CO2019012773A2 - Sistemas autoenderezables y componentes y métodos relacionados - Google Patents

Sistemas autoenderezables y componentes y métodos relacionados

Info

Publication number
CO2019012773A2
CO2019012773A2 CONC2019/0012773A CO2019012773A CO2019012773A2 CO 2019012773 A2 CO2019012773 A2 CO 2019012773A2 CO 2019012773 A CO2019012773 A CO 2019012773A CO 2019012773 A2 CO2019012773 A2 CO 2019012773A2
Authority
CO
Colombia
Prior art keywords
self
straightening
article
subject
tissue
Prior art date
Application number
CONC2019/0012773A
Other languages
English (en)
Spanish (es)
Inventor
Carlo Giovanni Traverso
Alex G Abramson
Salvador Ester Caffarel
Niclas Roxhed
Minsoo Khang
Taylor Bensel
Robert S Langer
Jorrit Jeroen Water
Morten Revsgaard Frederiksen
Bo Uldall Kristiansen
Mikkel Oliver Jespersen
Mette Poulsen
Peter Herskind
Brian Jensen
Original Assignee
Massachusetts Inst Technology
Brigham & Womens Hospital Inc
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Brigham & Womens Hospital Inc, Novo Nordisk As filed Critical Massachusetts Inst Technology
Publication of CO2019012773A2 publication Critical patent/CO2019012773A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/04—Endoscopic instruments, e.g. catheter-type instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/06—Biopsy forceps, e.g. with cup-shaped jaws
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring pH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1454—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons spring-actuated, e.g. by a clockwork
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A61M5/3015—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules for injecting a dose of particles in form of powdered drug, e.g. mounted on a rupturable membrane and accelerated by a gaseous shock wave or supersonic gas flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3287—Accessories for bringing the needle into the body; Automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B2010/0208—Biopsy devices with actuators, e.g. with triggered spring mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • A61M2005/14284—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation with needle insertion means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1581—Right-angle needle-type devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1585—Needle inserters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0238—General characteristics of the apparatus characterised by a particular materials the material being a coating or protective layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/10—General characteristics of the apparatus with powered movement mechanisms
    • A61M2205/106—General characteristics of the apparatus with powered movement mechanisms reciprocating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/21—General characteristics of the apparatus insensitive to tilting or inclination, e.g. spill-over prevention
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1042—Alimentary tract
    • A61M2210/1053—Stomach
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1042—Alimentary tract
    • A61M2210/106—Small intestine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/281—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/286—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/329—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3295—Multiple needle devices, e.g. a plurality of needles arranged coaxially or in parallel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0507—Electrodes for the digestive system
    • A61N1/0509—Stomach and intestinal electrodes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
CONC2019/0012773A 2017-05-17 2019-11-15 Sistemas autoenderezables y componentes y métodos relacionados CO2019012773A2 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762507665P 2017-05-17 2017-05-17
US201762507647P 2017-05-17 2017-05-17
US201762507653P 2017-05-17 2017-05-17
PCT/US2018/033217 WO2018213600A1 (en) 2017-05-17 2018-05-17 Self-righting systems and related components and methods

Publications (1)

Publication Number Publication Date
CO2019012773A2 true CO2019012773A2 (es) 2020-02-18

Family

ID=64274634

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0012773A CO2019012773A2 (es) 2017-05-17 2019-11-15 Sistemas autoenderezables y componentes y métodos relacionados

Country Status (19)

Country Link
US (13) US11207272B2 (enExample)
EP (6) EP3624778A4 (enExample)
JP (12) JP7045397B2 (enExample)
KR (5) KR102647153B1 (enExample)
CN (9) CN115804886A (enExample)
AU (7) AU2018269547B2 (enExample)
BR (1) BR112019023985A2 (enExample)
CA (6) CA3063711A1 (enExample)
CL (1) CL2019003269A1 (enExample)
CO (1) CO2019012773A2 (enExample)
DK (1) DK3624887T3 (enExample)
ES (1) ES3036948T3 (enExample)
IL (6) IL270450B2 (enExample)
MX (1) MX2019013747A (enExample)
MY (1) MY199911A (enExample)
PE (1) PE20200305A1 (enExample)
PH (1) PH12019502537A1 (enExample)
RU (1) RU2019141615A (enExample)
WO (6) WO2018213588A1 (enExample)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1762259E (pt) 2005-09-12 2010-12-10 Unomedical As Insersor para um conjunto de infusão com uma primeira e uma segunda unidades de mola
US10194938B2 (en) 2011-03-14 2019-02-05 UnoMedical, AS Inserter system with transport protection
CN109862821A (zh) 2016-09-09 2019-06-07 普罗根尼蒂公司 用于递送可配发物质的机电可摄入装置
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
JP7045397B2 (ja) 2017-05-17 2022-03-31 マサチューセッツ インスティテュート オブ テクノロジー 自己復元システムおよび関連構成要素
EP3793505A4 (en) 2018-05-17 2022-03-16 Massachusetts Institute of Technology Quick release capsules
AU2019269636A1 (en) * 2018-05-17 2020-11-19 Massachusetts Institute Of Technology Systems for electrical stimulation
WO2020106704A2 (en) 2018-11-19 2020-05-28 Progenity, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
US12194294B2 (en) * 2019-01-29 2025-01-14 The Regents Of The University Of California Oral drug delivery devices and methods using iontophoresis
WO2020160399A1 (en) 2019-02-01 2020-08-06 Massachusetts Institute Of Technology Systems and methods for liquid injection
CN113329777B (zh) 2019-02-01 2024-01-09 诺和诺德股份有限公司 具有致动机构的医疗装置
CA3131781A1 (en) 2019-03-01 2020-09-10 Rani Therapeutics, Llc Propulsive drug delivery from a swallowable device into a patient's intestinal tract
SG11202111673SA (en) 2019-05-20 2021-11-29 Unomedical As Rotatable infusion device and methods thereof
US20220313967A1 (en) 2019-06-07 2022-10-06 Novo Nordisk A/S Ingestible device with delivery member detachment
JP2022541060A (ja) * 2019-07-22 2022-09-21 ノボ・ノルデイスク・エー／エス 改善された自己復元能力を有するカプセル装置
EP3771451B1 (en) * 2019-08-02 2025-10-08 Bionime Corporation A container for carrying a sensor
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components
CN121197633A (zh) 2019-12-13 2025-12-26 比特比德科有限责任公司 用于将治疗剂递送至胃肠道的可摄取装置
PL3859829T3 (pl) 2020-01-29 2025-05-26 Lg Energy Solution, Ltd. Sposób analizowania zachowania się litowej baterii akumulatorowej związanego z pęcznieniem
CN111481812A (zh) * 2020-05-29 2020-08-04 陈建华 一种产科用给药装置
CN115697436A (zh) 2020-06-12 2023-02-03 诺和诺德股份有限公司 具有尖头组件的可摄取装置
EP4188508A2 (en) * 2020-07-30 2023-06-07 Verily Life Sciences LLC Pill with needle delivery system having outwardly expanding mechanical actuation
US12350380B1 (en) * 2020-07-30 2025-07-08 Verily Life Sciences Llc Enteric coating for targeting the duodenum
WO2022033949A1 (en) 2020-08-08 2022-02-17 Novo Nordisk A/S Lumen insertable capsule
CN116096452A (zh) 2020-08-10 2023-05-09 麻省理工学院 药物递送装置
WO2022035750A1 (en) 2020-08-10 2022-02-17 Massachusetts Institute Of Technology Ingestible drug delivery device
AU2021354905A1 (en) 2020-09-30 2023-03-16 Novo Nordisk A/S Lumen insertable capsule
CN116322877A (zh) 2020-10-09 2023-06-23 诺和诺德股份有限公司 胶囊装置
JP2024504188A (ja) 2021-01-28 2024-01-30 ノボ・ノルデイスク・エー／エス 流体作動の作動機構を有する医療装置
WO2022162102A1 (en) 2021-01-28 2022-08-04 Novo Nordisk A/S Medical device with improved actuation mechanism
WO2022174040A1 (en) * 2021-02-11 2022-08-18 10X Technology Llc Method and apparatus for fabricating brittle microneedle
WO2022195476A1 (en) 2021-03-15 2022-09-22 Clexio Biosciences Ltd. Gastroretentive devices for assessment of intragastric conditions
FI130351B (fi) * 2021-04-21 2023-07-05 Robomed Oy Langaton kapselirobotti ja järjestelmä langattoman kapselirobotin operoimiseksi
EP4355393A1 (en) 2021-06-18 2024-04-24 Novo Nordisk A/S Medical device with fluid acivated actuation mechanism
JP2024531127A (ja) * 2021-08-09 2024-08-29 マサチューセッツ インスティテュート オブ テクノロジー 摂取可能デバイス
CN116370811A (zh) * 2021-12-22 2023-07-04 厦门大学 一种用于胃肠道给药的自定向装置
CN114403948A (zh) * 2022-01-10 2022-04-29 烟台美神科美医疗美容门诊部有限公司 一种增加脂肪细胞存活率的自体脂肪移植设备
WO2023144402A1 (en) 2022-01-31 2023-08-03 Novo Nordisk A/S Ingestible device with detachment of tissue penetrating member
CN118632725A (zh) 2022-01-31 2024-09-10 诺和诺德股份有限公司 具有可分离的组织穿透构件的可摄取装置
TW202347959A (zh) 2022-03-31 2023-12-01 日商日東電工股份有限公司 體彈性波濾波器裝置
US20240009394A1 (en) * 2022-07-08 2024-01-11 Becton, Dickinson And Company Insertion Mechanism with Automatic Activation
WO2024038122A1 (en) 2022-08-17 2024-02-22 Novo Nordisk A/S Ingestible device with rotational trigger release
WO2024038123A1 (en) 2022-08-17 2024-02-22 Novo Nordisk A/S Ingestible device with rotational drive mechanism
WO2024115766A1 (en) 2022-12-01 2024-06-06 Novo Nordisk A/S Ingestible device with shielding arrangement
JP2025541251A (ja) * 2022-12-13 2025-12-18 ヴェリリー ライフ サイエンシズ エルエルシー インビボ環境での自己配向能を有する摂取可能なデバイス
KR102553293B1 (ko) * 2022-12-23 2023-07-07 대원제약주식회사 세마글루타이드를 포함하는 마이크로니들 및 이의 제조방법
WO2024163831A1 (en) * 2023-02-03 2024-08-08 Janssen Biotech, Inc. Devices and methods for delivering a drug via an api-loaded tissue penetrator
WO2024184282A1 (en) 2023-03-03 2024-09-12 Novo Nordisk A/S Lumen insertable capsule
CN116549827B (zh) * 2023-06-13 2024-08-02 中日友好医院(中日友好临床医学研究所) 用于向胃壁递送药物的微针及其制备方法和药物递送系统

Family Cites Families (344)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2601767A (en) 1946-04-22 1952-07-01 Thomas P Wall Self righting cup
US3442045A (en) * 1967-02-06 1969-05-06 Joseph Green Variable speed self-righting toy
US3386409A (en) 1967-05-16 1968-06-04 Dietz Co R E Self-righting traffic cone
US3656483A (en) * 1970-01-15 1972-04-18 Biolog Concepts Inc Intrauterine medicator
NL175029C (nl) 1970-12-23 1984-09-17 Boehringer Sohn Ingelheim Depotdragee, die bekleed is met een onoplosbare en onverteerbare schaal, die op een of meer plaatsen een uitsparing vertoont.
US3797492A (en) 1972-12-27 1974-03-19 Alza Corp Device for dispensing product with directional guidance member
US3826220A (en) 1973-01-22 1974-07-30 C Jacobson Self-righting power-driven aquatic vehicle
US4239040A (en) 1976-10-19 1980-12-16 Kabushiki Kaisha Daini Seikosha Capsule for medical use
US4193397A (en) 1977-12-01 1980-03-18 Metal Bellows Corporation Infusion apparatus and method
US4481952A (en) * 1978-03-22 1984-11-13 Jerzy Pawelec Device for the study of the alimentary canal
US4236525A (en) 1978-11-22 1980-12-02 Intermedics, Inc. Multiple function lead assembly
JPS55166142A (en) 1979-06-14 1980-12-25 Olympus Optical Co Capsule device for medical treatment
DE2928477C3 (de) * 1979-07-14 1982-04-15 Battelle-Institut E.V., 6000 Frankfurt Vorrichtung zur Freisetzung von Substanzen an definierten Orten des Verdauungstraktes
JPS57156736A (en) * 1981-03-23 1982-09-28 Olympus Optical Co Therapeutic capsule apparatus
JPS5819232A (ja) 1981-07-29 1983-02-04 オリンパス光学工業株式会社 医療用カプセル
US4407283A (en) 1981-10-19 1983-10-04 Dale C. Grier Self-injecting syringe
GB8508173D0 (en) 1985-03-28 1985-05-01 Standard Telephones Cables Ltd Controlled delivery device
DE8536337U1 (de) 1985-12-23 1986-02-13 R.P. Scherer GmbH, 6930 Eberbach Füllkeil für eine Maschine zum Herstellen von Gelatinekapseln
US5002772A (en) 1988-05-31 1991-03-26 Pfizer Inc. Gastric retention system for controlled drug release
JPH03163011A (ja) 1989-08-31 1991-07-15 Yamanouchi Pharmaceut Co Ltd 胃内滞留デバイス
US5474785A (en) 1990-01-24 1995-12-12 Alza Corporation Delivery system comprising means for controlling internal pressure
US5017187A (en) 1990-05-04 1991-05-21 Sullivan Robert J Self retracting hypodermic syringe
US5125491A (en) 1990-06-21 1992-06-30 Usui Kokusai Sangyo Kaisha Limited Temperature sensitive type fluid fan coupling apparatus
US5217449A (en) 1990-12-11 1993-06-08 Miyarisan Kabushiki Kaisha Medical capsule and apparatus for activating the same
US5279607A (en) 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
ES2246004T3 (es) 1996-02-02 2006-02-01 Alza Corporation Liberacion prolongada de un agente activo usando un sistema implantable.
US5690691A (en) 1996-05-08 1997-11-25 The Center For Innovative Technology Gastro-intestinal pacemaker having phased multi-point stimulation
FR2749955B1 (fr) 1996-06-14 1998-09-11 Thomson Csf Systeme de lecture d'empreintes digitales
AU4107297A (en) 1996-09-05 1998-03-26 Governors Of The University Of Alberta, The Gastro-intestinal electrical pacemaker
IT1292016B1 (it) 1997-05-28 1999-01-25 Valerio Cigaina Dispositivo di impianto particolarmente per elettrostimolazione e/o elettroregistrazione di visceri endoaddominali
US6030641A (en) 1997-06-03 2000-02-29 Uni Colloid Kabushiki Kaisha Sustained release capsule and method for preparing the same
WO1999007342A1 (en) 1997-08-11 1999-02-18 Alza Corporation Prolonged release active agent dosage form adapted for gastric retention
IE970782A1 (en) 1997-10-22 1999-05-05 Elan Corp An improved automatic syringe
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
WO1999064580A1 (en) 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6346519B1 (en) 1998-09-09 2002-02-12 Advanced Medical Instruments Method and composition for treating arthritis
IL126727A (en) * 1998-10-22 2006-12-31 Given Imaging Ltd A method of bringing a device to the goal
US7076307B2 (en) 2002-05-09 2006-07-11 Boveja Birinder R Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders
SE9804126D0 (sv) 1998-11-27 1998-11-27 Astra Ab New pharmaceutical composition
US6684104B2 (en) 1999-04-14 2004-01-27 Transneuronix, Inc. Gastric stimulator apparatus and method for installing
EP1173151B1 (en) 1999-04-16 2003-07-09 Novo Nordisk A/S Dry, mouldable drug formulation
FR2794654B1 (fr) 1999-06-08 2001-10-19 Ct De Transfert Des Microtechn Dispositif de largage de substances dans un tube digestif
US7744613B2 (en) 1999-06-25 2010-06-29 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US20050079214A1 (en) 1999-09-01 2005-04-14 John Cooker Oral delivery system and method for making same
EP1229885B1 (en) 1999-10-13 2004-05-19 Novo Nordisk A/S Method for producing an elongated drug formulation
US20070203531A9 (en) 1999-12-03 2007-08-30 Medtronic, Inc. Heart rate variability control of gastric electrical stimulator
GB9930001D0 (en) 1999-12-21 2000-02-09 Phaeton Research Ltd An ingestible device
GB9930000D0 (en) 1999-12-21 2000-02-09 Phaeton Research Ltd An ingestible device
US7039453B2 (en) 2000-02-08 2006-05-02 Tarun Mullick Miniature ingestible capsule
WO2001058424A1 (en) 2000-02-09 2001-08-16 West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited Floating drug delivery composition
AUPQ573300A0 (en) 2000-02-21 2000-03-16 Australian Nuclear Science & Technology Organisation Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use
US6488962B1 (en) 2000-06-20 2002-12-03 Depomed, Inc. Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms
US6929636B1 (en) 2000-11-08 2005-08-16 Hewlett-Packard Development Company, L.P. Internal drug dispenser capsule medical device
US6615084B1 (en) 2000-11-15 2003-09-02 Transneuronix, Inc. Process for electrostimulation treatment of morbid obesity
US6638246B1 (en) 2000-11-28 2003-10-28 Scimed Life Systems, Inc. Medical device for delivery of a biologically active material to a lumen
EP1345646A2 (en) 2000-12-14 2003-09-24 Georgia Tech Research Corporation Microneedle devices and production thereof
US6535764B2 (en) 2001-05-01 2003-03-18 Intrapace, Inc. Gastric treatment and diagnosis device and method
US7702394B2 (en) 2001-05-01 2010-04-20 Intrapace, Inc. Responsive gastric stimulator
US7756582B2 (en) 2001-05-01 2010-07-13 Intrapace, Inc. Gastric stimulation anchor and method
US6939292B2 (en) 2001-06-20 2005-09-06 Olympus Corporation Capsule type endoscope
US7160258B2 (en) 2001-06-26 2007-01-09 Entrack, Inc. Capsule and method for treating or diagnosing the intestinal tract
GB2379390B (en) 2001-09-11 2005-01-26 Caretek Medical Ltd A novel drug delivery technology
JP4578740B2 (ja) 2001-09-21 2010-11-10 オリンパス株式会社 カプセル型医療装置
JP4643089B2 (ja) 2001-09-27 2011-03-02 オリンパス株式会社 カプセル型医療装置
US7100274B2 (en) 2001-11-02 2006-09-05 Neptco Incorporated Apparatus for applying media to a conduit
US8454997B2 (en) 2001-12-18 2013-06-04 Novo Nordisk A/S Solid dose micro implant
WO2003057136A2 (en) 2001-12-24 2003-07-17 Teva Pharmaceutical Industries Ltd. Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it
US20030195415A1 (en) 2002-02-14 2003-10-16 Iddan Gavriel J. Device, system and method for accoustic in-vivo measuring
JP3869291B2 (ja) 2002-03-25 2007-01-17 オリンパス株式会社 カプセル型医療装置
US8241308B2 (en) 2002-04-24 2012-08-14 Boston Scientific Scimed, Inc. Tissue fastening devices and processes that promote tissue adhesion
JP4231657B2 (ja) 2002-05-10 2009-03-04 オリンパス株式会社 カプセル型医療装置
JP2004041709A (ja) 2002-05-16 2004-02-12 Olympus Corp カプセル医療装置
US20040193229A1 (en) 2002-05-17 2004-09-30 Medtronic, Inc. Gastric electrical stimulation for treatment of gastro-esophageal reflux disease
US8142365B2 (en) 2002-05-31 2012-03-27 Vidacare Corporation Apparatus and method for accessing the bone marrow of the sternum
US9314228B2 (en) 2002-05-31 2016-04-19 Vidacare LLC Apparatus and method for accessing the bone marrow
US6945952B2 (en) 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
WO2004009172A1 (en) 2002-07-19 2004-01-29 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
US20040044364A1 (en) 2002-08-29 2004-03-04 Devries Robert Tissue fasteners and related deployment systems and methods
US7118531B2 (en) 2002-09-24 2006-10-10 The Johns Hopkins University Ingestible medical payload carrying capsule with wireless communication
US8449452B2 (en) 2002-09-30 2013-05-28 Given Imaging Ltd. In-vivo sensing system
WO2004033021A1 (en) 2002-10-07 2004-04-22 Biovalve Technologies, Inc. Microneedle array patch
US20040106849A1 (en) * 2002-12-03 2004-06-03 Cho Jin-Ho Multi-functional, bi-directional communication telemetry capsule
US7946979B2 (en) 2002-12-26 2011-05-24 Given Imaging, Ltd. Immobilizable in vivo sensing device
US7833151B2 (en) 2002-12-26 2010-11-16 Given Imaging Ltd. In vivo imaging device with two imagers
CN1756571A (zh) 2002-12-30 2006-04-05 血管技术国际股份公司 组织反应性化合物和组合物及其应用
CA2511486A1 (en) 2002-12-30 2004-07-22 Angiotech International Ag Tissue reactive compounds and compositions and uses thereof
US7153454B2 (en) 2003-01-21 2006-12-26 University Of Southern California Multi-nozzle assembly for extrusion of wall
JP2004222998A (ja) 2003-01-23 2004-08-12 Olympus Corp 超音波診断用カプセル
US20050058701A1 (en) 2003-01-29 2005-03-17 Yossi Gross Active drug delivery in the gastrointestinal tract
RU2334506C2 (ru) 2003-01-29 2008-09-27 И-Пилл Фарма Лтд. Активная доставка лекарственного средства в желудочно-кишечном тракте
US20060058829A1 (en) 2003-03-19 2006-03-16 Sampson Douglas C Intragastric volume-occupying device
US7742818B2 (en) 2003-05-19 2010-06-22 Medtronic, Inc. Gastro-electric stimulation for increasing the acidity of gastric secretions or increasing the amounts thereof
US7620454B2 (en) 2003-05-19 2009-11-17 Medtronic, Inc. Gastro-electric stimulation for reducing the acidity of gastric secretions or reducing the amounts thereof
US9186233B2 (en) 2003-07-23 2015-11-17 Lothar Göbel Closing system for a natural or artificial anus
US9498366B2 (en) 2003-07-28 2016-11-22 Baronova, Inc. Devices and methods for pyloric anchoring
US20050055014A1 (en) 2003-08-04 2005-03-10 Coppeta Jonathan R. Methods for accelerated release of material from a reservoir device
US8353861B2 (en) 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
US8021356B2 (en) 2003-09-29 2011-09-20 Olympus Corporation Capsule medication administration system, medication administration method using capsule medication administration system, control method for capsule medication administration system
US20050124875A1 (en) 2003-10-01 2005-06-09 Olympus Corporation Vivo observation device
US20050075654A1 (en) 2003-10-06 2005-04-07 Brian Kelleher Methods and devices for soft tissue securement
US8029503B2 (en) 2003-10-11 2011-10-04 The Regents Of The University Of California Nerve repair by selective surgical repair of axons
US7918786B2 (en) 2003-11-11 2011-04-05 Olympus Corporation Capsule type medical device system, and capsule type medical device
US7177693B2 (en) 2004-01-07 2007-02-13 Medtronic, Inc. Gastric stimulation for altered perception to treat obesity
US20050149142A1 (en) 2004-01-07 2005-07-07 Starkebaum Warren L. Gastric stimulation responsive to sensing feedback
WO2005092189A1 (en) 2004-03-25 2005-10-06 Olympus Corporation In-vivo information acquisition apparatus and in-vivo information acquisition apparatus system
US8000784B2 (en) 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling device
CN1953737A (zh) * 2004-05-03 2007-04-25 埃-皮尔制药公司 胃肠道内的主动药物递送
US20050250988A1 (en) 2004-05-07 2005-11-10 Usgi Medical Inc. Removable apparatus for manipulating and securing tissue within a treatment space
DE102004026615A1 (de) 2004-06-01 2005-12-29 Siemens Ag Vorrichtung und Verfahren zur Freisetzung eines in das Körperinnere eines Patienten geführten therapeutischen Mittels
US7678135B2 (en) 2004-06-09 2010-03-16 Usgi Medical, Inc. Compressible tissue anchor assemblies
TWI253024B (en) 2004-07-20 2006-04-11 Realtek Semiconductor Corp Method and apparatus for block matching
DE102005021081B4 (de) 2004-07-23 2019-05-29 Advanced Medical Balloons Gmbh Rektal-Tubus
JP4589048B2 (ja) 2004-08-04 2010-12-01 オリンパス株式会社 カプセル型内視鏡
US20060034913A1 (en) 2004-08-13 2006-02-16 James Gaede Multiplex drug delivery device
DK1814622T3 (en) 2004-08-13 2016-02-29 Obalon Therapeutics Inc Intragastric volume-receiving device
US20060047309A1 (en) * 2004-08-25 2006-03-02 Cichocki Frank R Jr Metal injection molded suture needles
US8518022B2 (en) 2004-08-27 2013-08-27 Medimetrics Personalized Drug Delivery, Inc. Electronically and remotely controlled pill and system for delivering at least one medicament
JP4656909B2 (ja) 2004-10-15 2011-03-23 オリンパス株式会社 被検体内導入装置およびその製造方法
JP2008521794A (ja) 2004-11-29 2008-06-26 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 少なくとも一の薬剤を輸送するための、少なくとも一のセンサを有する電子制御式の錠剤およびシステム
JP2008522778A (ja) 2004-12-14 2008-07-03 イー−ピル ファーマ リミティド 電気透過性増加を用いた薬物又は物質の局所輸送
CN101107043A (zh) * 2005-01-18 2008-01-16 皇家飞利浦电子股份有限公司 用于释放辐射的电控胶囊
CN101237903A (zh) 2005-01-18 2008-08-06 皇家飞利浦电子股份有限公司 用于控制所摄入胶囊通过的系统和方法
WO2006077528A2 (en) * 2005-01-18 2006-07-27 Koninklijke Philips Electronics, N.V. Electronically controlled capsule
EP1843755B1 (en) 2005-02-01 2015-04-01 Emisphere Technologies, Inc. Gastric retention and controlled release delivery system
US8852083B2 (en) * 2005-02-04 2014-10-07 Uti Limited Partnership Self-stabilized encapsulated imaging system
US20060259074A1 (en) 2005-02-22 2006-11-16 Brian Kelleher Methods and devices for anchoring to soft tissue
US7699863B2 (en) 2005-03-01 2010-04-20 Tulip Medical Ltd. Bioerodible self-deployable intragastric implants
US20080193543A1 (en) 2005-05-17 2008-08-14 Brown University Research Foundation Drug Delivery Formulations For Targeted Delivery
US9585651B2 (en) 2005-05-26 2017-03-07 Usgi Medical, Inc. Methods and apparatus for securing and deploying tissue anchors
US8021357B2 (en) * 2005-05-27 2011-09-20 Olympus Corporation Body-insertable apparatus
US8777967B2 (en) 2005-06-09 2014-07-15 Xlumena, Inc. Methods and devices for anchoring to tissue
WO2006131522A1 (de) 2005-06-10 2006-12-14 Siemens Aktiengesellschaft Vorrichtung und verfahren zur diagnose und/oder behandlung funktioneller gastrointestinaler erkrankungen
US20050240239A1 (en) 2005-06-29 2005-10-27 Boveja Birinder R Method and system for gastric ablation and gastric pacing to provide therapy for obesity, motility disorders, or to induce weight loss
DE102005032290A1 (de) 2005-07-11 2007-01-18 Siemens Ag Endoskopiekapsel sowie Verfahren zur Diagnose und/oder Therapie mittles einer Endoskopiekapsel
US20070021760A1 (en) 2005-07-19 2007-01-25 Brian Kelleher Methods and apparatus for securing an anchor to soft tissue
US8021384B2 (en) 2005-07-26 2011-09-20 Ram Weiss Extending intrabody capsule
US20070038181A1 (en) 2005-08-09 2007-02-15 Alexander Melamud Method, system and device for delivering a substance to tissue
CN100376299C (zh) 2005-08-19 2008-03-26 华南理工大学 化学反应气压式微胶囊药物释放方法及其装置
US8295932B2 (en) 2005-12-05 2012-10-23 Metacure Limited Ingestible capsule for appetite regulation
JP4358821B2 (ja) 2005-12-15 2009-11-04 オリンパス株式会社 被検体内導入装置
JP4402648B2 (ja) 2005-12-16 2010-01-20 オリンパス株式会社 被検体内導入装置
US8062287B2 (en) 2005-12-22 2011-11-22 Koninklijke Philips Electronics N V Device for controlled release of chemical molecules
US8252329B2 (en) 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
CN1820798A (zh) 2006-01-28 2006-08-23 重庆大学 胶囊式消化道药物释放及采样装置
GB0603252D0 (en) 2006-02-17 2006-03-29 Axcess Ltd Dissolution aids for oral peptide delivery
CN100490916C (zh) 2006-04-03 2009-05-27 重庆大学 胶囊式消化道定时药物释放装置
DE102006019419B4 (de) 2006-04-26 2008-02-14 Siemens Ag Aktuator insbesondere eines Endoroboters
US8101114B2 (en) 2006-05-01 2012-01-24 Georgia Tech Research Corporation Particle based molding
EP2032093B1 (en) 2006-05-18 2013-09-04 Tulip Medical Ltd. Bioerodible intragastric implant
CN101453991B (zh) 2006-06-07 2012-02-01 诺瓦提斯公司 应用滚压机制备多颗粒的方法
RU2009101475A (ru) 2006-06-20 2010-07-27 Конинклейке Филипс Электроникс, Н.В. (Nl) Электронная капсула и способ для лечения желудочно-кишечного заболевания
EP2046434B1 (en) 2006-06-23 2012-02-08 Koninklijke Philips Electronics N.V. Medicament delivery system
US20100247453A1 (en) * 2006-07-12 2010-09-30 Thomas L. Jones Composition and method of treating a sore throat
RU2009115642A (ru) 2006-09-25 2010-11-20 Конинклейке Филипс Электроникс, Н.В. (Nl) Устройство для доставки лекарственного средства
WO2008038246A2 (en) 2006-09-29 2008-04-03 Koninklijke Philips Electronics, N.V. Miniaturized threshold sensor
CN101534711B (zh) 2006-10-31 2012-11-14 皇家飞利浦电子股份有限公司 用于在胃肠道中释放药物的可吞吃的多喷嘴给药设备的设计
EP1923083A1 (en) 2006-11-17 2008-05-21 Sanofi-Aventis Deutschland GmbH Drive mechanisms for use in drug delivery devices
JP5697871B2 (ja) 2006-11-21 2015-04-08 メディメトリクス ペルソナリズド ドルグ デリヴェリー ベー ヴェ 薬物送達カプセル、及び生体内での薬剤送達又は診断システム
JP5203962B2 (ja) 2006-11-24 2013-06-05 オリンパスメディカルシステムズ株式会社 カプセル型内視鏡
CN100482293C (zh) 2006-12-19 2009-04-29 重庆大学 缓释型遥控电子胶囊
US8702591B2 (en) 2007-01-12 2014-04-22 Olympus Medical Systems Corp. Capsule medical apparatus
US20080167680A1 (en) 2007-01-10 2008-07-10 Voegele James W Fingertip Surgical Instrument
CA2680814A1 (en) 2007-03-15 2008-09-18 Bioprotect Ltd. Soft tissue fixation devices
US20080257845A1 (en) 2007-04-23 2008-10-23 Esmeralda Reyes Rossi Self Righting Baby Bottle
US7925351B2 (en) 2007-06-13 2011-04-12 Betastim, Ltd. Gastrointestinal device for treating obesity and diabetes
WO2009041525A1 (ja) 2007-09-26 2009-04-02 Olympus Medical Systems Corp. 被検体内導入システム
EP2209456B1 (en) 2007-10-15 2013-03-06 Capsugel Belgium NV Linkers for multipart dosage forms for release of one or more pharmaceutical compositions, and the resulting dosage forms
US8789536B2 (en) * 2007-10-17 2014-07-29 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8333754B2 (en) 2007-10-31 2012-12-18 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
WO2009063376A1 (en) 2007-11-13 2009-05-22 Koninklijke Philips Electronics N.V. Ingestible electronic capsule
WO2009063377A1 (en) 2007-11-13 2009-05-22 Koninklijke Philips Electronics N.V. Ingestible electronic capsule
WO2009063375A1 (en) 2007-11-13 2009-05-22 Koninklijke Philips Electronics N.V. Ingestible electronic capsule
US20090137866A1 (en) 2007-11-28 2009-05-28 Searete Llc, A Limited Liability Corporation Of The State Delaware Medical or veterinary digestive tract utilization systems and methods
MX348005B (es) * 2007-12-11 2017-05-23 Massachusetts Inst Technology Dispositivo implantable de liberación de fármacos y métodos para tratar la vejiga y otras vesículas o lúmenes corporales.
US20090155354A1 (en) * 2007-12-14 2009-06-18 Mclean Barbara Wanamaker Dispensing encapsulated liquids into body cavities
EP2254464B1 (en) 2008-02-18 2017-01-04 Medimetrics Personalized Drug Delivery B.V. Administration of drugs to a patient
EP2262413B1 (en) 2008-03-31 2014-02-26 Medimetrics Personalized Drug Delivery B.V. Swallowable capsule comprising a sensor and method of its preparation
JP5314913B2 (ja) 2008-04-03 2013-10-16 オリンパスメディカルシステムズ株式会社 カプセル医療システム
JP5363020B2 (ja) 2008-04-07 2013-12-11 オリンパスメディカルシステムズ株式会社 カプセル型医療装置および医療システム
US8454632B2 (en) 2008-05-12 2013-06-04 Xlumena, Inc. Tissue anchor for securing tissue layers
ATE505128T1 (de) 2008-06-04 2011-04-15 Olympus Medical Systems Corp Kapselförmige medizinische vorrichtung
US9067011B2 (en) 2008-06-19 2015-06-30 MEDIMETRICS Personalized Drug Delivery B.V. Device for delivery of powder like medication in a humid environment
JP5599393B2 (ja) 2008-07-07 2014-10-01 コーニンクレッカ フィリップス エヌ ヴェ 薬物リザーバを有する電子ピル
US20100010294A1 (en) 2008-07-10 2010-01-14 Ethicon Endo-Surgery, Inc. Temporarily positionable medical devices
US8287902B2 (en) 2008-07-23 2012-10-16 Rainbow Medical Ltd. Enhanced-diffusion capsule
EP2335915A4 (en) 2008-09-08 2012-03-28 Taisho Pharmaceutical Co Ltd PRESS FOR TABLETING
WO2010055796A1 (ja) 2008-11-13 2010-05-20 オリンパスメディカルシステムズ株式会社 カプセル型医療装置
EP2201938A1 (en) 2008-12-18 2010-06-30 Koninklijke Philips Electronics N.V. Controllable drug delivery capsule
TWI602561B (zh) 2009-01-06 2017-10-21 波提亞斯數位康健公司 醫藥劑量傳送系統
US9107993B2 (en) 2011-11-21 2015-08-18 Incube Labs, Llc Myocardial drug delivery apparatus and method
CN102196763B (zh) 2009-01-28 2013-08-14 奥林巴斯医疗株式会社 胶囊型医疗装置系统
WO2010093834A2 (en) * 2009-02-12 2010-08-19 Incube Labs, Llc Skin penetrating device and method for subcutaneous solid drug delivery
US8538532B2 (en) 2009-03-03 2013-09-17 Medtronic, Inc. Electrical stimulation therapy to promote gastric distention for obesity management
US20100248828A1 (en) 2009-03-24 2010-09-30 Ty Huynh Kaing Educational toy
BRPI1006755A2 (pt) 2009-04-07 2019-03-26 Koninl Philips Electronics Nv dispositivo de administração de droga
EP2416834B1 (en) 2009-04-07 2013-10-16 Medimetrics Personalized Drug Delivery B.V. Modular ingestible drug delivery capsule
CN102458559B (zh) * 2009-04-10 2014-06-04 3M创新有限公司 制造中空微针阵列的方法以及由其制得的制品和用途
US20110052695A1 (en) 2009-04-20 2011-03-03 Allergan, Inc. Drug delivery platforms comprising silk fibroin hydrogels and uses thereof
US20100286628A1 (en) 2009-05-07 2010-11-11 Rainbow Medical Ltd Gastric anchor
US7967797B2 (en) 2009-05-19 2011-06-28 Nexus Medical, Llc Intravascular valve component with improved valve positioning
JP4642941B2 (ja) 2009-05-29 2011-03-02 オリンパスメディカルシステムズ株式会社 カプセル型医療装置
JP2011012050A (ja) 2009-06-03 2011-01-20 Bioserentack Co Ltd 多孔性基盤を用いたマイクロニードル・アレイとその製造方法
CN109157742B (zh) 2009-08-03 2022-04-05 因卡伯实验室有限责任公司 用于刺激肠道内肠促胰岛素产生的吞咽式囊和方法
WO2011018753A1 (en) 2009-08-12 2011-02-17 Koninklijke Philips Electronics N.V. Drug delivery device with compressible drug reservoir
JP2013501568A (ja) 2009-08-12 2013-01-17 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 薬品送出装置のための医薬貯槽
US20130011332A1 (en) 2009-09-15 2013-01-10 Searete Llc, Frozen Compositions and Methods for Piercing a Substrate
MX2012001181A (es) 2009-09-21 2012-04-30 Medtronic Inc Ondas para terapia de estimulacion electrica.
US9017310B2 (en) 2009-10-08 2015-04-28 Palo Alto Research Center Incorporated Transmucosal drug delivery device and method including microneedles
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
WO2011073892A1 (en) 2009-12-17 2011-06-23 Koninklijke Philips Electronics N.V. Swallowable capsule for monitoring a condition
US8721620B2 (en) * 2009-12-24 2014-05-13 Rani Therapeutics, Llc Swallowable drug delivery device and methods of drug delivery
EP3461478B1 (en) * 2009-12-24 2020-04-22 Rani Therapeutics, LLC Swallowable drug delivery device
WO2011112229A2 (en) * 2010-03-10 2011-09-15 Incube Labs, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
WO2011095486A1 (en) 2010-02-05 2011-08-11 Sanofi-Aventis Deutschland Gmbh Medicated module with lockable needle guard
BR112012019101A2 (pt) * 2010-02-05 2016-09-13 Sanofi Aventis Deutschland módulo medicamentoso com botão de uso duplo e sistema de fornecimento de medicamento.
WO2011118253A1 (ja) 2010-03-26 2011-09-29 オリンパスメディカルシステムズ株式会社 カプセル型医療装置用誘導システムおよびカプセル型医療装置の誘導方法
DE102010020614A1 (de) 2010-05-14 2011-11-17 Friedrich-Alexander-Universität Erlangen-Nürnberg Endoskopiekapsel zum Nachweis eines Stoffwechselproduktes eines in oder an der Wand eines Hohlorgans des menschlichen oder tierischen Gastrointestinaltraktes befindlichen Erregers
WO2012004231A1 (en) 2010-07-05 2012-01-12 Jagotec Ag Dosage form
US20180296814A1 (en) 2010-08-17 2018-10-18 Progenity, Inc. Administration of drugs to a patient
EP2433663A1 (en) * 2010-09-27 2012-03-28 Unomedical A/S Insertion system
EP2624907B1 (en) 2010-10-06 2014-11-12 Medimetrics Personalized Drug Delivery B.V. Electronic pill for delivery of powder medication
JP5969495B2 (ja) * 2010-12-02 2016-08-17 スリーエム イノベイティブ プロパティズ カンパニー 液晶ポリマーマイクロニードル
US8846040B2 (en) 2010-12-23 2014-09-30 Rani Therapeutics, Llc Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402807B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10639272B2 (en) 2010-12-23 2020-05-05 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US9283179B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809271B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising liraglutide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8734429B2 (en) 2010-12-23 2014-05-27 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US8809269B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8969293B2 (en) 2010-12-23 2015-03-03 Rani Therapeutics, Llc Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9149617B2 (en) 2010-12-23 2015-10-06 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US9402806B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9259386B2 (en) 2010-12-23 2016-02-16 Rani Therapeutics, Llc Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9284367B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8980822B2 (en) 2010-12-23 2015-03-17 Rani Therapeutics, Llc Therapeutic agent preparations comprising pramlintide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9415004B2 (en) 2010-12-23 2016-08-16 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9861683B2 (en) * 2010-12-23 2018-01-09 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9629799B2 (en) 2010-12-23 2017-04-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8764733B2 (en) 2010-12-23 2014-07-01 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US20130331792A1 (en) * 2011-01-18 2013-12-12 The Brigham And Women's Hospital, Inc. Device and uses thereof
US9089677B2 (en) 2011-01-25 2015-07-28 The Regents Of The University Of California Transcutaneous multimodal delivery system (TMDS)
US9687638B2 (en) 2011-03-24 2017-06-27 Medimetrics Personalized Drug Delivery Swallowable medication capsule
US20140228715A1 (en) 2011-05-13 2014-08-14 The General Hospital Corporation Method and Apparatus for Delivering a Substance
US20120305573A1 (en) 2011-06-03 2012-12-06 Deliang Shi Self-Righting Containers
US20120305574A1 (en) 2011-06-03 2012-12-06 Deliang Shi Self-Righting Container
EP2726141B1 (en) 2011-06-29 2019-12-25 Rani Therapeutics, LLC Device for the oral delivery of therapeutic compounds
JP5945882B2 (ja) 2011-07-22 2016-07-05 東芝メディカルシステムズ株式会社 マーキング用カプセル及びカプセル内視鏡システム
WO2013021374A2 (en) 2011-08-05 2013-02-14 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
KR101861307B1 (ko) * 2011-10-13 2018-07-06 한미약품 주식회사 정제를 포함하는 경질 캡슐 복합 제형
US10814115B2 (en) * 2011-12-27 2020-10-27 Massachusetts Institute Of Technology Microneedle devices and uses thereof
US9149172B2 (en) 2011-12-29 2015-10-06 Given Imaging Ltd. System and apparatus for anchoring and operation of in-vivo medical devices
ES2533576T3 (es) * 2011-12-30 2015-04-13 Q-Med Ab Cánula sin hematomas
US9610401B2 (en) 2012-01-13 2017-04-04 Medtronic Minimed, Inc. Infusion set component with modular fluid channel element
EP2819584B1 (en) 2012-02-17 2020-04-08 Progenity, Inc. Ingestible medical device
WO2013145855A1 (ja) 2012-03-27 2013-10-03 ソニー株式会社 カプセル型医療装置および医療システム
HK1209658A1 (en) * 2012-05-01 2016-04-08 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Tip-loaded microneedle arrays for transdermal insertion
DE102012207714A1 (de) 2012-05-09 2013-11-14 BSH Bosch und Siemens Hausgeräte GmbH Gerät, insbesondere ein Haarstylinggerät
WO2013183624A1 (ja) * 2012-06-08 2013-12-12 オリンパスメディカルシステムズ株式会社 カプセル型医療装置
CA2915358A1 (en) 2012-06-14 2013-12-19 Entrega, Inc. Mucoadhesive devices for delivery of active agents
US9938814B2 (en) 2012-07-05 2018-04-10 Halliburton Energy Services, Inc. Displaceable components in drilling operations
US8755888B2 (en) 2012-10-17 2014-06-17 Melcap Systems Ltd. Gastrointestinal system
CN102920418B (zh) 2012-10-24 2014-07-30 刘思德 一种消化道自稳探路胶囊
US9526884B2 (en) * 2012-11-16 2016-12-27 City University Of Hong Kong Mechanically robust fast-dissolving microneedles for transdermal drug and vaccine delivery
GB201304662D0 (en) * 2013-03-14 2013-05-01 Sigmoid Pharma Ltd Compositions
JP6522523B2 (ja) * 2013-02-28 2019-05-29 ソレント・セラピューティクス・インコーポレイテッド 経皮的薬物送達装置
ES2794018T3 (es) 2013-03-04 2020-11-17 Vtv Therapeutics Llc Composiciones sólidas que comprenden un activador de la glucoquinasa y métodos para crearlas y usarlas
US20160022873A1 (en) 2013-03-14 2016-01-28 Research Institute At Nationwide Children's Hospital, Inc. Tissue engineered intestine
PL2968071T3 (pl) * 2013-03-15 2021-12-20 Rani Therapeutics, Llc Urządzenie do doustnego dostarczania związków leczniczych
US10071199B2 (en) 2013-03-15 2018-09-11 Incube Labs, Llc Multi-stage biodegradable drug delivery platform
CA2944480C (en) * 2013-04-10 2021-05-18 Massachusetts Institute Of Technology Local drug delivery devices and methods for treating cancer
US20160074422A1 (en) 2013-05-08 2016-03-17 Northeastern University Mucus strengthening formulations to alter mucus barrier properties
US20150064241A1 (en) 2013-09-05 2015-03-05 Google Inc. Delivery of Functionalized Particles
CN105517605A (zh) 2013-09-16 2016-04-20 诺和诺德股份有限公司 用于选择性的按固定剂量给药或按可变剂量给药的注射设备
EP3750590B8 (en) 2013-09-26 2025-08-13 BT Bidco, Inc. Delivery capsule with threshold release
KR102457026B1 (ko) 2013-11-05 2022-10-21 신애질 코포레이션 입을 통한 연속적 약물 전달
EP2881141B1 (fr) 2013-12-04 2016-06-01 Sorin CRM SAS Capsule intracardiaque implantable sur une paroi mince, notamment la paroi septale
WO2015112575A1 (en) 2014-01-22 2015-07-30 The Board Of Regents Of The University Of Nebraska Gastrointestinal sensor implantation system
CN113908424B (zh) * 2014-04-24 2025-01-14 佐治亚科技研究公司 微针和其制造方法
WO2015176031A2 (en) 2014-05-15 2015-11-19 Incube Labs, Llc Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins
US10689460B2 (en) 2014-05-15 2020-06-23 Incube Labs, Llc PCSK9 antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US11548940B2 (en) 2014-05-15 2023-01-10 Rani Therapeutics, Llc Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
DE102014015919A1 (de) 2014-06-07 2015-12-17 Trans-Duodenal Concepts Ug I.G. Vorrichtung und Verfahren zur Aufnahme von Mageninhalt und Durchleitung in bzw. durch den Zwölffingerdarm
FI3725357T3 (fi) * 2014-06-11 2024-12-13 Massachusetts Inst Technology Pidättyviä rakenteita ja niihin liittyviä menetelmiä
US9492396B2 (en) 2014-07-15 2016-11-15 Yossi Gross Enhanced drug delivery pill
WO2016039418A1 (ja) 2014-09-11 2016-03-17 久光製薬株式会社 マイクロニードルデバイス
CA2964900C (en) 2014-09-25 2023-02-21 Progenity, Inc. Electromechanical pill device with localization capabilities
US10300259B2 (en) 2014-10-22 2019-05-28 Purdue Research Foundation Smart capsule with GI-tract-location-specific payload release
EP3212133B1 (de) 2014-10-29 2020-03-25 Trans-Duodenal Concepts UG Bypass-vorrichtung zur trans-pylorischen durchleitung von mageninhalt in bzw. durch den zwölffingerdarm sowie applikator zur positionierung desselben
CN104344272A (zh) 2014-10-30 2015-02-11 南京博创工业产品设计有限公司 不倒翁小夜灯
US20160136407A1 (en) * 2014-11-06 2016-05-19 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Microneedle arrays for cancer therapy applications
WO2016102526A1 (en) 2014-12-22 2016-06-30 Novo Nordisk A/S Spring-driven drug delivery device
WO2016155671A1 (zh) 2015-04-02 2016-10-06 傅君志 可吞咽式装置
CN107847446A (zh) 2015-05-01 2018-03-27 因库博实验室有限责任公司 药物组合物和用于制备包含多肽和/或蛋白质的固体块的方法
CN104983385B (zh) * 2015-05-21 2017-01-04 大连理工大学 一种主被动双半球形胶囊机器人及其姿态调整与转弯驱动控制方法
TW201707744A (zh) * 2015-06-03 2017-03-01 賽諾菲阿凡提斯德意志有限公司 藥物輸送裝置（二）
WO2017004000A1 (en) * 2015-06-30 2017-01-05 Entrega Inc. Device for oral delivery of active agents
EP3316872A4 (en) 2015-07-02 2018-12-26 Rani Therapeutics, LLC Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US20180192952A1 (en) 2015-07-02 2018-07-12 The Board Of Trustees Of The University Of Illinois Fully implantable soft medical devices for interfacing with biological tissue
EP3325080B1 (en) 2015-07-24 2021-09-01 Sorrento Therapeutics, Inc. Methods for better delivery of active agents to tumors
AU2016317040A1 (en) 2015-08-31 2018-03-29 Mercator Medsystems, Inc. Local administration of drugs for the treatment of asthma
DK3347050T3 (da) 2015-09-08 2025-04-14 Rani Therapeutics Llc PCSK9-antistofpræparater til afgivelse i et lumen i mave-tarmkanalen ved hjælp af en indtagelig enhed til afgivelse af lægemiddel
WO2017047437A1 (ja) 2015-09-17 2017-03-23 Ａｏｆ株式会社 マイクロニードル
US20170087299A1 (en) 2015-09-25 2017-03-30 Intel Corporation Carrier apparatus to deliver a substance and methods thereof
US11684763B2 (en) * 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
GB2545880A (en) 2015-10-20 2017-07-05 Glide Pharmaceutical Tech Ltd Solid formulation
AU2016342374B2 (en) 2015-10-23 2022-08-04 Lyndra Therapeutics, Inc. Gastric residence systems for sustained release of therapeutic agents and methods of use thereof
CN108697649A (zh) 2015-12-08 2018-10-23 林德拉有限公司 用于胃驻留系统的几何构型
US9913804B2 (en) 2015-12-31 2018-03-13 Incube Labs, Llc Solid drug storage apparatus, formulations and methods of use
US20190046721A1 (en) 2016-02-26 2019-02-14 Progenity Inc. Compact platform for accurate drug delivery
US10220003B2 (en) 2016-03-09 2019-03-05 Incube Labs, Llc Methods and articles for delivering viable cells into solid tissue
JP7189772B2 (ja) 2016-05-27 2022-12-14 リンドラ セラピューティクス， インコーポレイティド 胃内滞留システムのための材料構造物
AU2017312662B2 (en) 2016-08-18 2022-09-08 Bt Bidco, Inc. Sampling systems and related materials and methods
US10271764B2 (en) 2016-09-02 2019-04-30 Elwha Llc Intraluminal devices with deployable elements
CN109862821A (zh) 2016-09-09 2019-06-07 普罗根尼蒂公司 用于递送可配发物质的机电可摄入装置
CA3035125A1 (en) 2016-09-15 2018-03-22 Progenity, Inc. Fluid sampling device
CN106137099A (zh) 2016-09-27 2016-11-23 重庆大学 基于云端服务的智能胶囊检测系统
KR101886217B1 (ko) 2016-11-14 2018-08-07 전남대학교산학협력단 패치형 능동 약물전달 시스템
CN106730284A (zh) 2016-11-24 2017-05-31 上海理工大学 微胶囊式胃肠道药物释放系统
CN110072519A (zh) 2016-12-14 2019-07-30 普罗根尼蒂公司 使用jak抑制剂治疗胃肠道疾病及装置
US11134889B2 (en) 2016-12-14 2021-10-05 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a SMAD7 inhibitor
CA3046019A1 (en) 2016-12-14 2018-06-21 Progenity Inc. Treatment of a disease of the gastrointestinal tract with a tlr modulator
US11224364B2 (en) 2016-12-15 2022-01-18 Progenity, Inc. Ingestible device and associated methods
WO2018183932A1 (en) 2017-03-30 2018-10-04 Progenity Inc. Treatment of a disease of the gastrointestinal tract with a il-13 inhibitor
WO2018182623A1 (en) 2017-03-30 2018-10-04 Progenity Inc. Methods and ingestible devices for the regio-specific release of chst15 inhibitors at the site of gastrointestinal tract disease
CA3054159A1 (en) 2017-03-30 2018-10-04 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a chst15 inhibitor
WO2018182641A1 (en) 2017-03-30 2018-10-04 Progenity Inc. Methods and ingestible devices for the regio-specific release of il-13 inhibitors at the site of gastrointestinal tract disease
US20210401895A1 (en) 2017-03-30 2021-12-30 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with live biotherapeutics
WO2018182612A1 (en) 2017-03-30 2018-10-04 Progenity Inc. Methods and ingestible devices for the regio-specific release of stem cells at the site of gastrointestinal tract disease
JP7045397B2 (ja) 2017-05-17 2022-03-31 マサチューセッツ インスティテュート オブ テクノロジー 自己復元システムおよび関連構成要素
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
CN110996687A (zh) * 2017-05-26 2020-04-10 墨卡托医疗系统公司 用于治疗再狭窄的联合疗法
EP3409303A1 (en) * 2017-06-02 2018-12-05 Geistlich Pharma AG Use of a resorbable crosslinked form stable composition for preparing a membrane
US20200306516A1 (en) 2017-08-14 2020-10-01 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with glatiramer or a pharmaceutically acceptable salt thereof
EP3668544A1 (en) 2017-08-15 2020-06-24 Progenity, Inc. Treatment of inflammatory disease using ingestible device to release immune modulator
AU2018366110B2 (en) 2017-11-07 2024-08-08 Rani Therapeutics, Llc Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device
ES2947662T3 (es) 2017-12-18 2023-08-16 Biograil ApS Administración oral de sustancias farmacológicas activas
US20210031012A1 (en) 2018-01-26 2021-02-04 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a pde4 inhibitor
CA3093815A1 (en) 2018-03-13 2019-09-19 Progenity, Inc. Ingestible device with relatively large payload volume
AU2019269636A1 (en) 2018-05-17 2020-11-19 Massachusetts Institute Of Technology Systems for electrical stimulation
CN108836237B (zh) 2018-06-15 2024-05-10 安翰科技(武汉)股份有限公司 一种具有采样池密封结构的采样胶囊
WO2020160399A1 (en) 2019-02-01 2020-08-06 Massachusetts Institute Of Technology Systems and methods for liquid injection
CN113329777B (zh) 2019-02-01 2024-01-09 诺和诺德股份有限公司 具有致动机构的医疗装置
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components

Also Published As

Publication number Publication date
US20250367420A1 (en) 2025-12-04
MY199911A (en) 2023-11-29
WO2018213579A1 (en) 2018-11-22
PE20200305A1 (es) 2020-02-06
JP7219723B2 (ja) 2023-02-08
US20200147298A1 (en) 2020-05-14
JP2020520700A (ja) 2020-07-16
WO2018213576A8 (en) 2018-12-13
KR102391768B1 (ko) 2022-04-29
US20200129441A1 (en) 2020-04-30
JP7045397B2 (ja) 2022-03-31
KR102647153B1 (ko) 2024-03-15
AU2018269547A1 (en) 2019-11-28
US11179341B2 (en) 2021-11-23
CN110996878A (zh) 2020-04-10
CN117257753A (zh) 2023-12-22
JP2024020636A (ja) 2024-02-14
IL270450B1 (en) 2023-05-01
JP2020521534A (ja) 2020-07-27
EP3624752A4 (en) 2021-03-03
JP7295811B2 (ja) 2023-06-21
CN110996878B (zh) 2022-11-15
JP7329449B2 (ja) 2023-08-18
US20240024250A1 (en) 2024-01-25
AU2018269550A1 (en) 2019-11-28
CN115804886A (zh) 2023-03-17
MX2019013747A (es) 2020-07-20
US11369574B2 (en) 2022-06-28
CA3063426A1 (en) 2018-11-22
WO2018213588A1 (en) 2018-11-22
WO2018213593A9 (en) 2019-08-15
CN110891646B (zh) 2023-07-04
JP2025176082A (ja) 2025-12-03
BR112019023985A2 (pt) 2020-06-09
WO2018213600A1 (en) 2018-11-22
EP3624888A1 (en) 2020-03-25
JP2022095686A (ja) 2022-06-28
EP3624887A4 (en) 2021-02-24
JP2025108745A (ja) 2025-07-23
AU2018269711B2 (en) 2023-07-27
KR20200010334A (ko) 2020-01-30
IL270450A (enExample) 2019-12-31
KR102752992B1 (ko) 2025-01-13
EP3624751A1 (en) 2020-03-25
US20220280435A1 (en) 2022-09-08
CA3063928A1 (en) 2018-11-22
US12064520B2 (en) 2024-08-20
CN115708868A (zh) 2023-02-24
JP7780369B2 (ja) 2025-12-04
US11607390B2 (en) 2023-03-21
JP2022058815A (ja) 2022-04-12
IL315612A (en) 2024-11-01
AU2018269704B2 (en) 2024-02-08
JP2020520907A (ja) 2020-07-16
IL301683B2 (en) 2025-02-01
IL322452A (en) 2025-09-01
WO2018213582A1 (en) 2018-11-22
EP3624887A1 (en) 2020-03-25
EP3624888A4 (en) 2021-03-10
EP3624752A1 (en) 2020-03-25
IL270449A (enExample) 2020-01-30
US11207272B2 (en) 2021-12-28
EP3624880A1 (en) 2020-03-25
PH12019502537A1 (en) 2020-07-13
US20200324095A1 (en) 2020-10-15
CN110944708B (zh) 2022-12-27
EP3624880A4 (en) 2021-02-24
JP7038739B2 (ja) 2022-03-18
AU2018269704A1 (en) 2019-11-28
ES3036948T3 (en) 2025-09-25
CN110996919B (zh) 2023-07-18
RU2019141615A (ru) 2021-06-17
EP3624778A4 (en) 2021-03-10
CN110891635A (zh) 2020-03-17
CN110891635B (zh) 2023-07-04
CA3063712A1 (en) 2018-11-22
CN110785157A (zh) 2020-02-11
AU2018269544A1 (en) 2019-11-28
US20200306515A1 (en) 2020-10-01
IL270450B2 (en) 2023-09-01
WO2018213576A1 (en) 2018-11-22
AU2018269550B2 (en) 2024-02-29
DK3624887T3 (da) 2025-05-19
CA3063711A1 (en) 2018-11-22
US20220175681A1 (en) 2022-06-09
CN110785157B (zh) 2022-11-04
US20230050912A1 (en) 2023-02-16
KR102647155B1 (ko) 2024-03-15
JP2023036588A (ja) 2023-03-14
CA3063713A1 (en) 2018-11-22
WO2018213593A1 (en) 2018-11-22
US12036324B2 (en) 2024-07-16
AU2018269544B2 (en) 2024-06-13
IL301683A (en) 2023-05-01
IL270449B1 (en) 2024-10-01
AU2024205679A1 (en) 2024-08-29
US20220151940A1 (en) 2022-05-19
US11712421B2 (en) 2023-08-01
KR102391766B1 (ko) 2022-04-29
IL270449B2 (en) 2025-02-01
CL2019003269A1 (es) 2020-03-20
JP2020520913A (ja) 2020-07-16
WO2018213582A8 (en) 2018-12-27
US20210154396A1 (en) 2021-05-27
RU2019141615A3 (enExample) 2021-09-21
US20230218535A1 (en) 2023-07-13
JP2020520914A (ja) 2020-07-16
AU2018269556B2 (en) 2024-01-25
IL270448A (en) 2019-12-31
JP7044805B2 (ja) 2022-03-30
AU2018269547B2 (en) 2024-01-04
KR20200010332A (ko) 2020-01-30
CN110891646A (zh) 2020-03-17
AU2018269556A1 (en) 2019-11-28
IL270448B1 (en) 2025-09-01
EP3624751A4 (en) 2021-03-03
EP3624887B1 (en) 2025-02-26
US20220257855A1 (en) 2022-08-18
US12268832B2 (en) 2025-04-08
CN110996919A (zh) 2020-04-10
KR20220062125A (ko) 2022-05-13
JP2020520915A (ja) 2020-07-16
EP3624778A1 (en) 2020-03-25
AU2018269711A1 (en) 2019-12-05
JP7550201B2 (ja) 2024-09-12
CA3063418A1 (en) 2018-11-22
CN110944708A (zh) 2020-03-31
US12357802B2 (en) 2025-07-15
KR20200010333A (ko) 2020-01-30
KR20220062126A (ko) 2022-05-13
US11311489B2 (en) 2022-04-26
IL301683B1 (en) 2024-10-01

Similar Documents

Publication Publication Date Title
CO2019012773A2 (es) Sistemas autoenderezables y componentes y métodos relacionados
ZA201808537B (en) Combination therapies
PE20190205A1 (es) Uso de inhibidores de miostatina y terapias de combinacion
CR20170242A (es) Benzamidas sustituidas copn 1,3-tiazol-2-ilo
BR112016028957A2 (pt) estruturas de residência e métodos relativos
MX2020006664A (es) Composiciones liquidas de suministro.
MX2015012367A (es) Dispositivos de suministro de farmacos con un componente permeable al farmaco y metodos.
MX2018014906A (es) Composiciones farmaceuticas nasales con un excipiente poroso.
GT201400285A (es) Formulacion de anticuerpos
DOP2017000156A (es) Derivados de glucagón con estabilidad mejorada
CR20160477A (es) Nanopartículas terapéuticas que comprenden un agente terapéutico, y métodos para su elaboración y uso
MX2016011173A (es) Aparato de suministro de implantes intraoculares y metodos para su uso.
BR112015023818A2 (pt) camada de revestimento de fármaco
CL2015002968A1 (es) Tratamiento combinado (por ejemplo con abt-072 o abt-333) de agentes antivirales de acción directa (daas) para uso en el tratamiento de hcv.
CL2020001369A1 (es) Composición adecuada para usar como agroquímico, que comprende un componente de micropartícula y un agente activo de alta potencia encapsulado en la micropartícula. (divisional solicitud 201701964)
MX2016009379A (es) Adaptador de cateter con compuerta con retencion de accionador de septo integrado.
MY185793A (en) Absorbent article and wearable article including absorbent article
BR112015000587A2 (pt) artigo formador de espuma
CL2020000220A1 (es) Composiciones que comprenden aminoácidos para su uso en el tratamiento de enfermedades relacionadas con la disfunción mitocondrial.
AR084713A1 (es) Tapon lagrimal que contiene formulacion de farmaco
MX2016015241A (es) Metodo para almacenar una vacuna emulsionada con adyuvante en un dispositivo de inyeccion medical lubricado.
BR112017019595A2 (pt) artigo absorvente com estrutura de retenção em formato tridimensional
CL2021000998A1 (es) Agentes de liberación de gas antimicrobianos y sistemas y métodos para utilizarlos
BR112021017878A2 (pt) Carbonato de magnésio com superfície reagida, sistema de liberação, formulação de cuidados domiciliares, métodos para preparar um carbonato de magnésio com superfície reagida e para preparar um sistema de liberação, e, uso de um carbonato de magnésio com superfície reagida e de um sistema de liberação
CL2020000221A1 (es) Composiciones que comprenden aminoácidos para su uso en el tratamiento de enfermedades relacionadas con la disfunción mitocondrial.