KR100575403B1 - 세포 ｎａｄｐｈ를 증가시켜 ｌ-아미노산을 생산하는 방법 - Google Patents

세포 ｎａｄｐｈ를 증가시켜 ｌ-아미노산을 생산하는 방법 Download PDF

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KR100575403B1
KR100575403B1 KR1020027000925A KR20027000925A KR100575403B1 KR 100575403 B1 KR100575403 B1 KR 100575403B1 KR 1020027000925 A KR1020027000925 A KR 1020027000925A KR 20027000925 A KR20027000925 A KR 20027000925A KR 100575403 B1 KR100575403 B1 KR 100575403B1
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modified
amino acid
pgi
ala
cells
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KR20020048928A (ko
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오도노휴마이클알
핸크폴디
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아처 다니엘 미드랜드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020027000925A 1999-07-23 2000-07-21 세포 ｎａｄｐｈ를 증가시켜 ｌ-아미노산을 생산하는 방법 Expired - Lifetime KR100575403B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14521799P 1999-07-23 1999-07-23
US60/145,217 1999-07-23
US15001799P 1999-08-20 1999-08-20
US60/150,017 1999-08-20

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KR20020048928A KR20020048928A (ko) 2002-06-24
KR100575403B1 true KR100575403B1 (ko) 2006-05-03

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US (2) US6465238B1 (enExample)
EP (1) EP1208205B1 (enExample)
JP (2) JP4841093B2 (enExample)
KR (1) KR100575403B1 (enExample)
CN (1) CN1372597A (enExample)
AT (1) ATE340857T1 (enExample)
AU (1) AU6362200A (enExample)
BR (1) BR0012712B1 (enExample)
CA (1) CA2377693C (enExample)
DE (1) DE60030988T2 (enExample)
DK (1) DK1208205T3 (enExample)
ES (1) ES2272303T3 (enExample)
MX (1) MXPA02000729A (enExample)
NZ (1) NZ517295A (enExample)
PT (1) PT1208205E (enExample)
WO (1) WO2001007626A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101429814B1 (ko) * 2012-10-05 2014-08-12 상지대학교산학협력단 Ｇｄｈ 활성 조절을 통해 ｌ-쓰레오닌 생산능이 향상된 코리네박테리움 속 미생물 및 이를 이용한 ｌ-쓰레오닌 생산 방법

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US6830903B1 (en) 1999-07-23 2004-12-14 Archer-Daniels-Midland Company Methods for producing L-amino acids using a corynebacterium glutamicum with a disrupted pgi gene
US6465238B1 (en) * 1999-07-23 2002-10-15 Archer-Daniels-Midland Company Gene encoding phosphoglucoisomerase
US6586214B1 (en) 1999-09-15 2003-07-01 Degussa Ag Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene)
KR100826815B1 (ko) * 2000-03-20 2008-05-02 에보니크 데구사 게엠베하 ｇｎｄ 유전자의 증폭을 이용한 Ｌ-아미노산의 발효적생산 방법
DE10112992A1 (de) * 2001-03-17 2002-09-26 Degussa Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
US7160711B2 (en) * 2001-08-06 2007-01-09 Degussa Ag Coryneform bacteria which produce chemical compounds I
DE10220574A1 (de) * 2002-05-08 2003-11-20 Degussa Verfahren zur Herstellung von Aminosäuren mit coryneformen Bakterien unter Verwendung von Phosphoglucose-Isomerasen aus coryneformen Bakterien
US20070134768A1 (en) * 2003-12-18 2007-06-14 Basf Aktiengesellschaft Methods for the preparation of a fine chemical by fermentation
CN1890372A (zh) 2003-12-18 2007-01-03 巴斯福股份公司 通过发酵制备精细化学品的方法
KR20070026354A (ko) * 2003-12-18 2007-03-08 바스프 악티엔게젤샤프트 발효에 의해서 정밀화학 약품을 제조하는 방법
RU2288264C2 (ru) * 2004-02-12 2006-11-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Бактерия, принадлежащая к роду escherichia - продуцент l-треонина и способ получения l-треонина
EP1718731B2 (en) * 2004-02-25 2016-10-19 Ajinomoto Co., Inc. Microorganism expressing 6-phosphogluconolactonase and its use in the production of L-amino acids.
RU2004105179A (ru) * 2004-02-25 2005-08-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) 6-фосфоглюконолактоназа из escherichia coli, фрагмент днк, бактерия, принадлежащая к роду escherichia, -продуцент l-аминокислоты, и способ получения l-аминокислоты
US20050191684A1 (en) * 2004-02-25 2005-09-01 Zimenkov Danila V. Method for producing L-amino acids
JP4780783B2 (ja) * 2004-02-27 2011-09-28 協和発酵バイオ株式会社 アミノ酸の製造法
RU2004124226A (ru) 2004-08-10 2006-01-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Использование фосфокетолазы для продукции полезных метаболитов
KR100563226B1 (ko) * 2004-08-10 2006-03-21 한국생산기술연구원 연료전지용 분리판
EP2460872A1 (en) 2004-12-22 2012-06-06 Michigan Biotechnology Institute Recombinant microorganisms for increased production of organic acids
DE102005013676A1 (de) 2005-03-24 2006-09-28 Degussa Ag Allele des zwf-Gens aus coryneformen Bakterien
DE102005023829A1 (de) 2005-05-24 2006-11-30 Degussa Ag Allele des opcA-Gens aus coryneformen Bakterien
DE102005048818A1 (de) 2005-10-10 2007-04-12 Degussa Ag Mikrobiologische Herstellung von 3-Hydroxypropionsäure
KR100873168B1 (ko) * 2007-03-07 2008-12-10 전북대학교산학협력단 ｌｏｎ 유전자 및／또는 ｃｐｘＲ 유전자가 결실된살모넬라 변이균주 및 이를 함유하는 살모넬라 생백신
JP2011516029A (ja) 2007-11-10 2011-05-26 ジュール アンリミテッド インコーポレイテッド 高光合成生物
US20110244512A1 (en) * 2010-03-31 2011-10-06 E. I. Du Pont De Nemours And Company Pentose phosphate pathway upregulation to increase production of non-native products of interest in transgenic microorganisms
US9181568B2 (en) 2012-04-23 2015-11-10 Exxonmobil Research And Engineering Company Cell systems and methods for improving fatty acid synthesis by expression of dehydrogenases
US10689671B2 (en) 2014-05-12 2020-06-23 Metabolic Explorer Microorganism and method for the production of 1.2-propanediol based on NADPH dependent acetol reductase and improved NADPH supply
KR102384227B1 (ko) 2015-05-18 2022-04-07 삼성전자주식회사 Nadph 생성이 증가된 유전적으로 조작된 효모 세포, 효모 세포 중 nadph 수준을 증가시키는 방법, 상기 효모 세포를 제조하는 방법 및 상기 효모 세포를 이용하여 락테이트를 생산하는 방법
CN112725253B (zh) * 2020-12-30 2023-01-06 宁夏伊品生物科技股份有限公司 一种改造基因bbd29_14900的重组菌株及其构建方法与应用
CN113774096A (zh) * 2021-10-21 2021-12-10 呼伦贝尔东北阜丰生物科技有限公司 一种苏氨酸生产提取工艺的优化方法
CN113930465A (zh) * 2021-10-21 2022-01-14 呼伦贝尔东北阜丰生物科技有限公司 一种苏氨酸发酵代谢调控工艺
CN114181288B (zh) * 2022-02-17 2022-05-03 北京中科伊品生物科技有限公司 制备l-缬氨酸的方法及其所用的基因与该基因编码的蛋白质

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101429814B1 (ko) * 2012-10-05 2014-08-12 상지대학교산학협력단 Ｇｄｈ 활성 조절을 통해 ｌ-쓰레오닌 생산능이 향상된 코리네박테리움 속 미생물 및 이를 이용한 ｌ-쓰레오닌 생산 방법

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US6465238B1 (en) 2002-10-15
ES2272303T3 (es) 2007-05-01
NZ517295A (en) 2004-04-30
PT1208205E (pt) 2006-12-29
US6680190B2 (en) 2004-01-20
CN1372597A (zh) 2002-10-02
AU6362200A (en) 2001-02-13
US20030017557A1 (en) 2003-01-23
JP2003521888A (ja) 2003-07-22
EP1208205A2 (en) 2002-05-29
EP1208205B1 (en) 2006-09-27
JP4841093B2 (ja) 2011-12-21
CA2377693A1 (en) 2001-02-01
WO2001007626A2 (en) 2001-02-01
ATE340857T1 (de) 2006-10-15
DK1208205T3 (da) 2007-02-05
KR20020048928A (ko) 2002-06-24
MXPA02000729A (es) 2002-08-20
WO2001007626A3 (en) 2001-05-31
BR0012712B1 (pt) 2011-12-13
DE60030988T2 (de) 2007-01-04
JP2011041582A (ja) 2011-03-03
CA2377693C (en) 2016-11-08
BR0012712A (pt) 2002-04-09
DE60030988D1 (de) 2006-11-09

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