FR2452484A1 - Quinolones, leur procede de preparation et compositions therapeutiques qui les contiennent - Google Patents
Quinolones, leur procede de preparation et compositions therapeutiques qui les contiennentInfo
- Publication number
- FR2452484A1 FR2452484A1 FR8006811A FR8006811A FR2452484A1 FR 2452484 A1 FR2452484 A1 FR 2452484A1 FR 8006811 A FR8006811 A FR 8006811A FR 8006811 A FR8006811 A FR 8006811A FR 2452484 A1 FR2452484 A1 FR 2452484A1
- Authority
- FR
- France
- Prior art keywords
- compositions containing
- alkyl group
- alkoxy
- lower alkyl
- quinolones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
L'INVENTION A PRINCIPALEMENT POUR OBJET LES COMPOSITIONS CONTENANT UNE QUINOLONE DE FORMULE GENERALE: (CF DESSIN DANS BOPI) (DANS LAQUELLE N EST EGAL A 0, 1 OU 2; R EST UN GROUPE ALKYLE INFERIEUR EVENTUELLEMENT SUBSTITUE PAR UN RADICAL HYDROXY OU (ALKOXY EN C A C) CARBONYLE; ALLYLE; PROPYNYLE OU PHENYL(ALKYLE INFERIEUR), LE NOYAU DE PHENYLE ETANT EVENTUELLEMENT SUBSTITUE PAR 1 OU 2 GROUPES ALKOXY EN C A C; R EST UN GROUPE ALKYLE EN C A C A CONDITION QUE LORSQUE N EST EGAL A 0, R SOIT UN GROUPE METHYLE; ET R, R ET R, QUI PEUVENT ETRE IDENTIQUES OU DIFFERENTS, REPRESENTENT DE L'HYDROGENE, UN GROUPE ALKYLE INFERIEUR, ALKOXY INFERIEUR, ALCANOYLE INFERIEUR, HALOGENO, TRIFLUOROMETHYLE OU (ALKYLE INFERIEUR)-THIO. CES COMPOSITIONS SONT DOUEES D'UNE ACTIVITE ANTI-HYPERTENSIVE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7910558 | 1979-03-27 | ||
GB7939505 | 1979-11-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2452484A1 true FR2452484A1 (fr) | 1980-10-24 |
FR2452484B1 FR2452484B1 (fr) | 1983-08-12 |
Family
ID=26271029
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8006811A Granted FR2452484A1 (fr) | 1979-03-27 | 1980-03-27 | Quinolones, leur procede de preparation et compositions therapeutiques qui les contiennent |
FR8021107A Granted FR2468367A1 (fr) | 1979-03-27 | 1980-10-02 | Compositions therapeutiques a base de quinolones |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8021107A Granted FR2468367A1 (fr) | 1979-03-27 | 1980-10-02 | Compositions therapeutiques a base de quinolones |
Country Status (34)
Country | Link |
---|---|
US (1) | US4302460A (fr) |
KR (1) | KR840001612B1 (fr) |
AT (1) | AT379390B (fr) |
AU (1) | AU536616B2 (fr) |
BG (2) | BG37993A3 (fr) |
CA (1) | CA1151652A (fr) |
CH (1) | CH644366A5 (fr) |
CS (1) | CS221906B2 (fr) |
DD (1) | DD149608A5 (fr) |
DE (2) | DE3011994A1 (fr) |
DK (1) | DK151252C (fr) |
EG (1) | EG16606A (fr) |
FI (1) | FI77026C (fr) |
FR (2) | FR2452484A1 (fr) |
GR (1) | GR68007B (fr) |
HK (1) | HK94986A (fr) |
HU (1) | HU179845B (fr) |
IE (1) | IE49562B1 (fr) |
IL (1) | IL59710A (fr) |
IT (1) | IT1188916B (fr) |
KE (1) | KE3649D (fr) |
LU (1) | LU82295A1 (fr) |
MX (1) | MX6816E (fr) |
MY (1) | MY8600668A (fr) |
NL (1) | NL191306C (fr) |
NO (1) | NO156787C (fr) |
NZ (1) | NZ193167A (fr) |
PH (1) | PH16758A (fr) |
PL (1) | PL124037B1 (fr) |
PT (1) | PT71006A (fr) |
RO (1) | RO79397A (fr) |
SE (1) | SE455422B (fr) |
SG (1) | SG60886G (fr) |
YU (1) | YU42332B (fr) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0149519A2 (fr) * | 1984-01-13 | 1985-07-24 | The Boots Company PLC | Utilisation de quinolones pour la fabrication d'une composition pour le traitement de maladies cardiaques. |
EP0206616A2 (fr) * | 1985-06-15 | 1986-12-30 | The Boots Company PLC | Quinolones ayant une activité antihypertensive |
EP0209977A2 (fr) * | 1985-06-15 | 1987-01-28 | The Boots Company PLC | Thiénopyridones, procédés et intermédiaires pour leur préparation et compositions pharmaceutiques les contenant |
EP0317149A1 (fr) * | 1987-11-18 | 1989-05-24 | The Boots Company PLC | Procédé de synthèse de dérivés de la 3-thia-4-quinolone et composés intermédiaires utilisables dans ledit procédé et comme médicaments |
WO1991002724A1 (fr) * | 1989-08-19 | 1991-03-07 | The Boots Company Plc | Agents therapeutiques |
EP0498721A1 (fr) * | 1991-02-07 | 1992-08-12 | Roussel Uclaf | Dérivés N-substitués de la quinoléine, leur procédé de préparation, les intermédiaires obtenus, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant |
FR2672597A1 (fr) * | 1991-02-07 | 1992-08-14 | Roussel Uclaf | Nouveaux derives n-substitues de la quinoleine, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
FR2680511A1 (fr) * | 1991-08-20 | 1993-02-26 | Roussel Uclaf | Derives n-substitues de la quinoleine, leur procede de preparation, intermediaires obtenus, leur application comme medicaments et les compositions les renfermant. |
FR2684671A1 (fr) * | 1991-11-20 | 1993-06-11 | Roussel Uclaf | Nouveaux derives de la quinoleine, leur procede de preparation et intermediaires et leur application a titre de medicaments. |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE51542B1 (en) * | 1980-09-26 | 1987-01-07 | Boots Co Ltd | Therapeutic agents |
PT79031B (en) * | 1983-08-20 | 1986-08-22 | Boots Co Plc | Therapeutic agents |
EP0172004B1 (fr) * | 1984-08-15 | 1990-03-21 | The Boots Company PLC | Quinolinones, procédé pour leur préparation et compositions pharmaceutiques les contenant |
GB8627698D0 (en) * | 1986-11-20 | 1986-12-17 | Boots Co Plc | Therapeutic agents |
GB8804016D0 (en) * | 1988-02-22 | 1988-03-23 | Boots Co Plc | Therapeutic agents |
JP2002522388A (ja) * | 1998-08-03 | 2002-07-23 | ビーエーエスエフ コーポレーション | 性機能障害の治療のためのピリジノン |
US6307050B1 (en) * | 2000-08-29 | 2001-10-23 | R. T. Alamo Venture I Llc | Method of synthesizing flosequinan from 4-fluoroanthranilic acid |
US6451813B1 (en) | 2001-01-26 | 2002-09-17 | R. T. Alamo Ventures I, Llc | Treatment of gastroparesis in certain patient groups |
US6458804B1 (en) * | 2001-01-26 | 2002-10-01 | R.T. Alamo Venturesi, Llc | Methods for the treatment of central nervous system disorders in certain patient groups |
US6562838B2 (en) | 2001-01-26 | 2003-05-13 | R. T. Alamo Ventures I, L.L.C. | Treatment of cardiovascular disease with quinolinone enantiomers |
US6649764B2 (en) * | 2001-10-25 | 2003-11-18 | R. T. Alamo Ventures I, Llc | Stereospecific enrichment of heterocyclic enantiomers |
US6730790B2 (en) * | 2002-03-01 | 2004-05-04 | R.T. Alamo Ventures I. Llc | Chlorinated heterocyclic compounds and methods of synthesis |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4124587A (en) * | 1976-03-01 | 1978-11-07 | Sandoz, Inc. | 4-Hydroxy-3-sulfinyl-quinolin-2(1H)-ones |
US4127574A (en) * | 1976-03-01 | 1978-11-28 | Sandoz, Inc. | 4-Hydroxy-3-sulfonyl-quinolin-2(1H)-ones |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3178348A (en) * | 1961-02-08 | 1965-04-13 | Norwich Pharma Co | Hypotensive quinolines |
GB1066919A (en) | 1964-04-03 | 1967-04-26 | Hoffmann La Roche | Novel benzyl amine derivatives |
DE1770482A1 (de) * | 1968-05-22 | 1971-11-11 | Basf Ag | Verfahren zur Herstellung von 2,4-Dioxychinolinen |
US3798219A (en) * | 1971-10-18 | 1974-03-19 | Warner Lambert Co | 3-(methylsulfinyl)cinnolinones and their derivatives |
US3772301A (en) * | 1971-11-22 | 1973-11-13 | Warner Lambert Co | (4-substituted)4-(methylsulfinyl)methylcarbostyrils |
CH607848A5 (fr) * | 1974-06-04 | 1978-11-30 | Bayer Ag | |
GB1488411A (en) * | 1975-01-16 | 1977-10-12 | Wyeth John & Brother Ltd | 3,4-dihydro-4-arylquinolin-4-ol derivatives |
DE2616995A1 (de) | 1976-04-17 | 1977-10-27 | Bayer Ag | 1.4-dihydropyridine mit schwefelhaltigen substituenten mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE2616991A1 (de) | 1976-04-17 | 1977-10-27 | Bayer Ag | Heterocyclisch-substituierte schwefelhaltige dihydropyridine, mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE2639257A1 (de) | 1976-09-01 | 1978-03-02 | Bayer Ag | Aminoalkylidenamino-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE2639498A1 (de) | 1976-09-02 | 1978-03-09 | Bayer Ag | Neue schwefelhaltige amino-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE2641746C2 (de) | 1976-09-16 | 1986-11-06 | Bayer Ag, 5090 Leverkusen | 1,4-Dihydropyridin-Zuckerderivate, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
DE2658183A1 (de) | 1976-12-22 | 1978-07-06 | Bayer Ag | In 2-position substituierte 1,4- dihydropyridin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE2658804A1 (de) | 1976-12-24 | 1978-07-06 | Bayer Ag | Kreislaufbeeinflussende mittel |
DE2715182A1 (de) | 1977-04-05 | 1978-10-19 | Bayer Ag | 2-alkylenaminodihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US4177278A (en) * | 1977-04-05 | 1979-12-04 | Bayer Aktiengesellschaft | 2-Alkyleneaminodihydropyridines compounds, their production and their medicinal use |
JPS5424882A (en) * | 1977-07-22 | 1979-02-24 | Yamanouchi Pharmaceut Co Ltd | Novel heterocyclic compounds and their preparation |
DE2747513A1 (de) | 1977-10-22 | 1979-05-03 | Bayer Ag | Dihydropyridine mit schwefelhaltigen estergruppierungen |
-
1980
- 1980-03-18 NZ NZ193167A patent/NZ193167A/en unknown
- 1980-03-19 IE IE567/80A patent/IE49562B1/en not_active IP Right Cessation
- 1980-03-21 AU AU56702/80A patent/AU536616B2/en not_active Ceased
- 1980-03-22 GR GR61514A patent/GR68007B/el unknown
- 1980-03-24 US US06/133,310 patent/US4302460A/en not_active Expired - Lifetime
- 1980-03-24 PH PH23802A patent/PH16758A/en unknown
- 1980-03-25 PT PT71006A patent/PT71006A/pt not_active IP Right Cessation
- 1980-03-25 RO RO80100611A patent/RO79397A/fr unknown
- 1980-03-25 IL IL59710A patent/IL59710A/xx not_active IP Right Cessation
- 1980-03-25 LU LU82295A patent/LU82295A1/fr unknown
- 1980-03-25 FI FI800923A patent/FI77026C/fi not_active IP Right Cessation
- 1980-03-26 HU HU8080713A patent/HU179845B/hu not_active IP Right Cessation
- 1980-03-26 YU YU849/80A patent/YU42332B/xx unknown
- 1980-03-26 NO NO800881A patent/NO156787C/no unknown
- 1980-03-26 SE SE8002345A patent/SE455422B/sv not_active IP Right Cessation
- 1980-03-26 BG BG066170A patent/BG37993A3/xx unknown
- 1980-03-26 CA CA000348520A patent/CA1151652A/fr not_active Expired
- 1980-03-26 IT IT48262/80A patent/IT1188916B/it active
- 1980-03-26 AT AT0161880A patent/AT379390B/de not_active IP Right Cessation
- 1980-03-26 NL NL8001771A patent/NL191306C/xx not_active IP Right Cessation
- 1980-03-26 KR KR1019800001266A patent/KR840001612B1/ko active
- 1980-03-26 BG BG047135A patent/BG37836A3/xx unknown
- 1980-03-26 DK DK130180A patent/DK151252C/da not_active IP Right Cessation
- 1980-03-26 CH CH237680A patent/CH644366A5/fr not_active IP Right Cessation
- 1980-03-27 CS CS802156A patent/CS221906B2/cs unknown
- 1980-03-27 DE DE19803011994 patent/DE3011994A1/de active Granted
- 1980-03-27 DD DD80219973A patent/DD149608A5/de not_active IP Right Cessation
- 1980-03-27 MX MX808725U patent/MX6816E/es unknown
- 1980-03-27 FR FR8006811A patent/FR2452484A1/fr active Granted
- 1980-03-27 PL PL1980223050A patent/PL124037B1/pl unknown
- 1980-03-27 DE DE19803051205 patent/DE3051205C2/de not_active Expired - Lifetime
- 1980-03-29 EG EG188/80A patent/EG16606A/xx active
- 1980-10-02 FR FR8021107A patent/FR2468367A1/fr active Granted
-
1986
- 1986-07-08 KE KE3649BD patent/KE3649D/xx unknown
- 1986-07-10 SG SG608/86A patent/SG60886G/en unknown
- 1986-12-04 HK HK949/86A patent/HK94986A/xx not_active IP Right Cessation
- 1986-12-30 MY MY668/86A patent/MY8600668A/xx unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4124587A (en) * | 1976-03-01 | 1978-11-07 | Sandoz, Inc. | 4-Hydroxy-3-sulfinyl-quinolin-2(1H)-ones |
US4127574A (en) * | 1976-03-01 | 1978-11-28 | Sandoz, Inc. | 4-Hydroxy-3-sulfonyl-quinolin-2(1H)-ones |
Non-Patent Citations (1)
Title |
---|
EXBK/73 * |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0149519A3 (en) * | 1984-01-13 | 1987-09-23 | The Boots Company Plc | Method of treating heart disease |
EP0149519A2 (fr) * | 1984-01-13 | 1985-07-24 | The Boots Company PLC | Utilisation de quinolones pour la fabrication d'une composition pour le traitement de maladies cardiaques. |
US4772614A (en) * | 1985-06-15 | 1988-09-20 | The Boots Company | Quinolone sulphonamides useful as antihypertensive agents |
EP0209977A2 (fr) * | 1985-06-15 | 1987-01-28 | The Boots Company PLC | Thiénopyridones, procédés et intermédiaires pour leur préparation et compositions pharmaceutiques les contenant |
EP0206616A3 (fr) * | 1985-06-15 | 1988-06-01 | The Boots Company PLC | Quinolones ayant une activité antihypertensive |
EP0209977A3 (fr) * | 1985-06-15 | 1988-06-08 | The Boots Company PLC | Thiénopyridones, procédés et intermédiaires pour leur préparation et compositions pharmaceutiques les contenant |
EP0206616A2 (fr) * | 1985-06-15 | 1986-12-30 | The Boots Company PLC | Quinolones ayant une activité antihypertensive |
EP0317149A1 (fr) * | 1987-11-18 | 1989-05-24 | The Boots Company PLC | Procédé de synthèse de dérivés de la 3-thia-4-quinolone et composés intermédiaires utilisables dans ledit procédé et comme médicaments |
WO1989004827A1 (fr) * | 1987-11-18 | 1989-06-01 | The Boots Company Plc | Procede de synthese de derives de 3-thio-4-quinolone et composes intermediaires utilises dans celui-ci, ainsi que leur utilisation comme medicaments |
US5011931A (en) * | 1987-11-18 | 1991-04-30 | The Boots Company Plc | Process for the preparation of 1-methyl-3-methylthio-4-quinolone and the sulfinyl, and sulfonyl analogs thereof |
WO1991002724A1 (fr) * | 1989-08-19 | 1991-03-07 | The Boots Company Plc | Agents therapeutiques |
EP0498721A1 (fr) * | 1991-02-07 | 1992-08-12 | Roussel Uclaf | Dérivés N-substitués de la quinoléine, leur procédé de préparation, les intermédiaires obtenus, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant |
FR2672597A1 (fr) * | 1991-02-07 | 1992-08-14 | Roussel Uclaf | Nouveaux derives n-substitues de la quinoleine, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
FR2680511A1 (fr) * | 1991-08-20 | 1993-02-26 | Roussel Uclaf | Derives n-substitues de la quinoleine, leur procede de preparation, intermediaires obtenus, leur application comme medicaments et les compositions les renfermant. |
FR2684671A1 (fr) * | 1991-11-20 | 1993-06-11 | Roussel Uclaf | Nouveaux derives de la quinoleine, leur procede de preparation et intermediaires et leur application a titre de medicaments. |
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