CN1173736C - 白细胞介素-18抑制剂抑制肿瘤转移的用途 - Google Patents

白细胞介素-18抑制剂抑制肿瘤转移的用途 Download PDF

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Publication number
CN1173736C
CN1173736C CNB008106894A CN00810689A CN1173736C CN 1173736 C CN1173736 C CN 1173736C CN B008106894 A CNB008106894 A CN B008106894A CN 00810689 A CN00810689 A CN 00810689A CN 1173736 C CN1173736 C CN 1173736C
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China
Prior art keywords
cells
hse
adhesion
tnf
inhibitors
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Expired - Lifetime
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CNB008106894A
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Chinese (zh)
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CN1364086A (zh
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C
C·迪纳洛
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Ares Trading SA
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Ares Trading SA
Yeda Research and Development Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB008106894A 1999-07-22 2000-07-17 白细胞介素-18抑制剂抑制肿瘤转移的用途 Expired - Lifetime CN1173736C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL13104799A IL131047A0 (en) 1999-07-22 1999-07-22 Use of il-18 inhibitors
IL131047 1999-07-22

Publications (2)

Publication Number Publication Date
CN1364086A CN1364086A (zh) 2002-08-14
CN1173736C true CN1173736C (zh) 2004-11-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008106894A Expired - Lifetime CN1173736C (zh) 1999-07-22 2000-07-17 白细胞介素-18抑制剂抑制肿瘤转移的用途

Country Status (31)

Country Link
US (1) US7741276B2 (enExample)
EP (1) EP1206274B1 (enExample)
JP (1) JP4827352B2 (enExample)
KR (1) KR100682219B1 (enExample)
CN (1) CN1173736C (enExample)
AR (1) AR024907A1 (enExample)
AT (1) ATE363288T1 (enExample)
AU (1) AU782478B2 (enExample)
BG (1) BG65800B1 (enExample)
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CA (1) CA2380216C (enExample)
CY (1) CY1107932T1 (enExample)
CZ (1) CZ302114B6 (enExample)
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NZ (1) NZ516535A (enExample)
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PT (1) PT1206274E (enExample)
SK (1) SK287522B6 (enExample)
TR (1) TR200200169T2 (enExample)
UA (1) UA73745C2 (enExample)
WO (1) WO2001007480A2 (enExample)
ZA (1) ZA200200390B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL356836A1 (en) 2000-02-10 2004-07-12 Abbott Laboratories Antibodies that bind human interleukin-18 and methods of making and using
AU1174402A (en) 2000-10-11 2002-04-22 Viron Therapeutics Inc Nucleic acid molecules and polypeptides for immune modulation
US7718368B2 (en) 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
CN100556450C (zh) * 2001-05-16 2009-11-04 耶达研究发展有限公司 Il-18抑制剂在治疗或预防脓毒症中的应用
RU2225720C1 (ru) * 2002-08-12 2004-03-20 Научно-исследовательский институт онкологии Томского научного центра СО РАМН Средство, повышающее противоопухолевую и антиметастатическую активность циклофосфана
US7279155B2 (en) * 2002-10-08 2007-10-09 Ares Trading S.A. Method of treatment using a cytokine able to bind IL-18BP to inhibit the activity of a second cytokine
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
ES2385639T3 (es) 2005-06-03 2012-07-27 Ares Trading S.A. Producción de una proteína de unión a IL-18 recombinante
AU2006256763B2 (en) 2005-06-10 2012-08-02 Ares Trading S.A. Process for the purification of IL-18 binding protein
CL2008002153A1 (es) 2007-07-24 2009-06-05 Amgen Inc Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r.
US9812033B2 (en) * 2013-03-06 2017-11-07 Venkatesh R. Chari Tactile graphic display
AU2023236289A1 (en) 2022-03-15 2024-08-15 Compugen Ltd. Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer
JP2026503273A (ja) 2023-01-06 2026-01-28 ラッセン・セラピューティクス・インコーポレイテッド 抗ｉｌ－１８ｂｐ抗体
TW202515608A (zh) 2023-06-26 2025-04-16 以色列商坎布根有限公司 Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT69922A (en) * 1992-09-02 1995-09-28 Isis Pharmaceuticals Inc Oligonucleotide modification of cell adhesion
US7141393B2 (en) * 1996-12-26 2006-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18-receptor proteins
WO1998041232A2 (en) * 1997-03-18 1998-09-24 Basf Aktiengesellschaft Compositions for modulating responsiveness to corticosteroids
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use

Also Published As

Publication number Publication date
IL131047A0 (en) 2001-01-28
HU228780B1 (en) 2013-05-28
AU5843200A (en) 2001-02-13
KR20020027493A (ko) 2002-04-13
SK287522B6 (sk) 2011-01-04
ES2186596T1 (es) 2003-05-16
DE60035049T2 (de) 2007-09-27
NO329827B1 (no) 2011-01-03
DE60035049D1 (de) 2007-07-12
EP1206274A2 (en) 2002-05-22
HUP0202107A3 (en) 2005-01-28
MXPA02000838A (es) 2002-07-30
NZ516535A (en) 2004-04-30
BG65800B1 (bg) 2009-12-31
WO2001007480A2 (en) 2001-02-01
EE200200032A (et) 2003-02-17
US7741276B2 (en) 2010-06-22
JP2003505472A (ja) 2003-02-12
CA2380216C (en) 2012-01-31
DE1206274T1 (de) 2002-11-14
EP1206274B1 (en) 2007-05-30
ATE363288T1 (de) 2007-06-15
CA2380216A1 (en) 2001-02-01
NO20020153L (no) 2002-03-11
KR100682219B1 (ko) 2007-02-12
PL202477B1 (pl) 2009-06-30
EE04838B1 (et) 2007-06-15
EA200200189A1 (ru) 2002-12-26
IL147675A (en) 2009-05-04
CZ2002195A3 (cs) 2002-06-12
CY1107932T1 (el) 2013-09-04
BR0012675A (pt) 2002-04-09
AR024907A1 (es) 2002-10-30
HK1048248A1 (en) 2003-03-28
TR200200169T2 (tr) 2002-06-21
UA73745C2 (en) 2005-09-15
CN1364086A (zh) 2002-08-14
AU782478B2 (en) 2005-08-04
PL353732A1 (en) 2003-12-01
BRPI0012675B8 (enExample) 2021-05-25
EA005419B1 (ru) 2005-02-24
WO2001007480A3 (en) 2001-05-10
JP4827352B2 (ja) 2011-11-30
BRPI0012675B1 (pt) 2001-02-01
HUP0202107A2 (en) 2002-10-28
NO20020153D0 (no) 2002-01-11
DK1206274T3 (da) 2007-08-13
BG106311A (en) 2002-08-30
ES2186596T3 (es) 2007-11-16
SK882002A3 (en) 2002-07-02
PT1206274E (pt) 2007-07-06
ZA200200390B (en) 2003-04-30
US20080003216A1 (en) 2008-01-03
CZ302114B6 (cs) 2010-10-20
HK1048248B (zh) 2005-04-22

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