ES2191710T3 - Procedimiento para producir l-lisina y acido l-glutamico por fermentacion. - Google Patents
Procedimiento para producir l-lisina y acido l-glutamico por fermentacion.Info
- Publication number
- ES2191710T3 ES2191710T3 ES95927999T ES95927999T ES2191710T3 ES 2191710 T3 ES2191710 T3 ES 2191710T3 ES 95927999 T ES95927999 T ES 95927999T ES 95927999 T ES95927999 T ES 95927999T ES 2191710 T3 ES2191710 T3 ES 2191710T3
- Authority
- ES
- Spain
- Prior art keywords
- glutamic acid
- produce
- biotine
- lisine
- cepa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 title abstract 10
- 229960002989 glutamic acid Drugs 0.000 title abstract 6
- 238000000855 fermentation Methods 0.000 title 1
- 230000004151 fermentation Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 abstract 6
- 235000000638 D-biotin Nutrition 0.000 abstract 6
- 239000011665 D-biotin Substances 0.000 abstract 6
- 239000005557 antagonist Substances 0.000 abstract 4
- 241000186031 Corynebacteriaceae Species 0.000 abstract 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 235000013922 glutamic acid Nutrition 0.000 abstract 2
- 239000004220 glutamic acid Substances 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 230000035945 sensitivity Effects 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/14—Glutamic acid; Glutamine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/84—Brevibacterium
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/843—Corynebacterium
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
SE OBTIENE UNA CEPA MUTANTE CAPAZ DE PRODUCIR ACIDO LGLUTAMICO, EN AUSENCIA DE ANTAGONISTAS DE BIOTINA Y EN UN MEDIO QUE CONTIENE UNA CANTIDAD EN EXCESO DE BIOTINA. DICHA CEPA SE OBTIENE CONFIRIENDO SENSIBILIDAD A LA TEMPERATURA CON RESPECTO A LOS ANTAGONISTAS DE BIOTINA, A UNA BACTERIA CORYNEFORME PRODUCTORA DE ACIDO GLUTAMICO. LA CITADA CEPA SE CULTIVA EN UN MEDIO LIQUIDO, PARA PRODUCIR Y ACUMULAR ACIDO L-GLUTAMICO EN EL MISMO. LA LISINA Y EL ACIDO GLUTAMICO SE OBTIENEN SIMULTANEAMENTE, CONFIRIENDO A UNA BACTERIA CORYNEFORME, PRODUCTORA DE ACIDO L-GLUTAMICO, SENSIBILIDAD A LA TEMPERATURA CON RESPECTO A LOS ANTAGONISTAS DE BIOTINA, Y CAPACIDAD DE PRODUCCION DE L-LISINA, A FIN DE OBTENER UNA CEPA CAPAZ DE PRODUCIR ACIDO L-GLUTAMICO Y LISINA, EN UN MEDIO QUE CONTIENE BIOTINA EN EXCESO, Y EN AUSENCIA DE ANTAGONISTAS DE BIOTINA. DICHA CEPA SE CULTIVA EN UN MEDIO LIQUIDO, PARA PRODUCIR Y ACUMULAR L-LISINA Y ACIDO L-GLUTAMICO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19546594 | 1994-08-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2191710T3 true ES2191710T3 (es) | 2003-09-16 |
Family
ID=16341537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95927999T Expired - Lifetime ES2191710T3 (es) | 1994-08-19 | 1995-08-09 | Procedimiento para producir l-lisina y acido l-glutamico por fermentacion. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5846790A (es) |
| EP (2) | EP0780477B1 (es) |
| JP (1) | JP2926991B2 (es) |
| CN (1) | CN1079836C (es) |
| BR (1) | BR9508730A (es) |
| DE (2) | DE69535643D1 (es) |
| ES (1) | ES2191710T3 (es) |
| PE (1) | PE27597A1 (es) |
| WO (1) | WO1996006180A1 (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9610016A (pt) * | 1995-08-23 | 1999-07-06 | Ajinomoto Kk | Microorganismo e processo para a produção do ácido l-glutâmico por fermentação |
| JP3812019B2 (ja) * | 1996-11-21 | 2006-08-23 | 味の素株式会社 | 連続発酵によるｌ−グルタミン酸の製造法 |
| US20030077765A1 (en) * | 1997-07-09 | 2003-04-24 | Ajinomoto Co. Inc. | Temperature-sensitive dtsR gene |
| DE69835955D1 (de) * | 1997-07-09 | 2006-11-02 | Ajinomoto Kk | TEMPERATUR-EMPFINDLICHE dtsR GENE |
| EP1059358B1 (en) * | 1998-03-06 | 2008-05-07 | Ajinomoto Co., Inc. | Penicillin binding protein gene and process for producing l-glutamic acid |
| AU756507B2 (en) | 1998-03-18 | 2003-01-16 | Ajinomoto Co., Inc. | L-glutamic acid-producing bacterium and method for producing L-glutamic acid |
| EP1010755B1 (en) | 1998-12-18 | 2010-10-06 | Ajinomoto Co., Inc. | Method for producing L-Glutamic acid by fermentation |
| JP2003159092A (ja) * | 1999-07-02 | 2003-06-03 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| AU6362200A (en) * | 1999-07-23 | 2001-02-13 | Archer-Daniels-Midland Company | Methods for producing L-amino acids by increasing cellular NADPH |
| US6830903B1 (en) | 1999-07-23 | 2004-12-14 | Archer-Daniels-Midland Company | Methods for producing L-amino acids using a corynebacterium glutamicum with a disrupted pgi gene |
| US6984512B1 (en) * | 1999-08-02 | 2006-01-10 | Archer-Daniels-Midland Company | Bacterial strains, methods of preparing the same and use thereof in fermentation processes for L-lysine production |
| AU779019B2 (en) * | 1999-08-02 | 2005-01-06 | Archer-Daniels-Midland Company | Metabolic engineering of amino acid production |
| CN1367827A (zh) * | 1999-08-02 | 2002-09-04 | 阿彻-丹尼尔斯-米德兰公司 | 突变细菌株的l－赖氨酸生产 |
| JP4427878B2 (ja) * | 1999-08-20 | 2010-03-10 | 味の素株式会社 | 析出を伴う発酵法によるｌ−グルタミン酸の製造法 |
| US6927046B1 (en) * | 1999-12-30 | 2005-08-09 | Archer-Daniels-Midland Company | Increased lysine production by gene amplification using coryneform bacteria |
| US6737262B1 (en) * | 2000-07-11 | 2004-05-18 | Robert I. Bolla | Animal feed containing polypeptides |
| WO2006025735A2 (en) * | 2004-09-01 | 2006-03-09 | Agrotechnology And Food Innovations B. V. | Enhanced substrate conversion efficiency of fermentation processes |
| DE102005017508A1 (de) * | 2005-04-15 | 2006-10-19 | Basf Ag | Verfahren zur Gewinnung einer basischen Aminosäure aus einer Fermentationsbrühe II |
| JPWO2007024010A1 (ja) | 2005-08-26 | 2009-03-05 | 味の素株式会社 | Ｌ−グルタミン酸生産菌及びｌ−グルタミン酸の製造方法 |
| JP2010088301A (ja) * | 2007-02-01 | 2010-04-22 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| JP5218400B2 (ja) | 2007-04-17 | 2013-06-26 | 味の素株式会社 | カルボキシル基を有する酸性物質の製造法 |
| CN103088081B (zh) * | 2013-02-06 | 2014-12-03 | 中粮生化能源（龙江）有限公司 | 一种补加生物素的生产谷氨酸的发酵方法 |
| CN113444655B (zh) * | 2020-03-26 | 2023-05-16 | 吉林中粮生化有限公司 | 谷氨酸棒状杆菌、高谷氨酸产量的温度敏感型菌株及其获得方法、应用以及谷氨酸发酵方法 |
| CN113292758B (zh) * | 2021-05-25 | 2022-06-21 | 南京工业大学 | 一种同时具有电和温度响应的形状记忆复合材料及其制备方法和在固定化细胞中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5224593B2 (es) * | 1973-10-17 | 1977-07-01 | ||
| JPS561889A (en) * | 1979-06-20 | 1981-01-10 | Ajinomoto Co Inc | Preparation of l-glutamic acid by fermentation |
| JPS57102193A (en) * | 1980-12-17 | 1982-06-25 | Kyowa Hakko Kogyo Co Ltd | Preparation of l-glutamic acid |
| FR2590592B1 (fr) * | 1985-11-26 | 1989-12-22 | Asahi Chemical Ind | Fragment d'adn contenant un gene codant pour une enzyme catalysant une reaction dans le cycle tca et adn recombinant le contenant. |
| JPS62201585A (ja) * | 1985-11-26 | 1987-09-05 | Asahi Chem Ind Co Ltd | クエン酸合成酵素産生遺伝子を含むｄｎａ断片 |
| JPS6244171A (ja) * | 1986-08-07 | 1987-02-26 | Kyowa Hakko Kogyo Co Ltd | Ｌ−グルタミン酸生産性新規微生物 |
| JP2578463B2 (ja) * | 1988-02-03 | 1997-02-05 | 協和醗酵工業株式会社 | 発酵法によるｌ−リジンの製造法 |
| JPH029384A (ja) * | 1988-06-28 | 1990-01-12 | Kyowa Hakko Kogyo Co Ltd | 発酵法によるｌ−グルタミン酸の製造方法 |
| JP3245881B2 (ja) * | 1990-02-15 | 2002-01-15 | 味の素株式会社 | 塩基性アミノ酸と酸性アミノ酸の同時発酵法 |
| KR0130196B1 (ko) * | 1990-02-15 | 1998-04-03 | 도바 다다스 | 염기성 아미노산과 산성 아미노산의 동시 발효법 |
-
1995
- 1995-08-09 JP JP8507633A patent/JP2926991B2/ja not_active Expired - Fee Related
- 1995-08-09 EP EP95927999A patent/EP0780477B1/en not_active Expired - Lifetime
- 1995-08-09 DE DE69535643T patent/DE69535643D1/de not_active Expired - Lifetime
- 1995-08-09 CN CN95195728A patent/CN1079836C/zh not_active Expired - Lifetime
- 1995-08-09 DE DE69530306T patent/DE69530306T2/de not_active Expired - Fee Related
- 1995-08-09 US US08/776,597 patent/US5846790A/en not_active Expired - Lifetime
- 1995-08-09 BR BR9508730A patent/BR9508730A/pt not_active Application Discontinuation
- 1995-08-09 WO PCT/JP1995/001586 patent/WO1996006180A1/ja active IP Right Grant
- 1995-08-09 ES ES95927999T patent/ES2191710T3/es not_active Expired - Lifetime
- 1995-08-09 EP EP02025583A patent/EP1293560B1/en not_active Expired - Lifetime
- 1995-08-18 PE PE1995276735A patent/PE27597A1/es not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1293560B1 (en) | 2007-11-14 |
| BR9508730A (pt) | 1997-10-21 |
| EP0780477B1 (en) | 2003-04-09 |
| JP2926991B2 (ja) | 1999-07-28 |
| CN1161059A (zh) | 1997-10-01 |
| CN1079836C (zh) | 2002-02-27 |
| EP1293560A3 (en) | 2004-12-01 |
| DE69535643D1 (de) | 2007-12-27 |
| WO1996006180A1 (fr) | 1996-02-29 |
| US5846790A (en) | 1998-12-08 |
| EP0780477A4 (en) | 1999-06-30 |
| DE69530306D1 (de) | 2003-05-15 |
| EP0780477A1 (en) | 1997-06-25 |
| EP1293560A2 (en) | 2003-03-19 |
| PE27597A1 (es) | 1997-08-12 |
| DE69530306T2 (de) | 2003-12-11 |
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