PE20200305A1 - Sistemas autoenderezables y componentes y metodos relacionados - Google Patents

Sistemas autoenderezables y componentes y metodos relacionados

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Publication number
PE20200305A1
PE20200305A1 PE2019002414A PE2019002414A PE20200305A1 PE 20200305 A1 PE20200305 A1 PE 20200305A1 PE 2019002414 A PE2019002414 A PE 2019002414A PE 2019002414 A PE2019002414 A PE 2019002414A PE 20200305 A1 PE20200305 A1 PE 20200305A1
Authority
PE
Peru
Prior art keywords
self
straightening
article
tissue
subject
Prior art date
Application number
PE2019002414A
Other languages
English (en)
Inventor
Carlo Giovanni Traverso
Alex G Abramson
Salvador Ester Caffarel
Niclas Roxhed
Minsoo Khang
Taylor Bensel
Robert S Langer
Jorrit Jeroen Water
Morten Revsgaard Frederiksen
Bo Uldall Kristiansen
Mikkel Oliver Jespersen
Mette Poulsen
Peter Herskind
Brian Jensen
Original Assignee
Massachusetts Inst Technology
Brigham & Womens Hospital Inc
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Brigham & Womens Hospital Inc, Novo Nordisk As filed Critical Massachusetts Inst Technology
Publication of PE20200305A1 publication Critical patent/PE20200305A1/es

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    • A61M5/285Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/286Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/3129Syringe barrels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/329Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3295Multiple needle devices, e.g. a plurality of needles arranged coaxially or in parallel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0507Electrodes for the digestive system
    • A61N1/0509Stomach and intestinal electrodes

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
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  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se proporcionan de manera general articulos autoenderezable, como capsulas autoenderezable para la administracion a un sujeto. En algunas modalidades, el articulo autoenderezable puede configurarse de modo que el articulo pueda orientarse en relacion con una superficie (por ejemplo, una superficie de un tejido de un sujeto). Los articulos autoenderezables descritos en el presente documento pueden comprender una o mas superficies de enganche de tejido configuradas para contactarse (por ejemplo, interactuar con, inyectarse, anclarse) con una superficie (por ejemplo, una superficie de un tejido de un sujeto). En algunas modalidades, el articulo autoenderezable puede tener una forma particular y/o distribucion de densidad (o masa) que, por ejemplo, permite el comportamiento de autoenderezado del articulo. En algunas modalidades, el articulo autoenderezable puede comprender un componente de interfaz de tejido y/o un agente farmaceutico (por ejemplo, para la administracion del agente farmaceutico activo a una ubicacion interior del sujeto). En algunos casos, tras el contacto del tejido con la superficie de contacto con el tejido del articulo, el articulo autoenderezable puede configurarse para liberar uno o mas componentes de interfaz del tejido. En algunos casos, el componente de interfaz de tejido esta asociado con un componente autoaccionable. Por ejemplo, el articulo autoenderezable puede comprender un componente autoaccionable configurado, tras la exposicion a un fluido, para liberar el componente de interfaz de tejido del articulo autoenderezable. En algunos casos, el componente de interfaz de tejido puede comprender y/o estar asociado con el agente farmaceutico (por ejemplo, para la entrega a una ubicacion interna de un sujeto).
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Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1762259E (pt) 2005-09-12 2010-12-10 Unomedical As Insersor para um conjunto de infusão com uma primeira e uma segunda unidades de mola
US10194938B2 (en) 2011-03-14 2019-02-05 UnoMedical, AS Inserter system with transport protection
CN115591091A (zh) 2016-09-09 2023-01-13 比奥拉治疗股份有限公司(Us) 用于递送可配发物质的机电可摄入装置
RU2019141615A (ru) 2017-05-17 2021-06-17 Массачусетс Инститьют Оф Текнолоджи Самоустанавливающиеся системы и сопутствующие компоненты и способы
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
CA3098880A1 (en) 2018-05-17 2019-11-21 Massachusetts Institute Of Technology Quick release capsules
WO2019222570A1 (en) * 2018-05-17 2019-11-21 Massachusetts Institute Of Technology Systems for electrical stimulation
EP3883636A1 (en) 2018-11-19 2021-09-29 Progenity, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
EP3917596A1 (en) 2019-02-01 2021-12-08 Novo Nordisk A/S Medical device with actuation mechanism
CN113993560B (zh) * 2019-02-01 2024-05-07 麻省理工学院 用于液体注射的系统和方法
WO2020180746A1 (en) 2019-03-01 2020-09-10 Rani Therapeutics, Llc Propulsive drug delivery from a swallowable device into a patient's intestinal tract
AU2020279722A1 (en) 2019-05-20 2021-11-18 Unomedical A/S Rotatable infusion device and methods thereof
CN113966242A (zh) * 2019-06-07 2022-01-21 诺和诺德股份有限公司 具有递送构件脱离的可摄取装置
JP2022541060A (ja) * 2019-07-22 2022-09-21 ノボ・ノルデイスク・エー/エス 改善された自己復元能力を有するカプセル装置
JP7102469B2 (ja) * 2019-08-02 2022-07-19 華廣生技股▲ふん▼有限公司 センサーを搭載するための容器及びその操作方法
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components
EP4309722A2 (en) 2019-12-13 2024-01-24 Biora Therapeutics, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
EP3859829A1 (en) 2020-01-29 2021-08-04 Lg Chem, Ltd. Method and system for analyzing swelling behavior of lithium secondary battery
CN111481812A (zh) * 2020-05-29 2020-08-04 陈建华 一种产科用给药装置
CN115697436A (zh) 2020-06-12 2023-02-03 诺和诺德股份有限公司 具有尖头组件的可摄取装置
CN116171179A (zh) 2020-08-08 2023-05-26 诺和诺德股份有限公司 管腔可插入胶囊
US20220039686A1 (en) 2020-08-10 2022-02-10 Massachusetts Institute Of Technology Drug delivery device
JP2023542833A (ja) 2020-09-30 2023-10-12 ノボ・ノルデイスク・エー/エス 内腔に挿入可能なカプセル
JP2023544632A (ja) 2020-10-09 2023-10-24 ノボ・ノルデイスク・エー/エス カプセル装置
EP4284485A1 (en) 2021-01-28 2023-12-06 Novo Nordisk A/S Medical device with fluid acivated actuation mechanism
WO2022162102A1 (en) 2021-01-28 2022-08-04 Novo Nordisk A/S Medical device with improved actuation mechanism
WO2022174040A1 (en) * 2021-02-11 2022-08-18 10X Technology Llc Method and apparatus for fabricating brittle microneedle
WO2022195476A1 (en) 2021-03-15 2022-09-22 Clexio Biosciences Ltd. Gastroretentive devices for assessment of intragastric conditions
EP4355393A1 (en) 2021-06-18 2024-04-24 Novo Nordisk A/S Medical device with fluid acivated actuation mechanism
WO2023018591A1 (en) * 2021-08-09 2023-02-16 Massachusetts Institute Of Technology Ingestible device
CN114403948A (zh) * 2022-01-10 2022-04-29 烟台美神科美医疗美容门诊部有限公司 一种增加脂肪细胞存活率的自体脂肪移植设备
WO2023144402A1 (en) 2022-01-31 2023-08-03 Novo Nordisk A/S Ingestible device with detachment of tissue penetrating member
WO2024038122A1 (en) 2022-08-17 2024-02-22 Novo Nordisk A/S Ingestible device with rotational trigger release
WO2024038123A1 (en) 2022-08-17 2024-02-22 Novo Nordisk A/S Ingestible device with rotational drive mechanism

Family Cites Families (335)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2601767A (en) 1946-04-22 1952-07-01 Thomas P Wall Self righting cup
US3442045A (en) 1967-02-06 1969-05-06 Joseph Green Variable speed self-righting toy
US3386409A (en) 1967-05-16 1968-06-04 Dietz Co R E Self-righting traffic cone
US3656483A (en) * 1970-01-15 1972-04-18 Biolog Concepts Inc Intrauterine medicator
US3797492A (en) 1972-12-27 1974-03-19 Alza Corp Device for dispensing product with directional guidance member
US3826220A (en) 1973-01-22 1974-07-30 C Jacobson Self-righting power-driven aquatic vehicle
US4239040A (en) * 1976-10-19 1980-12-16 Kabushiki Kaisha Daini Seikosha Capsule for medical use
US4193397A (en) 1977-12-01 1980-03-18 Metal Bellows Corporation Infusion apparatus and method
US4481952A (en) * 1978-03-22 1984-11-13 Jerzy Pawelec Device for the study of the alimentary canal
US4236525A (en) 1978-11-22 1980-12-02 Intermedics, Inc. Multiple function lead assembly
JPS55166142A (en) 1979-06-14 1980-12-25 Olympus Optical Co Capsule device for medical treatment
DE2928477C3 (de) * 1979-07-14 1982-04-15 Battelle-Institut E.V., 6000 Frankfurt Vorrichtung zur Freisetzung von Substanzen an definierten Orten des Verdauungstraktes
JPS5819232A (ja) 1981-07-29 1983-02-04 オリンパス光学工業株式会社 医療用カプセル
US4407283A (en) * 1981-10-19 1983-10-04 Dale C. Grier Self-injecting syringe
GB8508173D0 (en) 1985-03-28 1985-05-01 Standard Telephones Cables Ltd Controlled delivery device
DE8536337U1 (de) 1985-12-23 1986-02-13 R.P. Scherer GmbH, 6930 Eberbach Füllkeil für eine Maschine zum Herstellen von Gelatinekapseln
US5002772A (en) 1988-05-31 1991-03-26 Pfizer Inc. Gastric retention system for controlled drug release
JPH03163011A (ja) 1989-08-31 1991-07-15 Yamanouchi Pharmaceut Co Ltd 胃内滞留デバイス
US5474785A (en) 1990-01-24 1995-12-12 Alza Corporation Delivery system comprising means for controlling internal pressure
US5017187A (en) 1990-05-04 1991-05-21 Sullivan Robert J Self retracting hypodermic syringe
US5125491A (en) 1990-06-21 1992-06-30 Usui Kokusai Sangyo Kaisha Limited Temperature sensitive type fluid fan coupling apparatus
US5217449A (en) * 1990-12-11 1993-06-08 Miyarisan Kabushiki Kaisha Medical capsule and apparatus for activating the same
US5279607A (en) 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
EP1238656A1 (en) 1996-02-02 2002-09-11 ALZA Corporation Sustained delivery of an active agent using an implantable system
US5690691A (en) 1996-05-08 1997-11-25 The Center For Innovative Technology Gastro-intestinal pacemaker having phased multi-point stimulation
FR2749955B1 (fr) 1996-06-14 1998-09-11 Thomson Csf Systeme de lecture d'empreintes digitales
CA2264831C (en) 1996-09-05 2003-08-12 The Governors Of The University Of Alberta Gastro-intestinal electrical pacemaker
IT1292016B1 (it) 1997-05-28 1999-01-25 Valerio Cigaina Dispositivo di impianto particolarmente per elettrostimolazione e/o elettroregistrazione di visceri endoaddominali
US6030641A (en) 1997-06-03 2000-02-29 Uni Colloid Kabushiki Kaisha Sustained release capsule and method for preparing the same
JP2001527023A (ja) 1997-08-11 2001-12-25 アルザ・コーポレーション 胃で保持するのに適合した長期放出性活性剤剤形
IE970782A1 (en) 1997-10-22 1999-05-05 Elan Corp An improved automatic syringe
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
JP2002517300A (ja) * 1998-06-10 2002-06-18 ジョージア テック リサーチ コーポレイション 微小針デバイスおよび製造方法ならびにそれらの使用
US6346519B1 (en) 1998-09-09 2002-02-12 Advanced Medical Instruments Method and composition for treating arthritis
IL126727A (en) * 1998-10-22 2006-12-31 Given Imaging Ltd A method of bringing a device to the goal
US7076307B2 (en) 2002-05-09 2006-07-11 Boveja Birinder R Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders
SE9804126D0 (sv) 1998-11-27 1998-11-27 Astra Ab New pharmaceutical composition
US6684104B2 (en) 1999-04-14 2004-01-27 Transneuronix, Inc. Gastric stimulator apparatus and method for installing
DE60003803T2 (de) 1999-04-16 2004-06-03 Novo Nordisk A/S Trockene formbare arzneistoffformulierung
FR2794654B1 (fr) 1999-06-08 2001-10-19 Ct De Transfert Des Microtechn Dispositif de largage de substances dans un tube digestif
US7955340B2 (en) 1999-06-25 2011-06-07 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US20050079214A1 (en) 1999-09-01 2005-04-14 John Cooker Oral delivery system and method for making same
AU7646400A (en) 1999-10-13 2001-04-23 Novo Nordisk A/S Method for producing an elongated drug formulation
US20070203531A9 (en) 1999-12-03 2007-08-30 Medtronic, Inc. Heart rate variability control of gastric electrical stimulator
GB9930000D0 (en) 1999-12-21 2000-02-09 Phaeton Research Ltd An ingestible device
GB9930001D0 (en) 1999-12-21 2000-02-09 Phaeton Research Ltd An ingestible device
US7039453B2 (en) 2000-02-08 2006-05-02 Tarun Mullick Miniature ingestible capsule
WO2001058424A1 (en) 2000-02-09 2001-08-16 West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited Floating drug delivery composition
AUPQ573300A0 (en) 2000-02-21 2000-03-16 Australian Nuclear Science & Technology Organisation Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use
US6488962B1 (en) 2000-06-20 2002-12-03 Depomed, Inc. Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms
US6929636B1 (en) 2000-11-08 2005-08-16 Hewlett-Packard Development Company, L.P. Internal drug dispenser capsule medical device
US6615084B1 (en) 2000-11-15 2003-09-02 Transneuronix, Inc. Process for electrostimulation treatment of morbid obesity
US6638246B1 (en) 2000-11-28 2003-10-28 Scimed Life Systems, Inc. Medical device for delivery of a biologically active material to a lumen
EP1345646A2 (en) 2000-12-14 2003-09-24 Georgia Tech Research Corporation Microneedle devices and production thereof
US7702394B2 (en) 2001-05-01 2010-04-20 Intrapace, Inc. Responsive gastric stimulator
US7756582B2 (en) 2001-05-01 2010-07-13 Intrapace, Inc. Gastric stimulation anchor and method
US6535764B2 (en) 2001-05-01 2003-03-18 Intrapace, Inc. Gastric treatment and diagnosis device and method
US7160258B2 (en) 2001-06-26 2007-01-09 Entrack, Inc. Capsule and method for treating or diagnosing the intestinal tract
GB2404865B (en) 2001-09-11 2005-09-28 Caretek Medical Ltd Novel drug delivery technology
JP4578740B2 (ja) 2001-09-21 2010-11-10 オリンパス株式会社 カプセル型医療装置
JP4643089B2 (ja) 2001-09-27 2011-03-02 オリンパス株式会社 カプセル型医療装置
US7100274B2 (en) 2001-11-02 2006-09-05 Neptco Incorporated Apparatus for applying media to a conduit
US8454997B2 (en) 2001-12-18 2013-06-04 Novo Nordisk A/S Solid dose micro implant
IL162459A0 (en) 2001-12-24 2005-11-20 Teva Pharma Dosage form with a core table of active ingredientsheathed in a compressed annular body of powder o r granular material, and process and toolin
US20030195415A1 (en) * 2002-02-14 2003-10-16 Iddan Gavriel J. Device, system and method for accoustic in-vivo measuring
JP3869291B2 (ja) 2002-03-25 2007-01-17 オリンパス株式会社 カプセル型医療装置
US8241308B2 (en) 2002-04-24 2012-08-14 Boston Scientific Scimed, Inc. Tissue fastening devices and processes that promote tissue adhesion
JP4231657B2 (ja) 2002-05-10 2009-03-04 オリンパス株式会社 カプセル型医療装置
JP2004041709A (ja) 2002-05-16 2004-02-12 Olympus Corp カプセル医療装置
US20040193229A1 (en) 2002-05-17 2004-09-30 Medtronic, Inc. Gastric electrical stimulation for treatment of gastro-esophageal reflux disease
US9314228B2 (en) 2002-05-31 2016-04-19 Vidacare LLC Apparatus and method for accessing the bone marrow
US8142365B2 (en) 2002-05-31 2012-03-27 Vidacare Corporation Apparatus and method for accessing the bone marrow of the sternum
US6945952B2 (en) * 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
EP1523367A1 (en) * 2002-07-19 2005-04-20 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
US20040044364A1 (en) 2002-08-29 2004-03-04 Devries Robert Tissue fasteners and related deployment systems and methods
US7118531B2 (en) 2002-09-24 2006-10-10 The Johns Hopkins University Ingestible medical payload carrying capsule with wireless communication
WO2004028335A2 (en) 2002-09-30 2004-04-08 Given Imaging Ltd. In-vivo sensing system
US20040106904A1 (en) * 2002-10-07 2004-06-03 Gonnelli Robert R. Microneedle array patch
US20040106849A1 (en) * 2002-12-03 2004-06-03 Cho Jin-Ho Multi-functional, bi-directional communication telemetry capsule
US7833151B2 (en) 2002-12-26 2010-11-16 Given Imaging Ltd. In vivo imaging device with two imagers
EP1587407B1 (en) 2002-12-26 2012-03-07 Given Imaging Ltd. Immobilizable in vivo sensing device
AU2003303513A1 (en) 2002-12-30 2004-07-29 Angiotech International Ag Tissue reactive compounds and compositions and uses thereof
CN1756571A (zh) 2002-12-30 2006-04-05 血管技术国际股份公司 组织反应性化合物和组合物及其应用
US7153454B2 (en) 2003-01-21 2006-12-26 University Of Southern California Multi-nozzle assembly for extrusion of wall
JP2004222998A (ja) 2003-01-23 2004-08-12 Olympus Corp 超音波診断用カプセル
KR20050098277A (ko) 2003-01-29 2005-10-11 이-필 파마 리미티드 위장관 내 약물의 능동 송달
US20050058701A1 (en) 2003-01-29 2005-03-17 Yossi Gross Active drug delivery in the gastrointestinal tract
US20060058829A1 (en) 2003-03-19 2006-03-16 Sampson Douglas C Intragastric volume-occupying device
US7620454B2 (en) 2003-05-19 2009-11-17 Medtronic, Inc. Gastro-electric stimulation for reducing the acidity of gastric secretions or reducing the amounts thereof
US7742818B2 (en) 2003-05-19 2010-06-22 Medtronic, Inc. Gastro-electric stimulation for increasing the acidity of gastric secretions or increasing the amounts thereof
US9186233B2 (en) 2003-07-23 2015-11-17 Lothar Göbel Closing system for a natural or artificial anus
US9498366B2 (en) 2003-07-28 2016-11-22 Baronova, Inc. Devices and methods for pyloric anchoring
US20050055014A1 (en) 2003-08-04 2005-03-10 Coppeta Jonathan R. Methods for accelerated release of material from a reservoir device
US8353861B2 (en) 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
US8021356B2 (en) 2003-09-29 2011-09-20 Olympus Corporation Capsule medication administration system, medication administration method using capsule medication administration system, control method for capsule medication administration system
US20050124875A1 (en) 2003-10-01 2005-06-09 Olympus Corporation Vivo observation device
US20050075654A1 (en) 2003-10-06 2005-04-07 Brian Kelleher Methods and devices for soft tissue securement
WO2005037070A2 (en) 2003-10-11 2005-04-28 The Regents Of The University Of California Method and system for nerve repair, nanoknife, mems platform and uses thereof
US7918786B2 (en) 2003-11-11 2011-04-05 Olympus Corporation Capsule type medical device system, and capsule type medical device
US20050149142A1 (en) 2004-01-07 2005-07-07 Starkebaum Warren L. Gastric stimulation responsive to sensing feedback
US7177693B2 (en) 2004-01-07 2007-02-13 Medtronic, Inc. Gastric stimulation for altered perception to treat obesity
DE602005014390D1 (de) 2004-03-25 2009-06-18 Olympus Corp Gerätesystem zur In-vivo-Informationserfassung
US8000784B2 (en) 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling device
CN1953737A (zh) * 2004-05-03 2007-04-25 埃-皮尔制药公司 胃肠道内的主动药物递送
US20050250988A1 (en) 2004-05-07 2005-11-10 Usgi Medical Inc. Removable apparatus for manipulating and securing tissue within a treatment space
DE102004026615A1 (de) 2004-06-01 2005-12-29 Siemens Ag Vorrichtung und Verfahren zur Freisetzung eines in das Körperinnere eines Patienten geführten therapeutischen Mittels
US7678135B2 (en) 2004-06-09 2010-03-16 Usgi Medical, Inc. Compressible tissue anchor assemblies
TWI253024B (en) 2004-07-20 2006-04-11 Realtek Semiconductor Corp Method and apparatus for block matching
DE102005021081B4 (de) 2004-07-23 2019-05-29 Advanced Medical Balloons Gmbh Rektal-Tubus
JP4589048B2 (ja) 2004-08-04 2010-12-01 オリンパス株式会社 カプセル型内視鏡
DK1814622T3 (en) * 2004-08-13 2016-02-29 Obalon Therapeutics Inc Intragastric volume-receiving device
US20060034913A1 (en) 2004-08-13 2006-02-16 James Gaede Multiplex drug delivery device
US20060047309A1 (en) 2004-08-25 2006-03-02 Cichocki Frank R Jr Metal injection molded suture needles
WO2006021932A1 (en) 2004-08-27 2006-03-02 Koninklijke Philips Electronics, N.V. Electronically and remotely controlled pill and system for delivering at least one medicament
JP4656909B2 (ja) 2004-10-15 2011-03-23 オリンパス株式会社 被検体内導入装置およびその製造方法
ATE485074T1 (de) 2004-11-29 2010-11-15 Koninkl Philips Electronics Nv Elektronisch gesteuerte tablette
JP2008522778A (ja) 2004-12-14 2008-07-03 イー−ピル ファーマ リミティド 電気透過性増加を用いた薬物又は物質の局所輸送
EP1861158A2 (en) * 2005-01-18 2007-12-05 Koninklijke Philips Electronics N.V. System for controlling traversal of an ingested capsule
US20090306633A1 (en) 2005-01-18 2009-12-10 Koninklijke Philips Electronics, N.V. Electronically controlled capsule
WO2006077527A2 (en) 2005-01-18 2006-07-27 Koninklijke Philips Electronics, N.V. Electronically controlled capsule for releasing radiation
US20080153779A1 (en) 2005-02-01 2008-06-26 Jun Liao Gastric Retention and Controlled Release Delivery System
US8852083B2 (en) 2005-02-04 2014-10-07 Uti Limited Partnership Self-stabilized encapsulated imaging system
US20060259074A1 (en) 2005-02-22 2006-11-16 Brian Kelleher Methods and devices for anchoring to soft tissue
US7699863B2 (en) 2005-03-01 2010-04-20 Tulip Medical Ltd. Bioerodible self-deployable intragastric implants
US20080193543A1 (en) 2005-05-17 2008-08-14 Brown University Research Foundation Drug Delivery Formulations For Targeted Delivery
US9585651B2 (en) 2005-05-26 2017-03-07 Usgi Medical, Inc. Methods and apparatus for securing and deploying tissue anchors
WO2006126653A1 (ja) * 2005-05-27 2006-11-30 Olympus Corporation 被検体内導入装置
US8777967B2 (en) 2005-06-09 2014-07-15 Xlumena, Inc. Methods and devices for anchoring to tissue
WO2006131522A1 (de) 2005-06-10 2006-12-14 Siemens Aktiengesellschaft Vorrichtung und verfahren zur diagnose und/oder behandlung funktioneller gastrointestinaler erkrankungen
US20050240239A1 (en) 2005-06-29 2005-10-27 Boveja Birinder R Method and system for gastric ablation and gastric pacing to provide therapy for obesity, motility disorders, or to induce weight loss
DE102005032290A1 (de) 2005-07-11 2007-01-18 Siemens Ag Endoskopiekapsel sowie Verfahren zur Diagnose und/oder Therapie mittles einer Endoskopiekapsel
US20070021760A1 (en) 2005-07-19 2007-01-25 Brian Kelleher Methods and apparatus for securing an anchor to soft tissue
US8021384B2 (en) 2005-07-26 2011-09-20 Ram Weiss Extending intrabody capsule
US20070038181A1 (en) 2005-08-09 2007-02-15 Alexander Melamud Method, system and device for delivering a substance to tissue
CN100376299C (zh) 2005-08-19 2008-03-26 华南理工大学 化学反应气压式微胶囊药物释放方法及其装置
US8295932B2 (en) 2005-12-05 2012-10-23 Metacure Limited Ingestible capsule for appetite regulation
JP4358821B2 (ja) 2005-12-15 2009-11-04 オリンパス株式会社 被検体内導入装置
JP4402648B2 (ja) * 2005-12-16 2010-01-20 オリンパス株式会社 被検体内導入装置
CN101340944B (zh) 2005-12-22 2013-04-03 皇家飞利浦电子股份有限公司 用于化学分子的控释的装置
US8252329B2 (en) 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
CN1820798A (zh) 2006-01-28 2006-08-23 重庆大学 胶囊式消化道药物释放及采样装置
GB0603252D0 (en) 2006-02-17 2006-03-29 Axcess Ltd Dissolution aids for oral peptide delivery
CN100490916C (zh) 2006-04-03 2009-05-27 重庆大学 胶囊式消化道定时药物释放装置
DE102006019419B4 (de) 2006-04-26 2008-02-14 Siemens Ag Aktuator insbesondere eines Endoroboters
WO2007127976A2 (en) 2006-05-01 2007-11-08 Georgia Tech Research Corporation Particle based molding
EP2032093B1 (en) 2006-05-18 2013-09-04 Tulip Medical Ltd. Bioerodible intragastric implant
EP2029113A2 (en) 2006-06-07 2009-03-04 Novartis AG Process for making multiparticulates using a roller compactor
EP2035075A1 (en) 2006-06-20 2009-03-18 Koninklijke Philips Electronics N.V. Electronic capsule for treating gastrointestinal disease
RU2009106062A (ru) 2006-06-23 2010-08-27 Конинклейке Филипс Электроникс, Н.В. (Nl) Система доставки медикамента
US20100247453A1 (en) 2006-07-12 2010-09-30 Thomas L. Jones Composition and method of treating a sore throat
US9550050B2 (en) 2006-09-25 2017-01-24 MEDIMETRICS Personalized Drug Delivery B.V. Medicament delivery apparatus
US9227011B2 (en) 2006-09-29 2016-01-05 MEDIMETRICS Personalized Drug Delivery B.V. Miniaturized threshold sensor
EP2101643B1 (en) 2006-10-31 2013-04-24 Medimetrics Personalized Drug Delivery B.V. Design of swallowable multi-nozzle, dosing device for releasing medicines in the gastrointestinal tract
EP1923083A1 (en) 2006-11-17 2008-05-21 Sanofi-Aventis Deutschland GmbH Drive mechanisms for use in drug delivery devices
JP5697871B2 (ja) 2006-11-21 2015-04-08 メディメトリクス ペルソナリズド ドルグ デリヴェリー ベー ヴェ 薬物送達カプセル、及び生体内での薬剤送達又は診断システム
EP2085015A4 (en) 2006-11-24 2010-03-10 Olympus Medical Systems Corp ENCAPSULATED ENDOSCOPE
CN100482293C (zh) 2006-12-19 2009-04-29 重庆大学 缓释型遥控电子胶囊
US8702591B2 (en) * 2007-01-12 2014-04-22 Olympus Medical Systems Corp. Capsule medical apparatus
AU2008224440A1 (en) 2007-03-15 2008-09-18 Bioprotect Ltd. Soft tissue fixation devices
US20080257845A1 (en) 2007-04-23 2008-10-23 Esmeralda Reyes Rossi Self Righting Baby Bottle
US7925351B2 (en) 2007-06-13 2011-04-12 Betastim, Ltd. Gastrointestinal device for treating obesity and diabetes
EP2196131A4 (en) * 2007-09-26 2012-12-05 Olympus Medical Systems Corp INTRODUCTION SYSTEM IN A SUBJECT
EP2537506A1 (en) 2007-10-15 2012-12-26 Capsugel Belgium NV Linkers for multipart dosage forms for release of one or more parmaceutical compositions, and the resulting dosage forms
US8789536B2 (en) 2007-10-17 2014-07-29 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8333754B2 (en) * 2007-10-31 2012-12-18 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
WO2009063375A1 (en) 2007-11-13 2009-05-22 Koninklijke Philips Electronics N.V. Ingestible electronic capsule
WO2009063377A1 (en) 2007-11-13 2009-05-22 Koninklijke Philips Electronics N.V. Ingestible electronic capsule
WO2009063376A1 (en) 2007-11-13 2009-05-22 Koninklijke Philips Electronics N.V. Ingestible electronic capsule
US20090137866A1 (en) 2007-11-28 2009-05-28 Searete Llc, A Limited Liability Corporation Of The State Delaware Medical or veterinary digestive tract utilization systems and methods
NZ585449A (en) 2007-12-11 2012-07-27 Massachusetts Inst Technology Implantable drug delivery device and methods for treatment of the bladder and other body vestcles or lumens
US20090155354A1 (en) * 2007-12-14 2009-06-18 Mclean Barbara Wanamaker Dispensing encapsulated liquids into body cavities
CN101945613B (zh) 2008-02-18 2014-08-13 皇家飞利浦电子股份有限公司 为患者用药
CN101983029B (zh) 2008-03-31 2015-01-14 皇家飞利浦电子股份有限公司 制备包括传感器的可吞服胶囊的方法
JP5314913B2 (ja) 2008-04-03 2013-10-16 オリンパスメディカルシステムズ株式会社 カプセル医療システム
JP5363020B2 (ja) 2008-04-07 2013-12-11 オリンパスメディカルシステムズ株式会社 カプセル型医療装置および医療システム
US8454632B2 (en) 2008-05-12 2013-06-04 Xlumena, Inc. Tissue anchor for securing tissue layers
US8517917B2 (en) 2008-06-04 2013-08-27 Olympus Medical Systems Corp. Capsule medical apparatus
JP5500600B2 (ja) 2008-06-19 2014-05-21 コーニンクレッカ フィリップス エヌ ヴェ 湿った環境における粉状薬物の供給のためのデバイス
CN107049928A (zh) 2008-07-07 2017-08-18 皇家飞利浦电子股份有限公司 包括储药器的电子药丸
US20100010294A1 (en) 2008-07-10 2010-01-14 Ethicon Endo-Surgery, Inc. Temporarily positionable medical devices
US8287902B2 (en) 2008-07-23 2012-10-16 Rainbow Medical Ltd. Enhanced-diffusion capsule
EP2335915A4 (en) 2008-09-08 2012-03-28 Taisho Pharmaceutical Co Ltd PRESS FOR TABLETING
EP2351511B1 (en) 2008-11-13 2014-04-02 Olympus Medical Systems Corp. Capsule medical apparatus
EP2201938A1 (en) 2008-12-18 2010-06-30 Koninklijke Philips Electronics N.V. Controllable drug delivery capsule
CA2750148C (en) 2009-01-06 2017-02-07 Proteus Biomedical, Inc. Pharmaceutical dosages delivery system
WO2010087368A1 (ja) 2009-01-28 2010-08-05 オリンパスメディカルシステムズ株式会社 カプセル型医療装置システム
WO2010093834A2 (en) 2009-02-12 2010-08-19 Incube Labs, Llc Skin penetrating device and method for subcutaneous solid drug delivery
WO2010101877A1 (en) 2009-03-03 2010-09-10 Medtronic, Inc. Electrical stimulation therapy to promote gastric distention for obesity management
US20100248828A1 (en) * 2009-03-24 2010-09-30 Ty Huynh Kaing Educational toy
BRPI1006765A2 (pt) 2009-04-07 2019-03-26 Koninl Philips Electronics Nv cápsula ingerível para a liberação de uma droga
BRPI1006755A2 (pt) 2009-04-07 2019-03-26 Koninl Philips Electronics Nv dispositivo de administração de droga
SG175135A1 (en) 2009-04-10 2011-12-29 3M Innovative Properties Co Methods of making hollow microneedle arrays and articles and uses therefrom
US20110052695A1 (en) * 2009-04-20 2011-03-03 Allergan, Inc. Drug delivery platforms comprising silk fibroin hydrogels and uses thereof
US20100286628A1 (en) 2009-05-07 2010-11-11 Rainbow Medical Ltd Gastric anchor
WO2010137705A1 (ja) 2009-05-29 2010-12-02 オリンパスメディカルシステムズ株式会社 カプセル型医療装置
JP2011012050A (ja) 2009-06-03 2011-01-20 Bioserentack Co Ltd 多孔性基盤を用いたマイクロニードル・アレイとその製造方法
EP2461818B1 (en) 2009-08-03 2018-10-17 Incube Labs, Llc Swallowable capsule and method for stimulating incretin production within the intestinal tract
JP5497176B2 (ja) 2009-08-12 2014-05-21 コーニンクレッカ フィリップス エヌ ヴェ 圧縮可能な薬品貯槽を備える薬品送出装置
CN102811762B (zh) 2009-08-12 2014-08-27 皇家飞利浦电子股份有限公司 用于药物输送装置的药物容器
US20130011332A1 (en) * 2009-09-15 2013-01-10 Searete Llc, Frozen Compositions and Methods for Piercing a Substrate
AU2010295275B2 (en) 2009-09-21 2013-10-17 Medtronic, Inc. Waveforms for electrical stimulation therapy
US9017310B2 (en) 2009-10-08 2015-04-28 Palo Alto Research Center Incorporated Transmucosal drug delivery device and method including microneedles
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
US20130172694A1 (en) 2009-12-17 2013-07-04 MEDIMETRICS Personalized Drug Delivery B.V. Swallowable capsule for monitoring a condition
US8759284B2 (en) * 2009-12-24 2014-06-24 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
CN105999526B (zh) * 2009-12-24 2019-07-05 拉尼医疗有限公司 可吞咽式药剂递送装置和药剂递送方法
WO2011095486A1 (en) 2010-02-05 2011-08-11 Sanofi-Aventis Deutschland Gmbh Medicated module with lockable needle guard
JP5781095B2 (ja) * 2010-02-05 2015-09-16 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ロック可能なニードルガードを備えた薬用モジュール
CN105168174B (zh) 2010-03-10 2019-01-08 拉尼医疗有限公司 用于利用可吞咽式药剂递送装置递送到肠道内腔中的治疗剂制剂
CN102665530B (zh) 2010-03-26 2014-11-26 奥林巴斯医疗株式会社 胶囊型医疗装置用引导系统以及胶囊型医疗装置的引导方法
DE102010020614A1 (de) 2010-05-14 2011-11-17 Friedrich-Alexander-Universität Erlangen-Nürnberg Endoskopiekapsel zum Nachweis eines Stoffwechselproduktes eines in oder an der Wand eines Hohlorgans des menschlichen oder tierischen Gastrointestinaltraktes befindlichen Erregers
US9314430B2 (en) * 2010-07-05 2016-04-19 Jagotec Ag Floating gastric retentive dosage form
US20180296814A1 (en) 2010-08-17 2018-10-18 Progenity, Inc. Administration of drugs to a patient
EP2433663A1 (en) * 2010-09-27 2012-03-28 Unomedical A/S Insertion system
CN103458955B (zh) 2010-10-06 2015-11-25 医学量度个性化药物输送有限公司 用于输送粉末药物的电子药丸
EP3047950A1 (en) 2010-12-02 2016-07-27 3M Innovative Properties Company Liquid crystalline polymer microneedles
US9402807B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8764733B2 (en) 2010-12-23 2014-07-01 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809269B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8969293B2 (en) * 2010-12-23 2015-03-03 Rani Therapeutics, Llc Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9284367B2 (en) * 2010-12-23 2016-03-15 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9861683B2 (en) 2010-12-23 2018-01-09 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9149617B2 (en) 2010-12-23 2015-10-06 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US8734429B2 (en) 2010-12-23 2014-05-27 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US9402806B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8846040B2 (en) 2010-12-23 2014-09-30 Rani Therapeutics, Llc Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9259386B2 (en) 2010-12-23 2016-02-16 Rani Therapeutics, Llc Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10639272B2 (en) 2010-12-23 2020-05-05 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US9283179B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8980822B2 (en) 2010-12-23 2015-03-17 Rani Therapeutics, Llc Therapeutic agent preparations comprising pramlintide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809271B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising liraglutide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9629799B2 (en) 2010-12-23 2017-04-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9415004B2 (en) 2010-12-23 2016-08-16 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
WO2012100002A1 (en) 2011-01-18 2012-07-26 Massachusetts Institute Of Technology Deployable barbed microneedle array and uses thereof
WO2012103257A2 (en) 2011-01-25 2012-08-02 The Regents Of The University Of California Transcutaneous multimodal delivery systems
CN103781474B (zh) 2011-03-24 2018-09-21 宝珍那提公司 可吞咽的药物胶囊
WO2012158648A1 (en) 2011-05-13 2012-11-22 Massachusetts Institute Of Technology Method and apparatus for delivering a substance
US20120305574A1 (en) 2011-06-03 2012-12-06 Deliang Shi Self-Righting Container
US20120305573A1 (en) * 2011-06-03 2012-12-06 Deliang Shi Self-Righting Containers
IN2014CN00338A (es) 2011-06-29 2015-04-03 Rani Therapeutics Llc
JP5945882B2 (ja) 2011-07-22 2016-07-05 東芝メディカルシステムズ株式会社 マーキング用カプセル及びカプセル内視鏡システム
WO2013021374A2 (en) 2011-08-05 2013-02-14 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
KR101861307B1 (ko) 2011-10-13 2018-07-06 한미약품 주식회사 정제를 포함하는 경질 캡슐 복합 제형
WO2013101908A1 (en) 2011-12-27 2013-07-04 Massachusetts Institute Of Technology Microneedle devices and uses thereof
US9149172B2 (en) 2011-12-29 2015-10-06 Given Imaging Ltd. System and apparatus for anchoring and operation of in-vivo medical devices
US9610401B2 (en) 2012-01-13 2017-04-04 Medtronic Minimed, Inc. Infusion set component with modular fluid channel element
WO2013120184A1 (en) 2012-02-17 2013-08-22 Micropharma Limited Ingestible medical device
US20150051589A1 (en) 2012-03-27 2015-02-19 Sony Corporation Capsule type medical device and medical system
EP2841147A4 (en) * 2012-05-01 2016-04-13 Univ Pittsburgh MICRO-NEEDLES NETWORKS WITH CHARGED END FOR TRANSDERMAL INSERTION
DE102012207714A1 (de) 2012-05-09 2013-11-14 BSH Bosch und Siemens Hausgeräte GmbH Gerät, insbesondere ein Haarstylinggerät
JP5551838B2 (ja) * 2012-06-08 2014-07-16 オリンパスメディカルシステムズ株式会社 カプセル型医療装置
EP2861220A2 (en) 2012-06-14 2015-04-22 Entrega, Inc. Mucoadhesive devices for delivery of active agents
US9938814B2 (en) 2012-07-05 2018-04-10 Halliburton Energy Services, Inc. Displaceable components in drilling operations
US8755888B2 (en) 2012-10-17 2014-06-17 Melcap Systems Ltd. Gastrointestinal system
CN102920418B (zh) * 2012-10-24 2014-07-30 刘思德 一种消化道自稳探路胶囊
US9526884B2 (en) 2012-11-16 2016-12-27 City University Of Hong Kong Mechanically robust fast-dissolving microneedles for transdermal drug and vaccine delivery
GB201304662D0 (en) * 2013-03-14 2013-05-01 Sigmoid Pharma Ltd Compositions
MX360121B (es) * 2013-02-28 2018-10-03 Kimberly Clark Co Dispositivo de administración transdérmica de fármacos.
AU2014226292B2 (en) 2013-03-04 2018-10-04 Vtv Therapeutics Llc Solid compositions comprising a glucokinase activator and methods of making and using the same
US20160022873A1 (en) * 2013-03-14 2016-01-28 Research Institute At Nationwide Children's Hospital, Inc. Tissue engineered intestine
US10071199B2 (en) 2013-03-15 2018-09-11 Incube Labs, Llc Multi-stage biodegradable drug delivery platform
US9301926B2 (en) * 2013-04-10 2016-04-05 Massachusetts Institute Of Technology Local drug delivery devices and methods for treating cancer
WO2014182940A1 (en) 2013-05-08 2014-11-13 Northeastern University Mucus strengthening formulations to alter mucus barrier properties
US20150064241A1 (en) * 2013-09-05 2015-03-05 Google Inc. Delivery of Functionalized Particles
WO2015036616A1 (en) 2013-09-16 2015-03-19 Novo Nordisk A/S Injection device for selective fixed or variable dosing
EP3049145B1 (en) 2013-09-26 2020-06-17 Progenity, Inc. Delivery capsule with threshold release
US20160278899A1 (en) 2013-11-05 2016-09-29 Synagile Corporation Devices and methods for continuous drug delivery via the mouth
US10219748B2 (en) 2014-01-22 2019-03-05 Nutech Ventures Gastrointestinal sensor implantation system
US10828478B2 (en) 2014-04-24 2020-11-10 Georgia Tech Research Corporation Microneedles and methods of manufacture thereof
AU2015258859B2 (en) 2014-05-15 2020-07-23 Rani Therapeutics, Llc Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins
US10689460B2 (en) 2014-05-15 2020-06-23 Incube Labs, Llc PCSK9 antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US11548940B2 (en) 2014-05-15 2023-01-10 Rani Therapeutics, Llc Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
DE102014015919A1 (de) 2014-06-07 2015-12-17 Trans-Duodenal Concepts Ug I.G. Vorrichtung und Verfahren zur Aufnahme von Mageninhalt und Durchleitung in bzw. durch den Zwölffingerdarm
SG10201912100SA (en) 2014-06-11 2020-02-27 Massachusetts Inst Technology Residence structures and related methods
US9492396B2 (en) 2014-07-15 2016-11-15 Yossi Gross Enhanced drug delivery pill
KR102169536B1 (ko) 2014-09-11 2020-10-23 히사미쓰 세이야꾸 가부시키가이샤 마이크로니들 디바이스
SG11201702308TA (en) 2014-09-25 2017-04-27 Progenity Inc Electromechanical pill device with localization capabilities
US10300259B2 (en) * 2014-10-22 2019-05-28 Purdue Research Foundation Smart capsule with GI-tract-location-specific payload release
US10667936B2 (en) 2014-10-29 2020-06-02 Trans-Duodenal Concepts Gmbh Bypass device for the transpyloric conducting of gastric content into or through the duodenum, and applicator for putting same in place
CN104344272A (zh) 2014-10-30 2015-02-11 南京博创工业产品设计有限公司 不倒翁小夜灯
EP3215213A4 (en) 2014-11-06 2018-06-20 University of Pittsburgh - Of the Commonwealth System of Higher Education Microneedle arrays for cancer therapy applications
WO2016102526A1 (en) 2014-12-22 2016-06-30 Novo Nordisk A/S Spring-driven drug delivery device
WO2016155671A1 (zh) 2015-04-02 2016-10-06 傅君志 可吞咽式装置
JP7202070B2 (ja) 2015-05-01 2023-01-11 ラニ セラピューティクス, エルエルシー ポリペプチドおよび/またはタンパク質を含む固体塊の製作のための薬学的組成物および方法
CN104983385B (zh) * 2015-05-21 2017-01-04 大连理工大学 一种主被动双半球形胶囊机器人及其姿态调整与转弯驱动控制方法
TW201707744A (zh) 2015-06-03 2017-03-01 賽諾菲阿凡提斯德意志有限公司 藥物輸送裝置(二)
US20180193621A1 (en) 2015-06-30 2018-07-12 Entrega Inc. Device for oral delivery of active agents
US20180192952A1 (en) * 2015-07-02 2018-07-12 The Board Of Trustees Of The University Of Illinois Fully implantable soft medical devices for interfacing with biological tissue
CN108055826A (zh) 2015-07-02 2018-05-18 拉尼医疗有限公司 用于使用可吞服药物递送装置递送到肠道内腔中的治疗药剂制剂
BR112018001292A2 (pt) 2015-07-24 2018-09-11 Kimberly Clark Co métodos para melhor liberação de agentes ativos a tumores
CN108348739A (zh) 2015-08-31 2018-07-31 墨卡托医疗系统公司 用于治疗哮喘的药物的局部施用
AU2016320867B2 (en) 2015-09-08 2023-03-30 Rani Therapeutics, Llc PCSK9 antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US20180250503A1 (en) 2015-09-17 2018-09-06 Aof Pte. Ltd. Microneedle
US20170087299A1 (en) 2015-09-25 2017-03-30 Intel Corporation Carrier apparatus to deliver a substance and methods thereof
US11684763B2 (en) * 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
GB2545880A (en) 2015-10-20 2017-07-05 Glide Pharmaceutical Tech Ltd Solid formulation
WO2017070612A1 (en) 2015-10-23 2017-04-27 Lyndra, Inc. Gastric residence systems for sustained release of therapeutic agents and methods of use thereof
CA3007633A1 (en) 2015-12-08 2017-06-15 Lyndra, Inc. Geometric configurations for gastric residence systems
US9913804B2 (en) 2015-12-31 2018-03-13 Incube Labs, Llc Solid drug storage apparatus, formulations and methods of use
US20190046721A1 (en) 2016-02-26 2019-02-14 Progenity Inc. Compact platform for accurate drug delivery
AU2017230737B2 (en) 2016-03-09 2022-07-14 Incube Labs, Llc Methods and articles for delivering viable cells into solid tissue
CN109310639A (zh) 2016-05-27 2019-02-05 林德拉有限公司 用于胃驻留系统的材料结构
EP3500178A1 (en) 2016-08-18 2019-06-26 Mitchell Lawrence Jones Sampling systems and related materials and methods
US10271764B2 (en) 2016-09-02 2019-04-30 Elwha Llc Intraluminal devices with deployable elements
CN115591091A (zh) 2016-09-09 2023-01-13 比奥拉治疗股份有限公司(Us) 用于递送可配发物质的机电可摄入装置
US20190223846A1 (en) 2016-09-15 2019-07-25 Progenity, Inc. Fluid Sampling Device
CN106137099A (zh) 2016-09-27 2016-11-23 重庆大学 基于云端服务的智能胶囊检测系统
KR101886217B1 (ko) 2016-11-14 2018-08-07 전남대학교산학협력단 패치형 능동 약물전달 시스템
CN106730284A (zh) 2016-11-24 2017-05-31 上海理工大学 微胶囊式胃肠道药物释放系统
MX2019006821A (es) 2016-12-14 2019-10-21 Progenity Inc Tratamiento de una enfermedad del tracto gastrointestinal con un inhibidor de cinasa de janus (jak) y dispositivos.
WO2018112235A1 (en) 2016-12-14 2018-06-21 Progenity Inc. Treatment of a disease of the gastrointestinal tract with a smad7 inhibitor
CA3046019A1 (en) 2016-12-14 2018-06-21 Progenity Inc. Treatment of a disease of the gastrointestinal tract with a tlr modulator
WO2018112441A1 (en) 2016-12-15 2018-06-21 Progenity Inc. Ingestible device and associated methods
WO2018183934A1 (en) 2017-03-30 2018-10-04 Progenity Inc. Treatment of a disease of the gastrointestinal tract with a chst15 inhibitor
WO2018182623A1 (en) 2017-03-30 2018-10-04 Progenity Inc. Methods and ingestible devices for the regio-specific release of chst15 inhibitors at the site of gastrointestinal tract disease
WO2018182612A1 (en) 2017-03-30 2018-10-04 Progenity Inc. Methods and ingestible devices for the regio-specific release of stem cells at the site of gastrointestinal tract disease
WO2018183932A1 (en) 2017-03-30 2018-10-04 Progenity Inc. Treatment of a disease of the gastrointestinal tract with a il-13 inhibitor
WO2018182641A1 (en) 2017-03-30 2018-10-04 Progenity Inc. Methods and ingestible devices for the regio-specific release of il-13 inhibitors at the site of gastrointestinal tract disease
JP2020515579A (ja) 2017-03-30 2020-05-28 プロジェニティ, インコーポレイテッド 消化管疾病の生菌生物学的製剤による治療
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
RU2019141615A (ru) 2017-05-17 2021-06-17 Массачусетс Инститьют Оф Текнолоджи Самоустанавливающиеся системы и сопутствующие компоненты и способы
WO2018218182A1 (en) 2017-05-26 2018-11-29 Mercator Medsystems, Inc. Combination therapy for treatment of restenosis
EP3409303A1 (en) 2017-06-02 2018-12-05 Geistlich Pharma AG Use of a resorbable crosslinked form stable composition for preparing a membrane
WO2019036363A1 (en) 2017-08-14 2019-02-21 Progenity Inc. TREATMENT OF GASTROINTESTINAL TRACT DISEASE WITH GLATIRAMER OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
WO2019036382A1 (en) 2017-08-15 2019-02-21 Progenity Inc. INFLAMMATORY DISEASE TREATMENT INVOLVING AN INGREDIENT DEVICE FOR RELEASING AN IMMUNOMODULATOR
AU2018366110A1 (en) 2017-11-07 2020-06-04 Rani Therapeutics, Llc Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device
US11452851B2 (en) 2017-12-18 2022-09-27 Biograil ApS Oral delivery of active drug substances
WO2019147824A1 (en) 2018-01-26 2019-08-01 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a pde4 inhibitor
EP3765138A1 (en) 2018-03-13 2021-01-20 Progenity, Inc. Ingestible device with relatively large payload volume
WO2019222570A1 (en) 2018-05-17 2019-11-21 Massachusetts Institute Of Technology Systems for electrical stimulation
CN108836237B (zh) 2018-06-15 2024-05-10 安翰科技(武汉)股份有限公司 一种具有采样池密封结构的采样胶囊
EP3917596A1 (en) 2019-02-01 2021-12-08 Novo Nordisk A/S Medical device with actuation mechanism
CN113993560B (zh) 2019-02-01 2024-05-07 麻省理工学院 用于液体注射的系统和方法
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components

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