MX2019013747A - Sistemas autoenderezables y componentes y métodos relacionados. - Google Patents

Sistemas autoenderezables y componentes y métodos relacionados.

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Publication number
MX2019013747A
MX2019013747A MX2019013747A MX2019013747A MX2019013747A MX 2019013747 A MX2019013747 A MX 2019013747A MX 2019013747 A MX2019013747 A MX 2019013747A MX 2019013747 A MX2019013747 A MX 2019013747A MX 2019013747 A MX2019013747 A MX 2019013747A
Authority
MX
Mexico
Prior art keywords
self
righting
tissue
article
subject
Prior art date
Application number
MX2019013747A
Other languages
English (en)
Inventor
Carlo Giovanni Traverso
Robert S Langer
Morten Revsgaard Frederiksen
Alex G Abramson
Salvador Ester Caffarel
Niclas Roxhed
Minsoo Khang
Taylor Bensel
Jorrit Jeroen Water
Bo Uldall Kristiansen
Mikkel Oliver Jespersen
Mette Poulsen
Peter Herskind
Brian Jensen
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of MX2019013747A publication Critical patent/MX2019013747A/es

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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00Anatomical parts of the body
    • A61M2210/10Trunk
    • A61M2210/1042Alimentary tract
    • A61M2210/106Small intestine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/3129Syringe barrels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/329Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0507Electrodes for the digestive system
    • A61N1/0509Stomach and intestinal electrodes

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Abstract

Se proporcionan de manera general artículos autoenderezable, como cápsulas autoenderezable para la administración a un sujeto; en algunas modalidades, el artículo autoenderezable puede configurarse de modo que el artículo pueda orientarse en relación con una superficie (por ejemplo, una superficie de un tejido de un sujeto); los artículos autoenderezables descritos en el presente documento pueden comprender una o más superficies de enganche de tejido configuradas para contactarse (por ejemplo, interactuar con, inyectarse, anclarse) con una superficie (por ejemplo, una superficie de un tejido de un sujeto); en algunas modalidades, el artículo autoenderezable puede tener una forma particular y/o distribución de densidad (o masa) que, por ejemplo, permite el comportamiento de autoenderezado del artículo; en algunas modalidades, el artículo autoenderezable puede comprender un componente de interfaz de tejido y/o un agente farmacéutico (por ejemplo, para la administración del agente farmacéutico activo a una ubicación interior del sujeto); en algunos casos, tras el contacto del tejido con la superficie de contacto con el tejido del artículo, el artículo autoenderezable puede configurarse para liberar uno o más componentes de interfaz del tejido; en algunos casos, el componente de interfaz de tejido está asociado con un componente autoaccionable; por ejemplo, el artículo autoenderezable puede comprender un componente autoaccionable configurado, tras la exposición a un fluido, para liberar el componente de interfaz de tejido del artículo autoenderezable; en algunos casos, el componente de interfaz de tejido puede comprender y/o estar asociado con el agente farmacéutico (por ejemplo, para la entrega a una ubicación interna de un sujeto).
MX2019013747A 2017-05-17 2018-05-17 Sistemas autoenderezables y componentes y métodos relacionados. MX2019013747A (es)

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Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1762259T3 (da) 2005-09-12 2011-01-03 Unomedical As Indføringsindretning til infusionssæt med en første og en anden fjederenhed
WO2012123274A1 (en) 2011-03-14 2012-09-20 Unomedical A/S Inserter system with transport protection
CN109862821A (zh) 2016-09-09 2019-06-07 普罗根尼蒂公司 用于递送可配发物质的机电可摄入装置
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
KR102391768B1 (ko) 2017-05-17 2022-04-29 메사추세츠 인스티튜트 오브 테크놀로지 자가-직립 시스템, 방법, 및 관련 구성요소
US20210361919A1 (en) 2018-05-17 2021-11-25 Massachusetts Institute Of Technology Quick release capsules
EP3793667A1 (en) * 2018-05-17 2021-03-24 Massachusetts Institute of Technology Systems for electrical stimulation
KR20210095165A (ko) 2018-11-19 2021-07-30 프로제너티, 인크. 바이오의약품으로 질환을 치료하기 위한 방법 및 디바이스
US11771829B2 (en) 2019-02-01 2023-10-03 Massachusetts Institute Of Technology Systems and methods for liquid injection
WO2020157324A1 (en) 2019-02-01 2020-08-06 Novo Nordisk A/S Medical device with actuation mechanism
AU2020233287A1 (en) 2019-03-01 2021-09-23 Rani Therapeutics, Llc Devices, systems, and methods for delivering therapeutic agents into a stomach wall
CA3141608A1 (en) 2019-05-20 2020-11-26 Unomedical A/S Rotatable infusion device and methods thereof
US20220313967A1 (en) * 2019-06-07 2022-10-06 Novo Nordisk A/S Ingestible device with delivery member detachment
WO2021013907A1 (en) 2019-07-22 2021-01-28 Novo Nordisk A/S Capsule device having improved self-righting ability
EP3771408A1 (en) * 2019-08-02 2021-02-03 Bionime Corporation Physiological signal monitoring system for fast assembly
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components
EP4309722A2 (en) 2019-12-13 2024-01-24 Biora Therapeutics, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
EP3859829A1 (en) 2020-01-29 2021-08-04 Lg Chem, Ltd. Method and system for analyzing swelling behavior of lithium secondary battery
CN111481812A (zh) * 2020-05-29 2020-08-04 陈建华 一种产科用给药装置
WO2021250222A1 (en) 2020-06-12 2021-12-16 Novo Nordisk A/S Ingestible device having a spike assembly
JP2023536760A (ja) 2020-08-08 2023-08-29 ノボ・ノルデイスク・エー/エス 内腔に挿入可能なカプセル
US20220039686A1 (en) 2020-08-10 2022-02-10 Massachusetts Institute Of Technology Drug delivery device
CN116261477A (zh) 2020-09-30 2023-06-13 诺和诺德股份有限公司 管腔可插入胶囊
EP4225420A1 (en) 2020-10-09 2023-08-16 Novo Nordisk A/S Capsule device
CN116829223A (zh) 2021-01-28 2023-09-29 诺和诺德股份有限公司 具有流体致动的致动机构的医疗装置
JP2024505475A (ja) 2021-01-28 2024-02-06 ノボ・ノルデイスク・エー/エス 改善された作動機構を有する医療装置
EP4291282A1 (en) * 2021-02-11 2023-12-20 10X Technology LLC Method and apparatus for fabricating brittle microneedle
WO2022195476A1 (en) 2021-03-15 2022-09-22 Clexio Biosciences Ltd. Gastroretentive devices for assessment of intragastric conditions
CN117500547A (zh) 2021-06-18 2024-02-02 诺和诺德股份有限公司 具有流体激活的致动机构的医疗装置
CN117715627A (zh) * 2021-08-09 2024-03-15 麻省理工学院 可摄入装置
CN114403948A (zh) * 2022-01-10 2022-04-29 烟台美神科美医疗美容门诊部有限公司 一种增加脂肪细胞存活率的自体脂肪移植设备
WO2023144402A1 (en) 2022-01-31 2023-08-03 Novo Nordisk A/S Ingestible device with detachment of tissue penetrating member
WO2024038123A1 (en) 2022-08-17 2024-02-22 Novo Nordisk A/S Ingestible device with rotational drive mechanism
WO2024038122A1 (en) 2022-08-17 2024-02-22 Novo Nordisk A/S Ingestible device with rotational trigger release
WO2024115766A1 (en) 2022-12-01 2024-06-06 Novo Nordisk A/S Ingestible device with shielding arrangement
WO2024115734A1 (en) 2022-12-01 2024-06-06 Novo Nordisk A/S Capsule device with improved actuator arrangement
WO2024129677A2 (en) * 2022-12-13 2024-06-20 Verily Life Sciences Llc Ingestible device with self-orientation capability in an in vivo environment
KR102553293B1 (ko) * 2022-12-23 2023-07-07 대원제약주식회사 세마글루타이드를 포함하는 마이크로니들 및 이의 제조방법

Family Cites Families (337)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2601767A (en) 1946-04-22 1952-07-01 Thomas P Wall Self righting cup
US3442045A (en) 1967-02-06 1969-05-06 Joseph Green Variable speed self-righting toy
US3386409A (en) 1967-05-16 1968-06-04 Dietz Co R E Self-righting traffic cone
US3656483A (en) * 1970-01-15 1972-04-18 Biolog Concepts Inc Intrauterine medicator
US3797492A (en) 1972-12-27 1974-03-19 Alza Corp Device for dispensing product with directional guidance member
US3826220A (en) 1973-01-22 1974-07-30 C Jacobson Self-righting power-driven aquatic vehicle
US4239040A (en) * 1976-10-19 1980-12-16 Kabushiki Kaisha Daini Seikosha Capsule for medical use
US4193397A (en) 1977-12-01 1980-03-18 Metal Bellows Corporation Infusion apparatus and method
US4481952A (en) 1978-03-22 1984-11-13 Jerzy Pawelec Device for the study of the alimentary canal
US4236525A (en) 1978-11-22 1980-12-02 Intermedics, Inc. Multiple function lead assembly
JPS55166142A (en) 1979-06-14 1980-12-25 Olympus Optical Co Capsule device for medical treatment
DE2928477C3 (de) 1979-07-14 1982-04-15 Battelle-Institut E.V., 6000 Frankfurt Vorrichtung zur Freisetzung von Substanzen an definierten Orten des Verdauungstraktes
JPS57156736A (en) * 1981-03-23 1982-09-28 Olympus Optical Co Therapeutic capsule apparatus
JPS5819232A (ja) 1981-07-29 1983-02-04 オリンパス光学工業株式会社 医療用カプセル
US4407283A (en) * 1981-10-19 1983-10-04 Dale C. Grier Self-injecting syringe
GB8508173D0 (en) 1985-03-28 1985-05-01 Standard Telephones Cables Ltd Controlled delivery device
DE8536337U1 (de) 1985-12-23 1986-02-13 R.P. Scherer GmbH, 6930 Eberbach Füllkeil für eine Maschine zum Herstellen von Gelatinekapseln
US5002772A (en) 1988-05-31 1991-03-26 Pfizer Inc. Gastric retention system for controlled drug release
JPH03163011A (ja) 1989-08-31 1991-07-15 Yamanouchi Pharmaceut Co Ltd 胃内滞留デバイス
US5474785A (en) 1990-01-24 1995-12-12 Alza Corporation Delivery system comprising means for controlling internal pressure
US5017187A (en) * 1990-05-04 1991-05-21 Sullivan Robert J Self retracting hypodermic syringe
US5125491A (en) 1990-06-21 1992-06-30 Usui Kokusai Sangyo Kaisha Limited Temperature sensitive type fluid fan coupling apparatus
US5217449A (en) 1990-12-11 1993-06-08 Miyarisan Kabushiki Kaisha Medical capsule and apparatus for activating the same
US5279607A (en) 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
US5318557A (en) * 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
PT1238660E (pt) 1996-02-02 2005-10-31 Alza Corp Distribuicao sustentada de um agente activo utilizando um sistema implantavel
US5690691A (en) 1996-05-08 1997-11-25 The Center For Innovative Technology Gastro-intestinal pacemaker having phased multi-point stimulation
FR2749955B1 (fr) 1996-06-14 1998-09-11 Thomson Csf Systeme de lecture d'empreintes digitales
US6243607B1 (en) 1996-09-05 2001-06-05 University Technologies International Inc. Gastro-intestinal electrical pacemaker
IT1292016B1 (it) 1997-05-28 1999-01-25 Valerio Cigaina Dispositivo di impianto particolarmente per elettrostimolazione e/o elettroregistrazione di visceri endoaddominali
US6030641A (en) 1997-06-03 2000-02-29 Uni Colloid Kabushiki Kaisha Sustained release capsule and method for preparing the same
AU8699298A (en) 1997-08-11 1999-03-01 Alza Corporation Prolonged release active agent dosage form adapted for gastric retention
IE970782A1 (en) 1997-10-22 1999-05-05 Elan Corp An improved automatic syringe
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
CA2330207C (en) 1998-06-10 2005-08-30 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6346519B1 (en) * 1998-09-09 2002-02-12 Advanced Medical Instruments Method and composition for treating arthritis
IL126727A (en) 1998-10-22 2006-12-31 Given Imaging Ltd A method of bringing a device to the goal
US7076307B2 (en) 2002-05-09 2006-07-11 Boveja Birinder R Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders
SE9804126D0 (sv) 1998-11-27 1998-11-27 Astra Ab New pharmaceutical composition
US6684104B2 (en) 1999-04-14 2004-01-27 Transneuronix, Inc. Gastric stimulator apparatus and method for installing
ATE244558T1 (de) 1999-04-16 2003-07-15 Novo Nordisk As Trockene formbare arzneistoffformulierung
FR2794654B1 (fr) 1999-06-08 2001-10-19 Ct De Transfert Des Microtechn Dispositif de largage de substances dans un tube digestif
US7955340B2 (en) 1999-06-25 2011-06-07 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US20050079214A1 (en) 1999-09-01 2005-04-14 John Cooker Oral delivery system and method for making same
WO2001026602A1 (en) 1999-10-13 2001-04-19 Novo Nordisk A/S Method for producing an elongated drug formulation
US20070203531A9 (en) 1999-12-03 2007-08-30 Medtronic, Inc. Heart rate variability control of gastric electrical stimulator
GB9930001D0 (en) 1999-12-21 2000-02-09 Phaeton Research Ltd An ingestible device
GB9930000D0 (en) * 1999-12-21 2000-02-09 Phaeton Research Ltd An ingestible device
US7039453B2 (en) * 2000-02-08 2006-05-02 Tarun Mullick Miniature ingestible capsule
WO2001058424A1 (en) 2000-02-09 2001-08-16 West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited Floating drug delivery composition
AUPQ573300A0 (en) 2000-02-21 2000-03-16 Australian Nuclear Science & Technology Organisation Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use
US6488962B1 (en) 2000-06-20 2002-12-03 Depomed, Inc. Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms
US6929636B1 (en) 2000-11-08 2005-08-16 Hewlett-Packard Development Company, L.P. Internal drug dispenser capsule medical device
US6615084B1 (en) 2000-11-15 2003-09-02 Transneuronix, Inc. Process for electrostimulation treatment of morbid obesity
US6638246B1 (en) 2000-11-28 2003-10-28 Scimed Life Systems, Inc. Medical device for delivery of a biologically active material to a lumen
WO2002064193A2 (en) 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
US6535764B2 (en) 2001-05-01 2003-03-18 Intrapace, Inc. Gastric treatment and diagnosis device and method
US7756582B2 (en) 2001-05-01 2010-07-13 Intrapace, Inc. Gastric stimulation anchor and method
US7702394B2 (en) 2001-05-01 2010-04-20 Intrapace, Inc. Responsive gastric stimulator
US7160258B2 (en) 2001-06-26 2007-01-09 Entrack, Inc. Capsule and method for treating or diagnosing the intestinal tract
GB2379390B (en) 2001-09-11 2005-01-26 Caretek Medical Ltd A novel drug delivery technology
JP4578740B2 (ja) 2001-09-21 2010-11-10 オリンパス株式会社 カプセル型医療装置
JP4643089B2 (ja) 2001-09-27 2011-03-02 オリンパス株式会社 カプセル型医療装置
US7100274B2 (en) 2001-11-02 2006-09-05 Neptco Incorporated Apparatus for applying media to a conduit
US8454997B2 (en) 2001-12-18 2013-06-04 Novo Nordisk A/S Solid dose micro implant
WO2003057136A2 (en) * 2001-12-24 2003-07-17 Teva Pharmaceutical Industries Ltd. Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it
US20030195415A1 (en) 2002-02-14 2003-10-16 Iddan Gavriel J. Device, system and method for accoustic in-vivo measuring
JP3869291B2 (ja) 2002-03-25 2007-01-17 オリンパス株式会社 カプセル型医療装置
US8241308B2 (en) 2002-04-24 2012-08-14 Boston Scientific Scimed, Inc. Tissue fastening devices and processes that promote tissue adhesion
JP4231657B2 (ja) 2002-05-10 2009-03-04 オリンパス株式会社 カプセル型医療装置
JP2004041709A (ja) 2002-05-16 2004-02-12 Olympus Corp カプセル医療装置
US20040193229A1 (en) 2002-05-17 2004-09-30 Medtronic, Inc. Gastric electrical stimulation for treatment of gastro-esophageal reflux disease
US8142365B2 (en) * 2002-05-31 2012-03-27 Vidacare Corporation Apparatus and method for accessing the bone marrow of the sternum
US9314228B2 (en) 2002-05-31 2016-04-19 Vidacare LLC Apparatus and method for accessing the bone marrow
US6945952B2 (en) * 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
JP2005533625A (ja) * 2002-07-19 2005-11-10 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルデバイスおよびマイクロニードル送達装置
US20040044364A1 (en) 2002-08-29 2004-03-04 Devries Robert Tissue fasteners and related deployment systems and methods
US7118531B2 (en) 2002-09-24 2006-10-10 The Johns Hopkins University Ingestible medical payload carrying capsule with wireless communication
US8449452B2 (en) 2002-09-30 2013-05-28 Given Imaging Ltd. In-vivo sensing system
EP1590034B1 (en) 2002-10-07 2014-05-14 Biovalve Technologies, Inc. Microneedle array patch
US20040106849A1 (en) * 2002-12-03 2004-06-03 Cho Jin-Ho Multi-functional, bi-directional communication telemetry capsule
US7833151B2 (en) 2002-12-26 2010-11-16 Given Imaging Ltd. In vivo imaging device with two imagers
EP1587407B1 (en) 2002-12-26 2012-03-07 Given Imaging Ltd. Immobilizable in vivo sensing device
CN1756571A (zh) * 2002-12-30 2006-04-05 血管技术国际股份公司 组织反应性化合物和组合物及其应用
JP2006519766A (ja) 2002-12-30 2006-08-31 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 組織反応性化合物および組成物、ならびにそれらの使用法
US7153454B2 (en) 2003-01-21 2006-12-26 University Of Southern California Multi-nozzle assembly for extrusion of wall
JP2004222998A (ja) 2003-01-23 2004-08-12 Olympus Corp 超音波診断用カプセル
EP1594477A4 (en) 2003-01-29 2009-07-15 Pill Pharma Ltd E ACTIVE MEDICATION CONTRIBUTION IN THE DIGESTIVE TUBE
US20050058701A1 (en) 2003-01-29 2005-03-17 Yossi Gross Active drug delivery in the gastrointestinal tract
US20060058829A1 (en) * 2003-03-19 2006-03-16 Sampson Douglas C Intragastric volume-occupying device
US7620454B2 (en) 2003-05-19 2009-11-17 Medtronic, Inc. Gastro-electric stimulation for reducing the acidity of gastric secretions or reducing the amounts thereof
US7742818B2 (en) 2003-05-19 2010-06-22 Medtronic, Inc. Gastro-electric stimulation for increasing the acidity of gastric secretions or increasing the amounts thereof
US9186233B2 (en) 2003-07-23 2015-11-17 Lothar Göbel Closing system for a natural or artificial anus
US9498366B2 (en) 2003-07-28 2016-11-22 Baronova, Inc. Devices and methods for pyloric anchoring
WO2005016558A2 (en) 2003-08-04 2005-02-24 Microchips, Inc. Methods for accelerated release of material from a reservoir device
US8353861B2 (en) 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
US8021356B2 (en) 2003-09-29 2011-09-20 Olympus Corporation Capsule medication administration system, medication administration method using capsule medication administration system, control method for capsule medication administration system
US20050124875A1 (en) 2003-10-01 2005-06-09 Olympus Corporation Vivo observation device
US20050075654A1 (en) 2003-10-06 2005-04-07 Brian Kelleher Methods and devices for soft tissue securement
US8029503B2 (en) * 2003-10-11 2011-10-04 The Regents Of The University Of California Nerve repair by selective surgical repair of axons
EP1690490B1 (en) 2003-11-11 2012-04-18 Olympus Corporation Capsule type medical device system
US20050149142A1 (en) 2004-01-07 2005-07-07 Starkebaum Warren L. Gastric stimulation responsive to sensing feedback
US7177693B2 (en) 2004-01-07 2007-02-13 Medtronic, Inc. Gastric stimulation for altered perception to treat obesity
WO2005092189A1 (en) 2004-03-25 2005-10-06 Olympus Corporation In-vivo information acquisition apparatus and in-vivo information acquisition apparatus system
US8000784B2 (en) 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling device
CN1953737A (zh) * 2004-05-03 2007-04-25 埃-皮尔制药公司 胃肠道内的主动药物递送
US20050250988A1 (en) 2004-05-07 2005-11-10 Usgi Medical Inc. Removable apparatus for manipulating and securing tissue within a treatment space
DE102004026615A1 (de) * 2004-06-01 2005-12-29 Siemens Ag Vorrichtung und Verfahren zur Freisetzung eines in das Körperinnere eines Patienten geführten therapeutischen Mittels
US7678135B2 (en) 2004-06-09 2010-03-16 Usgi Medical, Inc. Compressible tissue anchor assemblies
TWI253024B (en) 2004-07-20 2006-04-11 Realtek Semiconductor Corp Method and apparatus for block matching
DE102005021081B4 (de) 2004-07-23 2019-05-29 Advanced Medical Balloons Gmbh Rektal-Tubus
JP4589048B2 (ja) 2004-08-04 2010-12-01 オリンパス株式会社 カプセル型内視鏡
DK1814622T3 (en) 2004-08-13 2016-02-29 Obalon Therapeutics Inc Intragastric volume-receiving device
US20060034913A1 (en) 2004-08-13 2006-02-16 James Gaede Multiplex drug delivery device
US20060047309A1 (en) 2004-08-25 2006-03-02 Cichocki Frank R Jr Metal injection molded suture needles
EP1789128B1 (en) 2004-08-27 2018-05-09 STOCO 10 GmbH Electronically and remotely controlled pill and system for delivering at least one medicament
JP4656909B2 (ja) 2004-10-15 2011-03-23 オリンパス株式会社 被検体内導入装置およびその製造方法
CN101065161B (zh) 2004-11-29 2013-03-13 皇家飞利浦电子股份有限公司 电子可控药丸
WO2006064503A2 (en) 2004-12-14 2006-06-22 E-Pill Pharma, Ltd. Prolonged transit time of permeability-enhancing drug eluting pill
CN101237903A (zh) 2005-01-18 2008-08-06 皇家飞利浦电子股份有限公司 用于控制所摄入胶囊通过的系统和方法
JP2008526418A (ja) 2005-01-18 2008-07-24 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 放射線を放出するための電子制御されるカプセル
JP2008532568A (ja) * 2005-01-18 2008-08-21 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 電子制御されるカプセル
US20080153779A1 (en) 2005-02-01 2008-06-26 Jun Liao Gastric Retention and Controlled Release Delivery System
US8852083B2 (en) 2005-02-04 2014-10-07 Uti Limited Partnership Self-stabilized encapsulated imaging system
US20060259074A1 (en) 2005-02-22 2006-11-16 Brian Kelleher Methods and devices for anchoring to soft tissue
US7699863B2 (en) 2005-03-01 2010-04-20 Tulip Medical Ltd. Bioerodible self-deployable intragastric implants
WO2006125074A1 (en) 2005-05-17 2006-11-23 Brown University Research Foundation Drug delivery formulations for targeted delivery
US9585651B2 (en) 2005-05-26 2017-03-07 Usgi Medical, Inc. Methods and apparatus for securing and deploying tissue anchors
US8021357B2 (en) 2005-05-27 2011-09-20 Olympus Corporation Body-insertable apparatus
US8777967B2 (en) 2005-06-09 2014-07-15 Xlumena, Inc. Methods and devices for anchoring to tissue
WO2006131522A1 (de) 2005-06-10 2006-12-14 Siemens Aktiengesellschaft Vorrichtung und verfahren zur diagnose und/oder behandlung funktioneller gastrointestinaler erkrankungen
US20050240239A1 (en) 2005-06-29 2005-10-27 Boveja Birinder R Method and system for gastric ablation and gastric pacing to provide therapy for obesity, motility disorders, or to induce weight loss
DE102005032290A1 (de) 2005-07-11 2007-01-18 Siemens Ag Endoskopiekapsel sowie Verfahren zur Diagnose und/oder Therapie mittles einer Endoskopiekapsel
US20070021760A1 (en) 2005-07-19 2007-01-25 Brian Kelleher Methods and apparatus for securing an anchor to soft tissue
US8021384B2 (en) 2005-07-26 2011-09-20 Ram Weiss Extending intrabody capsule
US20070038181A1 (en) * 2005-08-09 2007-02-15 Alexander Melamud Method, system and device for delivering a substance to tissue
CN100376299C (zh) 2005-08-19 2008-03-26 华南理工大学 化学反应气压式微胶囊药物释放方法及其装置
US8295932B2 (en) 2005-12-05 2012-10-23 Metacure Limited Ingestible capsule for appetite regulation
JP4358821B2 (ja) 2005-12-15 2009-11-04 オリンパス株式会社 被検体内導入装置
JP4402648B2 (ja) * 2005-12-16 2010-01-20 オリンパス株式会社 被検体内導入装置
ATE528038T1 (de) 2005-12-22 2011-10-15 Koninkl Philips Electronics Nv Vorrichtung zur gesteuerten freisetzung chemischer moleküle
US8252329B2 (en) 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
CN1820798A (zh) 2006-01-28 2006-08-23 重庆大学 胶囊式消化道药物释放及采样装置
GB0603252D0 (en) 2006-02-17 2006-03-29 Axcess Ltd Dissolution aids for oral peptide delivery
CN100490916C (zh) 2006-04-03 2009-05-27 重庆大学 胶囊式消化道定时药物释放装置
DE102006019419B4 (de) 2006-04-26 2008-02-14 Siemens Ag Aktuator insbesondere eines Endoroboters
US8101114B2 (en) 2006-05-01 2012-01-24 Georgia Tech Research Corporation Particle based molding
EP2032093B1 (en) 2006-05-18 2013-09-04 Tulip Medical Ltd. Bioerodible intragastric implant
WO2007141282A2 (en) 2006-06-07 2007-12-13 Novartis Ag Process for making multiparticulates using a roller compactor
EP2035075A1 (en) 2006-06-20 2009-03-18 Koninklijke Philips Electronics N.V. Electronic capsule for treating gastrointestinal disease
CN101472640B (zh) 2006-06-23 2012-12-12 皇家飞利浦电子股份有限公司 药物输送系统
US20100247453A1 (en) * 2006-07-12 2010-09-30 Thomas L. Jones Composition and method of treating a sore throat
US9550050B2 (en) 2006-09-25 2017-01-24 MEDIMETRICS Personalized Drug Delivery B.V. Medicament delivery apparatus
US9227011B2 (en) 2006-09-29 2016-01-05 MEDIMETRICS Personalized Drug Delivery B.V. Miniaturized threshold sensor
US8597279B2 (en) 2006-10-31 2013-12-03 Medimetrics Personalized Drug Delivery, Inc. Swallowable multi-nozzle dosing device for releasing medicines in the gastrointestinal tract
EP1923083A1 (en) 2006-11-17 2008-05-21 Sanofi-Aventis Deutschland GmbH Drive mechanisms for use in drug delivery devices
US9878094B2 (en) 2006-11-21 2018-01-30 Stoco 10 GmbH Medicament delivery device, capsule and in vivo medicine delivery or diagnostic system
JP5203962B2 (ja) 2006-11-24 2013-06-05 オリンパスメディカルシステムズ株式会社 カプセル型内視鏡
CN100482293C (zh) 2006-12-19 2009-04-29 重庆大学 缓释型遥控电子胶囊
US8702591B2 (en) 2007-01-12 2014-04-22 Olympus Medical Systems Corp. Capsule medical apparatus
CA2680814A1 (en) 2007-03-15 2008-09-18 Bioprotect Ltd. Soft tissue fixation devices
US20080257845A1 (en) 2007-04-23 2008-10-23 Esmeralda Reyes Rossi Self Righting Baby Bottle
US7925351B2 (en) 2007-06-13 2011-04-12 Betastim, Ltd. Gastrointestinal device for treating obesity and diabetes
JP5399253B2 (ja) 2007-09-26 2014-01-29 オリンパスメディカルシステムズ株式会社 被検体内導入システム
US20090110723A1 (en) 2007-10-15 2009-04-30 Mcallister Stephen Mark Linkers for multipart dosage forms for release of one or more pharmaceutical compositions, and the resulting dosage forms
US8789536B2 (en) 2007-10-17 2014-07-29 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8333754B2 (en) 2007-10-31 2012-12-18 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
WO2009063375A1 (en) 2007-11-13 2009-05-22 Koninklijke Philips Electronics N.V. Ingestible electronic capsule
WO2009063377A1 (en) 2007-11-13 2009-05-22 Koninklijke Philips Electronics N.V. Ingestible electronic capsule
WO2009063376A1 (en) 2007-11-13 2009-05-22 Koninklijke Philips Electronics N.V. Ingestible electronic capsule
US20090137866A1 (en) 2007-11-28 2009-05-28 Searete Llc, A Limited Liability Corporation Of The State Delaware Medical or veterinary digestive tract utilization systems and methods
DK2231254T3 (da) * 2007-12-11 2014-07-21 Massachusetts Inst Technology Implanterbar lægemiddelafgivelsesindretning
US20090155354A1 (en) * 2007-12-14 2009-06-18 Mclean Barbara Wanamaker Dispensing encapsulated liquids into body cavities
JP6230772B2 (ja) 2008-02-18 2017-11-15 シュトコ・ツェーン・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 患者に対する薬物の投与
CN101983029B (zh) 2008-03-31 2015-01-14 皇家飞利浦电子股份有限公司 制备包括传感器的可吞服胶囊的方法
JP5314913B2 (ja) 2008-04-03 2013-10-16 オリンパスメディカルシステムズ株式会社 カプセル医療システム
JP5363020B2 (ja) 2008-04-07 2013-12-11 オリンパスメディカルシステムズ株式会社 カプセル型医療装置および医療システム
US8454632B2 (en) 2008-05-12 2013-06-04 Xlumena, Inc. Tissue anchor for securing tissue layers
ATE505128T1 (de) 2008-06-04 2011-04-15 Olympus Medical Systems Corp Kapselförmige medizinische vorrichtung
JP5500600B2 (ja) 2008-06-19 2014-05-21 コーニンクレッカ フィリップス エヌ ヴェ 湿った環境における粉状薬物の供給のためのデバイス
CN102088955A (zh) 2008-07-07 2011-06-08 皇家飞利浦电子股份有限公司 包括储药器的电子药丸
US20100010294A1 (en) 2008-07-10 2010-01-14 Ethicon Endo-Surgery, Inc. Temporarily positionable medical devices
US8287902B2 (en) 2008-07-23 2012-10-16 Rainbow Medical Ltd. Enhanced-diffusion capsule
WO2010027069A1 (ja) 2008-09-08 2010-03-11 大正製薬株式会社 打錠用臼
WO2010055796A1 (ja) 2008-11-13 2010-05-20 オリンパスメディカルシステムズ株式会社 カプセル型医療装置
EP2201938A1 (en) 2008-12-18 2010-06-30 Koninklijke Philips Electronics N.V. Controllable drug delivery capsule
US8597186B2 (en) 2009-01-06 2013-12-03 Proteus Digital Health, Inc. Pharmaceutical dosages delivery system
EP2340757A4 (en) 2009-01-28 2012-08-01 Olympus Medical Systems Corp SYSTEM FOR CAPSUED MEDICAL EQUIPMENT
WO2010093834A2 (en) 2009-02-12 2010-08-19 Incube Labs, Llc Skin penetrating device and method for subcutaneous solid drug delivery
EP2408517A1 (en) 2009-03-03 2012-01-25 Medtronic, Inc Electrical stimulation therapy to promote gastric distention for obesity management
US20100248828A1 (en) * 2009-03-24 2010-09-30 Ty Huynh Kaing Educational toy
WO2010116304A1 (en) 2009-04-07 2010-10-14 Koninklijke Philips Electronics N.V. Valveless drug delivery device
JP5681875B2 (ja) 2009-04-07 2015-03-11 メディメトリクス ペルソナリズド ドルグ デリヴェリー ベー ヴェ モジュラ経口摂取医薬品供給カプセル
CN102458559B (zh) 2009-04-10 2014-06-04 3M创新有限公司 制造中空微针阵列的方法以及由其制得的制品和用途
US20110052695A1 (en) * 2009-04-20 2011-03-03 Allergan, Inc. Drug delivery platforms comprising silk fibroin hydrogels and uses thereof
US20100286628A1 (en) 2009-05-07 2010-11-11 Rainbow Medical Ltd Gastric anchor
WO2010137705A1 (ja) 2009-05-29 2010-12-02 オリンパスメディカルシステムズ株式会社 カプセル型医療装置
JP2011012050A (ja) 2009-06-03 2011-01-20 Bioserentack Co Ltd 多孔性基盤を用いたマイクロニードル・アレイとその製造方法
US8682440B2 (en) 2009-08-03 2014-03-25 Incube Labs, Llc Swallowable capsule and method for stimulating incretin production within the intestinal tract
JP5497176B2 (ja) 2009-08-12 2014-05-21 コーニンクレッカ フィリップス エヌ ヴェ 圧縮可能な薬品貯槽を備える薬品送出装置
WO2011018743A1 (en) 2009-08-12 2011-02-17 Koninklijke Philips Electronics N.V. Medicine reservoir for drug delivery device
US20130011332A1 (en) * 2009-09-15 2013-01-10 Searete Llc, Frozen Compositions and Methods for Piercing a Substrate
MX2012001181A (es) 2009-09-21 2012-04-30 Medtronic Inc Ondas para terapia de estimulacion electrica.
US9017310B2 (en) * 2009-10-08 2015-04-28 Palo Alto Research Center Incorporated Transmucosal drug delivery device and method including microneedles
US8834423B2 (en) * 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
US20130172694A1 (en) 2009-12-17 2013-07-04 MEDIMETRICS Personalized Drug Delivery B.V. Swallowable capsule for monitoring a condition
US8562589B2 (en) * 2009-12-24 2013-10-22 Rani Therapeutics, Llc Swallowable drug delivery device and method of delivery
EP2544668B1 (en) * 2009-12-24 2019-07-10 Rani Therapeutics, LLC Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
AU2010336330B2 (en) * 2009-12-24 2016-04-28 Rani Therapeutics, Llc Swallowable drug delivery device and methods of drug delivery
US9033933B2 (en) * 2010-02-05 2015-05-19 Sanofi-Aventis Deutschland Gmbh Medicated module with lockable needle guard
WO2011095486A1 (en) 2010-02-05 2011-08-11 Sanofi-Aventis Deutschland Gmbh Medicated module with lockable needle guard
JP4932971B2 (ja) 2010-03-26 2012-05-16 オリンパスメディカルシステムズ株式会社 カプセル型医療装置用誘導システム
DE102010020614A1 (de) 2010-05-14 2011-11-17 Friedrich-Alexander-Universität Erlangen-Nürnberg Endoskopiekapsel zum Nachweis eines Stoffwechselproduktes eines in oder an der Wand eines Hohlorgans des menschlichen oder tierischen Gastrointestinaltraktes befindlichen Erregers
ES2651743T3 (es) * 2010-07-05 2018-01-29 Jagotec Ag Forma farmacéutica
US20180296814A1 (en) 2010-08-17 2018-10-18 Progenity, Inc. Administration of drugs to a patient
EP2433663A1 (en) * 2010-09-27 2012-03-28 Unomedical A/S Insertion system
US9616206B2 (en) 2010-10-06 2017-04-11 Medimetrics Personalized Drug Delivery Electronic pill for delivery of powder medication
KR101851034B1 (ko) 2010-12-02 2018-04-20 쓰리엠 이노베이티브 프로퍼티즈 컴파니 액정성 중합체 미세바늘
US8764733B2 (en) 2010-12-23 2014-07-01 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9861683B2 (en) 2010-12-23 2018-01-09 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402807B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9415004B2 (en) 2010-12-23 2016-08-16 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9283179B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9284367B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8969293B2 (en) 2010-12-23 2015-03-03 Rani Therapeutics, Llc Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809271B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising liraglutide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402806B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809269B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9629799B2 (en) 2010-12-23 2017-04-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9149617B2 (en) 2010-12-23 2015-10-06 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US8846040B2 (en) 2010-12-23 2014-09-30 Rani Therapeutics, Llc Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9259386B2 (en) 2010-12-23 2016-02-16 Rani Therapeutics, Llc Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8980822B2 (en) 2010-12-23 2015-03-17 Rani Therapeutics, Llc Therapeutic agent preparations comprising pramlintide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8734429B2 (en) 2010-12-23 2014-05-27 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US10639272B2 (en) 2010-12-23 2020-05-05 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
EP2665504A4 (en) 2011-01-18 2017-01-25 Massachusetts Institute of Technology Deployable barbed microneedle array and uses thereof
US9089677B2 (en) * 2011-01-25 2015-07-28 The Regents Of The University Of California Transcutaneous multimodal delivery system (TMDS)
CN103781474B (zh) 2011-03-24 2018-09-21 宝珍那提公司 可吞咽的药物胶囊
WO2012158648A1 (en) 2011-05-13 2012-11-22 Massachusetts Institute Of Technology Method and apparatus for delivering a substance
US20120305574A1 (en) 2011-06-03 2012-12-06 Deliang Shi Self-Righting Container
US20120305573A1 (en) 2011-06-03 2012-12-06 Deliang Shi Self-Righting Containers
JP6101261B2 (ja) * 2011-06-29 2017-03-22 ラニ セラピューティクス, エルエルシー 治療用化合物の経口送達のためのデバイス、システム、および方法
JP5945882B2 (ja) 2011-07-22 2016-07-05 東芝メディカルシステムズ株式会社 マーキング用カプセル及びカプセル内視鏡システム
WO2013021374A2 (en) 2011-08-05 2013-02-14 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
KR101861307B1 (ko) * 2011-10-13 2018-07-06 한미약품 주식회사 정제를 포함하는 경질 캡슐 복합 제형
WO2013101908A1 (en) 2011-12-27 2013-07-04 Massachusetts Institute Of Technology Microneedle devices and uses thereof
US9149172B2 (en) 2011-12-29 2015-10-06 Given Imaging Ltd. System and apparatus for anchoring and operation of in-vivo medical devices
EP2609952B1 (en) * 2011-12-30 2015-01-14 Q-Med AB Bruiseless cannula
US9610401B2 (en) 2012-01-13 2017-04-04 Medtronic Minimed, Inc. Infusion set component with modular fluid channel element
EP3725234A1 (en) 2012-02-17 2020-10-21 Progenity, Inc. Ingestible medical device
JP5983736B2 (ja) 2012-03-27 2016-09-06 ソニー株式会社 カプセル型医療装置
CN104703651A (zh) 2012-05-01 2015-06-10 高等教育联邦系统-匹兹堡大学 用于经皮插入的尖端负载的微针阵列
DE102012207714A1 (de) 2012-05-09 2013-11-14 BSH Bosch und Siemens Hausgeräte GmbH Gerät, insbesondere ein Haarstylinggerät
JP5551838B2 (ja) * 2012-06-08 2014-07-16 オリンパスメディカルシステムズ株式会社 カプセル型医療装置
WO2013188819A2 (en) 2012-06-14 2013-12-19 Entrega, Inc. Mucoadhesive devices for delivery of active agents
EP2870317A4 (en) 2012-07-05 2016-09-07 Halliburton Energy Services Inc ELEMENTS THAT CAN BE DISPLACED IN DRILLING OPERATIONS
US8755888B2 (en) 2012-10-17 2014-06-17 Melcap Systems Ltd. Gastrointestinal system
CN102920418B (zh) * 2012-10-24 2014-07-30 刘思德 一种消化道自稳探路胶囊
US9526884B2 (en) * 2012-11-16 2016-12-27 City University Of Hong Kong Mechanically robust fast-dissolving microneedles for transdermal drug and vaccine delivery
GB201304662D0 (en) * 2013-03-14 2013-05-01 Sigmoid Pharma Ltd Compositions
KR102370538B1 (ko) 2013-02-28 2022-03-07 소렌토 쎄라퓨틱스, 인코포레이티드 경피 약물 전달 장치
KR20150126362A (ko) 2013-03-04 2015-11-11 브이티브이엑스 홀딩스 아이 엘엘씨 글루코키나제 활성화제를 포함하는 고체 조성물 및 그것의 제조 및 사용 방법
US20160022873A1 (en) 2013-03-14 2016-01-28 Research Institute At Nationwide Children's Hospital, Inc. Tissue engineered intestine
JP6395800B2 (ja) 2013-03-15 2018-09-26 インキューブ ラブズ, エルエルシー 多段階生分解性薬物送達プラットフォーム
JP6431528B2 (ja) * 2013-04-10 2018-11-28 マサチューセッツ インスチテュート オブ テクノロジーMassachusetts Institute Of Technology 癌治療のための薬物局所送達装置及び方法
WO2014182940A1 (en) 2013-05-08 2014-11-13 Northeastern University Mucus strengthening formulations to alter mucus barrier properties
US20150064241A1 (en) * 2013-09-05 2015-03-05 Google Inc. Delivery of Functionalized Particles
WO2015036616A1 (en) 2013-09-16 2015-03-19 Novo Nordisk A/S Injection device for selective fixed or variable dosing
CN105916541A (zh) 2013-09-26 2016-08-31 医学量度个性化药物输送有限公司 具有阈值释放装置的传送胶囊
AU2014346855B2 (en) 2013-11-05 2019-07-18 Synagile Corporation Devices and methods for continuous drug delivery via the mouth
WO2015112575A1 (en) 2014-01-22 2015-07-30 The Board Of Regents Of The University Of Nebraska Gastrointestinal sensor implantation system
CN106232159B (zh) * 2014-04-24 2021-10-08 佐治亚科技研究公司 微针和其制造方法
US10039810B2 (en) 2014-05-15 2018-08-07 Incube Labs, Llc Pharmaceutical compositions and methods for fabrication of solid masses comprising anti-interleukin antibodies
US11548940B2 (en) 2014-05-15 2023-01-10 Rani Therapeutics, Llc Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10689460B2 (en) 2014-05-15 2020-06-23 Incube Labs, Llc PCSK9 antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
DE102014015919A1 (de) 2014-06-07 2015-12-17 Trans-Duodenal Concepts Ug I.G. Vorrichtung und Verfahren zur Aufnahme von Mageninhalt und Durchleitung in bzw. durch den Zwölffingerdarm
RU2766335C2 (ru) * 2014-06-11 2022-03-15 Массачусетс Инститьют Оф Текнолоджи Удерживаемые структуры и связанные способы
US9492396B2 (en) 2014-07-15 2016-11-15 Yossi Gross Enhanced drug delivery pill
EP3192556A4 (en) 2014-09-11 2018-05-09 Hisamitsu Pharmaceutical Co., Inc. Microneedle device
EP3799776A1 (en) 2014-09-25 2021-04-07 Progenity, Inc. Electromechanical pill device with localization capabilities
US10300259B2 (en) 2014-10-22 2019-05-28 Purdue Research Foundation Smart capsule with GI-tract-location-specific payload release
EP3212133B1 (de) 2014-10-29 2020-03-25 Trans-Duodenal Concepts UG Bypass-vorrichtung zur trans-pylorischen durchleitung von mageninhalt in bzw. durch den zwölffingerdarm sowie applikator zur positionierung desselben
CN104344272A (zh) * 2014-10-30 2015-02-11 南京博创工业产品设计有限公司 不倒翁小夜灯
JP2018501300A (ja) 2014-11-06 2018-01-18 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 癌療法用途のためのマイクロニードルアレイ
EP3237042B1 (en) * 2014-12-22 2019-02-27 Novo Nordisk A/S Spring-driven drug delivery device
WO2016155671A1 (zh) 2015-04-02 2016-10-06 傅君志 可吞咽式装置
CA2983337A1 (en) 2015-05-01 2016-11-10 Incube Labs, Llc Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins
CN104983385B (zh) 2015-05-21 2017-01-04 大连理工大学 一种主被动双半球形胶囊机器人及其姿态调整与转弯驱动控制方法
TW201707744A (zh) 2015-06-03 2017-03-01 賽諾菲阿凡提斯德意志有限公司 藥物輸送裝置(二)
US20180193621A1 (en) 2015-06-30 2018-07-12 Entrega Inc. Device for oral delivery of active agents
CN108055826A (zh) 2015-07-02 2018-05-18 拉尼医疗有限公司 用于使用可吞服药物递送装置递送到肠道内腔中的治疗药剂制剂
US20180192952A1 (en) * 2015-07-02 2018-07-12 The Board Of Trustees Of The University Of Illinois Fully implantable soft medical devices for interfacing with biological tissue
WO2017019526A2 (en) 2015-07-24 2017-02-02 Kimberly-Clark Worldwide, Inc. Methods for better delivery of active agents to tumors
WO2017040605A1 (en) 2015-08-31 2017-03-09 Mercator Medsystems, Inc. Local administration of drugs for the treatment of asthma
AU2016320867B2 (en) 2015-09-08 2023-03-30 Rani Therapeutics, Llc PCSK9 antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
CN108290031A (zh) 2015-09-17 2018-07-17 Aof株式会社 微针
US20170087299A1 (en) 2015-09-25 2017-03-30 Intel Corporation Carrier apparatus to deliver a substance and methods thereof
US11684763B2 (en) * 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
GB2545880A (en) 2015-10-20 2017-07-05 Glide Pharmaceutical Tech Ltd Solid formulation
EP3364946A4 (en) 2015-10-23 2019-06-26 Lyndra, Inc. STOMACH DISTRIBUTION SYSTEMS FOR DELAYED RELEASE OF THERAPEUTIC ACTIVE SUBSTANCES AND METHOD FOR THEIR USE
EP4302817A3 (en) 2015-12-08 2024-02-21 Lyndra Therapeutics, Inc. Geometric configurations for gastric residence systems
US9913804B2 (en) 2015-12-31 2018-03-13 Incube Labs, Llc Solid drug storage apparatus, formulations and methods of use
EP3419695B1 (en) 2016-02-26 2021-04-07 Progenity, Inc. Compact platform for accurate drug delivery
CN109152796A (zh) 2016-03-09 2019-01-04 因库博实验室有限责任公司 用于将活细胞递送至实体组织的方法和制品
AU2017268840B2 (en) 2016-05-27 2022-02-10 Lyndra Therapeutics, Inc. Materials architecture for gastric residence systems
WO2018035394A1 (en) 2016-08-18 2018-02-22 Mitchell Lawrence Jones Systems for obtaining samples using ingestible devices
US10271764B2 (en) 2016-09-02 2019-04-30 Elwha Llc Intraluminal devices with deployable elements
CN109862821A (zh) 2016-09-09 2019-06-07 普罗根尼蒂公司 用于递送可配发物质的机电可摄入装置
EP3512433B1 (en) 2016-09-15 2023-06-07 Biora Therapeutics, Inc. Fluid sampling device
CN106137099A (zh) 2016-09-27 2016-11-23 重庆大学 基于云端服务的智能胶囊检测系统
KR101886217B1 (ko) 2016-11-14 2018-08-07 전남대학교산학협력단 패치형 능동 약물전달 시스템
CN106730284A (zh) 2016-11-24 2017-05-31 上海理工大学 微胶囊式胃肠道药物释放系统
KR20190097107A (ko) 2016-12-14 2019-08-20 프로제너티, 인크. Jak 저해제로의 위장관 질환의 치료 및 장치
US11426566B2 (en) 2016-12-14 2022-08-30 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with a TLR modulator
US11134889B2 (en) 2016-12-14 2021-10-05 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a SMAD7 inhibitor
EP3554363A1 (en) 2016-12-15 2019-10-23 Progenity, Inc. Ingestible device and associated methods
WO2018183932A1 (en) 2017-03-30 2018-10-04 Progenity Inc. Treatment of a disease of the gastrointestinal tract with a il-13 inhibitor
EP3600249A1 (en) 2017-03-30 2020-02-05 Progenity Inc. Treatment of a disease of the gastrointestinal tract with a chst15 inhibitor
WO2018182641A1 (en) 2017-03-30 2018-10-04 Progenity Inc. Methods and ingestible devices for the regio-specific release of il-13 inhibitors at the site of gastrointestinal tract disease
WO2018182612A1 (en) 2017-03-30 2018-10-04 Progenity Inc. Methods and ingestible devices for the regio-specific release of stem cells at the site of gastrointestinal tract disease
AU2018244922A1 (en) 2017-03-30 2019-09-12 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with live biotherapeutics
WO2018182623A1 (en) 2017-03-30 2018-10-04 Progenity Inc. Methods and ingestible devices for the regio-specific release of chst15 inhibitors at the site of gastrointestinal tract disease
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
KR102391768B1 (ko) 2017-05-17 2022-04-29 메사추세츠 인스티튜트 오브 테크놀로지 자가-직립 시스템, 방법, 및 관련 구성요소
US10576063B2 (en) 2017-05-26 2020-03-03 Mercator Medsystems, Inc. Combination therapy for treatment of restenosis
EP3409303A1 (en) 2017-06-02 2018-12-05 Geistlich Pharma AG Use of a resorbable crosslinked form stable composition for preparing a membrane
US20200306516A1 (en) 2017-08-14 2020-10-01 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with glatiramer or a pharmaceutically acceptable salt thereof
EP3668544A1 (en) 2017-08-15 2020-06-24 Progenity, Inc. Treatment of inflammatory disease using ingestible device to release immune modulator
WO2019094521A1 (en) 2017-11-07 2019-05-16 Rani Therapeutics, Llc Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device
JP7423530B2 (ja) 2017-12-18 2024-01-29 バイオグライル アンパーツゼルスカブ 活性薬剤物質の経口送達
WO2019147824A1 (en) 2018-01-26 2019-08-01 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a pde4 inhibitor
EP3765138A1 (en) 2018-03-13 2021-01-20 Progenity, Inc. Ingestible device with relatively large payload volume
EP3793667A1 (en) 2018-05-17 2021-03-24 Massachusetts Institute of Technology Systems for electrical stimulation
CN108836237B (zh) 2018-06-15 2024-05-10 安翰科技(武汉)股份有限公司 一种具有采样池密封结构的采样胶囊
WO2020157324A1 (en) 2019-02-01 2020-08-06 Novo Nordisk A/S Medical device with actuation mechanism
US11771829B2 (en) 2019-02-01 2023-10-03 Massachusetts Institute Of Technology Systems and methods for liquid injection
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components

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