NL (1) NL191306C (ko)
NO (1) NO156787C (ko)
NZ (1) NZ193167A (ko)
PH (1) PH16758A (ko)
PL (1) PL124037B1 (ko)
PT (1) PT71006A (ko)
RO (1) RO79397A (ko)
SE (1) SE455422B (ko)
SG (1) SG60886G (ko)
YU (1) YU42332B (ko)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE51542B1 (en) * 1980-09-26 1987-01-07 Boots Co Ltd Therapeutic agents
PT79031B (en) * 1983-08-20 1986-08-22 Boots Co Plc Therapeutic agents
DE3578374D1 (de) * 1984-01-13 1990-08-02 Boots Co Ltd Verwendung von chinolonen fuer die herstellung eines arzneimittels zur behandlung von herzerkrankungen.
DE3576686D1 (de) * 1984-08-15 1990-04-26 Boots Co Ltd Chinolinone, verfahren zu ihrer herstellung und die sie enthaltenden pharmazeutischen praeparate.
GB8515207D0 (en) * 1985-06-15 1985-07-17 Boots Co Plc Therapeutic agents
GB8515209D0 (en) * 1985-06-15 1985-07-17 Boots Co Plc Therapeutic agents
GB8627698D0 (en) * 1986-11-20 1986-12-17 Boots Co Plc Therapeutic agents
GB8726950D0 (en) * 1987-11-18 1987-12-23 Boots Co Plc Chemical process
GB8804016D0 (en) * 1988-02-22 1988-03-23 Boots Co Plc Therapeutic agents
GB8918952D0 (en) * 1989-08-19 1989-10-04 Boots Co Plc Therapeutic agents
FR2684671B1 (fr) * 1991-11-20 1995-05-19 Roussel Uclaf Nouveaux derives de la quinoleine, leur procede de preparation et intermediaires et leur application a titre de medicaments.
FR2672597B1 (fr) * 1991-02-07 1995-05-19 Roussel Uclaf Nouveaux derives n-substitues de la quinoleine, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
IL100555A (en) * 1991-02-07 2000-08-31 Hoechst Marion Roussel Inc N-substituted quinoline derivatives their preparation their use for the preparation of medicaments and the pharmaceutical compositions containing them
FR2680511B1 (fr) * 1991-08-20 1995-05-19 Roussel Uclaf Derives n-substitues de la quinoleine, leur procede de preparation, intermediaires obtenus, leur application comme medicaments et les compositions les renfermant.
CA2339484A1 (en) * 1998-08-03 2000-02-17 Robert A. O'brien Pyridinones for the treatment of sexual dysfunction
US6307050B1 (en) * 2000-08-29 2001-10-23 R. T. Alamo Venture I Llc Method of synthesizing flosequinan from 4-fluoroanthranilic acid
US6562838B2 (en) 2001-01-26 2003-05-13 R. T. Alamo Ventures I, L.L.C. Treatment of cardiovascular disease with quinolinone enantiomers
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US6458804B1 (en) * 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6649764B2 (en) * 2001-10-25 2003-11-18 R. T. Alamo Ventures I, Llc Stereospecific enrichment of heterocyclic enantiomers
US6730790B2 (en) * 2002-03-01 2004-05-04 R.T. Alamo Ventures I. Llc Chlorinated heterocyclic compounds and methods of synthesis

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US3178348A (en) * 1961-02-08 1965-04-13 Norwich Pharma Co Hypotensive quinolines
GB1066919A (en) 1964-04-03 1967-04-26 Hoffmann La Roche Novel benzyl amine derivatives
DE1770482A1 (de) * 1968-05-22 1971-11-11 Basf Ag Verfahren zur Herstellung von 2,4-Dioxychinolinen
US3798219A (en) * 1971-10-18 1974-03-19 Warner Lambert Co 3-(methylsulfinyl)cinnolinones and their derivatives
US3772301A (en) * 1971-11-22 1973-11-13 Warner Lambert Co (4-substituted)4-(methylsulfinyl)methylcarbostyrils
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DE2616995A1 (de) 1976-04-17 1977-10-27 Bayer Ag 1.4-dihydropyridine mit schwefelhaltigen substituenten mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2616991A1 (de) 1976-04-17 1977-10-27 Bayer Ag Heterocyclisch-substituierte schwefelhaltige dihydropyridine, mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2639257A1 (de) 1976-09-01 1978-03-02 Bayer Ag Aminoalkylidenamino-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
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DE2747513A1 (de) 1977-10-22 1979-05-03 Bayer Ag Dihydropyridine mit schwefelhaltigen estergruppierungen

Also Published As

Publication number Publication date
FI77026B (fi) 1988-09-30
DE3011994C2 (ko) 1991-06-27
LU82295A1 (fr) 1981-04-17
DD149608A5 (de) 1981-07-22
FR2452484A1 (fr) 1980-10-24
FR2468367B1 (ko) 1983-09-30
CH644366A5 (fr) 1984-07-31
IE800567L (en) 1980-09-27
IE49562B1 (en) 1985-10-30
RO79397A (ro) 1982-06-25
CA1151652A (en) 1983-08-09
HK94986A (en) 1986-12-12
PH16758A (en) 1984-02-15
FR2452484B1 (ko) 1983-08-12
HU179845B (en) 1982-12-28
KR840001612B1 (ko) 1984-10-11
SE8002345L (sv) 1980-11-14
FR2468367A1 (fr) 1981-05-08
GR68007B (ko) 1981-10-26
MX6816E (es) 1986-08-05
BG37993A3 (en) 1985-09-16
EG16606A (en) 1989-01-30
ATA161880A (de) 1985-05-15
IT8048262A0 (it) 1980-03-26
YU84980A (en) 1983-09-30
IT1188916B (it) 1988-01-28
SE455422B (sv) 1988-07-11
AU536616B2 (en) 1984-05-17
BG37836A3 (en) 1985-08-15
FI800923A (fi) 1980-09-28
DK130180A (da) 1980-09-28
IL59710A (en) 1984-01-31
MY8600668A (en) 1986-12-31
AT379390B (de) 1985-12-27
NO156787C (no) 1987-11-25
DE3011994A1 (de) 1980-10-16
FI77026C (fi) 1989-01-10
IT8048262A1 (it) 1981-09-26
NZ193167A (en) 1984-08-24
NO800881L (no) 1980-09-29
NL191306B (nl) 1994-12-16
NL191306C (nl) 1995-05-16
AU5670280A (en) 1980-10-02
NL8001771A (nl) 1980-09-30
DE3051205C2 (de) 1991-01-24
CS221906B2 (en) 1983-04-29
DK151252B (da) 1987-11-16
DK151252C (da) 1988-05-16
US4302460A (en) 1981-11-24
NO156787B (no) 1987-08-17
PL124037B1 (en) 1982-12-31
SG60886G (en) 1987-03-27
PL223050A1 (ko) 1981-01-30
KE3649D (en) 1986-08-01
PT71006A (en) 1980-04-01
YU42332B (en) 1988-08-31

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