CN205626622U - 与输液容器一起使用的液体转移装置 - Google Patents
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Abstract
基于共同拥有的WIPO国际公开号WO2007/052252的液体转移装置,发明名称为无针添加剂控制阀。该液体转移装置包括一体的小瓶转接器和/或一体的输液器,用于通过减少用户步骤降低成本和方便使用。
Description
技术领域
本发明涉及与输液容器(infusion liquid containers)一起使用的液体转移装置。
背景技术
共同拥有的WIPO国际申请号PCT/IL2006/001228,发明名称:无针添加剂控制阀(Needleless Additive Control Valve),以WIPO国际公布号WO 2007/052252公布,准备与含有输注液并且具有静脉(IV)或给药端口的输液容器一起使用。该输液容器可呈输液包、输液瓶等形式。该无针添加剂控制阀还准备与包括公连接头并且含有药剂添加剂的添加剂转移装置一起使用。合适的添加剂转移装置尤其包括无针注射器、公小瓶转接器等。该无针添加剂控制阀还准备与用于向患者投药目的的具有IV矛状物和连接头的输液器(infusionsets)一起使用。
该无针添加物控制阀包括三叉的连接头体,其包括用于密封插入到输液容器的IV端口中的IV矛状物、具有母连接头的常闭(NC)无针添加端口和替代IV端口。该IV矛状物具有单腔,所述NC无针添加物端口具有单腔并且该替代IV端口具有单腔。3个腔为3路直接的和连续的流体连通。该替代IV端口由合适的软塑料材料(例如PVC等)构成,用于密封地接收输液器的IV矛状物。该替代的IV矛状物包括当插入输液器的IV矛状物时准备被刺穿的膜。
在该无针添加剂控制阀的一个实施例中,该NC无针添加端口是由自密封入口阀构成,它具有可擦拭的暴露表面用于实现药剂添加剂的多次添加。合适的自密封入口阀被公开在,尤其是,美国专利5,676,346(Leinsing)中。多次添加可比现有单次添加相对快速连续地引入更多量的添加剂。或者,多次添加可连续数个小时,这取决于患者的医疗状况。在无针添加剂控制阀的另一个实施例中,该NC无针添加端口是由手动操作的活塞(stopcock)等构成的。
WO 2007/052252图4A和4B显示了无针添加剂控制阀与无针注射器的使用,用于实现注射注射器内容物到输液容器以形成含药的输注液或直接向患者给药。
WO 2007/052252图5A和5B显示了无针添加剂控制阀与小瓶转接器和小瓶一起使用,其用于通过使输注液从该输液容器进入小瓶并且反过来操作1次或多次实现小瓶内含物和输注液内含物的混合以形成含药的输注液。
具有自密封入口阀的无针添加剂控制阀目前从West Pharmaceutical Services,Inc.,530Herman O.West Drive,Exton,PA 19341www.westpharma.com市售可得,注册商标为VIAL2BAG。该无针添加剂控制阀已经发现了广泛的用于床边准备输液容器的用法,这与先前的在复合药房中准备此类输液容器的普遍做法相反。再者,该无针添加剂控制 阀已经发现了更为普遍的与小瓶的使用,这点与注射器相反。
发明内容
本发明针对的是基于上述WO 2007/052252公开的无针添加剂控制阀的液体转移装置。
液体转移装置,其与输液容器、小瓶和输液器一起使用,所述输液容器含有输注液并且具有用于投予输注液的静脉注射端口,所述小瓶包括由小瓶瓶塞密封的小瓶瓶体并且含有药剂添加剂,以及所述输液器包括用于密封插入到静脉注射端口中的静脉注射矛状物和用于向患者给药目的的连接头,
所述液体转移装置包括三叉的连接头体,所述三叉的连接头体具有
i)用于密封插入到输液容器的静脉注射端口中的静脉注射矛状物,
ii)由用于伸缩地安装到小瓶上的一体的小瓶转接器构成的无针添加剂端口,所述一体的小瓶转接器包括穿刺套管,所述穿刺套管用于当所述安装所述小瓶转接器到小瓶上时刺穿小瓶瓶塞用于与之流体连通,以及
iii)由用于密封接收所述输液器的静脉注射矛状物的替代静脉注射端口构成的给药端口,
所述静脉注射矛状物、所述一体的小瓶转接器和所述给药端口为3路直接的和连续的流体连通,从而使得所述药剂添加剂从小瓶初始地引入到所述输液容器用来与所述输注液混合以形成含药的输注液并且随后将所述含药的输注液向患者投予。
液体转移装置,其与输液容器和小瓶一起使用,所述输液容器含有输注液并且具有用于投予所述输注液的静脉注射端口,所述小瓶包括由小瓶瓶塞密封的小瓶瓶体并且含有药剂添加剂,
所述液体转移装置包括三叉的连接头体,所述三叉的连接头体具有
i)用于密封插入到所述输液容器的静脉注射端口中的静脉注射矛状物,
ii)由用于伸缩地安装到小瓶上的一体的小瓶转接器构成的无针添加剂端口,所述一体的小瓶转接器包括穿刺套管,所述穿刺套管用于当所述安装所述小瓶转接器到小瓶上时刺穿小瓶瓶塞用于与之流体连通,以及
iii)由具有用于向患者投予目的的连接头的一体的输液器构成的给药端口,
所述静脉注射矛状物、所述一体的小瓶转接器和所述一体的输液器为3路直接的和连续的流体连通,从而使得所述药剂添加剂从小瓶初始地引入到所述输液容器用于与输注液混合以形成含药的输注液并且随后将所述含药的输注液向患者投予。
液体转移装置,其与输液容器和添加剂转移装置一起使用,所述输液容器含有输注液并且具有用于投予所述输注液的静脉注射端口,所述添加剂转移装置含有药剂添加剂并且具有公连接头,
所述液体转移装置包括三叉的连接头体,所述三叉的连接头体具有
i)用于密封插入到所述输液容器的静脉注射端口中的静脉注射矛状物,
ii)具有用于密封地接收所述添加剂转移装置的公连接头的母连接头的常闭无针添加剂端口,所述常闭无针添加剂端口包括暴露的无针进入表面,所述暴露的无针进入表面能够被消毒用于多次从中无菌地插入公连接头,并且所述常闭无针添加剂端口包括自密封入口阀,当在其中密封插入公连接头时,所述自密封入口阀被促使从常闭状态到打开状态,以及
iii)由具有用于给药目的的连接头的一体的输液器构成的给药端口,
所述静脉注射矛状物、所述常闭无针添加端口和所述一体的输液器为3路直接的和连续的流体连通,从而所述添加剂转移装置的添加剂能够与所述输注液混合或直接向患者给药。
根据本发明的第一实施例,液体转移装置包括三叉的连接头体,其具有一体的小瓶转接器而不是迄今为止描述的NC无针添加端口。该液体转移装置提供了相当大的节约成本,它是通过排除NC无针添加端口但有效地限制它用于单次添加药剂添加剂到输液容器来实现的,这点与先前可行的多次添加相反。因此,相对于上述的WO 2007/052252公开的无针添加剂控制阀,液体转移装置和一体的小瓶转接器的一起使用是简化的。
该一体的小瓶转接器优选地准备用于卡扣配合安装到小瓶上以排除它的随后的移除,从而提供可视指示它的药剂添加剂已经被添加到输液容器。在向患者给药期间,小瓶至少部分地并且通常完全地填充有来自输液容器的含药的输注液,并且避免了不经意的泄露。
根据本发明的第二实施例,液体转移装置包括一体的小瓶转接器和一体的输液器。该一体的小瓶转接器提供了上述提到的优点,该一体的输液器排除了替代静脉注射端口的开支和在其中插入输液器的静脉注射矛状物用于刺穿替代静脉注射端口的步骤,从而简化了它的使用,这点对于床边投予含药的输注液尤其有优势。
根据本发明的第三实施例,液体转移装置类似于上述WO 2007/052252公开的无针添加剂控制阀但包括一体的输液器而不是类似于本发明第二实施例的替代静脉注射端口。
附图说明
为了理解本发明且看清楚如何在实践中实施它,仅仅借助非限制性实施例,参照附图描述优选的实施例,附图中相同的部分采用了同样的编号,并且其中:
图1是传统的给药装置的示图,其包括输液包,上述WO 2007/052252公开的无针添加剂控制阀、预填充的注射器、公小瓶转接器、小瓶和输液器;
图2A是具有自密封入口阀的图1无针添加剂控制阀的正视图;
图2B是自密封入口阀的正视图;
图3A是沿着图2A中A-A线在其闭合状态的自密封入口阀的横截面;
图3B是沿着图2A中A-A线在其闭合状态的自密封入口阀的横截面;
图4是给药装置的示图,其包括输液包、根据本发明第一优选实施例的液体转移装置、小瓶和输液器;
图5A是图4液体转移装置的俯视图;
图5B是沿着图5A中A-A线的图4的液体转移装置的纵向截面图;
图6是给药装置的示图,其包括输液包、根据本发明第二优选实施例的液体转移装置和小瓶;以及
图7是给药装置的示图,其包括输液包、根据本发明第三优选实施例的液体转移装置、预填充的注射器、小瓶转接器和小瓶
本发明优选实施例的详细描述
图1、2A、2B、3A和3B分别与上述WO 2007/052252中公开的图1、2A、2B、3A和3B相对应。
图1显示了输液包10,其含有输注液并且具有静脉注射端口11和添加剂端口12。图1还显示了上述WO 2007/052252公开的无针添加剂控制阀13和具有公鲁尔锁接头16的添加剂转移装置14。添加剂转移装置14可由注射器17、用于卡扣配合伸缩地安装到小瓶19上的小瓶转接器18等构成。注射器17预填充有药剂液体用于向输液包10注射用来与输注液混合以形成含药的输注液用于向患者投予或直接向患者投予。小瓶19包括由小瓶瓶塞20B密封的小瓶瓶体20A。小瓶19含有药剂液体添加剂或在给药之前要求重构的冻干粉药物形式的小瓶内含物。小瓶内含物准备被引入到输液包10中用来与输注液混合以形成含药的输注液用于向患者投予。
此外,图1显示了传统的输液器50,其具有静脉注射矛状物51用于密封插入到静脉注射端口11中。输液器50还包括第一管子52、夹子53、滴注腔54、第二管子56、滚轮夹子57、公鲁尔锁接头58和鲁尔防护物59。第一管子52通常具有尺寸4.1mm x 200mm以及第二管子56通常具有尺寸4.1mm和500mm。
图2A显示了上述WO 2007/052252公开的无针添加剂控制阀13具有三叉的连接头体21。三叉的连接头体21包括静脉注射矛状物22用于密封插入到静脉注射端口11中。静脉注射矛状物22是由合适的刚塑性材料比如聚碳酸酯等构成。静脉注射矛状物22包括周边设置孔24的尖端23、腔26和出口27。静脉注射矛状物22与圆法兰28整体形成为注射模塑整体结构(injection molded monolithic structure),用于限制插入到静脉注射端口11和朝向出口孔27设置的常闭(NC)无针添加端口29中。
无针添加端口29具有内腔31并且配备了自密封入口阀32用于螺纹接收公鲁尔锁接头16。入口阀32具有包括抵靠表面(abutment surface)34和边缘36的阶梯状外表面33。入口阀32内部有硅自密封阀部件37,其具有管状的主要部分38和圆柱形的无针进入部分39。无针进入部分39具有暴露的进入表面41和沿着其延伸的预成形的裂缝 42(参见图2B)。
阀部件具有自然长度L1,尺寸被设计成使得进入表面41与边缘36齐平,从而使得进入表面41很容易被擦拭用于消毒目的(图3A)。螺纹安装到入口阀32上的公鲁尔锁接头16行进直至它紧靠抵靠表面34。在它的行进期间,公鲁尔锁接头16按压阀门部件37到压缩长度L2<L1,其沿着它的预成形的裂缝42分开进入部分39用于在添加剂转移装置和内腔31之间实现流体连通(参见图3B)。
三叉的连接头体21包括由替代静脉注射端口构成的给药端口43,其具有内腔44和密封膜46。内腔44与出口27连续地流体连通。替代静脉注射端口43是与静脉注射端口11类似的传统的静脉注射端口,其由合适的软塑料例如PVC等制成的,用于密封地接收约5mm到6mm直径的静脉注射矛状物。替代静脉注射端口43准备密封地接收静脉注射矛状物51。
图4显示了给药装置100,其包括输液包10、液体转移装置101、小瓶19和输液器50。液体转移装置101在构造上类似于无针添加剂控制阀13,因此,包括静脉注射矛状物22、无针添加端口29和给药端口43。液体转移装置101不同于无针添加剂控制阀13之处在于无针添加端口29是由一体的小瓶转接器102构成。后者101还包括保护静脉注射矛状物22的防护物103。
图5A和5B显示了一体的小瓶转接器102具有传统的设计,其包括用于卡扣配合安装到小瓶19上的裙104和刺穿部件106,刺穿部件106用于刺穿它的小瓶瓶塞20B用来当在小瓶19上卡扣配合一体的小瓶转接器102时与小瓶内部的流体连通。刺穿部件106与静脉注射矛状物22和替代静脉注射端口43直接和连续流体连通。
给药工具100的使用如下:静脉注射矛状物22密封地插入到静脉注射端口11中以及小瓶转接器102被卡扣配合到小瓶19上用于将它的药剂添加剂添加到输液包10中。此类添加通常是通过挤压输液包10以促使输注液进入小瓶19中,然后倒置输液包10使得小瓶内含物流入其中来实现的。在这种情况下,小瓶19包括冻干的药剂添加剂,该输注液溶解该冻干的药剂添加剂。此类溶解也许要求数个促使输注液进入小瓶19中以及使小瓶内含物流入输液包10的循环。此后,静脉注射矛状物51密封地插入到液体转移装置的替代静脉注射端口43中用于向患者给药目的。
图6显示了给药工具110,其包括输液包10、液体转移装置111和小瓶19。液体转移装置111在结构上类似于液体转移装置101,因此包括静脉注射矛状物22、无针添加端口29和给药端口43。液体转移装置111不同于液体转移装置101之处在于后者111包括由一体的输液器122构成的给药端口43,而不是替代静脉注射端口。一体的输液器112类似于输液器50,除了第一管子52与连接头体21直接连接之外。
在添加制剂添加剂到输液包10方面,液体转移装置111的使用类似于液体转移装置101的使用。
图7显示了给药装置120,其包括输液包10、添加剂转移装置14和液体转移装置121。液体转移装置121在构造上类似于无针添加剂控制阀13,因此,包括静脉注射矛状物22、无针添加端口29和给药端口43。液体转移装置121不同于无针添加剂控制阀13之处在于后者121包括由一体的输液器122构成的给药端口43,而不是替代静脉注射端口。液体转移装置121的使用类似于上述WO 2007/052252公开的无针添加剂控制装置13,除了它的输液器122可直接地与患者连接。
虽然本发明已经对有限数目的实施例进行了描述,应该认识到,许多变化、修改及本发明的其它应用都可在权利要求书的范围内做出。
Claims (3)
1.液体转移装置,其与输液容器、小瓶和输液器一起使用,所述输液容器含有输注液并且具有用于投予输注液的静脉注射端口,所述小瓶包括由小瓶瓶塞密封的小瓶瓶体并且含有药剂添加剂,以及所述输液器包括用于密封插入到静脉注射端口中的静脉注射矛状物和用于向患者给药目的的连接头,
所述液体转移装置包括三叉的连接头体,所述三叉的连接头体具有
i)用于密封插入到输液容器的静脉注射端口中的静脉注射矛状物,
ii)由用于伸缩地安装到小瓶上的一体的小瓶转接器构成的无针添加剂端口,所述一体的小瓶转接器包括穿刺套管,所述穿刺套管用于当所述安装所述小瓶转接器到小瓶上时刺穿小瓶瓶塞用于与之流体连通,以及
iii)由用于密封接收所述输液器的静脉注射矛状物的替代静脉注射端口构成的给药端口,
所述静脉注射矛状物、所述一体的小瓶转接器和所述给药端口为3路直接的和连续的流体连通,从而使得所述药剂添加剂从小瓶初始地引入到所述输液容器用来与所述输注液混合以形成含药的输注液并且随后将所述含药的输注液向患者投予。
2.液体转移装置,其与输液容器和小瓶一起使用,所述输液容器含有输注液并且具有用于投予所述输注液的静脉注射端口,所述小瓶包括由小瓶瓶塞密封的小瓶瓶体并且含有药剂添加剂,
所述液体转移装置包括三叉的连接头体,所述三叉的连接头体具有
i)用于密封插入到所述输液容器的静脉注射端口中的静脉注射矛状物,
ii)由用于伸缩地安装到小瓶上的一体的小瓶转接器构成的无针添加剂端口,所述一体的小瓶转接器包括穿刺套管,所述穿刺套管用于当所述安装所述小瓶转接器到小瓶上时刺穿小瓶瓶塞用于与之流体连通,以及
iii)由具有用于向患者投予目的的连接头的一体的输液器构成的给药端口,
所述静脉注射矛状物、所述一体的小瓶转接器和所述一体的输液器为3路直接的和连续的流体连通,从而使得所述药剂添加剂从小瓶初始地引入到所述输液容器用于与输注液混合以形成含药的输注液并且随后将所述含药的输注液向患者投予。
3.液体转移装置,其与输液容器和添加剂转移装置一起使用,所述输液容器含有输注液并且具有用于投予所述输注液的静脉注射端口,所述添加剂转移装置含有药剂添加剂并且具有公连接头,
所述液体转移装置包括三叉的连接头体,所述三叉的连接头体具有
i)用于密封插入到所述输液容器的静脉注射端口中的静脉注射矛状物,
ii)具有用于密封地接收所述添加剂转移装置的公连接头的母连接头的常闭无针添加剂端口,所述常闭无针添加剂端口包括暴露的无针进入表面,所述暴露的无针进入表面能够被消毒用于多次从中无菌地插入公连接头,并且所述常闭无针添加剂端口包括自 密封入口阀,当在其中密封插入公连接头时,所述自密封入口阀被促使从常闭状态到打开状态,以及
iii)由具有用于给药目的的连接头的一体的输液器构成的给药端口,
所述静脉注射矛状物、所述常闭无针添加端口和所述一体的输液器为3路直接的和连续的流体连通,从而所述添加剂转移装置的添加剂能够与所述输注液混合或直接向患者给药。
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2014
- 2014-07-25 JP JP2016600070U patent/JP3205560U/ja active Active
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- 2014-07-25 WO PCT/IL2014/050680 patent/WO2015019343A1/en active Application Filing
- 2014-07-25 KR KR2020167000008U patent/KR200486088Y1/ko active IP Right Grant
- 2014-07-25 GB GB1602766.6A patent/GB2533714B/en active Active
- 2014-07-25 CN CN201490000949.5U patent/CN205626622U/zh active Active
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CN110167509A (zh) * | 2016-12-06 | 2019-08-23 | 西部制药服务以色列有限公司 | 具有用来与输液容器和单独的注射小瓶一起使用的一体的伸缩的小瓶转接器的液体转移装置 |
CN110167509B (zh) * | 2016-12-06 | 2022-05-06 | 西部制药服务以色列有限公司 | 具有用来与输液容器和单独的注射小瓶一起使用的一体的伸缩的小瓶转接器的液体转移装置 |
CN111867545A (zh) * | 2017-12-03 | 2020-10-30 | 西部制药服务有限公司(以色列) | 与输液容器和离散注射瓶一起使用的带伸缩瓶子适配器的液体传输装置 |
CN111867545B (zh) * | 2017-12-03 | 2021-11-23 | 西部制药服务有限公司(以色列) | 与输液容器和离散注射瓶一起使用的带伸缩瓶子适配器的液体传输装置 |
CN113543761A (zh) * | 2019-01-18 | 2021-10-22 | 西医药服务以色列有限公司 | 用于静脉(iv)瓶的液体输送设备 |
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GB202002233D0 (en) | 2020-04-01 |
GB2533714B (en) | 2020-04-08 |
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IL243896B (en) | 2020-07-30 |
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JP3205560U (ja) | 2016-08-04 |
GB201602766D0 (en) | 2016-03-30 |
GB2533714A (en) | 2016-06-29 |
GB2578705B (en) | 2020-11-11 |
DE212014000169U1 (de) | 2016-03-14 |
FR3009495A3 (fr) | 2015-02-13 |
BR112016001905A2 (pt) | 2017-08-01 |
BR112016001905B1 (pt) | 2021-12-28 |
DK201600035Y3 (da) | 2016-04-08 |
GB2578705A (en) | 2020-05-20 |
US20160166824A1 (en) | 2016-06-16 |
IL243896A0 (en) | 2016-04-21 |
FR3009495B3 (fr) | 2015-10-02 |
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