BRPI0413542A - molécula isolada de polinucleotìdeo, polipeptìdeo, molécula de dna recombinante, vetor de expressão, organismo recombinante, bem como processos para produção de ácido l-ascórbico, de l-sorbosona desidrogenase e de vitamina c - Google Patents

molécula isolada de polinucleotìdeo, polipeptìdeo, molécula de dna recombinante, vetor de expressão, organismo recombinante, bem como processos para produção de ácido l-ascórbico, de l-sorbosona desidrogenase e de vitamina c

Info

Publication number
BRPI0413542A
BRPI0413542A BRPI0413542-3A BRPI0413542A BRPI0413542A BR PI0413542 A BRPI0413542 A BR PI0413542A BR PI0413542 A BRPI0413542 A BR PI0413542A BR PI0413542 A BRPI0413542 A BR PI0413542A
Authority
BR
Brazil
Prior art keywords
vitamin
polypeptide
ascorbic acid
producing
isolated polynucleotide
Prior art date
Application number
BRPI0413542-3A
Other languages
English (en)
Inventor
Alan Berry
Connie Lee
Anne Francoise Mayer
Masako Shinjoh
Original Assignee
Dsm Ip Assests Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assests Bv filed Critical Dsm Ip Assests Bv
Publication of BRPI0413542A publication Critical patent/BRPI0413542A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C12P7/60—2-Ketogulonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

"MOLéCULA ISOLADA DE POLINUCLEOTìDEO, POLIPEPTìDEO, MOLéCULA DE DNA RECOMBINANTE, VETOR DE EXPRESSãO, ORGANISMO RECOMBINANTE, BEM COMO PROCESSOS PARA PRODUçãO DE áCIDO L-ASCóRBICO, DE L-SORBOSONA DESIDROGENASE E DE VITAMINA C". A presente invenção refere-se a uma molécula isolada de polinucleotídio derivada de um polinucleotídio codificando um polipeptídio possuindo atividade L-sorbosona desidrogenase compreendendo uma seqüência parcial de nucleotídios de pelo menos 20 nucleotídios consecutivos da SEQ ID N<0>:1. A presente invenção também se refere a um processo para produção do ácido L-ascórbico com altos rendimentos, em particular um processo utilizando células em repouso de um microorganismo capaz de converter umas dadas fontes de carbono em vitamina C. A vitamina C assim obtida pode ser também processada por etapas de purificação e/ou separação.
BRPI0413542-3A 2003-08-14 2004-08-16 molécula isolada de polinucleotìdeo, polipeptìdeo, molécula de dna recombinante, vetor de expressão, organismo recombinante, bem como processos para produção de ácido l-ascórbico, de l-sorbosona desidrogenase e de vitamina c BRPI0413542A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03017677 2003-08-14
PCT/CH2004/000511 WO2005017159A2 (en) 2003-08-14 2004-08-16 Microbial production of l-ascorbic acid

Publications (1)

Publication Number Publication Date
BRPI0413542A true BRPI0413542A (pt) 2006-10-17

Family

ID=34178381

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413542-3A BRPI0413542A (pt) 2003-08-14 2004-08-16 molécula isolada de polinucleotìdeo, polipeptìdeo, molécula de dna recombinante, vetor de expressão, organismo recombinante, bem como processos para produção de ácido l-ascórbico, de l-sorbosona desidrogenase e de vitamina c

Country Status (9)

Country Link
US (3) US7700723B2 (pt)
EP (2) EP1664303B1 (pt)
JP (1) JP4896718B2 (pt)
KR (1) KR101311562B1 (pt)
CN (2) CN104004776A (pt)
BR (1) BRPI0413542A (pt)
EA (1) EA009287B1 (pt)
ES (2) ES2421294T3 (pt)
WO (2) WO2005017159A2 (pt)

Families Citing this family (23)

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WO2006084724A1 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Novel gene rcs 28
WO2006084733A1 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Gene rcs 21
CA2597499A1 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Recombinant microorganisms in fermentative production of vitamin c and a process thereof
WO2006084643A2 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Novel gene vcs 07
EP1859033A1 (en) * 2005-02-11 2007-11-28 DSMIP Assets B.V. Gene sms 02
WO2006084735A1 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Gene for coenzyme pqq synthesis protein b from gluconobacter oxydans
WO2006084645A1 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Novel gene rcs 10
US20080193972A1 (en) * 2005-02-11 2008-08-14 Bastian Chevreux Gene Rcs 25
US20090023191A1 (en) * 2005-02-11 2009-01-22 Bastien Chevreux Gene RCS 23
US20080274520A1 (en) 2005-09-08 2008-11-06 Bastien Chevreux Novel Gene Sms 37
WO2007028611A2 (en) * 2005-09-09 2007-03-15 Dsm Ip Assets B.V. Process for biomass production using a microorganism with a disrupted glucose-dehydrogenase gene (gms 01)
US8137940B2 (en) 2005-09-09 2012-03-20 Dsm Ip Assets B.V. Method for production of biomass using a gluconobacter oxydans comprising an inactivated NADP dependent glucose dehydrogenase gene
FR2906817B1 (fr) * 2006-10-04 2012-04-06 Gervais Danone Sa Procede de culture pour favoriser la production de vitamine k2 par les bacteries lactiques et ses applications a la preparation de produits alimentaires
EP1918382A1 (en) * 2006-11-02 2008-05-07 DSMIP Assets B.V. Semi-continuous cascade fermentation process for pantothenate production
EP1918383A1 (en) * 2006-11-02 2008-05-07 DSMIP Assets B.V. Semi-continuous fermentation process for pantothenate production
EP2229450A1 (en) * 2008-01-10 2010-09-22 DSM IP Assets B.V. Novel gene sms 44
CN103073601B (zh) * 2013-02-01 2015-08-19 东北制药集团股份有限公司 一种2-酮基-l-古龙酸溶液加晶种的可控浓缩结晶方法
NZ743055A (en) * 2013-03-08 2020-03-27 Xyleco Inc Equipment protecting enclosures
AU2014241191A1 (en) 2013-03-27 2015-10-22 Sample Technologies, Inc. Recombinant phage and bacterial detection methods
US9828625B2 (en) 2013-06-19 2017-11-28 Phage Diagnostics, Inc. Phage-based bacterial detection assay
AU2014310479B2 (en) 2013-08-23 2020-01-30 Boehringer Ingelheim Rcv Gmbh & Co Kg Novel adsorbent composition and use thereof
WO2015148680A1 (en) * 2014-03-25 2015-10-01 Ginkgo Bioworks, Inc. Methods and genetic systems for cell engineering
CN116053017B (zh) * 2022-11-04 2023-08-22 医波(厦门)科技有限公司 一种复合磁性微球及其制备方法和应用

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US5082785A (en) 1987-01-30 1992-01-21 Hoffmann-La Roche Inc. Biosynthesis of 2 keto-l-gulonic acid
EP0373181B1 (en) 1988-01-14 1995-11-08 F. Hoffmann-La Roche Ag Novel coenzyme independent l-sorbosone dehydrogenase
ATE180831T1 (de) * 1990-09-17 1999-06-15 Hoffmann La Roche L-gulono-gamma-lacton dehydrogenase
US5376544A (en) * 1992-09-08 1994-12-27 Rutgers The State University Of New Jersey Enzymes for the production of 2-keto-L-gulonic acid
AU6731896A (en) 1995-07-17 1997-02-18 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Cyclitol
DE69821326T2 (de) 1997-12-01 2004-11-18 Dsm Ip Assets B.V. Aldehyd-Dehydrogenase
US20020012979A1 (en) * 1998-06-08 2002-01-31 Alan Berry Vitamin c production in microorganisms and plants
GB0119864D0 (en) 2001-08-15 2001-10-10 Cerestar Holding Bv Process for the manufacture of 2-keto-L-gulonic acid
EP1499715A1 (en) 2002-04-22 2005-01-26 DSM IP Assets B.V. Aldehyde dehydrogenase ii
EP1509599A1 (en) 2002-06-06 2005-03-02 DSM IP Assets B.V. Aldehyde dehydrogenase
AU2003280338A1 (en) 2002-09-27 2004-04-19 Dsm Ip Assets B.V. Process for producing vitamin c
KR101070110B1 (ko) 2002-09-27 2011-10-05 디에스엠 아이피 어셋츠 비.브이. 알데히드 데하이드로게나제 유전자
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CA2597499A1 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Recombinant microorganisms in fermentative production of vitamin c and a process thereof

Also Published As

Publication number Publication date
EP2348113A2 (en) 2011-07-27
ES2421294T3 (es) 2013-08-30
EP2348113A3 (en) 2012-11-14
WO2005017159A3 (en) 2005-11-03
US7700723B2 (en) 2010-04-20
ES2593811T3 (es) 2016-12-13
EP1664303B1 (en) 2013-04-24
WO2005017159A2 (en) 2005-02-24
KR20060064629A (ko) 2006-06-13
WO2005017172A1 (en) 2005-02-24
EA009287B1 (ru) 2007-12-28
US20100203598A1 (en) 2010-08-12
JP2007502102A (ja) 2007-02-08
US20130217080A1 (en) 2013-08-22
EP1664303A2 (en) 2006-06-07
JP4896718B2 (ja) 2012-03-14
US20070184534A1 (en) 2007-08-09
CN104004776A (zh) 2014-08-27
US8338144B2 (en) 2012-12-25
KR101311562B1 (ko) 2013-09-26
EA200600408A1 (ru) 2006-08-25
CN1882691B (zh) 2014-05-28
CN1882691A (zh) 2006-12-20
EP2348113B1 (en) 2016-06-29

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements