CN1894225A - 作为鞘氨醇1－磷酸(内皮分化基因)受体激动剂的(3,4－二取代)丙酸酯 - Google Patents

作为鞘氨醇1－磷酸(内皮分化基因)受体激动剂的(3,4－二取代)丙酸酯 Download PDF

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Publication number
CN1894225A
CN1894225A CNA2004800372085A CN200480037208A CN1894225A CN 1894225 A CN1894225 A CN 1894225A CN A2004800372085 A CNA2004800372085 A CN A2004800372085A CN 200480037208 A CN200480037208 A CN 200480037208A CN 1894225 A CN1894225 A CN 1894225A
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alkoxy
independently selected
alkyl
atoms
alkenyl
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Chinese (zh)
Inventor
V·J·科兰德里
G·A·多赫尔蒂
J·J·哈尔
霍培
I·E·勒吉克
L·托思
P·瓦查尔
严林
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Merck and Co Inc
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Merck and Co Inc
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Publication of CN1894225A publication Critical patent/CN1894225A/zh
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    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Diabetes (AREA)
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  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
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  • Biotechnology (AREA)
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CNA2004800372085A 2003-12-17 2004-12-13 作为鞘氨醇1－磷酸(内皮分化基因)受体激动剂的(3,4－二取代)丙酸酯 Pending CN1894225A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53018603P 2003-12-17 2003-12-17
US60/530,186 2003-12-17

Publications (1)

Publication Number Publication Date
CN1894225A true CN1894225A (zh) 2007-01-10

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CNA2004800372085A Pending CN1894225A (zh) 2003-12-17 2004-12-13 作为鞘氨醇1－磷酸(内皮分化基因)受体激动剂的(3,4－二取代)丙酸酯

Country Status (7)

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US (1) US7605171B2 (https=)
EP (1) EP1697333A4 (https=)
JP (1) JP4773972B2 (https=)
CN (1) CN1894225A (https=)
AU (1) AU2004299456B2 (https=)
CA (1) CA2547198A1 (https=)
WO (1) WO2005058848A1 (https=)

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CN101965345A (zh) * 2008-03-06 2011-02-02 埃科特莱茵药品有限公司 吡啶化合物
CN102015695A (zh) * 2008-03-07 2011-04-13 埃科特莱茵药品有限公司 吡啶-2-基衍生物
CN102459206A (zh) * 2009-04-03 2012-05-16 默克雪兰诺有限公司 噁二唑衍生物
CN102471328A (zh) * 2009-07-16 2012-05-23 埃科特莱茵药品有限公司 吡啶-4-基衍生物
CN102648198A (zh) * 2007-08-17 2012-08-22 埃科特莱茵药品有限公司 作为s1p1/edg1受体调节剂的吡啶衍生物
CN103097365A (zh) * 2010-07-08 2013-05-08 默克塞罗诺股份有限公司 作为鞘氨醇-1-磷酸(s1p)受体上的配体的5-(联苯-4-基)-3-苯基-1,2,4-噁二唑基衍生物
CN101627034B (zh) * 2007-03-16 2013-05-15 埃科特莱茵药品有限公司 氨基-吡啶衍生物作为s1p1/edg1受体激动剂
CN103124727A (zh) * 2010-07-20 2013-05-29 百时美施贵宝公司 取代的3-苯基-1,2,4-噁二唑化合物
CN103338770A (zh) * 2010-12-03 2013-10-02 阿勒根公司 作为鞘氨醇1-磷酸(s1p)受体调节剂的新型吡啶衍生物
WO2018214860A1 (zh) * 2017-05-22 2018-11-29 北京蔚蓝之源医药科技有限公司 治疗再生障碍性贫血的方法和药物组合物
WO2019101045A1 (zh) * 2017-11-21 2019-05-31 苏州朗科生物技术股份有限公司 鞘氨醇-1-磷酸受体调节剂化合物及其制备方法与应用

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CA2558585C (en) 2004-02-27 2010-10-12 Amgen Inc. Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders
US7781617B2 (en) 2004-07-16 2010-08-24 Kyorin Pharmaceutical Co., Ltd Effective use method of medicaments and method of preventing expression of side effect
WO2006010379A1 (en) 2004-07-29 2006-02-02 Actelion Pharmaceuticals Ltd. Novel thiophene derivatives as immunosuppressive agents
EP1806338B1 (en) 2004-10-12 2016-01-20 Kyorin Pharmaceutical Co., Ltd. Process for producing 2-amino-2-[2-[4-(3-benzyloxy-phenylthio)-2-chlorophenyl[ethyl]-1,3-propanediol hydrochloride and hydrates thereof. and intermediates the production thereof
KR20080002850A (ko) 2005-03-23 2008-01-04 액테리온 파마슈티칼 리미티드 신규한 티오펜 유도체
CA2602474C (en) 2005-03-23 2014-06-10 Actelion Pharmaceuticals Ltd Hydrogenated benzo (c) thiophene derivatives as immunomodulators
US8017631B2 (en) 2005-04-26 2011-09-13 Neurosearch A/S Oxadiazole derivatives and their medical use
US7465804B2 (en) 2005-05-20 2008-12-16 Amgen Inc. Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders
WO2006131336A1 (en) * 2005-06-08 2006-12-14 Novartis Ag POLYCYCLIC OXADIAZOLES OR I SOXAZOLES AND THEIR USE AS SlP RECEPTOR LIGANDS
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