FR2857361B1 - PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one - Google Patents
PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-oneInfo
- Publication number
- FR2857361B1 FR2857361B1 FR0308354A FR0308354A FR2857361B1 FR 2857361 B1 FR2857361 B1 FR 2857361B1 FR 0308354 A FR0308354 A FR 0308354A FR 0308354 A FR0308354 A FR 0308354A FR 2857361 B1 FR2857361 B1 FR 2857361B1
- Authority
- FR
- France
- Prior art keywords
- preparation
- diphenyprop
- derivatives
- group
- diphenylprop
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- DQFBYFPFKXHELB-VAWYXSNFSA-N trans-chalcone Chemical group C=1C=CC=CC=1C(=O)\C=C\C1=CC=CC=C1 DQFBYFPFKXHELB-VAWYXSNFSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/65—Halogen-containing esters of unsaturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (22)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0308354A FR2857361B1 (fr) | 2003-07-08 | 2003-07-08 | PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one |
| EP04767629A EP1644312B1 (fr) | 2003-07-08 | 2004-07-08 | Preparation de derives de 1,3-diphenylprop-2-en-1-one |
| AT04767629T ATE468317T1 (de) | 2003-07-08 | 2004-07-08 | Herstellung von 1,3-diphenylprop-2-en-1- onderivaten |
| SG200700644A SG129448A1 (en) | 2003-07-08 | 2004-07-08 | Preparation of 1,3-diphenylprop-2-en-1-one derivatives |
| CA2531443A CA2531443C (fr) | 2003-07-08 | 2004-07-08 | Preparation de derives de 1,3-diphenylprop-2-en-1-one |
| KR1020067000562A KR20060030110A (ko) | 2003-07-08 | 2004-07-08 | 1,3-디페닐프로프-2-엔-1-온 유도체의 제조 방법 |
| AU2004255905A AU2004255905B2 (en) | 2003-07-08 | 2004-07-08 | Preparation of 1,3-diphenylprop-2-en-1-one derivatives |
| ES04767629T ES2343803T3 (es) | 2003-07-08 | 2004-07-08 | Preparacion de derivados de 1,3-difenilprop-2-en-1-ona. |
| JP2006518300A JP2007516189A (ja) | 2003-07-08 | 2004-07-08 | １，３−ジフェニルプロパ−２−エン−１−オン誘導体の製造 |
| CN2004800195644A CN1819986B (zh) | 2003-07-08 | 2004-07-08 | 1,3-二苯基丙-2-烯-1-酮衍生物的制备 |
| DK04767629.1T DK1644312T3 (da) | 2003-07-08 | 2004-07-08 | Fremstilling af derivater af 1,3-diphenylprop-2-en-1-on |
| PL379543A PL213226B1 (pl) | 2003-07-08 | 2004-07-08 | Wytwarzanie pochodnych 1,3-difenyloprop-2-en-1-onu |
| US10/563,057 US7385082B2 (en) | 2003-07-08 | 2004-07-08 | Preparation of 1,3-diphenylprop-2-en-1-one derivatives |
| BRPI0412370-0A BRPI0412370A (pt) | 2003-07-08 | 2004-07-08 | processo de preparação de derivados de 1,3-difenilprop-2-en-1-ona substituìdos por um grupamento carboxialquilóxi ou carboxialquiltio |
| EA200600197A EA010410B1 (ru) | 2003-07-08 | 2004-07-08 | Получение производных соединения 1,3-дифенилпроп-2-ен-1-он |
| PCT/FR2004/001797 WO2005005369A1 (fr) | 2003-07-08 | 2004-07-08 | Preparation de derives de 1,3-diphenylprop-2-en-1-one |
| DE602004027251T DE602004027251D1 (de) | 2003-07-08 | 2004-07-08 | Herstellung von 1,3-diphenylprop-2-en-1-onderivaten |
| NZ544792A NZ544792A (en) | 2003-07-08 | 2004-07-08 | Preparation of 1,3-diphenylprop-2-en-1-one derivatives |
| MXPA06000159A MXPA06000159A (es) | 2003-07-08 | 2004-07-08 | Preparacion de derivados de 1,3-difenilprop-2-en-1-ona. |
| IL172825A IL172825A (en) | 2003-07-08 | 2005-12-26 | Preparation of 1,3-diphenylprop-2-en-1-one derivatives |
| NO20060087A NO332411B1 (no) | 2003-07-08 | 2006-01-06 | Fremgangsmate for fremstilling av 1,3-difenylprop-2-en-1-on-derivater |
| ZA200601040A ZA200601040B (en) | 2003-07-08 | 2006-02-06 | Preparation of 1,3-diphenylprop-2-en-1-one derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0308354A FR2857361B1 (fr) | 2003-07-08 | 2003-07-08 | PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2857361A1 FR2857361A1 (fr) | 2005-01-14 |
| FR2857361B1 true FR2857361B1 (fr) | 2005-09-09 |
Family
ID=33522868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR0308354A Expired - Fee Related FR2857361B1 (fr) | 2003-07-08 | 2003-07-08 | PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7385082B2 (enExample) |
| EP (1) | EP1644312B1 (enExample) |
| JP (1) | JP2007516189A (enExample) |
| KR (1) | KR20060030110A (enExample) |
| CN (1) | CN1819986B (enExample) |
| AT (1) | ATE468317T1 (enExample) |
| AU (1) | AU2004255905B2 (enExample) |
| BR (1) | BRPI0412370A (enExample) |
| CA (1) | CA2531443C (enExample) |
| DE (1) | DE602004027251D1 (enExample) |
| DK (1) | DK1644312T3 (enExample) |
| EA (1) | EA010410B1 (enExample) |
| ES (1) | ES2343803T3 (enExample) |
| FR (1) | FR2857361B1 (enExample) |
| IL (1) | IL172825A (enExample) |
| MX (1) | MXPA06000159A (enExample) |
| NO (1) | NO332411B1 (enExample) |
| NZ (1) | NZ544792A (enExample) |
| PL (1) | PL213226B1 (enExample) |
| SG (1) | SG129448A1 (enExample) |
| WO (1) | WO2005005369A1 (enExample) |
| ZA (1) | ZA200601040B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2841784B1 (fr) | 2002-07-08 | 2007-03-02 | Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations | |
| FR2841900B1 (fr) * | 2002-07-08 | 2007-03-02 | Genfit S A | Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations |
| ES2441665T3 (es) | 2009-11-26 | 2014-02-05 | Genfit | Utilización de derivados de 1,3-difenilprop-2-en-1-ona para tratar trastornos hepáticos |
| WO2011080276A1 (en) | 2009-12-29 | 2011-07-07 | Genfit | Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative |
| CA2800337C (en) * | 2010-05-17 | 2019-01-29 | Genfit | Improved preparation of chalcone derivatives |
| DK2948137T3 (en) * | 2013-01-18 | 2019-01-07 | Genfit | METHODS OF TREATING FIBROSE AND CANCER TYPES |
| US10442761B2 (en) | 2016-02-16 | 2019-10-15 | Concert Pharmaceuticals, Inc. | Deuterated GFT-505 |
| CN106674069B (zh) * | 2016-12-06 | 2018-05-11 | 上海博志研新药物技术有限公司 | Gft505及其中间体的制备方法 |
| JP2020505355A (ja) * | 2017-01-22 | 2020-02-20 | クリスタル ファーマシューティカル（スーチョウ）カンパニー，リミテッド | Ｇｆｔ−５０５の結晶形及びその製造方法並びに用途 |
| JP7618384B2 (ja) | 2017-02-21 | 2025-01-21 | ジェンフィ | Ｐｐａｒアゴニストとｆｘｒアゴニストとの組合せ |
| EP3661914A1 (en) | 2017-08-04 | 2020-06-10 | Advitech Advisory and Technologies SA | Process for the preparation of elafibranor and novel synthesis intermediates |
| US20200283381A1 (en) | 2017-11-16 | 2020-09-10 | Teva Pharmaceuticals International Gmbh | Solid state forms of elafibranor |
| CN109608318A (zh) * | 2019-01-31 | 2019-04-12 | 上海生农生化制品股份有限公司 | 一种戊唑醇中间体α的工业合成方法 |
| CN110156648A (zh) * | 2019-05-30 | 2019-08-23 | 河北科技大学 | 一种Elafibranor中间体的制备方法 |
| CN110143902B (zh) * | 2019-06-12 | 2021-06-04 | 天津科技大学 | 含硒查尔酮衍生物Compound 1和合成方法及在抗非酒精性脂肪肝炎药物中的应用 |
| CN110143890B (zh) * | 2019-06-12 | 2020-12-22 | 天津科技大学 | 一种查尔酮衍生物和合成方法及其在制备抗非酒精性脂肪肝炎药物中的应用 |
| EP4034236A1 (en) | 2019-09-26 | 2022-08-03 | Abionyx Pharma SA | Compounds useful for treating liver diseases |
| CN113121394B (zh) * | 2019-12-30 | 2022-11-08 | 中国药科大学 | 一种苯氧乙酸类衍生物的制备方法 |
| MX2022014364A (es) | 2020-05-18 | 2022-12-15 | Genfit | Elafibranor para el tratamiento de la colangitis esclerosante primaria. |
| CN115884765A (zh) | 2020-08-26 | 2023-03-31 | 基恩菲特公司 | 用于治疗原发性胆汁性胆管炎的组合物和方法 |
| WO2022189856A1 (en) | 2021-03-08 | 2022-09-15 | Abionyx Pharma Sa | Compounds useful for treating liver diseases |
| CN113230240B (zh) * | 2021-03-22 | 2022-12-27 | 广州医科大学 | 1,3-二苯基丙-2-烯-1-酮衍生物及其应用 |
| WO2022238448A1 (en) | 2021-05-11 | 2022-11-17 | Genfit | Elafibranor derivatives agonists of ppar for use in the treatment of sepsis |
| US20240216312A1 (en) | 2021-05-11 | 2024-07-04 | Genfit | Ppar-agonists for use in the treatment of liver failure |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2359621C2 (de) * | 1973-11-30 | 1982-11-18 | Hoechst Ag, 6000 Frankfurt | Antiviral wirksame Alkalimetall- oder Ammoniumsalze der Polyacrylsäure |
| GB8426424D0 (en) * | 1984-10-19 | 1984-11-28 | Biorex Laboratories Ltd | Chalcone derivatives |
| JPH023670A (ja) * | 1988-06-22 | 1990-01-09 | Nippon Oil & Fats Co Ltd | アルキルチオカルコン誘導体 |
| JPH05255655A (ja) * | 1992-03-12 | 1993-10-05 | Kanebo Ltd | 紫外線吸収剤 |
| US5523302A (en) * | 1993-11-24 | 1996-06-04 | The Du Pont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
| EP0947511A1 (en) * | 1998-03-30 | 1999-10-06 | F. Hoffmann-La Roche Ag | Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity |
| JPH11302243A (ja) * | 1998-04-24 | 1999-11-02 | Mitsubishi Chemical Corp | ジエチレントリアミン５酢酸誘導体 |
-
2003
- 2003-07-08 FR FR0308354A patent/FR2857361B1/fr not_active Expired - Fee Related
-
2004
- 2004-07-08 AU AU2004255905A patent/AU2004255905B2/en not_active Ceased
- 2004-07-08 CA CA2531443A patent/CA2531443C/fr not_active Expired - Fee Related
- 2004-07-08 EP EP04767629A patent/EP1644312B1/fr not_active Expired - Lifetime
- 2004-07-08 DE DE602004027251T patent/DE602004027251D1/de not_active Expired - Lifetime
- 2004-07-08 WO PCT/FR2004/001797 patent/WO2005005369A1/fr not_active Ceased
- 2004-07-08 EA EA200600197A patent/EA010410B1/ru not_active IP Right Cessation
- 2004-07-08 ES ES04767629T patent/ES2343803T3/es not_active Expired - Lifetime
- 2004-07-08 MX MXPA06000159A patent/MXPA06000159A/es active IP Right Grant
- 2004-07-08 KR KR1020067000562A patent/KR20060030110A/ko not_active Ceased
- 2004-07-08 SG SG200700644A patent/SG129448A1/en unknown
- 2004-07-08 BR BRPI0412370-0A patent/BRPI0412370A/pt not_active Application Discontinuation
- 2004-07-08 NZ NZ544792A patent/NZ544792A/en not_active IP Right Cessation
- 2004-07-08 US US10/563,057 patent/US7385082B2/en not_active Expired - Lifetime
- 2004-07-08 AT AT04767629T patent/ATE468317T1/de active
- 2004-07-08 PL PL379543A patent/PL213226B1/pl unknown
- 2004-07-08 JP JP2006518300A patent/JP2007516189A/ja active Pending
- 2004-07-08 DK DK04767629.1T patent/DK1644312T3/da active
- 2004-07-08 CN CN2004800195644A patent/CN1819986B/zh not_active Expired - Lifetime
-
2005
- 2005-12-26 IL IL172825A patent/IL172825A/en unknown
-
2006
- 2006-01-06 NO NO20060087A patent/NO332411B1/no not_active IP Right Cessation
- 2006-02-06 ZA ZA200601040A patent/ZA200601040B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL379543A1 (pl) | 2006-10-02 |
| NO20060087L (no) | 2006-02-07 |
| AU2004255905A1 (en) | 2005-01-20 |
| DK1644312T3 (da) | 2010-08-23 |
| FR2857361A1 (fr) | 2005-01-14 |
| ES2343803T3 (es) | 2010-08-10 |
| ZA200601040B (en) | 2007-05-30 |
| ATE468317T1 (de) | 2010-06-15 |
| EP1644312B1 (fr) | 2010-05-19 |
| JP2007516189A (ja) | 2007-06-21 |
| IL172825A0 (en) | 2006-06-11 |
| SG129448A1 (en) | 2007-02-26 |
| EA010410B1 (ru) | 2008-08-29 |
| CA2531443C (fr) | 2012-05-01 |
| BRPI0412370A (pt) | 2006-09-05 |
| DE602004027251D1 (de) | 2010-07-01 |
| NZ544792A (en) | 2009-02-28 |
| EA200600197A1 (ru) | 2006-06-30 |
| US20060142611A1 (en) | 2006-06-29 |
| WO2005005369A1 (fr) | 2005-01-20 |
| NO332411B1 (no) | 2012-09-17 |
| US7385082B2 (en) | 2008-06-10 |
| MXPA06000159A (es) | 2006-03-21 |
| PL213226B1 (pl) | 2013-01-31 |
| IL172825A (en) | 2010-11-30 |
| KR20060030110A (ko) | 2006-04-07 |
| CN1819986A (zh) | 2006-08-16 |
| EP1644312A1 (fr) | 2006-04-12 |
| CN1819986B (zh) | 2011-02-02 |
| AU2004255905B2 (en) | 2010-11-18 |
| CA2531443A1 (fr) | 2005-01-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |
Effective date: 20120330 |