CA2531443C - Preparation de derives de 1,3-diphenylprop-2-en-1-one - Google Patents

Preparation de derives de 1,3-diphenylprop-2-en-1-one Download PDF

Info

Publication number
CA2531443C
CA2531443C CA2531443A CA2531443A CA2531443C CA 2531443 C CA2531443 C CA 2531443C CA 2531443 A CA2531443 A CA 2531443A CA 2531443 A CA2531443 A CA 2531443A CA 2531443 C CA2531443 C CA 2531443C
Authority
CA
Canada
Prior art keywords
group
compound
substituted
diphenylprop
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2531443A
Other languages
English (en)
French (fr)
Other versions
CA2531443A1 (fr
Inventor
Jean-Francois Delhomel
Karine Caumont-Bertrand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genfit SA
Original Assignee
Genfit SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genfit SA filed Critical Genfit SA
Publication of CA2531443A1 publication Critical patent/CA2531443A1/fr
Application granted granted Critical
Publication of CA2531443C publication Critical patent/CA2531443C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2531443A 2003-07-08 2004-07-08 Preparation de derives de 1,3-diphenylprop-2-en-1-one Expired - Fee Related CA2531443C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0308354A FR2857361B1 (fr) 2003-07-08 2003-07-08 PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one
FR03/08354 2003-07-08
PCT/FR2004/001797 WO2005005369A1 (fr) 2003-07-08 2004-07-08 Preparation de derives de 1,3-diphenylprop-2-en-1-one

Publications (2)

Publication Number Publication Date
CA2531443A1 CA2531443A1 (fr) 2005-01-20
CA2531443C true CA2531443C (fr) 2012-05-01

Family

ID=33522868

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2531443A Expired - Fee Related CA2531443C (fr) 2003-07-08 2004-07-08 Preparation de derives de 1,3-diphenylprop-2-en-1-one

Country Status (22)

Country Link
US (1) US7385082B2 (enExample)
EP (1) EP1644312B1 (enExample)
JP (1) JP2007516189A (enExample)
KR (1) KR20060030110A (enExample)
CN (1) CN1819986B (enExample)
AT (1) ATE468317T1 (enExample)
AU (1) AU2004255905B2 (enExample)
BR (1) BRPI0412370A (enExample)
CA (1) CA2531443C (enExample)
DE (1) DE602004027251D1 (enExample)
DK (1) DK1644312T3 (enExample)
EA (1) EA010410B1 (enExample)
ES (1) ES2343803T3 (enExample)
FR (1) FR2857361B1 (enExample)
IL (1) IL172825A (enExample)
MX (1) MXPA06000159A (enExample)
NO (1) NO332411B1 (enExample)
NZ (1) NZ544792A (enExample)
PL (1) PL213226B1 (enExample)
SG (1) SG129448A1 (enExample)
WO (1) WO2005005369A1 (enExample)
ZA (1) ZA200601040B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2841784B1 (fr) * 2002-07-08 2007-03-02 Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations
FR2841900B1 (fr) * 2002-07-08 2007-03-02 Genfit S A Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
ES2441665T3 (es) 2009-11-26 2014-02-05 Genfit Utilización de derivados de 1,3-difenilprop-2-en-1-ona para tratar trastornos hepáticos
WO2011080276A1 (en) 2009-12-29 2011-07-07 Genfit Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative
PH12012502213A1 (en) 2010-05-17 2015-10-09 Genfit Improved preparation of chalcone derivatives
SI2948137T1 (sl) * 2013-01-18 2019-01-31 Genfit Metode zdravljenja fibroz in rakov
EP3416629A4 (en) 2016-02-16 2019-08-07 CoNCERT Pharmaceuticals, Inc. DEUTERATED GFT-505
CN106674069B (zh) * 2016-12-06 2018-05-11 上海博志研新药物技术有限公司 Gft505及其中间体的制备方法
WO2018133705A1 (zh) * 2017-01-22 2018-07-26 苏州科睿思制药有限公司 Gft-505的晶型及其制备方法和用途
SG11201906987RA (en) 2017-02-21 2019-09-27 Genfit Combination of a ppar agonist with a fxr agonist
WO2019025017A1 (en) 2017-08-04 2019-02-07 Advitech Advisory And Technologies Sa PROCESS FOR THE PREPARATION OF ELAFIBRANOR AND NEW SYNTHETIC INTERMEDIATES
EP3710425A1 (en) 2017-11-16 2020-09-23 Teva Pharmaceuticals International GmbH Solid state forms of elafibranor
CN109608318A (zh) * 2019-01-31 2019-04-12 上海生农生化制品股份有限公司 一种戊唑醇中间体α的工业合成方法
CN110156648A (zh) * 2019-05-30 2019-08-23 河北科技大学 一种Elafibranor中间体的制备方法
CN110143890B (zh) * 2019-06-12 2020-12-22 天津科技大学 一种查尔酮衍生物和合成方法及其在制备抗非酒精性脂肪肝炎药物中的应用
CN110143902B (zh) * 2019-06-12 2021-06-04 天津科技大学 含硒查尔酮衍生物Compound 1和合成方法及在抗非酒精性脂肪肝炎药物中的应用
US20230008367A1 (en) 2019-09-26 2023-01-12 Abionyx Pharma Sa Compounds useful for treating liver diseases
CN113121394B (zh) * 2019-12-30 2022-11-08 中国药科大学 一种苯氧乙酸类衍生物的制备方法
KR20230011958A (ko) 2020-05-18 2023-01-25 장피트 원발성 경화성 담관염의 치료를 위한 엘라피브라노
WO2022043367A1 (en) 2020-08-26 2022-03-03 Genfit Compositions and methods for the treatment of primary biliary cholangitis
WO2022189856A1 (en) 2021-03-08 2022-09-15 Abionyx Pharma Sa Compounds useful for treating liver diseases
CN113230240B (zh) * 2021-03-22 2022-12-27 广州医科大学 1,3-二苯基丙-2-烯-1-酮衍生物及其应用
WO2022238448A1 (en) 2021-05-11 2022-11-17 Genfit Elafibranor derivatives agonists of ppar for use in the treatment of sepsis
WO2022238445A1 (en) 2021-05-11 2022-11-17 Genfit Ppar-agonists for use in the treatment of liver failure

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2359621C2 (de) * 1973-11-30 1982-11-18 Hoechst Ag, 6000 Frankfurt Antiviral wirksame Alkalimetall- oder Ammoniumsalze der Polyacrylsäure
GB8426424D0 (en) * 1984-10-19 1984-11-28 Biorex Laboratories Ltd Chalcone derivatives
JPH023670A (ja) * 1988-06-22 1990-01-09 Nippon Oil & Fats Co Ltd アルキルチオカルコン誘導体
JPH05255655A (ja) * 1992-03-12 1993-10-05 Kanebo Ltd 紫外線吸収剤
US5523302A (en) * 1993-11-24 1996-06-04 The Du Pont Merck Pharmaceutical Company Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists
EP0947511A1 (en) * 1998-03-30 1999-10-06 F. Hoffmann-La Roche Ag Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity
JPH11302243A (ja) * 1998-04-24 1999-11-02 Mitsubishi Chemical Corp ジエチレントリアミン５酢酸誘導体

Also Published As

Publication number Publication date
CA2531443A1 (fr) 2005-01-20
DE602004027251D1 (de) 2010-07-01
IL172825A0 (en) 2006-06-11
JP2007516189A (ja) 2007-06-21
IL172825A (en) 2010-11-30
ATE468317T1 (de) 2010-06-15
FR2857361B1 (fr) 2005-09-09
FR2857361A1 (fr) 2005-01-14
NZ544792A (en) 2009-02-28
NO20060087L (no) 2006-02-07
PL213226B1 (pl) 2013-01-31
EP1644312B1 (fr) 2010-05-19
EP1644312A1 (fr) 2006-04-12
US20060142611A1 (en) 2006-06-29
EA010410B1 (ru) 2008-08-29
BRPI0412370A (pt) 2006-09-05
WO2005005369A1 (fr) 2005-01-20
NO332411B1 (no) 2012-09-17
AU2004255905B2 (en) 2010-11-18
US7385082B2 (en) 2008-06-10
CN1819986A (zh) 2006-08-16
MXPA06000159A (es) 2006-03-21
EA200600197A1 (ru) 2006-06-30
ES2343803T3 (es) 2010-08-10
SG129448A1 (en) 2007-02-26
DK1644312T3 (da) 2010-08-23
CN1819986B (zh) 2011-02-02
AU2004255905A1 (en) 2005-01-20
ZA200601040B (en) 2007-05-30
PL379543A1 (pl) 2006-10-02
KR20060030110A (ko) 2006-04-07

Similar Documents

Publication Publication Date Title
CA2531443C (fr) Preparation de derives de 1,3-diphenylprop-2-en-1-one
EP0245156B1 (fr) Nouveau procédé de préparation de fibrates
JP6488472B2 (ja) メタセシスを用いるプロスタグランジンおよびプロスタグランジン中間体の新規合成経路
EP1701938B1 (fr) Composes derives de 1,3-diphenylprop-2-en-1-one, preparation et utilisations
EP0425359B1 (fr) Procédé de préparation de dérivés de benzoyl-3 benzofuranne
EP0206899B1 (fr) Procédé de fabrication de (méth)acrylates d'alkyles fluorés
FR2904311A1 (fr) Nouveau procede de synthese de derives (e) stilbeniques perm permettant d'obtenir le resveratrol et le piceatannol
EP0171320A1 (fr) Procédé de préparation de composés insaturés chlorés en alpha de deux groupements électroattracteurs en position bêta
WO2003010156A1 (fr) Procede de preparation de alpha-halogenoalkylarylcetones et de leurs produits intermediaires halogenes de type cetal cyclique
FR2864956A1 (fr) Compose derive de 1,3-diphenylprop-2-en-1-one, preparation et utilisations
CA1224485A (fr) PROCEDE DE PREPARATION DE COMPOSES HALOGENES EN .alpha. D'UN GROUPEMENT ELECTROATTRACTEUR
FR2963004A1 (fr) Procede de preparation de 3-(methylthio)propanal
EP0430806B1 (fr) Procédé de préparation d'halogénoacétals à partir d'énamines
EP0260472B1 (fr) Procédé pour la préparation de cétones cycloaliphatiques
WO2005058918A1 (fr) Nouveaux derives d’acides phenyl-boronique et leurs procedes de preparation
FR2784986A1 (fr) Procede de preparation d'un compose de type indanone ou thioindanone
WO2006090072A1 (fr) Derives activateurs de ppar, procede de preparation et application en therapeutique
BE852030A (fr) Derives d'acide acetique aromatique ayant un atome de soufre a la position alpha et procede pour leur preparation
FR2530242A1 (en) Antiinflammatory 2-phenyl:benzoxazolyl-propionic acid prepn.
FR2847896A1 (fr) Procede de preparation de 2-bromoalcanoates d'alkyle
CA2646346A1 (fr) Procede de preparation de derives [2-(2,3-dihydro-benzofuran- ou benzofuran-7-yloxy)-ethyl]-(3-cyclopenten-1-yl-benzyl)-amines et intermediaire de synthese
FR2700335A1 (fr) Procédé de préparation du méthacrylate de chlorohydroxypropyle en présence d'un catalyseur dianine.

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20210708