CN1819986B - 1,3-二苯基丙-2-烯-1-酮衍生物的制备 - Google Patents

1,3-二苯基丙-2-烯-1-酮衍生物的制备 Download PDF

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Publication number
CN1819986B
CN1819986B CN2004800195644A CN200480019564A CN1819986B CN 1819986 B CN1819986 B CN 1819986B CN 2004800195644 A CN2004800195644 A CN 2004800195644A CN 200480019564 A CN200480019564 A CN 200480019564A CN 1819986 B CN1819986 B CN 1819986B
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CN
China
Prior art keywords
alkene
phenyl
ketone
dimethyl
group
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Expired - Lifetime
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CN2004800195644A
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English (en)
Chinese (zh)
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CN1819986A (zh
Inventor
让-弗朗索瓦·德洛梅尔
卡里纳·科蒙-贝特朗
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Genfit SA
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Genfit SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2004800195644A 2003-07-08 2004-07-08 1,3-二苯基丙-2-烯-1-酮衍生物的制备 Expired - Lifetime CN1819986B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0308354A FR2857361B1 (fr) 2003-07-08 2003-07-08 PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one
FR03/08354 2003-07-08
PCT/FR2004/001797 WO2005005369A1 (fr) 2003-07-08 2004-07-08 Preparation de derives de 1,3-diphenylprop-2-en-1-one

Publications (2)

Publication Number Publication Date
CN1819986A CN1819986A (zh) 2006-08-16
CN1819986B true CN1819986B (zh) 2011-02-02

Family

ID=33522868

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2004800195644A Expired - Lifetime CN1819986B (zh) 2003-07-08 2004-07-08 1,3-二苯基丙-2-烯-1-酮衍生物的制备

Country Status (22)

Country Link
US (1) US7385082B2 (enExample)
EP (1) EP1644312B1 (enExample)
JP (1) JP2007516189A (enExample)
KR (1) KR20060030110A (enExample)
CN (1) CN1819986B (enExample)
AT (1) ATE468317T1 (enExample)
AU (1) AU2004255905B2 (enExample)
BR (1) BRPI0412370A (enExample)
CA (1) CA2531443C (enExample)
DE (1) DE602004027251D1 (enExample)
DK (1) DK1644312T3 (enExample)
EA (1) EA010410B1 (enExample)
ES (1) ES2343803T3 (enExample)
FR (1) FR2857361B1 (enExample)
IL (1) IL172825A (enExample)
MX (1) MXPA06000159A (enExample)
NO (1) NO332411B1 (enExample)
NZ (1) NZ544792A (enExample)
PL (1) PL213226B1 (enExample)
SG (1) SG129448A1 (enExample)
WO (1) WO2005005369A1 (enExample)
ZA (1) ZA200601040B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2841784B1 (fr) 2002-07-08 2007-03-02 Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations
FR2841900B1 (fr) * 2002-07-08 2007-03-02 Genfit S A Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
SI2504005T1 (sl) 2009-11-26 2014-04-30 Genfit Uporaba 1,3-difenilprop-2-en-1-on derivatov za zdravljenje ledviäśnih bolezni
WO2011080276A1 (en) 2009-12-29 2011-07-07 Genfit Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative
AU2011254670B2 (en) * 2010-05-17 2014-09-25 Genfit Improved preparation of chalcone derivatives
SI2948137T1 (sl) * 2013-01-18 2019-01-31 Genfit Metode zdravljenja fibroz in rakov
EP3416629A4 (en) 2016-02-16 2019-08-07 CoNCERT Pharmaceuticals, Inc. DEUTERATED GFT-505
CN106674069B (zh) * 2016-12-06 2018-05-11 上海博志研新药物技术有限公司 Gft505及其中间体的制备方法
WO2018133705A1 (zh) * 2017-01-22 2018-07-26 苏州科睿思制药有限公司 Gft-505的晶型及其制备方法和用途
KR20190117632A (ko) 2017-02-21 2019-10-16 장피트 Ppar 효현제와 fxr 효현제의 병용
US11465967B2 (en) 2017-08-04 2022-10-11 Advitech Advisory And Technologies Sa Process for the preparation of elafibranor and novel synthesis intermediates
US20200283381A1 (en) 2017-11-16 2020-09-10 Teva Pharmaceuticals International Gmbh Solid state forms of elafibranor
CN109608318A (zh) * 2019-01-31 2019-04-12 上海生农生化制品股份有限公司 一种戊唑醇中间体α的工业合成方法
CN110156648A (zh) * 2019-05-30 2019-08-23 河北科技大学 一种Elafibranor中间体的制备方法
CN110143890B (zh) * 2019-06-12 2020-12-22 天津科技大学 一种查尔酮衍生物和合成方法及其在制备抗非酒精性脂肪肝炎药物中的应用
CN110143902B (zh) * 2019-06-12 2021-06-04 天津科技大学 含硒查尔酮衍生物Compound 1和合成方法及在抗非酒精性脂肪肝炎药物中的应用
US20230008367A1 (en) 2019-09-26 2023-01-12 Abionyx Pharma Sa Compounds useful for treating liver diseases
CN113121394B (zh) * 2019-12-30 2022-11-08 中国药科大学 一种苯氧乙酸类衍生物的制备方法
US20230165821A1 (en) 2020-05-18 2023-06-01 Genfit Elafibranor for the treatment of primary sclerosing cholangitis
KR20230058104A (ko) 2020-08-26 2023-05-02 장피트 원발 담즙성 담관염의 치료를 위한 조성물 및 방법
WO2022189856A1 (en) 2021-03-08 2022-09-15 Abionyx Pharma Sa Compounds useful for treating liver diseases
CN113230240B (zh) * 2021-03-22 2022-12-27 广州医科大学 1,3-二苯基丙-2-烯-1-酮衍生物及其应用
WO2022238450A1 (en) 2021-05-11 2022-11-17 Genfit Ppar-agonists for use in the treatment of liver failure
EP4337185A1 (en) 2021-05-11 2024-03-20 Genfit Elafibranor derivatives agonists of ppar for use in the treatment of sepsis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1469845A (en) * 1973-11-30 1977-04-06 Hoechst Ag Antiviral polymer
US4656305A (en) * 1984-10-19 1987-04-07 Biorex Laboratories, Limited Chalcone derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH023670A (ja) * 1988-06-22 1990-01-09 Nippon Oil & Fats Co Ltd アルキルチオカルコン誘導体
JPH05255655A (ja) * 1992-03-12 1993-10-05 Kanebo Ltd 紫外線吸収剤
US5523302A (en) * 1993-11-24 1996-06-04 The Du Pont Merck Pharmaceutical Company Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists
EP0947511A1 (en) * 1998-03-30 1999-10-06 F. Hoffmann-La Roche Ag Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity
JPH11302243A (ja) * 1998-04-24 1999-11-02 Mitsubishi Chemical Corp ジエチレントリアミン５酢酸誘導体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1469845A (en) * 1973-11-30 1977-04-06 Hoechst Ag Antiviral polymer
US4656305A (en) * 1984-10-19 1987-04-07 Biorex Laboratories, Limited Chalcone derivatives

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JP平5-255655A 1993.10.05
M.SZAJDA and B.KEDZIA.New alkoxycarbonylalkyloxychalcones andtheirα,β-dibromo derivatives of potential antimicrobialactivity.Pharmazie44 3.1989,44(3),190-191. *
M.SZAJDAandB.KEDZIA.Newalkoxycarbonylalkyloxychalconesandtheirα β-dibromo derivatives of potential antimicrobialactivity.Pharmazie44 3.1989
Palanowski, Ryszard, et al..Synthesis ofpotential vasoactive compounds.I.Phenylacrylophenonederivatives.CA 69:26935.1968, *
Safak,O.Cihat, et al..Chalcones. II. Synthesis of some chalconederivatives and their antifungal activity againstCandida albicans.CA 100:51185.1984, *

Also Published As

Publication number Publication date
IL172825A (en) 2010-11-30
AU2004255905A1 (en) 2005-01-20
FR2857361A1 (fr) 2005-01-14
ATE468317T1 (de) 2010-06-15
DK1644312T3 (da) 2010-08-23
DE602004027251D1 (de) 2010-07-01
SG129448A1 (en) 2007-02-26
US7385082B2 (en) 2008-06-10
IL172825A0 (en) 2006-06-11
EA010410B1 (ru) 2008-08-29
PL213226B1 (pl) 2013-01-31
FR2857361B1 (fr) 2005-09-09
EP1644312B1 (fr) 2010-05-19
CA2531443A1 (fr) 2005-01-20
US20060142611A1 (en) 2006-06-29
NO20060087L (no) 2006-02-07
BRPI0412370A (pt) 2006-09-05
AU2004255905B2 (en) 2010-11-18
WO2005005369A1 (fr) 2005-01-20
ES2343803T3 (es) 2010-08-10
NO332411B1 (no) 2012-09-17
MXPA06000159A (es) 2006-03-21
CN1819986A (zh) 2006-08-16
NZ544792A (en) 2009-02-28
CA2531443C (fr) 2012-05-01
PL379543A1 (pl) 2006-10-02
EA200600197A1 (ru) 2006-06-30
KR20060030110A (ko) 2006-04-07
EP1644312A1 (fr) 2006-04-12
JP2007516189A (ja) 2007-06-21
ZA200601040B (en) 2007-05-30

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