EA200600408A1 - Получение l-аскорбиновой кислоты в результате микробиологического процесса - Google Patents

Получение l-аскорбиновой кислоты в результате микробиологического процесса

Info

Publication number
EA200600408A1
EA200600408A1 EA200600408A EA200600408A EA200600408A1 EA 200600408 A1 EA200600408 A1 EA 200600408A1 EA 200600408 A EA200600408 A EA 200600408A EA 200600408 A EA200600408 A EA 200600408A EA 200600408 A1 EA200600408 A1 EA 200600408A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ascorbic acid
obtaining
result
present
vitamin
Prior art date
Application number
EA200600408A
Other languages
English (en)
Other versions
EA009287B1 (ru
Inventor
Алан Берри
Конни Ли
Анн Франсуаз Майер
Масако Синдзё
Original Assignee
ДСМ Ай Пи ЭССЕТС Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ДСМ Ай Пи ЭССЕТС Б.В. filed Critical ДСМ Ай Пи ЭССЕТС Б.В.
Publication of EA200600408A1 publication Critical patent/EA200600408A1/ru
Publication of EA009287B1 publication Critical patent/EA009287B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C12P7/60—2-Ketogulonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

В настоящем изобретении раскрывается выделенная полинуклеотидная молекула, полученная из полинуклеотида, кодирующего полипептид, имеющий L-сорбозондегидрогеназную активность, включающая в себя по крайней мере 20 последовательных нуклеотидов из частичной нуклеотидной последовательности SEQ ID NO:1. Настоящее изобретение, кроме того, относится к способу получения L-аскорбиновой кислоты с высоким выходом продукта, в частности к способу с использованием покоящихся клеток микроорганизма, способного превращать источники углерода в витамин С. Таким образом полученный витамин С может быть дополнительно подвергнут стадиям очистки и/или разделения.
EA200600408A 2003-08-14 2004-08-16 Получение l-аскорбиновой кислоты в результате микробиологического процесса EA009287B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03017677 2003-08-14
PCT/CH2004/000511 WO2005017159A2 (en) 2003-08-14 2004-08-16 Microbial production of l-ascorbic acid

Publications (2)

Publication Number Publication Date
EA200600408A1 true EA200600408A1 (ru) 2006-08-25
EA009287B1 EA009287B1 (ru) 2007-12-28

Family

ID=34178381

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600408A EA009287B1 (ru) 2003-08-14 2004-08-16 Получение l-аскорбиновой кислоты в результате микробиологического процесса

Country Status (9)

Country Link
US (3) US7700723B2 (ru)
EP (2) EP1664303B1 (ru)
JP (1) JP4896718B2 (ru)
KR (1) KR101311562B1 (ru)
CN (2) CN104004776A (ru)
BR (1) BRPI0413542A (ru)
EA (1) EA009287B1 (ru)
ES (2) ES2593811T3 (ru)
WO (2) WO2005017172A1 (ru)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006084645A1 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Novel gene rcs 10
US20080176297A1 (en) * 2005-02-11 2008-07-24 Bastien Chevreux Gene Rcs 21
EP1853715A1 (en) * 2005-02-11 2007-11-14 DSMIP Assets B.V. Gene rcs 23
WO2006084734A1 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Gene rcs 25
WO2006084643A2 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Novel gene vcs 07
WO2006084724A1 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Novel gene rcs 28
BRPI0608224A2 (pt) * 2005-02-11 2009-11-24 Dsm Ip Assets Bv gene sms 02
US20080305532A1 (en) * 2005-02-11 2008-12-11 Bastien Chevreux Gene For Coenzyme Pqq Synthesis Protein B From Gluconobacter Oxydans
WO2006084719A1 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Fermentive vitamin c production
US20080274520A1 (en) 2005-09-08 2008-11-06 Bastien Chevreux Novel Gene Sms 37
EP1931785A2 (en) * 2005-09-09 2008-06-18 DSMIP Assets B.V. Novel gene gms 01
EP1934337A1 (en) 2005-09-09 2008-06-25 DSMIP Assets B.V. Nadp-dependent glucose dehydrogenase from gluconobacter oxydans
FR2906817B1 (fr) * 2006-10-04 2012-04-06 Gervais Danone Sa Procede de culture pour favoriser la production de vitamine k2 par les bacteries lactiques et ses applications a la preparation de produits alimentaires
EP1918383A1 (en) * 2006-11-02 2008-05-07 DSMIP Assets B.V. Semi-continuous fermentation process for pantothenate production
EP1918382A1 (en) * 2006-11-02 2008-05-07 DSMIP Assets B.V. Semi-continuous cascade fermentation process for pantothenate production
EP2229450A1 (en) * 2008-01-10 2010-09-22 DSM IP Assets B.V. Novel gene sms 44
CN103073601B (zh) * 2013-02-01 2015-08-19 东北制药集团股份有限公司 一种2-酮基-l-古龙酸溶液加晶种的可控浓缩结晶方法
NZ706072A (en) * 2013-03-08 2018-12-21 Xyleco Inc Equipment protecting enclosures
CA2908266A1 (en) 2013-03-27 2014-10-02 Sample Technologies, Inc. Recombinant phage and bacterial detection methods
JP2016521996A (ja) 2013-06-19 2016-07-28 サンプルシックス テクノロジーズ，インコーポレイティド ファージベースの細菌検出アッセイ
SG10201801371PA (en) 2013-08-23 2018-04-27 Boehringer Ingelheim Rcv Gmbh Microparticles for cell disruption and/or biomolecule recovery
WO2015148680A1 (en) * 2014-03-25 2015-10-01 Ginkgo Bioworks, Inc. Methods and genetic systems for cell engineering
CN116053017B (zh) * 2022-11-04 2023-08-22 医波(厦门)科技有限公司 一种复合磁性微球及其制备方法和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5082785A (en) 1987-01-30 1992-01-21 Hoffmann-La Roche Inc. Biosynthesis of 2 keto-l-gulonic acid
DE68924761T2 (de) 1988-01-14 1996-04-04 Hoffmann La Roche Neue coenzym unabhängige l-sorbosone dehydrogenase.
ATE180831T1 (de) * 1990-09-17 1999-06-15 Hoffmann La Roche L-gulono-gamma-lacton dehydrogenase
US5376544A (en) 1992-09-08 1994-12-27 Rutgers The State University Of New Jersey Enzymes for the production of 2-keto-L-gulonic acid
WO1997004101A2 (de) * 1995-07-17 1997-02-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Enzym geeignet zur oxidation von cyclitolen und ihren derivaten
DE69821326T2 (de) * 1997-12-01 2004-11-18 Dsm Ip Assets B.V. Aldehyd-Dehydrogenase
US20020012979A1 (en) * 1998-06-08 2002-01-31 Alan Berry Vitamin c production in microorganisms and plants
GB0119864D0 (en) * 2001-08-15 2001-10-10 Cerestar Holding Bv Process for the manufacture of 2-keto-L-gulonic acid
US20050153412A1 (en) * 2002-04-22 2005-07-14 Tatsuo Hoshino Aldehyde dehydrogenase II
JP2005528917A (ja) * 2002-06-06 2005-09-29 ディーエスエム アイピー アセッツ ビー．ブイ． アルデヒドデヒドロゲナーゼ
DE60310738T2 (de) 2002-09-27 2007-10-11 Dsm Ip Assets B.V. Mikrobielle herstellung von vitamin c
EP1543114B1 (en) * 2002-09-27 2008-08-13 DSM IP Assets B.V. Aldehyde dehydrogenase gene
WO2004029269A1 (en) * 2002-09-27 2004-04-08 Dsm Ip Assets B.V. Process for producing vitamin c
ATE469976T1 (de) 2004-01-30 2010-06-15 Dsm Ip Assets Bv Mikrobielle vitamin-c-produktion
US20080226126A1 (en) * 2005-01-31 2008-09-18 Yoshinori Ohno Object-Tracking Apparatus, Microscope System, and Object-Tracking Program
WO2006084719A1 (en) 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Fermentive vitamin c production

Also Published As

Publication number Publication date
US8338144B2 (en) 2012-12-25
KR20060064629A (ko) 2006-06-13
BRPI0413542A (pt) 2006-10-17
EP1664303A2 (en) 2006-06-07
CN1882691A (zh) 2006-12-20
WO2005017159A3 (en) 2005-11-03
EP1664303B1 (en) 2013-04-24
CN104004776A (zh) 2014-08-27
US7700723B2 (en) 2010-04-20
WO2005017172A1 (en) 2005-02-24
US20100203598A1 (en) 2010-08-12
EP2348113A2 (en) 2011-07-27
EP2348113A3 (en) 2012-11-14
WO2005017159A2 (en) 2005-02-24
EA009287B1 (ru) 2007-12-28
US20130217080A1 (en) 2013-08-22
CN1882691B (zh) 2014-05-28
ES2421294T3 (es) 2013-08-30
JP2007502102A (ja) 2007-02-08
EP2348113B1 (en) 2016-06-29
ES2593811T3 (es) 2016-12-13
US20070184534A1 (en) 2007-08-09
KR101311562B1 (ko) 2013-09-26
JP4896718B2 (ja) 2012-03-14

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