AU2004255905B2 - Preparation of 1,3-diphenylprop-2-en-1-one derivatives - Google Patents

Preparation of 1,3-diphenylprop-2-en-1-one derivatives Download PDF

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Publication number
AU2004255905B2
AU2004255905B2 AU2004255905A AU2004255905A AU2004255905B2 AU 2004255905 B2 AU2004255905 B2 AU 2004255905B2 AU 2004255905 A AU2004255905 A AU 2004255905A AU 2004255905 A AU2004255905 A AU 2004255905A AU 2004255905 B2 AU2004255905 B2 AU 2004255905B2
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AU
Australia
Prior art keywords
group
diphenylprop
acid
substituted
carried out
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2004255905A
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English (en)
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AU2004255905A1 (en
Inventor
Karine Caumont-Bertrand
Jean-Francois Delhomel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genfit SA
Original Assignee
Genfit SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genfit SA filed Critical Genfit SA
Publication of AU2004255905A1 publication Critical patent/AU2004255905A1/en
Application granted granted Critical
Publication of AU2004255905B2 publication Critical patent/AU2004255905B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU2004255905A 2003-07-08 2004-07-08 Preparation of 1,3-diphenylprop-2-en-1-one derivatives Ceased AU2004255905B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR03/08354 2003-07-08
FR0308354A FR2857361B1 (fr) 2003-07-08 2003-07-08 PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one
PCT/FR2004/001797 WO2005005369A1 (fr) 2003-07-08 2004-07-08 Preparation de derives de 1,3-diphenylprop-2-en-1-one

Publications (2)

Publication Number Publication Date
AU2004255905A1 AU2004255905A1 (en) 2005-01-20
AU2004255905B2 true AU2004255905B2 (en) 2010-11-18

Family

ID=33522868

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004255905A Ceased AU2004255905B2 (en) 2003-07-08 2004-07-08 Preparation of 1,3-diphenylprop-2-en-1-one derivatives

Country Status (22)

Country Link
US (1) US7385082B2 (enExample)
EP (1) EP1644312B1 (enExample)
JP (1) JP2007516189A (enExample)
KR (1) KR20060030110A (enExample)
CN (1) CN1819986B (enExample)
AT (1) ATE468317T1 (enExample)
AU (1) AU2004255905B2 (enExample)
BR (1) BRPI0412370A (enExample)
CA (1) CA2531443C (enExample)
DE (1) DE602004027251D1 (enExample)
DK (1) DK1644312T3 (enExample)
EA (1) EA010410B1 (enExample)
ES (1) ES2343803T3 (enExample)
FR (1) FR2857361B1 (enExample)
IL (1) IL172825A (enExample)
MX (1) MXPA06000159A (enExample)
NO (1) NO332411B1 (enExample)
NZ (1) NZ544792A (enExample)
PL (1) PL213226B1 (enExample)
SG (1) SG129448A1 (enExample)
WO (1) WO2005005369A1 (enExample)
ZA (1) ZA200601040B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2841784B1 (fr) 2002-07-08 2007-03-02 Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations
FR2841900B1 (fr) * 2002-07-08 2007-03-02 Genfit S A Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
ES2441665T3 (es) 2009-11-26 2014-02-05 Genfit Utilización de derivados de 1,3-difenilprop-2-en-1-ona para tratar trastornos hepáticos
WO2011080276A1 (en) 2009-12-29 2011-07-07 Genfit Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative
CA2800337C (en) * 2010-05-17 2019-01-29 Genfit Improved preparation of chalcone derivatives
DK2948137T3 (en) * 2013-01-18 2019-01-07 Genfit METHODS OF TREATING FIBROSE AND CANCER TYPES
US10442761B2 (en) 2016-02-16 2019-10-15 Concert Pharmaceuticals, Inc. Deuterated GFT-505
CN106674069B (zh) * 2016-12-06 2018-05-11 上海博志研新药物技术有限公司 Gft505及其中间体的制备方法
JP2020505355A (ja) * 2017-01-22 2020-02-20 クリスタル ファーマシューティカル（スーチョウ）カンパニー，リミテッド Ｇｆｔ−５０５の結晶形及びその製造方法並びに用途
JP7618384B2 (ja) 2017-02-21 2025-01-21 ジェンフィ Ｐｐａｒアゴニストとｆｘｒアゴニストとの組合せ
EP3661914A1 (en) 2017-08-04 2020-06-10 Advitech Advisory and Technologies SA Process for the preparation of elafibranor and novel synthesis intermediates
US20200283381A1 (en) 2017-11-16 2020-09-10 Teva Pharmaceuticals International Gmbh Solid state forms of elafibranor
CN109608318A (zh) * 2019-01-31 2019-04-12 上海生农生化制品股份有限公司 一种戊唑醇中间体α的工业合成方法
CN110156648A (zh) * 2019-05-30 2019-08-23 河北科技大学 一种Elafibranor中间体的制备方法
CN110143902B (zh) * 2019-06-12 2021-06-04 天津科技大学 含硒查尔酮衍生物Compound 1和合成方法及在抗非酒精性脂肪肝炎药物中的应用
CN110143890B (zh) * 2019-06-12 2020-12-22 天津科技大学 一种查尔酮衍生物和合成方法及其在制备抗非酒精性脂肪肝炎药物中的应用
EP4034236A1 (en) 2019-09-26 2022-08-03 Abionyx Pharma SA Compounds useful for treating liver diseases
CN113121394B (zh) * 2019-12-30 2022-11-08 中国药科大学 一种苯氧乙酸类衍生物的制备方法
MX2022014364A (es) 2020-05-18 2022-12-15 Genfit Elafibranor para el tratamiento de la colangitis esclerosante primaria.
CN115884765A (zh) 2020-08-26 2023-03-31 基恩菲特公司 用于治疗原发性胆汁性胆管炎的组合物和方法
WO2022189856A1 (en) 2021-03-08 2022-09-15 Abionyx Pharma Sa Compounds useful for treating liver diseases
CN113230240B (zh) * 2021-03-22 2022-12-27 广州医科大学 1,3-二苯基丙-2-烯-1-酮衍生物及其应用
WO2022238448A1 (en) 2021-05-11 2022-11-17 Genfit Elafibranor derivatives agonists of ppar for use in the treatment of sepsis
US20240216312A1 (en) 2021-05-11 2024-07-04 Genfit Ppar-agonists for use in the treatment of liver failure

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523302A (en) * 1993-11-24 1996-06-04 The Du Pont Merck Pharmaceutical Company Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2359621C2 (de) * 1973-11-30 1982-11-18 Hoechst Ag, 6000 Frankfurt Antiviral wirksame Alkalimetall- oder Ammoniumsalze der Polyacrylsäure
GB8426424D0 (en) * 1984-10-19 1984-11-28 Biorex Laboratories Ltd Chalcone derivatives
JPH023670A (ja) * 1988-06-22 1990-01-09 Nippon Oil & Fats Co Ltd アルキルチオカルコン誘導体
JPH05255655A (ja) * 1992-03-12 1993-10-05 Kanebo Ltd 紫外線吸収剤
EP0947511A1 (en) * 1998-03-30 1999-10-06 F. Hoffmann-La Roche Ag Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity
JPH11302243A (ja) * 1998-04-24 1999-11-02 Mitsubishi Chemical Corp ジエチレントリアミン５酢酸誘導体

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523302A (en) * 1993-11-24 1996-06-04 The Du Pont Merck Pharmaceutical Company Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists

Also Published As

Publication number Publication date
PL379543A1 (pl) 2006-10-02
NO20060087L (no) 2006-02-07
AU2004255905A1 (en) 2005-01-20
DK1644312T3 (da) 2010-08-23
FR2857361A1 (fr) 2005-01-14
ES2343803T3 (es) 2010-08-10
FR2857361B1 (fr) 2005-09-09
ZA200601040B (en) 2007-05-30
ATE468317T1 (de) 2010-06-15
EP1644312B1 (fr) 2010-05-19
JP2007516189A (ja) 2007-06-21
IL172825A0 (en) 2006-06-11
SG129448A1 (en) 2007-02-26
EA010410B1 (ru) 2008-08-29
CA2531443C (fr) 2012-05-01
BRPI0412370A (pt) 2006-09-05
DE602004027251D1 (de) 2010-07-01
NZ544792A (en) 2009-02-28
EA200600197A1 (ru) 2006-06-30
US20060142611A1 (en) 2006-06-29
WO2005005369A1 (fr) 2005-01-20
NO332411B1 (no) 2012-09-17
US7385082B2 (en) 2008-06-10
MXPA06000159A (es) 2006-03-21
PL213226B1 (pl) 2013-01-31
IL172825A (en) 2010-11-30
KR20060030110A (ko) 2006-04-07
CN1819986A (zh) 2006-08-16
EP1644312A1 (fr) 2006-04-12
CN1819986B (zh) 2011-02-02
CA2531443A1 (fr) 2005-01-20

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired