ATE340857T1 - Verfahren zur herstellung von l-aminosäuren durch erhöhung des zellulären nadph - Google Patents
Verfahren zur herstellung von l-aminosäuren durch erhöhung des zellulären nadphInfo
- Publication number
- ATE340857T1 ATE340857T1 AT00950529T AT00950529T ATE340857T1 AT E340857 T1 ATE340857 T1 AT E340857T1 AT 00950529 T AT00950529 T AT 00950529T AT 00950529 T AT00950529 T AT 00950529T AT E340857 T1 ATE340857 T1 AT E340857T1
- Authority
- AT
- Austria
- Prior art keywords
- amino acids
- producing
- bacterial cells
- increasing cellular
- nadph
- Prior art date
Links
- 150000008575 L-amino acids Chemical class 0.000 title abstract 3
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 title abstract 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 title abstract 2
- 230000001413 cellular effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000001580 bacterial effect Effects 0.000 abstract 4
- 238000012258 culturing Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
- C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14521799P | 1999-07-23 | 1999-07-23 | |
| US15001799P | 1999-08-20 | 1999-08-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE340857T1 true ATE340857T1 (de) | 2006-10-15 |
Family
ID=26842765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00950529T ATE340857T1 (de) | 1999-07-23 | 2000-07-21 | Verfahren zur herstellung von l-aminosäuren durch erhöhung des zellulären nadph |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6465238B1 (enExample) |
| EP (1) | EP1208205B1 (enExample) |
| JP (2) | JP4841093B2 (enExample) |
| KR (1) | KR100575403B1 (enExample) |
| CN (1) | CN1372597A (enExample) |
| AT (1) | ATE340857T1 (enExample) |
| AU (1) | AU6362200A (enExample) |
| BR (1) | BR0012712B1 (enExample) |
| CA (1) | CA2377693C (enExample) |
| DE (1) | DE60030988T2 (enExample) |
| DK (1) | DK1208205T3 (enExample) |
| ES (1) | ES2272303T3 (enExample) |
| MX (1) | MXPA02000729A (enExample) |
| NZ (1) | NZ517295A (enExample) |
| PT (1) | PT1208205E (enExample) |
| WO (1) | WO2001007626A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6830903B1 (en) | 1999-07-23 | 2004-12-14 | Archer-Daniels-Midland Company | Methods for producing L-amino acids using a corynebacterium glutamicum with a disrupted pgi gene |
| US6465238B1 (en) * | 1999-07-23 | 2002-10-15 | Archer-Daniels-Midland Company | Gene encoding phosphoglucoisomerase |
| US6586214B1 (en) | 1999-09-15 | 2003-07-01 | Degussa Ag | Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene) |
| KR100826815B1 (ko) * | 2000-03-20 | 2008-05-02 | 에보니크 데구사 게엠베하 | ｇｎｄ 유전자의 증폭을 이용한 Ｌ-아미노산의 발효적생산 방법 |
| DE10112992A1 (de) * | 2001-03-17 | 2002-09-26 | Degussa | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien |
| US7160711B2 (en) * | 2001-08-06 | 2007-01-09 | Degussa Ag | Coryneform bacteria which produce chemical compounds I |
| DE10220574A1 (de) * | 2002-05-08 | 2003-11-20 | Degussa | Verfahren zur Herstellung von Aminosäuren mit coryneformen Bakterien unter Verwendung von Phosphoglucose-Isomerasen aus coryneformen Bakterien |
| US20070134768A1 (en) * | 2003-12-18 | 2007-06-14 | Basf Aktiengesellschaft | Methods for the preparation of a fine chemical by fermentation |
| CN1890372A (zh) | 2003-12-18 | 2007-01-03 | 巴斯福股份公司 | 通过发酵制备精细化学品的方法 |
| KR20070026354A (ko) * | 2003-12-18 | 2007-03-08 | 바스프 악티엔게젤샤프트 | 발효에 의해서 정밀화학 약품을 제조하는 방법 |
| RU2288264C2 (ru) * | 2004-02-12 | 2006-11-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Бактерия, принадлежащая к роду escherichia - продуцент l-треонина и способ получения l-треонина |
| EP1718731B2 (en) * | 2004-02-25 | 2016-10-19 | Ajinomoto Co., Inc. | Microorganism expressing 6-phosphogluconolactonase and its use in the production of L-amino acids. |
| RU2004105179A (ru) * | 2004-02-25 | 2005-08-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | 6-фосфоглюконолактоназа из escherichia coli, фрагмент днк, бактерия, принадлежащая к роду escherichia, -продуцент l-аминокислоты, и способ получения l-аминокислоты |
| US20050191684A1 (en) * | 2004-02-25 | 2005-09-01 | Zimenkov Danila V. | Method for producing L-amino acids |
| JP4780783B2 (ja) * | 2004-02-27 | 2011-09-28 | 協和発酵バイオ株式会社 | アミノ酸の製造法 |
| RU2004124226A (ru) | 2004-08-10 | 2006-01-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Использование фосфокетолазы для продукции полезных метаболитов |
| KR100563226B1 (ko) * | 2004-08-10 | 2006-03-21 | 한국생산기술연구원 | 연료전지용 분리판 |
| EP2460872A1 (en) | 2004-12-22 | 2012-06-06 | Michigan Biotechnology Institute | Recombinant microorganisms for increased production of organic acids |
| DE102005013676A1 (de) | 2005-03-24 | 2006-09-28 | Degussa Ag | Allele des zwf-Gens aus coryneformen Bakterien |
| DE102005023829A1 (de) | 2005-05-24 | 2006-11-30 | Degussa Ag | Allele des opcA-Gens aus coryneformen Bakterien |
| DE102005048818A1 (de) | 2005-10-10 | 2007-04-12 | Degussa Ag | Mikrobiologische Herstellung von 3-Hydroxypropionsäure |
| KR100873168B1 (ko) * | 2007-03-07 | 2008-12-10 | 전북대학교산학협력단 | ｌｏｎ 유전자 및／또는 ｃｐｘＲ 유전자가 결실된살모넬라 변이균주 및 이를 함유하는 살모넬라 생백신 |
| JP2011516029A (ja) | 2007-11-10 | 2011-05-26 | ジュール アンリミテッド インコーポレイテッド | 高光合成生物 |
| US20110244512A1 (en) * | 2010-03-31 | 2011-10-06 | E. I. Du Pont De Nemours And Company | Pentose phosphate pathway upregulation to increase production of non-native products of interest in transgenic microorganisms |
| US9181568B2 (en) | 2012-04-23 | 2015-11-10 | Exxonmobil Research And Engineering Company | Cell systems and methods for improving fatty acid synthesis by expression of dehydrogenases |
| KR101429814B1 (ko) * | 2012-10-05 | 2014-08-12 | 상지대학교산학협력단 | Ｇｄｈ 활성 조절을 통해 ｌ-쓰레오닌 생산능이 향상된 코리네박테리움 속 미생물 및 이를 이용한 ｌ-쓰레오닌 생산 방법 |
| US10689671B2 (en) | 2014-05-12 | 2020-06-23 | Metabolic Explorer | Microorganism and method for the production of 1.2-propanediol based on NADPH dependent acetol reductase and improved NADPH supply |
| KR102384227B1 (ko) | 2015-05-18 | 2022-04-07 | 삼성전자주식회사 | Nadph 생성이 증가된 유전적으로 조작된 효모 세포, 효모 세포 중 nadph 수준을 증가시키는 방법, 상기 효모 세포를 제조하는 방법 및 상기 효모 세포를 이용하여 락테이트를 생산하는 방법 |
| CN112725253B (zh) * | 2020-12-30 | 2023-01-06 | 宁夏伊品生物科技股份有限公司 | 一种改造基因bbd29_14900的重组菌株及其构建方法与应用 |
| CN113774096A (zh) * | 2021-10-21 | 2021-12-10 | 呼伦贝尔东北阜丰生物科技有限公司 | 一种苏氨酸生产提取工艺的优化方法 |
| CN113930465A (zh) * | 2021-10-21 | 2022-01-14 | 呼伦贝尔东北阜丰生物科技有限公司 | 一种苏氨酸发酵代谢调控工艺 |
| CN114181288B (zh) * | 2022-02-17 | 2022-05-03 | 北京中科伊品生物科技有限公司 | 制备l-缬氨酸的方法及其所用的基因与该基因编码的蛋白质 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS594988B2 (ja) * | 1976-02-03 | 1984-02-02 | 日石三菱株式会社 | グリコ−スイソメラ−ゼの製法 |
| CA2148622A1 (en) | 1992-11-05 | 1994-05-11 | Anu Marjukka Harkki | Recombinant method and host for manufacture of xylitol |
| EP0672161B1 (en) | 1992-11-05 | 1999-09-22 | Xyrofin Oy | Recombinant method and host for manufacture of xylitol |
| JP2817400B2 (ja) | 1993-10-28 | 1998-10-30 | 味の素株式会社 | 物質の製造法 |
| DE69535643D1 (de) * | 1994-08-19 | 2007-12-27 | Ajinomoto Kk | Verfahren zur fermentativen Herstellung von L-Lysin und L-glutaminsäure |
| JPH09224662A (ja) * | 1996-02-23 | 1997-09-02 | Mitsubishi Chem Corp | ６−ホスホグルコン酸デヒドロゲナーゼおよびそれをコードするｄｎａ |
| JPH09224661A (ja) * | 1996-02-23 | 1997-09-02 | Mitsubishi Chem Corp | グルコース−６−リン酸デヒドロゲナーゼおよびそれをコードするｄｎａ |
| KR100697552B1 (ko) * | 1997-07-18 | 2007-03-21 | 아지노모토 가부시키가이샤 | 발효에 의한 퓨린 뉴클레오사이드의 제조 방법 |
| FR2772788B1 (fr) | 1997-12-19 | 2000-11-17 | Roquette Freres | Procede pour accroitre la production de certains polyols par une souche osmotolerante |
| US6465238B1 (en) * | 1999-07-23 | 2002-10-15 | Archer-Daniels-Midland Company | Gene encoding phosphoglucoisomerase |
| US6586214B1 (en) | 1999-09-15 | 2003-07-01 | Degussa Ag | Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene) |
-
2000
- 2000-07-21 US US09/621,451 patent/US6465238B1/en not_active Expired - Lifetime
- 2000-07-21 AU AU63622/00A patent/AU6362200A/en not_active Abandoned
- 2000-07-21 BR BRPI0012712-4A patent/BR0012712B1/pt not_active IP Right Cessation
- 2000-07-21 KR KR1020027000925A patent/KR100575403B1/ko not_active Expired - Lifetime
- 2000-07-21 JP JP2001512892A patent/JP4841093B2/ja not_active Expired - Lifetime
- 2000-07-21 DK DK00950529T patent/DK1208205T3/da active
- 2000-07-21 NZ NZ517295A patent/NZ517295A/en not_active IP Right Cessation
- 2000-07-21 AT AT00950529T patent/ATE340857T1/de not_active IP Right Cessation
- 2000-07-21 DE DE60030988T patent/DE60030988T2/de not_active Expired - Lifetime
- 2000-07-21 CA CA2377693A patent/CA2377693C/en not_active Expired - Fee Related
- 2000-07-21 CN CN00810748A patent/CN1372597A/zh active Pending
- 2000-07-21 EP EP00950529A patent/EP1208205B1/en not_active Expired - Lifetime
- 2000-07-21 MX MXPA02000729A patent/MXPA02000729A/es active IP Right Grant
- 2000-07-21 ES ES00950529T patent/ES2272303T3/es not_active Expired - Lifetime
- 2000-07-21 PT PT00950529T patent/PT1208205E/pt unknown
- 2000-07-21 WO PCT/US2000/019914 patent/WO2001007626A2/en not_active Ceased
-
2002
- 2002-08-20 US US10/223,355 patent/US6680190B2/en not_active Expired - Lifetime
-
2010
- 2010-12-01 JP JP2010268851A patent/JP2011041582A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US6465238B1 (en) | 2002-10-15 |
| ES2272303T3 (es) | 2007-05-01 |
| NZ517295A (en) | 2004-04-30 |
| PT1208205E (pt) | 2006-12-29 |
| US6680190B2 (en) | 2004-01-20 |
| KR100575403B1 (ko) | 2006-05-03 |
| CN1372597A (zh) | 2002-10-02 |
| AU6362200A (en) | 2001-02-13 |
| US20030017557A1 (en) | 2003-01-23 |
| JP2003521888A (ja) | 2003-07-22 |
| EP1208205A2 (en) | 2002-05-29 |
| EP1208205B1 (en) | 2006-09-27 |
| JP4841093B2 (ja) | 2011-12-21 |
| CA2377693A1 (en) | 2001-02-01 |
| WO2001007626A2 (en) | 2001-02-01 |
| DK1208205T3 (da) | 2007-02-05 |
| KR20020048928A (ko) | 2002-06-24 |
| MXPA02000729A (es) | 2002-08-20 |
| WO2001007626A3 (en) | 2001-05-31 |
| BR0012712B1 (pt) | 2011-12-13 |
| DE60030988T2 (de) | 2007-01-04 |
| JP2011041582A (ja) | 2011-03-03 |
| CA2377693C (en) | 2016-11-08 |
| BR0012712A (pt) | 2002-04-09 |
| DE60030988D1 (de) | 2006-11-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE340857T1 (de) | Verfahren zur herstellung von l-aminosäuren durch erhöhung des zellulären nadph | |
| DE69939901D1 (de) | Verfahren und materialien zur herstellung von glucosamin | |
| ATE405644T1 (de) | Verfahren zur herstellung und reinigung von erythropoietin | |
| ATE441714T1 (de) | Verfahren zur herstellung von l-aminosäuren durch enterobakteriaceae-stämmen mit verstärkter exprimierung des rsea-gens | |
| ATE493502T1 (de) | Glucosamin und verfahren zur herstellung von glucosamin aus mikrobieller biomasse | |
| ATE501264T1 (de) | Enzymatische verfahren zur herstellung 4- substituierter 3-hydroxybuttersäure-derivate | |
| DE60227653D1 (de) | Verfahren zur herstellung von l-aminosäuren, unter verwendung von stämmen aus der familie der enterohalten | |
| ATE474847T1 (de) | Verfahren zur herstellung von dipeptiden | |
| ATE489377T1 (de) | Verfahren zur herstellung von 3-methylamino-1- (thien-2-yl)-propan-1-ol | |
| ATE326523T1 (de) | Verfahren zur fermentativen herstellung von l- methionin | |
| DE69931394D1 (de) | Verfahren zur herstellung von ascorbinsäure-zwischenprodukten | |
| ATE309353T1 (de) | Verfahren zur herstellung von rekombinanten peptiden | |
| UA92157C2 (ru) | Способ продуцирования гормона роста | |
| ATE488597T1 (de) | Verfahren zur herstellung optisch aktiver aminosäuren unter verwendung eines ganzzellenkatalysators | |
| ATE374831T1 (de) | Verfahren zur fermentativen herstellung von l- aminosäuren durch verstärkung des tkt-gens | |
| ATE427996T1 (de) | Verfahren zur herstellung von (s)-butan-2-ol | |
| ATE522604T1 (de) | Verfahren zur herstellung von proteinen durch elektropulsierung | |
| ATE536411T1 (de) | Verfahren zur herstellung von nichtaromatischen l-aminosäuren durch stämme aus der famile der enterobacteriaceae | |
| DE60318882D1 (de) | Uroplakin-ii-promotor aus schwein und verfahren zur herstellung nützlicher proteine unter verwendung des promotors | |
| WO2002033093A3 (en) | Aggrecanase molecules | |
| DE50002865D1 (de) | Verfahren zur herstellung von benzofuranonoximen | |
| ATE389710T1 (de) | L-glutamine produzierende mikroorganismen und verfahren zur herstellung von l-glutamine unter verwendung derselben | |
| ATE428794T1 (de) | Verfahren zur herstellung von l-aminosäuren unter verwendung von stämmen der familie enterobacteriaceae | |
| ATE233822T1 (de) | Verfahren zur stereoselektiven herstellung von substituierten cyclohexylcyanhydrinen | |
| WO2003064597A3 (en) | Aggrecanase molecules |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |