BR0012712B1 - métodos de produção de l-aminoácidos aumentando-se o nadph celular. - Google Patents

métodos de produção de l-aminoácidos aumentando-se o nadph celular.

Info

Publication number
BR0012712B1
BR0012712B1 BRPI0012712-4A BR0012712A BR0012712B1 BR 0012712 B1 BR0012712 B1 BR 0012712B1 BR 0012712 A BR0012712 A BR 0012712A BR 0012712 B1 BR0012712 B1 BR 0012712B1
Authority
BR
Brazil
Prior art keywords
increasing
amino acid
production methods
acid production
bacterial cells
Prior art date
Application number
BRPI0012712-4A
Other languages
English (en)
Portuguese (pt)
Other versions
BR0012712A (pt
Inventor
Michael R O'donohue
Paul D Hanke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BR0012712A publication Critical patent/BR0012712A/pt
Publication of BR0012712B1 publication Critical patent/BR0012712B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI0012712-4A 1999-07-23 2000-07-21 métodos de produção de l-aminoácidos aumentando-se o nadph celular. BR0012712B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14521799P 1999-07-23 1999-07-23
US15001799P 1999-08-20 1999-08-20
PCT/US2000/019914 WO2001007626A2 (en) 1999-07-23 2000-07-21 Methods for producing l-amino acids by increasing cellular nadph

Publications (2)

Publication Number Publication Date
BR0012712A BR0012712A (pt) 2002-04-09
BR0012712B1 true BR0012712B1 (pt) 2011-12-13

Family

ID=26842765

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0012712-4A BR0012712B1 (pt) 1999-07-23 2000-07-21 métodos de produção de l-aminoácidos aumentando-se o nadph celular.

Country Status (16)

Country Link
US (2) US6465238B1 (enExample)
EP (1) EP1208205B1 (enExample)
JP (2) JP4841093B2 (enExample)
KR (1) KR100575403B1 (enExample)
CN (1) CN1372597A (enExample)
AT (1) ATE340857T1 (enExample)
AU (1) AU6362200A (enExample)
BR (1) BR0012712B1 (enExample)
CA (1) CA2377693C (enExample)
DE (1) DE60030988T2 (enExample)
DK (1) DK1208205T3 (enExample)
ES (1) ES2272303T3 (enExample)
MX (1) MXPA02000729A (enExample)
NZ (1) NZ517295A (enExample)
PT (1) PT1208205E (enExample)
WO (1) WO2001007626A2 (enExample)

Families Citing this family (32)

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PT1208205E (pt) * 1999-07-23 2006-12-29 Archer Daniels Midland Co Métodos para produzir l-aminoácidos por aumento do nadph celular
US6830903B1 (en) 1999-07-23 2004-12-14 Archer-Daniels-Midland Company Methods for producing L-amino acids using a corynebacterium glutamicum with a disrupted pgi gene
US6586214B1 (en) * 1999-09-15 2003-07-01 Degussa Ag Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene)
KR100826815B1 (ko) * 2000-03-20 2008-05-02 에보니크 데구사 게엠베하 ｇｎｄ 유전자의 증폭을 이용한 Ｌ-아미노산의 발효적생산 방법
DE10112992A1 (de) * 2001-03-17 2002-09-26 Degussa Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
US7160711B2 (en) * 2001-08-06 2007-01-09 Degussa Ag Coryneform bacteria which produce chemical compounds I
DE10220574A1 (de) * 2002-05-08 2003-11-20 Degussa Verfahren zur Herstellung von Aminosäuren mit coryneformen Bakterien unter Verwendung von Phosphoglucose-Isomerasen aus coryneformen Bakterien
MXPA06006759A (es) 2003-12-18 2006-09-04 Basf Ag Metodos para la preparacion de lisina por fermentacion de corynebacterium glutamicum.
WO2005059154A2 (en) * 2003-12-18 2005-06-30 Basf Aktiengesellschaft Methods for the preparation of a fine chemical by fermentation
CA2546847A1 (en) * 2003-12-18 2005-12-22 Basf Aktiengesellschaft Methods for the preparation of a fine chemical by fermentation
RU2288264C2 (ru) * 2004-02-12 2006-11-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Бактерия, принадлежащая к роду escherichia - продуцент l-треонина и способ получения l-треонина
US20050191684A1 (en) * 2004-02-25 2005-09-01 Zimenkov Danila V. Method for producing L-amino acids
RU2004105179A (ru) * 2004-02-25 2005-08-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) 6-фосфоглюконолактоназа из escherichia coli, фрагмент днк, бактерия, принадлежащая к роду escherichia, -продуцент l-аминокислоты, и способ получения l-аминокислоты
JP4670811B2 (ja) * 2004-02-25 2011-04-13 味の素株式会社 Ｌ−アミノ酸の生産方法
EP1724344B1 (en) * 2004-02-27 2011-02-23 Kyowa Hakko Bio Co., Ltd. Process for producing amino acid
KR100563226B1 (ko) * 2004-08-10 2006-03-21 한국생산기술연구원 연료전지용 분리판
RU2004124226A (ru) * 2004-08-10 2006-01-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Использование фосфокетолазы для продукции полезных метаболитов
KR101357015B1 (ko) * 2004-12-22 2014-02-03 더 미시간 바이오테크노로지 인스티튜트 유기산의 증가된 생성을 위한 재조합 미생물
DE102005013676A1 (de) 2005-03-24 2006-09-28 Degussa Ag Allele des zwf-Gens aus coryneformen Bakterien
DE102005023829A1 (de) 2005-05-24 2006-11-30 Degussa Ag Allele des opcA-Gens aus coryneformen Bakterien
DE102005048818A1 (de) 2005-10-10 2007-04-12 Degussa Ag Mikrobiologische Herstellung von 3-Hydroxypropionsäure
KR100873168B1 (ko) * 2007-03-07 2008-12-10 전북대학교산학협력단 ｌｏｎ 유전자 및／또는 ｃｐｘＲ 유전자가 결실된살모넬라 변이균주 및 이를 함유하는 살모넬라 생백신
US7785861B2 (en) 2007-11-10 2010-08-31 Joule Unlimited, Inc. Hyperphotosynthetic organisms
EP2553107A2 (en) * 2010-03-31 2013-02-06 E.I. Du Pont De Nemours And Company Pentose phosphate pathway upregulation to increase production of non-native products of interest in transgenic microorganisms
US9181568B2 (en) 2012-04-23 2015-11-10 Exxonmobil Research And Engineering Company Cell systems and methods for improving fatty acid synthesis by expression of dehydrogenases
KR101429814B1 (ko) * 2012-10-05 2014-08-12 상지대학교산학협력단 Ｇｄｈ 활성 조절을 통해 ｌ-쓰레오닌 생산능이 향상된 코리네박테리움 속 미생물 및 이를 이용한 ｌ-쓰레오닌 생산 방법
US10689671B2 (en) 2014-05-12 2020-06-23 Metabolic Explorer Microorganism and method for the production of 1.2-propanediol based on NADPH dependent acetol reductase and improved NADPH supply
KR102384227B1 (ko) 2015-05-18 2022-04-07 삼성전자주식회사 Nadph 생성이 증가된 유전적으로 조작된 효모 세포, 효모 세포 중 nadph 수준을 증가시키는 방법, 상기 효모 세포를 제조하는 방법 및 상기 효모 세포를 이용하여 락테이트를 생산하는 방법
CN112725253B (zh) * 2020-12-30 2023-01-06 宁夏伊品生物科技股份有限公司 一种改造基因bbd29_14900的重组菌株及其构建方法与应用
CN113930465A (zh) * 2021-10-21 2022-01-14 呼伦贝尔东北阜丰生物科技有限公司 一种苏氨酸发酵代谢调控工艺
CN113774096A (zh) * 2021-10-21 2021-12-10 呼伦贝尔东北阜丰生物科技有限公司 一种苏氨酸生产提取工艺的优化方法
CN114181288B (zh) * 2022-02-17 2022-05-03 北京中科伊品生物科技有限公司 制备l-缬氨酸的方法及其所用的基因与该基因编码的蛋白质

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JPS594988B2 (ja) * 1976-02-03 1984-02-02 日石三菱株式会社 グリコ−スイソメラ−ゼの製法
EP0672161B1 (en) 1992-11-05 1999-09-22 Xyrofin Oy Recombinant method and host for manufacture of xylitol
DE69326559T2 (de) 1992-11-05 2000-02-10 Xyrofin Oy, Espoo Rekombinante methode und wirt zur herstellung von xylitol
US5830716A (en) 1993-10-28 1998-11-03 Ajinomoto Co., Inc. Increased amounts of substances by modifying a microorganism to increase production of NADPH from NADH
EP0780477B1 (en) 1994-08-19 2003-04-09 Ajinomoto Co., Inc. Process for producing l-lysine and l-glutamic acid by fermentation
JPH09224662A (ja) * 1996-02-23 1997-09-02 Mitsubishi Chem Corp ６−ホスホグルコン酸デヒドロゲナーゼおよびそれをコードするｄｎａ
JPH09224661A (ja) * 1996-02-23 1997-09-02 Mitsubishi Chem Corp グルコース−６−リン酸デヒドロゲナーゼおよびそれをコードするｄｎａ
ID25613A (id) * 1997-07-18 2000-10-19 Ajinomoto Kk Metode untuk menghasilkan purin nukleosida melalui fermentasi
FR2772788B1 (fr) 1997-12-19 2000-11-17 Roquette Freres Procede pour accroitre la production de certains polyols par une souche osmotolerante
PT1208205E (pt) * 1999-07-23 2006-12-29 Archer Daniels Midland Co Métodos para produzir l-aminoácidos por aumento do nadph celular
US6586214B1 (en) * 1999-09-15 2003-07-01 Degussa Ag Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene)

Also Published As

Publication number Publication date
JP2003521888A (ja) 2003-07-22
DK1208205T3 (da) 2007-02-05
JP4841093B2 (ja) 2011-12-21
ATE340857T1 (de) 2006-10-15
WO2001007626A2 (en) 2001-02-01
EP1208205B1 (en) 2006-09-27
WO2001007626A3 (en) 2001-05-31
AU6362200A (en) 2001-02-13
JP2011041582A (ja) 2011-03-03
KR100575403B1 (ko) 2006-05-03
DE60030988T2 (de) 2007-01-04
CA2377693C (en) 2016-11-08
DE60030988D1 (de) 2006-11-09
US6465238B1 (en) 2002-10-15
ES2272303T3 (es) 2007-05-01
KR20020048928A (ko) 2002-06-24
NZ517295A (en) 2004-04-30
BR0012712A (pt) 2002-04-09
CA2377693A1 (en) 2001-02-01
EP1208205A2 (en) 2002-05-29
US20030017557A1 (en) 2003-01-23
CN1372597A (zh) 2002-10-02
MXPA02000729A (es) 2002-08-20
US6680190B2 (en) 2004-01-20
PT1208205E (pt) 2006-12-29

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07B Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette]

Free format text: REF. A RPI NO 2068 DE 24/08/2010.

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 13/12/2011, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 19A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2523 DE 14-05-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.