UA73745C2 - Use of il-18 inhibitors for preparing pharmaceutical composition inhibiting tumor metastasis - Google Patents
Use of il-18 inhibitors for preparing pharmaceutical composition inhibiting tumor metastasis Download PDFInfo
- Publication number
- UA73745C2 UA73745C2 UA2002021472A UA2002021472A UA73745C2 UA 73745 C2 UA73745 C2 UA 73745C2 UA 2002021472 A UA2002021472 A UA 2002021472A UA 2002021472 A UA2002021472 A UA 2002021472A UA 73745 C2 UA73745 C2 UA 73745C2
- Authority
- UA
- Ukraine
- Prior art keywords
- cells
- sep
- adhesion
- apa
- inhibitors
- Prior art date
Links
- 206010027476 Metastases Diseases 0.000 title abstract description 19
- 239000003112 inhibitor Substances 0.000 title abstract description 17
- 206010028980 Neoplasm Diseases 0.000 title abstract description 10
- 230000009401 metastasis Effects 0.000 title abstract description 5
- 239000008194 pharmaceutical composition Substances 0.000 title description 4
- 230000002401 inhibitory effect Effects 0.000 title 1
- 108090000171 Interleukin-18 Proteins 0.000 abstract description 69
- 210000004027 cell Anatomy 0.000 description 97
- 101001052500 Homo sapiens Membrane metallo-endopeptidase-like 1 Proteins 0.000 description 72
- 101001067174 Homo sapiens Plexin-B1 Proteins 0.000 description 72
- 102100024197 Membrane metallo-endopeptidase-like 1 Human genes 0.000 description 72
- 229920001098 polystyrene-block-poly(ethylene/propylene) Polymers 0.000 description 72
- 241000699670 Mus sp. Species 0.000 description 24
- 238000004519 manufacturing process Methods 0.000 description 20
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- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 16
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- 241001529936 Murinae Species 0.000 description 11
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- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 6
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- 206010002091 Anaesthesia Diseases 0.000 description 2
- 101001033249 Homo sapiens Interleukin-1 beta Proteins 0.000 description 2
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- 108010002352 Interleukin-1 Proteins 0.000 description 2
- 102100039065 Interleukin-1 beta Human genes 0.000 description 2
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- 108010063738 Interleukins Proteins 0.000 description 2
- 101000960949 Mus musculus Interleukin-18 Proteins 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 102100040247 Tumor necrosis factor Human genes 0.000 description 2
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- 238000000540 analysis of variance Methods 0.000 description 2
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- 238000004113 cell culture Methods 0.000 description 2
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- 108020001507 fusion proteins Proteins 0.000 description 2
- 102000037865 fusion proteins Human genes 0.000 description 2
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- 206010061289 metastatic neoplasm Diseases 0.000 description 2
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- 238000003757 reverse transcription PCR Methods 0.000 description 2
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- 230000019491 signal transduction Effects 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- -1 6-carboxy-fluorescein acetoxymethyl ester Chemical class 0.000 description 1
- 239000005541 ACE inhibitor Substances 0.000 description 1
- 235000008375 Decussocarpus nagi Nutrition 0.000 description 1
- 244000309456 Decussocarpus nagi Species 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
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- 102000004190 Enzymes Human genes 0.000 description 1
- 208000001382 Experimental Melanoma Diseases 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 239000012981 Hank's balanced salt solution Substances 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000019223 Interleukin-1 receptor Human genes 0.000 description 1
- 108050006617 Interleukin-1 receptor Proteins 0.000 description 1
- 102100026018 Interleukin-1 receptor antagonist protein Human genes 0.000 description 1
- 101710144554 Interleukin-1 receptor antagonist protein Proteins 0.000 description 1
- 206010027457 Metastases to liver Diseases 0.000 description 1
- 101100434616 Mus musculus Akna gene Proteins 0.000 description 1
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 description 1
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
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- 230000003750 conditioning effect Effects 0.000 description 1
- 239000012050 conventional carrier Substances 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 230000016396 cytokine production Effects 0.000 description 1
- 238000010217 densitometric analysis Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 102000057041 human TNF Human genes 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 108010027775 interleukin-1beta-converting enzyme inhibitor Proteins 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 239000013038 irreversible inhibitor Substances 0.000 description 1
- 230000000684 melanotic effect Effects 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 210000004088 microvessel Anatomy 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 229940105631 nembutal Drugs 0.000 description 1
- 230000008816 organ damage Effects 0.000 description 1
- 230000003076 paracrine Effects 0.000 description 1
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
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- 230000028327 secretion Effects 0.000 description 1
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- 230000000638 stimulation Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL13104799A IL131047A0 (en) | 1999-07-22 | 1999-07-22 | Use of il-18 inhibitors |
| PCT/IL2000/000419 WO2001007480A2 (en) | 1999-07-22 | 2000-07-17 | Use of interleukin-18 inhibitors to inhibit tumor metastasis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA73745C2 true UA73745C2 (en) | 2005-09-15 |
Family
ID=11073044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2002021472A UA73745C2 (en) | 1999-07-22 | 2000-07-17 | Use of il-18 inhibitors for preparing pharmaceutical composition inhibiting tumor metastasis |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US7741276B2 (enExample) |
| EP (1) | EP1206274B1 (enExample) |
| JP (1) | JP4827352B2 (enExample) |
| KR (1) | KR100682219B1 (enExample) |
| CN (1) | CN1173736C (enExample) |
| AR (1) | AR024907A1 (enExample) |
| AT (1) | ATE363288T1 (enExample) |
| AU (1) | AU782478B2 (enExample) |
| BG (1) | BG65800B1 (enExample) |
| BR (1) | BR0012675A (enExample) |
| CA (1) | CA2380216C (enExample) |
| CY (1) | CY1107932T1 (enExample) |
| CZ (1) | CZ302114B6 (enExample) |
| DE (2) | DE1206274T1 (enExample) |
| DK (1) | DK1206274T3 (enExample) |
| EA (1) | EA005419B1 (enExample) |
| EE (1) | EE04838B1 (enExample) |
| ES (1) | ES2186596T3 (enExample) |
| HK (1) | HK1048248B (enExample) |
| HU (1) | HU228780B1 (enExample) |
| IL (2) | IL131047A0 (enExample) |
| MX (1) | MXPA02000838A (enExample) |
| NO (1) | NO329827B1 (enExample) |
| NZ (1) | NZ516535A (enExample) |
| PL (1) | PL202477B1 (enExample) |
| PT (1) | PT1206274E (enExample) |
| SK (1) | SK287522B6 (enExample) |
| TR (1) | TR200200169T2 (enExample) |
| UA (1) | UA73745C2 (enExample) |
| WO (1) | WO2001007480A2 (enExample) |
| ZA (1) | ZA200200390B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120011898A (ko) * | 2000-02-10 | 2012-02-08 | 아보트 러보러터리즈 | 사람 인터류킨-１８에 결합하는 항체 및 이를 제조하고 사용하는 방법 |
| CA2424983A1 (en) | 2000-10-11 | 2002-04-18 | Viron Therapeutics, Inc. | Nucleic acid molecules and polypeptides for immune modulation |
| US7718368B2 (en) | 2000-12-04 | 2010-05-18 | Viron Therapeutics Inc. | Immunomodulatory protein and useful embodiments thereof |
| UA85531C2 (uk) * | 2001-05-16 | 2009-02-10 | Йеда Рисерч Энд Дивелопмент Ко. Лтд. | Застосування il-18 інгібіторів для лікування або попередження пов'язаної з сепсисом дисфункції серця |
| RU2225720C1 (ru) * | 2002-08-12 | 2004-03-20 | Научно-исследовательский институт онкологии Томского научного центра СО РАМН | Средство, повышающее противоопухолевую и антиметастатическую активность циклофосфана |
| KR101015682B1 (ko) * | 2002-10-08 | 2011-02-22 | 아레스 트레이딩 에스.에이. | Ｉｌ-18ｂｐ에 결합할 수 있고 제 2 사이토킨의 활성을저해할 수 있는 사이토킨의 용도 |
| US7968684B2 (en) * | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| DK1885753T3 (da) | 2005-06-03 | 2011-10-03 | Ares Trading Sa | Fremstilling af rekombinant II-18-proteiner |
| HRP20110948T1 (hr) | 2005-06-10 | 2012-01-31 | Ares Trading S.A. | Postupak za pročišćavanje il-18 vezujućeg proteina |
| CL2008002153A1 (es) | 2007-07-24 | 2009-06-05 | Amgen Inc | Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r. |
| US9812033B2 (en) * | 2013-03-06 | 2017-11-07 | Venkatesh R. Chari | Tactile graphic display |
| EP4493195A1 (en) | 2022-03-15 | 2025-01-22 | Compugen Ltd. | Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer |
| AU2024206448A1 (en) | 2023-01-06 | 2025-08-21 | Lassen Therapeutics, Inc. | Anti-il-18bp antibodies |
| TW202515608A (zh) | 2023-06-26 | 2025-04-16 | 以色列商坎布根有限公司 | Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE231915T1 (de) * | 1992-09-02 | 2003-02-15 | Isis Pharmaceuticals Inc | Beeinflussing der zelladhäsie durch oligonukleotide |
| US7141393B2 (en) * | 1996-12-26 | 2006-11-28 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interleukin-18-receptor proteins |
| TR199902615T2 (xx) * | 1997-03-18 | 2000-03-21 | Basf Aktiengesellschaft | Kortikosteroidlere verilen cevab�n mod�lasyonuna y�nelik metodlar ve kompozisyonlar. |
| IL121860A0 (en) * | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
-
1999
- 1999-07-22 IL IL13104799A patent/IL131047A0/xx unknown
-
2000
- 2000-07-17 NZ NZ516535A patent/NZ516535A/en not_active IP Right Cessation
- 2000-07-17 HU HU0202107A patent/HU228780B1/hu unknown
- 2000-07-17 PT PT00944201T patent/PT1206274E/pt unknown
- 2000-07-17 PL PL353732A patent/PL202477B1/pl unknown
- 2000-07-17 BR BR0012675-6A patent/BR0012675A/pt not_active IP Right Cessation
- 2000-07-17 CZ CZ20020195A patent/CZ302114B6/cs not_active IP Right Cessation
- 2000-07-17 WO PCT/IL2000/000419 patent/WO2001007480A2/en not_active Ceased
- 2000-07-17 ES ES00944201T patent/ES2186596T3/es not_active Expired - Lifetime
- 2000-07-17 CN CNB008106894A patent/CN1173736C/zh not_active Expired - Lifetime
- 2000-07-17 JP JP2001512563A patent/JP4827352B2/ja not_active Expired - Lifetime
- 2000-07-17 TR TR2002/00169T patent/TR200200169T2/ unknown
- 2000-07-17 SK SK88-2002A patent/SK287522B6/sk not_active IP Right Cessation
- 2000-07-17 DK DK00944201T patent/DK1206274T3/da active
- 2000-07-17 DE DE1206274T patent/DE1206274T1/de active Pending
- 2000-07-17 MX MXPA02000838A patent/MXPA02000838A/es active IP Right Grant
- 2000-07-17 DE DE60035049T patent/DE60035049T2/de not_active Expired - Lifetime
- 2000-07-17 AU AU58432/00A patent/AU782478B2/en not_active Expired
- 2000-07-17 AT AT00944201T patent/ATE363288T1/de active
- 2000-07-17 HK HK02108154.3A patent/HK1048248B/zh not_active IP Right Cessation
- 2000-07-17 EP EP00944201A patent/EP1206274B1/en not_active Expired - Lifetime
- 2000-07-17 KR KR1020027000682A patent/KR100682219B1/ko not_active Expired - Lifetime
- 2000-07-17 CA CA2380216A patent/CA2380216C/en not_active Expired - Lifetime
- 2000-07-17 EE EEP200200032A patent/EE04838B1/xx unknown
- 2000-07-17 UA UA2002021472A patent/UA73745C2/uk unknown
- 2000-07-17 EA EA200200189A patent/EA005419B1/ru not_active IP Right Cessation
- 2000-07-21 AR ARP000103786A patent/AR024907A1/es unknown
-
2002
- 2002-01-11 NO NO20020153A patent/NO329827B1/no not_active IP Right Cessation
- 2002-01-16 ZA ZA200200390A patent/ZA200200390B/xx unknown
- 2002-01-16 BG BG106311A patent/BG65800B1/bg unknown
- 2002-01-17 IL IL147675A patent/IL147675A/en unknown
-
2007
- 2007-07-06 US US11/825,548 patent/US7741276B2/en not_active Expired - Fee Related
- 2007-07-13 CY CY20071100938T patent/CY1107932T1/el unknown
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