CN1372597A - 通过提高细胞nadph生产l－氨基酸的方法 - Google Patents

通过提高细胞nadph生产l－氨基酸的方法 Download PDF

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Publication number
CN1372597A
CN1372597A CN00810748A CN00810748A CN1372597A CN 1372597 A CN1372597 A CN 1372597A CN 00810748 A CN00810748 A CN 00810748A CN 00810748 A CN00810748 A CN 00810748A CN 1372597 A CN1372597 A CN 1372597A
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CN
China
Prior art keywords
bacterial cell
amino acid
ala
cell
leu
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Pending
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CN00810748A
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English (en)
Chinese (zh)
Inventor
M·R·奥唐诺休
P·D·汉克
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Archer Daniels Midland Co
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Archer Daniels Midland Co
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Publication of CN1372597A publication Critical patent/CN1372597A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN00810748A 1999-07-23 2000-07-21 通过提高细胞nadph生产l－氨基酸的方法 Pending CN1372597A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14521799P 1999-07-23 1999-07-23
US60/145,217 1999-07-23
US15001799P 1999-08-20 1999-08-20
US60/150,017 1999-08-20

Publications (1)

Publication Number Publication Date
CN1372597A true CN1372597A (zh) 2002-10-02

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ID=26842765

Family Applications (1)

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CN00810748A Pending CN1372597A (zh) 1999-07-23 2000-07-21 通过提高细胞nadph生产l－氨基酸的方法

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US (2) US6465238B1 (enExample)
EP (1) EP1208205B1 (enExample)
JP (2) JP4841093B2 (enExample)
KR (1) KR100575403B1 (enExample)
CN (1) CN1372597A (enExample)
AT (1) ATE340857T1 (enExample)
AU (1) AU6362200A (enExample)
BR (1) BR0012712B1 (enExample)
CA (1) CA2377693C (enExample)
DE (1) DE60030988T2 (enExample)
DK (1) DK1208205T3 (enExample)
ES (1) ES2272303T3 (enExample)
MX (1) MXPA02000729A (enExample)
NZ (1) NZ517295A (enExample)
PT (1) PT1208205E (enExample)
WO (1) WO2001007626A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1997747B (zh) * 2004-02-12 2010-12-08 味之素株式会社 使用属于埃希氏菌属的细菌产生l-苏氨酸的方法
CN101052707B (zh) * 2004-02-25 2012-06-27 味之素株式会社 生产l-氨基酸的方法
CN112725253A (zh) * 2020-12-30 2021-04-30 宁夏伊品生物科技股份有限公司 一种改造基因bbd29_14900的重组菌株及其构建方法与应用
CN113774096A (zh) * 2021-10-21 2021-12-10 呼伦贝尔东北阜丰生物科技有限公司 一种苏氨酸生产提取工艺的优化方法
CN113930465A (zh) * 2021-10-21 2022-01-14 呼伦贝尔东北阜丰生物科技有限公司 一种苏氨酸发酵代谢调控工艺
CN114181288A (zh) * 2022-02-17 2022-03-15 北京中科伊品生物科技有限公司 制备l-缬氨酸的方法及其所用的基因与该基因编码的蛋白质

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001007626A2 (en) * 1999-07-23 2001-02-01 Archer-Daniels-Midland Company Methods for producing l-amino acids by increasing cellular nadph
US6830903B1 (en) 1999-07-23 2004-12-14 Archer-Daniels-Midland Company Methods for producing L-amino acids using a corynebacterium glutamicum with a disrupted pgi gene
US6586214B1 (en) * 1999-09-15 2003-07-01 Degussa Ag Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene)
WO2001071012A1 (en) * 2000-03-20 2001-09-27 Degussa Ag Process for the fermentative preparation of l-amino acids with amplification of the gnd gene
DE10112992A1 (de) * 2001-03-17 2002-09-26 Degussa Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
US7160711B2 (en) * 2001-08-06 2007-01-09 Degussa Ag Coryneform bacteria which produce chemical compounds I
DE10220574A1 (de) * 2002-05-08 2003-11-20 Degussa Verfahren zur Herstellung von Aminosäuren mit coryneformen Bakterien unter Verwendung von Phosphoglucose-Isomerasen aus coryneformen Bakterien
CA2546847A1 (en) * 2003-12-18 2005-12-22 Basf Aktiengesellschaft Methods for the preparation of a fine chemical by fermentation
BRPI0417773A (pt) * 2003-12-18 2007-03-20 Basf Ag métodos para aumentar o fluxo metabólico através da via de pentose fosfato em um microorganismo e para produzir uma substáncia quìmica fina, e, microorganismo recombinante
US20080032374A1 (en) 2003-12-18 2008-02-07 Basf Aktiengesellschaft Method for the Preparation of Lysine by Fermentation of Corynebacterium Glutamicum
US20050191684A1 (en) * 2004-02-25 2005-09-01 Zimenkov Danila V. Method for producing L-amino acids
KR101201687B1 (ko) * 2004-02-25 2012-11-15 아지노모토 가부시키가이샤 Ｌ-아미노산을 생산하는 방법
ATE499441T1 (de) * 2004-02-27 2011-03-15 Kyowa Hakko Bio Co Ltd Verfahren zur herstellung von aminosäuren
KR100563226B1 (ko) * 2004-08-10 2006-03-21 한국생산기술연구원 연료전지용 분리판
RU2004124226A (ru) 2004-08-10 2006-01-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Использование фосфокетолазы для продукции полезных метаболитов
BRPI0519174A2 (pt) * 2004-12-22 2008-12-30 Michigan Biotech Inst cepa recombinante de um microorganismo produtor de Ácido succÍnico, mÉtodo para produzir Ácido succÍnico, molÉcula de dna, plasmÍdeo de dna, e, cÉlula hospedeira
DE102005013676A1 (de) 2005-03-24 2006-09-28 Degussa Ag Allele des zwf-Gens aus coryneformen Bakterien
DE102005023829A1 (de) 2005-05-24 2006-11-30 Degussa Ag Allele des opcA-Gens aus coryneformen Bakterien
DE102005048818A1 (de) 2005-10-10 2007-04-12 Degussa Ag Mikrobiologische Herstellung von 3-Hydroxypropionsäure
KR100873168B1 (ko) * 2007-03-07 2008-12-10 전북대학교산학협력단 ｌｏｎ 유전자 및／또는 ｃｐｘＲ 유전자가 결실된살모넬라 변이균주 및 이를 함유하는 살모넬라 생백신
EP2327769B1 (en) 2007-11-10 2013-03-27 Joule Unlimited Technologies, Inc. Hyperphotosynthetic organisms
EP2553107A2 (en) * 2010-03-31 2013-02-06 E.I. Du Pont De Nemours And Company Pentose phosphate pathway upregulation to increase production of non-native products of interest in transgenic microorganisms
US9181568B2 (en) 2012-04-23 2015-11-10 Exxonmobil Research And Engineering Company Cell systems and methods for improving fatty acid synthesis by expression of dehydrogenases
KR101429814B1 (ko) * 2012-10-05 2014-08-12 상지대학교산학협력단 Ｇｄｈ 활성 조절을 통해 ｌ-쓰레오닌 생산능이 향상된 코리네박테리움 속 미생물 및 이를 이용한 ｌ-쓰레오닌 생산 방법
MX377509B (es) 2014-05-12 2025-03-10 Metabolic Explorer Sa Microorganismo y metodo nuevos para la produccion de 1,2-propanodiol basada en acetol reductasa dependiente de nadph y suministro mejorado de nadph.
KR102384227B1 (ko) 2015-05-18 2022-04-07 삼성전자주식회사 Nadph 생성이 증가된 유전적으로 조작된 효모 세포, 효모 세포 중 nadph 수준을 증가시키는 방법, 상기 효모 세포를 제조하는 방법 및 상기 효모 세포를 이용하여 락테이트를 생산하는 방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS594988B2 (ja) * 1976-02-03 1984-02-02 日石三菱株式会社 グリコ−スイソメラ−ゼの製法
EP0672161B1 (en) 1992-11-05 1999-09-22 Xyrofin Oy Recombinant method and host for manufacture of xylitol
PL178040B1 (pl) * 1992-11-05 2000-02-29 Xyrofin Oy Sposób wytwarzania ksylitolu i zrekombinowany gospodarz drobnoustrojowy
WO1995011985A1 (en) * 1993-10-28 1995-05-04 Ajinomoto Co., Inc. Process for producing substance
ES2191710T3 (es) * 1994-08-19 2003-09-16 Ajinomoto Kk Procedimiento para producir l-lisina y acido l-glutamico por fermentacion.
JPH09224661A (ja) * 1996-02-23 1997-09-02 Mitsubishi Chem Corp グルコース−６−リン酸デヒドロゲナーゼおよびそれをコードするｄｎａ
JPH09224662A (ja) * 1996-02-23 1997-09-02 Mitsubishi Chem Corp ６−ホスホグルコン酸デヒドロゲナーゼおよびそれをコードするｄｎａ
ID25613A (id) * 1997-07-18 2000-10-19 Ajinomoto Kk Metode untuk menghasilkan purin nukleosida melalui fermentasi
FR2772788B1 (fr) 1997-12-19 2000-11-17 Roquette Freres Procede pour accroitre la production de certains polyols par une souche osmotolerante
WO2001007626A2 (en) * 1999-07-23 2001-02-01 Archer-Daniels-Midland Company Methods for producing l-amino acids by increasing cellular nadph
US6586214B1 (en) * 1999-09-15 2003-07-01 Degussa Ag Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1997747B (zh) * 2004-02-12 2010-12-08 味之素株式会社 使用属于埃希氏菌属的细菌产生l-苏氨酸的方法
CN101052707B (zh) * 2004-02-25 2012-06-27 味之素株式会社 生产l-氨基酸的方法
CN112725253A (zh) * 2020-12-30 2021-04-30 宁夏伊品生物科技股份有限公司 一种改造基因bbd29_14900的重组菌株及其构建方法与应用
CN113774096A (zh) * 2021-10-21 2021-12-10 呼伦贝尔东北阜丰生物科技有限公司 一种苏氨酸生产提取工艺的优化方法
CN113930465A (zh) * 2021-10-21 2022-01-14 呼伦贝尔东北阜丰生物科技有限公司 一种苏氨酸发酵代谢调控工艺
CN114181288A (zh) * 2022-02-17 2022-03-15 北京中科伊品生物科技有限公司 制备l-缬氨酸的方法及其所用的基因与该基因编码的蛋白质

Also Published As

Publication number Publication date
DE60030988D1 (de) 2006-11-09
BR0012712A (pt) 2002-04-09
JP2003521888A (ja) 2003-07-22
BR0012712B1 (pt) 2011-12-13
DE60030988T2 (de) 2007-01-04
CA2377693C (en) 2016-11-08
KR20020048928A (ko) 2002-06-24
US6680190B2 (en) 2004-01-20
CA2377693A1 (en) 2001-02-01
AU6362200A (en) 2001-02-13
EP1208205A2 (en) 2002-05-29
JP2011041582A (ja) 2011-03-03
WO2001007626A3 (en) 2001-05-31
ATE340857T1 (de) 2006-10-15
NZ517295A (en) 2004-04-30
MXPA02000729A (es) 2002-08-20
EP1208205B1 (en) 2006-09-27
DK1208205T3 (da) 2007-02-05
WO2001007626A2 (en) 2001-02-01
PT1208205E (pt) 2006-12-29
ES2272303T3 (es) 2007-05-01
JP4841093B2 (ja) 2011-12-21
US6465238B1 (en) 2002-10-15
KR100575403B1 (ko) 2006-05-03
US20030017557A1 (en) 2003-01-23

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